Table Of Content

CONTENTS VOLUME 117 . NUMBER 1 : JANUARY 2001 OLAF SPARRE ANDERSEN. Editorial MIKKO JUUSOLA and RoGer C. Harpir. Light adaptation in Drosophila photoreceptors: 1. Response dynamics and signaling efficiency at 25°C MIkkO JUUSOLA and RoGer C. Harpie. Light adaptation in Drosophila photoreceptors: Il. Rising temperature increases the bandwidth of reliable signaling J. Kurokawa, H.K. Mororke, and R.S. Kass. TEAI-sensitive KCNQI constructs reveal pore-independent access to KCNE1 in assembed i, channels ANTHONY M. PARADISO, CARLA M.P. RIBEIRO, and RICHARD C. BOUCHER. Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia LEON D. IsLas and FRepJ . SiGworTn. Electrostatics and the gating pore of Shaker potassium channels VOLUME 117 . NUMBER 2 ' FEBRUARY 2001 Ki SOON SHIN, BRAD S. ROTHBERG, and GARY YELLEN. Blocker state dependence and trapping in hyperpolarization-activated cation channels: Evidence for an intracellular activation gate YANHE TONG, GABRIEL S. BRANDT, MING LI, GEORGE SHAPOVALOV, ERIC SLIMKO, ANDREAS KARSCHIN, DENNIS A. DOUGHERTY, and HENry A. LESTER. Tyrosine decaging leads to substantial membrane trafficking dur- ing modulation of an inward rectifier potassium channel CHRISTOPHER R. WEBER, KENNETH S. GINSBURG, KENNETH D. PHILIPSON, THOMAS R. SHANNON, and DONALD M. Bers. Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes DANIEL P. FitZstMons, JI1TANDRAKUMAR R. PATEL, KENNETH S. CAMPBELL, and RICHARD L. Moss. Cooperative mechanisms in the activation dependence of the rate of force development in rabbit skinned skeletal muscle fibers RICCARDO OLCESE, DANIEL SIGG, RAMON LATORRE, FRANCISCO BEZANILLA, and ENRICO STEFANI. A conducting state with properties of a slow inactivated state in a Shaker K* channel mutant D. MARIEN Cortes, Luis G. CUELLO, and EDUARDO PEROzO. Molecular architecture of full-length KesA: Role of cytoplasmic domains in ion permeation and activation gating ANNA Yu BOGDANOVA and MIKKO NIKINMAA. Reactive oxygen species regulate oxygen-sensitive potassium flux in rainbow trout erythrocytes CORRECTION ACKNOWLEDGMEN1 VOLUME 117 . NUMBER 3 . MARCH 2001 JANos K. LANyt and Cxris MILter. The 54th annual meeting and symposium of the Society of General Physiol- ogists: Structures and mechanisms of channels and transport proteins PAUL F. Cranefield Award to Tzyh-Chang Hwang YINGYING Li-SMERIN and KENTONJ . Swartz. Helical structure of the COOH terminus of $3 and its contribu- tion to the gating modifier toxin receptor in voltage-gated ion channels ELENA MOLOKANOVA and RICHARD H. KRAMER. Mechanism of inhibition of cyclic nucleotide—gated channel by protein tyrosine kinase probed with genistein ARTHUR KARLIN. Commentary: SCAM feels the pinch THE JOURNAL OF GENERAL PHYSIOLOGY » VOLUME 117 - 2001 - PAGES iii—v Liviu MOVILEANU, STEPHEN CHELEY, STEFAN HoworkKa, OrIT BRAHA, and HAGAN BAYLEY. Location of a con- striction in the lumen of a transmembrane pore by targeted covalent attachment of polymer molecules XIANG D. TANG, HEATHER DAGGETT, MARKUS HANNER, MARIA L. GARCIA, OWEN B. MCMANUus, NATHAN Brot, HERBERT WEISSBACH, STEFAN H. HEINEMANN, and TosHINORI HOsHI. Oxidative regulation of large con- ductance calcium-activated potassium channels YONGLING ZHU and ANTHONY AUERBACH. Na* occupancy and Mg** block of the Mmethyl-p-aspartate receptor channel YONGLING ZHU and ANTHONY AUERBACH. K* occupancy of the -methyl-b-aspartate receptor channel probed by Mg** block VOLUME 117 . NUMBER 4 . APRIL 2001 Don-ON DanteL MAk, SEAN MCBrIbE, and J. Kevin Foskerr. ATP-dependent adenophostin activation of inositol | .4,5-trisphosphate receptor channel gating: Kinetic implications for the durations of calcium puffs in cells PauL De WerrR, Davip C. Gapssy, and R.F. RAkowskI. Voltage dependence of the apparent affinity for exter- nal Na* of the backward-running sodium pump MicHaer GraBe and Georce Oster. Regulation of organelle acidity® VictTOR A. PANCHENKO, CARLA R. GLASSER, and MARK L. MAyer. Structural similarities between glutamate receptor channels and K* channels examined by scanning mutagenesis® Davip R. PEPPERBERG. Letter to the Editor: Transduction gain in light adaptation of rod photoreceptors S. Nikonov, T.D. LAms, and E.N. PuGH, JR. Letter to the Editor: Photoreceptor sensitivity and kinetics in light adaptation CORRECTION CORRECTION CORRECTION VOLUME 117 : NUMBER 5 ; MAY 2001 Jin. THOMPSON and Tep BreGENISsIcH. Affinity and location of an internal K* ion binding site in ShaKk cheanrnel s BHAVNA TANNA, WILLIAM WELCH, Luc RUEsT, JOHN L. SuTKO, and ALANJ . WILLIAMS. Ryanoid modification of the cardiac muscle ryanodine receptor channel results in relocation of the tetraethylammonium binding site DONGLIN Guo and ZHE Lu. Kinetics of inward-rectifier KX channel block by quaternary alkylammonium ions: Dimension and properties of the inner pore MtA LOrGREN, ULF MALMQvisT, and ANDERS ARNER. Substrate and product dependence of force and shorten- ing in fast and slow smooth muscle JENNIFER S. LANDRY and Davip H. E1tpeELMAN. Commentary: Airway surface liquid: End of the controversy? SUJATHA JAYARAMAN, YUANLIN SONG, and A.S. VERKMAN. Airway surface liquid osmolality measured using fluo- rophore-encapsulated liposomes Davip I. YULE. Commentary: Subtype-specific regulation of inositol 1,4,5-trisphosphate receptors: Controlling calcium signals in time and space Don-ON DANIEL MAK, SEAN McBripe, andJ . Kevin Foskerr. Regulation by Ca** and inositol 1,4,5-trisphosphate (InsP;) of single recombinant type 3 InsP, receptor channels: Ca?* activation uniquely distinguishes types | and 3 InsP, receptors *The online version of this article contains supplemental material. THE JOURNAL OF GENERAL PHYSIOLOGY » VOLUME 117 - 2001 Don-ON DANIEL Mak, SEAN MCBRIDE, andJ . Kevin Fosketr. ATP regulation of recombinant type 3 inositol 1,4,5-trisphosphate receptor gating BRIAN Butron, Luis Reuss, and GUILLERMO A. ALTENBERG. PKC-mediated stimulation of amphibCiFTaR nde - pends on a single phosphorylation consensus site. Insertion of this site confers PKC sensitivity to human CFTR DorIneE M. STARACE and FRANCISCO BEZANILLA. Histidine scanning mutagenesis of basic residues of the S4 seg- ment of the ShakerK * channel i SHAN CHEN, JING WANG, and STEVEN A. SIEGELBAUM. Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN] and HCN2 subunits and basal modulation by cyclic nucleotide VOLUME 117 , NUMBER 6 : JUNE 2001 HAIjUN CHEN and STEFAN H. HEINEMANN. Interaction of scorpion a-toxins with cardiac sodium channels: Bind- ing properties and enhancement of slow inactivation CLAUDIA ALTOMARE, ANNALISA BUCCHI, EVA CAMATINI, MIRKO BARUSCOTTI, CARLO VISCOMI, ANNA MORONI, and Dario DiFRANCESCO. Integrated allosteric model of voltage gating of HCN channels GEORG LAMBERT, IAN C. FORSTER, GERTI STANGE, KATJA KOHLER, JORG BIBER, and HEInt Murer. Cysteine mutagenesis reveals novel structure-function features within the predicted third extracellular loop of the type Ila Na* /P; cotransporter NATALIE WATZKE, ERNST BAMBERG, and CHRISTOF GREWER. Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1 PING ZHANG and CECILIA M. CANnEssa. Single-channel properties of recombinant acid-sensitive ion channels formed by the subunits ASIC2 and ASIC3 from dorsal root ganglion neurons expressed in Xenopus oocytes YUANLIN SONG, SUJATHA JAYARAMAN, BAOXUE YANG, MICHAEL A. MATTHAY, and A.S. VERKMAN. Role of aqua- porin water channels in airway fluid transport, humidification, and surface liquid hydration CHRISTOPHERJ . LINGLE, Xu-Hut ZENG, J.-P. DING, and X1A0- MING X1A. Inactivation of BK channels mediated by the NH, terminus of the B3b auxiliary subunit involves a two-step mechanism: Possible separation of binding and blockade® Xu-Hut ZENG, J.-P. DING, X1A0-MING XIA, and CHRISTOPHER J. LINGLE. Gating properties conferred on BK channels by the B3b auxiliary subunit in the absence of its NHo- and COOH termini ©The online version of this article contains supplemental material. THE JOURNAL OF GENERAL PHYSIOLOGY - VOLUME 117 - 2001 ce