Table Of Content

CONTENTS VOLUME 125 NUMBER 1 JANUARY 2005 OLAF SPARRE ANDERSEN. Editorial OLAF S. ANDERSEN. A brief history of The Journal of General Physiology DONALD D.F. Loo, BRucE A. HiRAYAMA, ALBERT CHA, FRANCISCO BEZANILLA, and ERNEST M. WRIGHT. Perturbation analysis of the voltage-sensitive conformational changes of the Na* /glucose cotransporter ROBERTA R. ALFIERI, MARA A. BONELLI, PIER GIORGIO PETRONINI, SILVIA DESENZANI, ANDREA CAVAZZONI, ANGELO F. BORGHETTI, and KENNETH P. WHEELER. Leller to the Editor: Hypertonic stress and amino acid deprivation both increase expression of mRNA for amino acid transport system A MARCAL PASTOR-ANGLADA, BENOIT DERIJARD, and F. JAVIER CAsAbo. Letter to the Editor: Mechanisms im- plicated in the response of system A to hypertonic stress and amino acid deprivation still can be different LASZLO CsANApy, Kim W. CHAN, ANGus C. NAIRN, and Davip C. Gapssy. Functional roles of noncon- served structural segments in CFTR’s NH.-terminal nucleotide binding domain MEDHA PATHAK, Lisa Kurtz, FRANCESCO TOMBOLA, and EHup IsAcorr. The cooperative voltage sensor motion that gates a potassium channel ALAINJ . LABRO, ADAM L. Rags, and DirkJ . SNyDERS. Coupling of voltage sensing to channel opening re- flects intrasubunit interactions in Kv channels MICHAEL B. BUTTERWORTH, ROBERT S. EDINGER, JOHN P. JOHNSON, and RAYMOND A. FRIZZELL. Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool VOLUME 125 NUMBER 2 FEBRUARY 2005 Oar S. ANDERSEN. The 58" Annual Meeting and Symposium of the Society of General Physiologists: Lipid Signaling in Physiology. (Organized by Donald W. Hilgemann, Scott D. Emr, and Pietro de Camilli) Paul F. Cranefield Award to Tsung-Yu Chen JeROD DENTON, KEITH NEHRKE, XIAOYAN YIN, REBECCA MORRISON, and KEVIN STRANGE. GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent CIC anion channel WEI WANG, CLAUDIA OLIva, GE Li, ARNE HOLMGREN, CHRISTOPHER Horst LILLIG, and Kevin L. Kirk. Reversible silencing of CFTR chloride channels by glutathionylation BRADLEY AKITAKE, ANDRIY ANISHKIN, and SERGEI SUKHAREV. The “dashpot” mechanism of stretch-dependent gating in MscS ANDRIY ANISHKIN, CHIEN-SUNG CHIANG, and SERGEI SUKHAREV. Gain-of-function mutations reveal ex- panded intermediate states and a sequential action of two gates in MscL. LASZLO CsANADY, DONNA SETO-YOUNG, Kim W. CHAN, CRISTINA CENCIARELLI, BENJAMIN B. ANGEL, JUN Qin, DerREK T. MCLACHLIN, ANDREW N. KRUTCHINSKY, BRIAN T. CHarr, ANGUS C. NaIRN, and Davip C, GapsBy. Preferential phosphorylation of R-domain serine 768 dampens activation of CFTR channels by PKA MARI EKMAN, KATARINA FAGHER, MIA WEDE, KAROLINA STAKEBERG, and ANDERS ARNER. Decreased phosphatase activity, increased Ca** sensitivity, and myosin light chain phosphorylation in urinary blad- der smooth muscle of newborn mice THE JOURNAL OF GENERAL PHYSIOLOGY - VOLUME 125 - 2005. PAGES iii-vi ALEXANDER ZHOLOS, BENJAMIN BECK, VADYM SYDORENKO, LOiC LEMONNIER, PASCAL BORDAT, NATALIA PREVARSKAYA, and ROMAN SkKRYMA. Ca**- and volume-sensitive chloride currents are differentially regu- lated by agonists and store-operated Ca** entry GUANGPING ZHANG and FRANK T. HorriGAn. Cysteine modification alters voltage- and Ca**-dependent gating of large conductance (BK) potassium channels THOMAS H. PEDERSEN, FRANK DE PAOLI, and OLE B. NIELSEN. Increased excitability of acidified skeletal muscle: role of chloride conductance ACKNOWLEDGMENT VOLUME 125 NUMBER 3 MARCH 2005 Curr CHEw Lim and DouGLas B. SAwYER. Commentary: Modulation of cardiac function: titin springs into action DANIEL H. Cox. CommentaryT:h e BKe,, channel’s Ca**-binding sites, multiple sites, multiple ions Norio Fukuba, YIMING WU, PREETHA Narr, and HENK L. GRANZIER. Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner Xu-Hut ZENG, X1A0-MING X1A, and CHRISTOPHERJ . LINGLE. Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites SERGE! S. NIKONOV, LAUREN L. DANIELE, XUEMEI ZHU, CHERYL M. CRAFT, ANAND SWAROOP, and ED- WARD N. PUGH JR. Photoreceptors of Nri mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms RoopE MANNIKKO, SHILPI PANDEY, H. PETER LARSSON, and FREDRIK ELINDER. Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties Hua YANG, HUISHENG Liv, ZHITAO Hu, HONGLIANG ZHu, and Tao Xu. PKC-induced sensitization of Ca**-dependent exocytosis is mediated by reducing the Ca?* cooperativity in pituitary gonadotropes Li Hua and SHARONA E. GORDON. Functional interactions between A’ helices in the Clinker of open CNG channels CORRECTION VOLUME 125 ° NUMBER 4 ° APRIL 2005 SHAI D. SILBERBERG, TsG-Hut CHANG, and KENTONJ .S wARTZ. Secondary structure and gating rearrange- ments of transmembrane segments in rat P2X, receptor channels SILVIA G, BOMPADRE, TOMOHIKO AI, JEONG HAN CHO, XIAOHUI WANG, YOSHIRO SOHMA, MIN LI, and TzyH-CHANG Hwanc. CFTR gating I: characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (AR-CFTR) SitviA G. BOMPADRE, JEONG HAN CHO, XIAOHUI WANG, XIAOQIN ZOU, YOSHIRO SOHMA, MIN LI, and TzyH-CHANG Hwan. CFTR gating II: effects of nucleotide binding on the stability of open states ParRiciO ORIO and RAMON LaTorreE. Differential effects of B1 and B2 subunits on BK channel activity Hyron-Gyu SHIN and ZHE Lu. Mechanism of the voltage sensitivity of IRK1 inward-rectifier K* channel block by the polyamine spermine YUN-MIN ZHENG, QING-SONG WANG, RAKESH RATHORE, WAN-Hul ZHANG, JOSEPH E. MAZURKIEWICZ, VINCENZO SORRENTINO, HAROLD A. SINGER, MICHAEL I. KoTLikorr, and YONG-X1AO WANG. Type-3 ryan- odine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells THE JOURNAL OF GENERAL PHYSIOLOGY - VOLUME 125 - 2005 VOLUME 125 NUMBER 5 MAY 2005 OLAF SPARRE ANDERSEN. Editorial KING-HO CHEUNG, GEORGE P.H. LEUNG, MATTHEW C.T. LEUNG, WINNIE W.C. SHUM, WEN-LIANG ZHOU, and Patrick Y.D. WonG. Cell-cell interaction underlies formation of fluid in the male reproductive tract of the rat MARIA DEL PILAR GOMEZ and Enrico Nasi. On the gating mechanisms of the light-dependent conductance in Pecten hyperpolarizing photoreceptors: does light remove inactivation in voltage-dependent K channels? YA-CHIN YANG and CHUNG-CHIN Kuo. An inactivation stabilizer of the Na* channel acts as an opportu- nistic pore blocker modulated by external Na* NATALYA IVASHIKINA, ROSALIA DEEKEN, SUSANNE FISCHER, PETER ACHE, and RAINER HEDRICH. AKT2/3 subunits render guard cell K* channels Ca** sensitive NAZZARENO D’AvANzO, HEE CHEOL CHO, ILLYA TOLOKH, ROMAN PEKHLETSKI, IGOR TOLOKH, CHRIS Gray, SAUL GOLDMAN, and PETER H. BAckx. Conduction through the inward rectifier potassium channel, Kir2.1, is increased by negatively charged extracellular residues ROBERT E. DEMPSK1I, THOMAS FRIEDRICH, and ERNST BAMBERG. The B subunit of the Na* /K*-ATPase follows the conformational state of the holoenzyme VOLUME 125 NUMBER 6 JUNE 2005 STEPHEN H. Loukin, Mario M.-C. Kuo, X1n-LIANG ZHOu, W. JOHN HAYNES, CHING KUNG, and YOSHIRO SAIMI. Brief Review: Microbial K* channels MicHae- I. Kor.ikorr and N. YVONNE TALLINI. Commentary: Imaging dynamic cellular events in the lung SIDNEY A. SIMON and IvAN E. bE ARAUJO. Commentary: The salty and burning taste of capsaicin Jose F. Perez and MICHAELJ . SANDERSON. The frequency of calcium oscillations induced by 5-HT, ACH, and KC] determine the contraction of smooth muscle cells of intrapulmonary bronchioles Jose F. Perez and MICHAELJ .S ANDERSON. The contraction of smooth muscle cells of intrapulmonary ar- terioles is easel “ai:t he frequency of Ca?* oscillations induced by 5-HT and KCl Vyay LYALL, GERARD L. Heck, TAM-HAo T. PHAN, SHOBHA MUMMALANENI, SHAHBAZ A. MALIK, ANNA K. VINNIKOVA, and JOHN A. DEStIMoNE. Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. I. Effect on TRC volume and Na* flux VyAy LYALL, GERARD L. Heck, TAM-HAO T. PHAN, SHOBHA MUMMALANENI, SHAHBAZ A. MALIK, ANNA K. VINNIKOVA, and JOHN A. DeSimone. Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor. II. Effect on chorda tympani salt responses ANITA M. ENGH and MERRITT MADURE. Cysteine accessibility in CIC-O0 supports conservation of the CIC intracellular vestibule Jit. THoMpsoN and TED BEGENISICH. Two stable, conducting conformations of the selectivity filter in ShakerK * channels Haoyu ZENG, THOMAS M. WEIGER, HONG Fei, ANGELA M. JARAMILLO, and IRWIN B. Levitan. The amino terminus of Slob, Slowpoke channel binding protein, critically influences its modulation of the channel Davip HouicMaN and JUAN I. KorenBroT. The limit of photoreceptor sensitivity: molecular mechanisms of dark noise in retinal cones THE JOURNAL OF GENERAL PHYSIOLOGY - VOLUME 125 - 2005 “te