The Journal of Clinical Investigation 1992: Vol 90 Table of Contents

13 Pages·1992·4.1 MB·English

Contents
The Journal of Clinical Investigation
July 1992, Volume 90, Number 1
Perspectives Different localization of two types of endothelin receptor
Transforming growth factor-6 in disease: the dark side of mRNA in microdissected rat nephron segments using
tissue repair. W. A. Border and E. Ruoslahti reverse transcription and polymerase chain reaction assay.
Y. Terada, K. Tomita, H. Nonoguchi, and F. Marumo .
Regular Articles
Thyroid hormone modulation of the hypothalamic growth
Human immunodeficiency virus-infected adherent cell- hormone (GH)-releasing factor—pituitary GH axis in the
derived inhibitory factor (p29) inhibits normal T cell rat. N. Miki, M. Ono, N. Hizuka, T. Aoki, and H. Demura
proliferation through decreased expression of high affinity
Nuclear expression of the 50- and 65-kD rel-related
interleukin-2 receptors and production of interleukin-2. subunits of nuclear factor-«B is differentially regulated in
A. Ammar, Y. Sahraoui, A. Tsapis, A.-M. Bertoli, human monocytic cells. P. A. Kaufman, J. B. Weinberg,
C. Jasmin, and V. Georgoulias and W. C. Greene
Human enterocyte (Caco-2) migration is modulated in Only three mutations account for almost alld efective
vitro by extracellular matrix composition and epidermal alleles causing adenine phosphoribosyltransferase
growth factor. M. D. Basson, I. M. Modlin, and J. A. Madri deficiency in Japanese patients. N. Kamatani, M. Hakoda,
Abnormal sympathetic overactivity evoked by insulin in S. Otsuka, H. Yoshikawa, andS . Kashiwazaki .
the skeletal muscle of patients with essential hypertension. Glomerular actions of a free radical-generated novel
G. Lembo, R. Napoli, B. Capaldo, V. Rendina, prostaglandin, 8-epi-prostaglandin F,,, in the rat. Evidence
G. laccarino, M. Volpe, B. Trimarco, and L. Sacca for interaction with thromboxane A, receptors.
Molecular sieving of albumin by the ascending vasa recta K. Takahashi, T. M.N ammour, M. Fukunaga, J. Ebert,
wall. 7. L. Pallone . J. D. Morrow, L. J. Roberts Il, R. L. Hoover,
and K. F. Badr
Dog mastocytoma cells produce transforming growth factor
beta,. D. W. Pennington, A. R. Lopez, P. S. Thomas, Activin and inhibin in the human adrenaln y
C. Peck, and W. M. Gold Regulation and differential effects in fetal and adult cells.
S. J. Spencer, J. Rabinovici, S. Mesiano, P. C. Goldsmith,
Adenosine triphosphate stimulates phosphoinositide
and R. B. Jaffe
metabolism, mobilizes intracellular calcium, and inhibits
terminal differentiation of human epidermal wenmmenas Identification of a genetic alteration in the code for
S. Pillai and D. D. Bikle . bilirubin UDP-glucuronosyltransferase in the UGT/ gene
complex of a Crigler-Najjar type I patient. J. K. Ritter,
Apolipoprotein (a) gene accounts for greater than 90% of
M. T. Yeatman, P. Ferreira, and I. S. Owens
the variation in plasma lipoprotein (a) concentrations.
E. Boerwinkle, C. C. Leffert, J. Lin, C. Lackner, Detection of enteroviral RNA in idiopathic dilated
G. Chiesa, and H. H. Hobbs cardiomyopathy and other human cardiac tissues.
L. M. Weiss, X.-F. Liu, K. L. —
Multiple deletions of mitochondrial DNA in several tissues
of a patient with severe retarded depression and familial and M. E. Billingham. ,
progressive external ophthalmoplegia. A. Suomalainen, Identification of a common mutation in Finnish patients
A. Majander, M. Haltia, H. Somer, J. ene with nonketotic hyperglycinemia. S. Kure, M. a
M.-L. Savontaus, and L. Peltonen K. Narisawa, K. Tada, andJ . Leisti.
Fibrinogen lima: a homozygous initiation with an Aa- Autoantibodies associated with lupus induced i diverse
arginine-141 to serine substitution associated with extra drugs target a similar epitope in the (H2A-H2B)-DNA
N-glycosylation at Aa-asparagine-139. Impaired fibrin gel complex. R. L. Rubin, S. A. Bell, and R. W. Burlingame
formation but normal fibrin-facilitated plasminogen Differential regulation of multiple hepatic protein tyrosine
activation catalyzed by tissue-type plasminogen activator. phosphatases in alloxan diabetic rats. J. M. Boylan,
H. Maekawa, K. Yamazumi, S.-i. Muramatsu, M. Kaneko, D. L. Brautigan, J. Madden, T. Raven, L. Ellis,
H. Hirata, N. Takahashi, C. L. Arocha-Pifiango, and P. A. Gruppuso
S. Rodriguez, H. Nagy, J. L. Perez- ee
Mineralocorticoid modulation of tena and basolateral
and M. Matsuda ; : an
membrane H*/OH~/HCO; transport processes in the
The loss of GLUT2 expression by glucose-unresponsive 8 rabbit inner stripe of outer medullary collecting duct.
cells of db/db mice is reversible and is induced by the S. R. Hays . Oe Ae Ot Bee 8 ree
diabetic environment. B. Thorens, Y.-J. Wu, J. L. Leahy, Integrin adhesion molecules in the human endometrium.
and G. C. Weir
Correlation with the normal and abnormal menstrual cycle.
Stimulus-dependent secretion of atin proteins from B. A. Lessey, L. Damjanovich, C. Coutifaris,
human neutrophils. N. Borregaard, L. Kjeldsen, A. Castelbaum, S. M. Albelda, and C. A. Buck .
K. Rygaard, L. Bastholm, M. H. Nielsen, H. —
A T cell-dependent experimental liver injury in mice
O. W. Bjerrum, and A. H. Johnsen . inducible by concanavalin A. G. Tiegs, J. Hentschel,
Interactions of surfactant protein D with bacterial and A. Wendel ‘
lipopolysaccharides. Surfactant protein D is an Escherichia
coli-binding protein in bronchoalveolar lavage.
S.-F. Kuan, K. Rust, and E. Crouch .
Predominant activation and expansion of V79-bearing yédT Modification of the apolipoprotein B gene in HepG2 cells
cells in vivo as well as in vitro in Salmonella infection. by gene targeting. R. V. Farese, Jr., L. M. —
T. Hara, Y. Mizuno, K. Takaki, H. Takada, H. Akeda, andS . G. Young.
T. Aoki, M. Nagata, K. Ueda, G. Matsuzaki, Y. Yoshikai,
Recombinant interleukin-12 suppresses the ntitte of
and K. Nomoto MY ee an 6 a a ag immunoglobulin E by interleukin-4 stimulated human
Effect of in vitro metabolic acidosis on luminal Na*/H* lymphocytes. M. Kiniwa, M. Gately, U. Gubler,
exchange and basolateral Na*:HCO; cotransport in rabbit R. Chizzonite, C. Fargeas, and G. Delespesse
kidney proximal tubules. M. Soleimani, G. L. Bizal, Induction of Heme oxygenase is a rapid, protective
T. D. McKinney, and Y. J. Hattabaugh
response in rhabdomyolysis in the rat. K. A. Nath, G. Balla,
The familial hypercholesterolemia (FH)-North Karelia G. M. Vercellotti, J. Balla, H. S. Jacob, M. D. Levitt,
mutation of the low density lipoprotein receptor gene and M. E. Rosenberg .
deletes seven nucleotides of exon 6 and is a common cause
Expression of a missense mutation in the messenger RNA
of FH in Finland. U.-M. Koivisto, H. Turtola,
for B-myosin heavy chain in myocardial tissue in
K. Aalto-Setdlé, B. Top, R. R. Frants, P. T. Kovanen, hypertrophic cardiomyopathy. M. B. Perryman, Q.-t. Yu,
A.-C. Syviinen, and K. Kontula A. J. Marian, A. Mares, Jr., G. Czernuszewicz, Jd. ictetan
The B7/BBI antigen provides one of several utetous R. Hill, andR . Roberts
signals for the activation of CD4* T lymphocytes by human
Chronic blockade of nitric oxide inate’ in the rat
blood dendritic cells in vitro. J. W. Young, L. Koulova,
produces systemic hypertension and glomerular —
S. A. Soergel, E. A. Clark, R. M. Steinman, C. Baylis, B. Mitruka, andA . Deng. ee
and B. Dupont
Human hepatic lipocytes synthesize tissue inhibitor of
Molecular basis of fibrinogen Naples associated with metalloproteinases-1. Implications for regulation of matrix
defective thrombin binding and thrombophilia.
degradation in liver. J. P. Iredale, G. Murphy,
Homozygous substitution of B@ 68 Ala ~ Thr.
R. M. Hembry, S. L. Friedman, and M. J. P. Arthur .
J. Koopman, F. Haverkate, S. T. Lord, J. Grimbergen,
Adenine nucleotides stimulate migration in wounded
and P. M. Mannucci ae naa we <a te
cultures of kidney epithelial cells. S. Kartha
Rapid Publications and F. G. Toback
Transplantation of thymic autoimmune microenvironment Correction .
to severe combined immunodeficiency mice. A new model Correction .
of myasthenia gravis. S. Schénbeck, F. Padberg,
July Author Index
R. Hohlfeld, and H. Wekerle
Human hematopoietic stem cell adherence to cytokines
and matrix molecules. M. W. Long, R. Briddell,
4. W. Walter, E. Bruno, andR . Hoffman .
Contents
The Journal of Clinical Investigation
August 1992, Volume 90, Number 2
Perspectives Evaluation in volunteers of a candidate live oral attenuated
Salmonella typhi vector vaccine. D. M. Hone, C. O. Tacket,
Receptor guanylyl oo S. K.-F. Wong
A. M. Harris, B. Kay, G. Losonsky, and M. M. Levine .
and D. L. Garbers . oa
Bronchodilator action of inhaled nitric oxide in guinea pigs.
Regular Articles
P. M. Dupuy, S. A. Shore, J. M. Drazen, C. Frostell,
An unusual splicing mutation in the HEXB gene is W. A. Hill, and W. M. Zapol .
associated with dramatically different phenotypes in Mechanism of calcium transport stimulated ne
patients from different racial backgrounds. B. McInnes, chlorothiazide in mouse distal convoluted tubule cells.
M. Potier, N. Wakamatsu, S. B. Melancon, M. H. Klavins, F. A. Gesek and P. A. Friedman .
S. Tsuji, andD . J. Mahuran
Receptor-specific induction of insulin-like adn factor ,
Deficiency of coagulation Factor XIII A subunit caused io in human monocytes by advanced glycosylation end
the dinucleotide deletion at the 5’ end of exon III. product-modified proteins. M. Kirstein, C. Aston, R. Hintz,
T. Kamura, T. Okamura, M. Murakawa, H. Tsuda, and H. Vlassara .
T. Teshima, T. Shibuya, M. Harada, and Y. Niho
Peptides related to the iain terminus of hh uman ore
Preservation of insulin mRNA levels and insulin secretion Factor IV with antibacterial activity. R. P. Darveau,
in HIT cells by avoidance of chronic exposure to high J. Blake, C. L. Seachord, W. L. Cosand,
glucose concentrations. R. P. Robertson, H.-J. Zhang, M. D. Cunningham, L. Cassiano-Clough, and G. Maloney
K. L. Pyzdrowski, and T. F. Walseth
Vascular smooth muscle cell hypertrophy vs. hyperplasia.
Restricted heterogeneity of T cell receptor transcripts in Autocrine transforming growth factor-8, expression
rheumatoid synovium. W. V. Williams, Q. Fang, determines growth response to angiotensin II.
D. Demarco, J. VonFeldt, R. B. Zurier, and D. B. Weiner G. H. Gibbons, R. E. Pratt, and V. J. Dzau .
A novel lymphoproliferative/autoimmune syndrome Surface expression of Fey receptor III (CD16) on
resembling murine /pr/gld disease. M. C. Sneller, chemoattractant-stimulated neutrophils is determined by
S. E. Straus, E. S. Jaffe, J. S. Jaffe, T. A. Fleisher, both surface shedding and translocation from intracellular
M. Stetler-Stevenson, and W. Strober storage compartments. M. F. Tosi and H. Zakem .
Retroviral-mediated transfer of the human Neutrophil attractant protein-!-immunoglobulin G
glucocerebrosidase gene into cultured Gaucher bone immune complexes and free anti-NAP-1 antibody in
marrow. J. A. Nolta, X. J. Yu, I. Bahner, and D. B. Kohn normal human serum. J. Sylvester, T. Yoshimura,
Effects of atrial natriuretic peptide and vasopressin on M. Sticherling, J.-M. Schréder, M. Ceska, P. Peichl,
chloride transport in long- and short-looped medullary andE . J. Leonard .
thick ascending limbs. H. eeanende K. Tomita, Cutaneous barrier ontadhetien Gusta cytokine
and F. Marumo . production in the epidermis of mice. L. C. Wood,
Role of 8, and 8, integrins in the adhesion of human S. M. Jackson, P. M. Elias, C. Grunfeld, and K. R. Feingold
CD34" stem cells to bone marrow stroma. J. Teixidé, Monocyte chemoattractant protein-1 (MCP-1) expression
M. E. Hemler, J. S. Greenberger, and P. Anklesaria . in human articular cartilage. Induction by peptide -
Blockade of cardiac sodium channels. Competition regulatory factors and differential effects of dexamethasone
between the permeant ion and antiarrhythmic drugs. and retinoic acid. P. M. — R. Terkeltaub,
M. J. Barber, D. J. Wendt, C. F. Starmer, and A. O. Grant and M. Lotz é
Suppression of metalloproteinase biosynthesis in human Roles of insulin resistance and B-cell dyetenction i| n
alveolar macrophages by interleukin-4. S. Lacraz, L. Nicod, dexamethasone-induced diabetes. A. Ogawa, J. H. Johnson,
B. Galve-de Rochemonteix, C. neuen J.-M. Dayer, M. Ohneda, C. T. McAllister, L. Inman, T. Alam,
and H. G. Welgus and R. H. Unger .
Left ventricular systolic and diastolic dysfunction after An interaction between the human acti ester transfer
infusion of tumor necrosis factor-a in conscious dogs. protein (CETP) and apolipoprotein A-I genes in transgenic
F. D. Pagani, L. S. Baker, C. Hsi, M. Knox, M. P. Fink, mice results in a profound CETP-mediated depression of
and M. S. Visner high density lipoprotein cholesterol levels. 7. Hayek,
T. Chajek-Shaul, A. Walsh, L. B. Agellon, P. Moulin,
Experimental allergic cuenta) in oneiainens A. R. Tall, and J. L. Breslow
monkeys. Quantitation of T cell responses in peripheral
blood. L. Massacesi, N. Joshi, D. Lee-Parritz, Herpes simplex virus-2 (HSV-2) emaneiitin watiate
A. Rombos, N. L. Letvin, and S. L. Hauser . correlates of protection in infants exposed to HSV-2 at
birth. R. L. Ashley, J. Dalessio, S. Burchett, Z. Brown,
Monoclonal antibody C242-Pseudomonas exotoxin A. A
S. Berry, K. Mohan, and L. Corey
specific and potent immunotoxin with antitumor activity
on a human colon cancer xenograft in nude mice.
W. Debinski, B. Karlsson, L. Lindholm, C. B. Siegall,
M. C. Willingham, D. FitzGerald, and I. Pastan
Serum cytokine profiles in experimental human malaria. Rapid Publications
Relationship to protection and disease course after
Localization of cystic fibrosis transmembrane conductance
challenge. R. Harpaz, R. Edelman, S. S. Wasserman,
regulator mRNA in human fetal lung tissue by in situ
M. M. Levine, J. R. Davis, and M. B. Sztein
hybridization. P. B. McCray, Jr., C. L. lena Lenane,
Insulin and glucocorticoid dependence of hepatic 7- and J. M. Snyder
glutamylcysteine synthetase and glutathione synthesis in
Widespread long-term gene ‘nd, to mouse cated
the rat. Studies in cultured hepatocytes and in vivo.
muscles and heart. L. D. Stratford-Perricaudet, I. Makeh,
S. C. Lu, J.-L. Ge, J.K uhlenkamp, and N. Kaplowitz
M. Perricaudet, and P. Briand.
Release of soluble receptors for tumor necrosis factor
Evidence for reactive nitrogen intermediates in killing of
(TNF) in relation to circulating TNF during experimental
staphylococci by human neutrophil cytoplasts. A new
endotoxinemia. G. A. Spinas, U. Keller, and M. Brockhaus
microbicidal pathway for polymorphonuclear leukocytes.
Human neutrophil annexin I promotes granule aggregation S. E. Malawista, R. R. Montgomery, and G. Van Blaricom
and modulates Ca?*-dependent membrane fusion.
Pentoxifylline inhibits interleukin-2-induced toxicity in
J. W. Francis, K. J. Balazovich, J. E. Smolen, D. I. Margolis,
C57BL/6 mice but preserves antitumor efficacy.
and L. A. Boxer . Ay woe ee
M. J. Edwards, B. T. Heniford, E. A. Klar, K. W. Doak,
Low- and high-frequency insulin secretion pulses in normal and F_N. Miller .
subjects and pancreas transplant recipients: role of extrinsic
Fat-storing cells as iain pericytes. Spatial ainea mics
innervation. G. E. Sonnenberg, R. G. Hoffmann,
of agonist-stimulated intracellular calcium transients.
C. P. Johnson, and A. H. Kissebah
M. Pinzani, P. Failli, C. Ruocco, A. Casini, S. Milani,
Adult rat brain is sensitive to thyroid hormone. Regulation E. Baldi, A. Giotti, andP . Gentilini .
of RC3/neurogranin mRNA. M. A. Ifiguez,
A. Rodriguez-Pefia, N. Ibarrola, G. Morreale de Escobar, Determinants of aortic cyclic guanosine snieiiniinais in
hypertension induced by chronic inhibition of nitric oxide
and J. Bernal.
synthase. J.-F. Arnal, L. Warin, and J.-B. Michel .
Cloning of a eenbeiiuaes DNA —o for the 100-kD
Absence of hereditary p53 mutations in 10 familial
antigenic protein of the PM-Scl autoantigen. Q. Ge,
leukemia pedigrees. C. A. Felix, D. D'Amico,
M. B. Frank, C. O’Brien, and I. N. Targoff .
T. Mitsudomi, M. M. Nau, F. P. Li, J. F. Fraumeni, Jr.,
Interleukin-| receptor antagonist in normal and psoriatic D. E. Cole, J. McCalla, G. H. Reaman, J. Whang-Peng,
epidermis. C.H ammerberg, W. P. Arend, G. J. Fisher, T. Knutsen, J. D. Minna, and D. G. Poplack . :
L. S. Chan, A. E. Berger, J. S. Haskill, J. J. Voorhees,
Polymerase chain reaction localization of constitutive nitric
andK . D. Cooper
oxide synthase and soluble guanylate cyclase messenger
Disease expression and molecular genotype in congenital RNAs in microdissected rat nephron segments. Y. Terada,
adrenal hyperplasia due to 21-hydroxylase deficiency. K. Tomita, H. Nonoguchi, and F. Marumo
P. W. Speiser, J. Dupont, D. Zhu, J. Serrat, M. Buegeleisen,
An intact cysteine-rich domain is required for hiabiiinin
M.-T. Tusie-Luna, M. Lesser, M. I. New, and P. C. White
function. R. D. Bies, C. T. Caskey, andR . Fenwick .
Endogenous cortisol regulates immunoglobulin E-
Both immunity and hyperresponsiveness to Pneumocystis
dependent late phase reactions. R. F. Herrscher, C. Kasper,
carinii result from transfer of CD4* but not CD8* T cells
and T. J. Sullivan
into severe combined emcees mice. J. B. Roths
Interaction between a,-adrenergic and angiotensin II and C. L. Sidman
systems in the control of glomerular hemodynamics as
Nitric oxide production in host-versus-graft and graft-
assessed by renal micropuncture in the rat. S. C. Thomson,
F. B. Gabbai, B. J. Tucker, and R. C. Blantz versus-host reactions in the rat. J. M. Langrehr, N. Murase,
P. M. Markus, X. Cai, P. Neuhaus, W. Schraut,
Differing roles for platelet-activating factor during R. L. Simmons, andR . A. Hoffman .
inflammation of the lung and subarachnoid space. The
August Author Index
special case of Streptococcus pneumoniae. C. Cabellos,
D. E. MaclIntyre, M. Forrest, M.— —— S. Prasad,
and E. Tuomanen 7
Contents
The Journal of Clinical Investigation
September 1992, Volume 90, Number 3
Perspectives A fatty neuropeptide. Potential drug for noninvasive
impotence treatment in a rat model. J. Gozes and M. Fridkin
Molecular genetics of the cutaneous basement membrane
zone. Perspectives on epidermolysis bullosa and other Differential pp60°** activity in well and poorly differentiated
blistering skin diseases. J. Uitto and A. M. Christiano human colon carcinomas and cell lines. 7. K. Weber,
G. Steele, and I. C. Summerhayes
Regular Articles
Diminished Clostridium difficile toxin A cnutinity in
The tissue distribution of tumor necrosis factor biosynthesis newborn rabbit ileum is associated with decreased toxin A
during endotoxemia. B. P. Giroir, J. H. Johnson, T. Brown, receptor. R. Eglow, C. Pothoulakis, S. Itzkowitz, E. J. Israel,
G. L. Allen, andB . Beutler . C. J. O’Keane, D. Gong, N. Gao, Y. L. Xu, W. A. Walker,
Airway cooling and rewarming. The — reaction sequence andJ . T. LaMont
in exercise-induced asthma. J. A. Gilbert Regulation of Ca”* influx in» mpeteld calle. Role ofs m
and E. R. McFadden, Jr. membrane potential, inositol phosphates, cytosolic free [Ca?*],
and filling state of intracellular Ca** stores.
Bromocriptine inhibits sepegineaieneunain mRNA ond
ACTH precursor secretion in small cell lung cancer cell lines. N. Demaurex, W. Schlegel, P. Varnai, G. Mayr, D. P. Lew,
W. E. Farrell, A. J. L. Clark, M. F. Stewart, S. R. a and K.-H. Krause
and A. White. Transfection of a Gescuned showhetidetincdtebenchesed
Combined mannitol ou Otmanion ou for folate-binding protein complementary DNA provides cells
myohemoglobinuric renal injury and oxidant tubular stress. with the ability to survive in low folate medium. C. A. Luhrs,
C. A. Raskin, R. Durbin, B. Wu, E. Sadasivan, W. McAllister,
Mechanistic and therapeutic implications. R. A. Zager .
andS . P. Rothenberg.
Recognition by recombinant autoimmune thyroid disease-
Mechanisms whereby exteaceliaien etenatine 3S -
derived Fab fragments of a dominant conformational epitope
monophosphate inhibits phosphate transport in cultured
on human thyroid peroxidase. S. Portolano,
opossum kidney cells and in rat kidney. Physiological
G. D. Chazenbalk, P. Seto, J. S. Hutchison, B. eaten
andS . M. McLachlan . ; implication. G. Friedlander, S. Couette, C. Coureau,
and C. Amiel.
Endothelium-dependent inhibition ofN a’ K* ATPase activity
in rabbit aorta by hyperglycemia. Possible role of Disorders of bile acid matabelions inn chatanee oiheene
disease. F. Berr, E. Pratschke, S. Fischer, andG . Paumgartner
endothelium-derived nitric oxide. S. Gupta, I. Sussman,
C. S. McArthur, K. Tornheim, R. A. Cohen, Electroneutral K*/HCO; cotransport in cells of medullary
and N. B. Ruderman . thick ascending limb of rat kidney. F. Leviel, P. Borensztein,
P. Houillier, M. Paillard, and M. Bichara
Intracellular ATP can regulate un ennteies tone via
ATP-sensitive K* channels in the rabbit. J. N. Lorenz, Effects of interferon-y on nitric oxide synthase activity ond
J. Schnermann, F. C. Brosius, J. P. Briggs, and P. B. Furspan endothelin-| production by vascular endothelial cells.
S. Lamas, T. Michel, T. Collins, B. M. Brenner,
Prevention of diabetes in nonobese diabetic mice by dendritic
and P. A. Marsden .
cell transfer. M. J. Clare-Salzler, J. Brooks, A. Chai,
K. Van Herle, and C. Anderson Leukemia inhibitory factor is emma in conten on
synovium and can contribute to the pathogenesis of arthritis.
On the mechanism of parathyroid heseees ehenteten of
M. Lotz, T. Moats, and P. M. Villiger .
calcium uptake by mouse distal convoluted tubule cells.
F. A. Gesek and P. A. Friedman . The K1 capsule is the critical determinant in the Qe
of Escherichia coli meningitis in the rat. K. S. Kim,
Platelet-activating factor-mediated eames iuaiies
H. Itabashi, P. Gemski, J. Sadoff, R. L. Warren,
in human B lymphocytes is regulated through a pertussis- and
andA . S. Cross .
cholera toxin-sensitive pathway. B. D. Mazer, H. Sawami,
A. Tordai, and E. W. Gelfand. Live Borrelia burgdorferi outeentieliesa ctivate interleukin-1
gene expression and protein synthesis over the interleukin-|
Angiotensin II receptor blockade limits gente tinej ury in
receptor antagonist. L. C. Miller, S. Isa, E. Vannier,
rats with reduced renal mass. R. A. Lafayette, G. —
S. K. Park, and T. W. Meyer K. Georgilis, A. C. Steere, and C. A. Dinarello .
Serum neutralizing antibody response to the vacuolating
Enhanced production of monocyte aumemes gute 1
in rheumatoid arthritis. A. E. Koch, S. L. Kunkel, cytotoxin of Helicobacter pylori. T. L. Cover, P. Cao,
L. A. Harlow, B. Johnson, H. L. Evanoff, G. K. Haines, U. K. Murthy, M. S. Sipple, and M. J. Blaser
M. D. Burdick, R. M. Pope, andR . M. Strieter. Autoantibodies against the amino-terminal cadherin- like
binding domain of pemphigus vulgaris antigen are pathogenic.
Lower sedentary metabolic rate in women compared a
M. Amagai, S. Karpati, R. Prussick,
men. R. Ferraro, S. Lillioja, A.-M. Fontvieille, R. —
V. Klaus-Kovtun, and J. R. Stanley . a nae ere
C. Bogardus, and E. Ravussin.
Expression of dihydropyridine receptor (Ca”* channel) and
Extensive posttranscriptional deletion of the oti sequences
for part of nucleotide-binding fold | in respiratory epithelial calsequestrin genes in the myocardium of patients with end-
stage heart failure. 7. Takahashi, P. D. Allen, R. V. Lacro,
mRNA transcripts of the cystic fibrosis transmembrane A. R. Marks, A. R. Dennis, F. J. Schoen, W. Grossman,
conductance regulator gene is not associated with the clinical
J. D. Marsh, andS . Izumo .
manifestations of cystic fibrosis. C.-S. Chu, B. C. Trapnell, S.
M. Curristin, G. R. Cutting, and R. G. Crystal. Percutaneous arterial gene transfer in a rabbit meted.
Efficiency in normal and balloon-dilated atherosclerotic
Anoxia-hyperoxia induces monocyte-derived interteukia-8. arteries. G. Leclerc, D. Gal, S. Takeshita, S. Nikol, L. Weir,
A. P. Metinko, S. L. Kunkel, T. J. Standiford,
and J.M .Isner .
and R. M. Strieter .
Control of human B cell tumor> growth iinn severe combined
Molecular genetics of seeroid Sa:s utamen 2 jtine.
immunodeficiency mice by monoclonal anti-B cell antibodies.
A. E. Thigpen, D. L. Davis, A. Milatovich, B. B. Mendonca, A. Durandy, N. Brousse, F. peep G. De Saint Basile,
J. Imperato-McGinley, J. E. Griffin, U. Francke, A. M. Fischer, and A. Fischer . ;
J. D. Wilson, andD . W. Russell.
Mechanism of resistance to complement-mediated killing of Cellular immune reactivity to recombinant OspA and flagellin
bacteria encoded by the Sa/monella typhimurium virulence from Borrelia burgdorferi in patients with Lyme borreliosis.
plasmid gene rck. E. J. Heffernan, S. Reed, J. Hackett, Complexity of humoral and cellular immune responses.
J. Fierer, C. Roudier, and D. Guiney A. Krause, G. R. Burmester, A. Rensing, C. Schoerner,
Binding of uropathogenic Escherichia coli R45 to glycolipids U. E. Schaible, M. M. Simon, P. Herzer, M. D. Kramer,
extracted from vaginal epithelial cells is dependent on histo- and R. Wallich
blood group secretor status. A. Stapleton, E. Nudelman, Phagocytosis of sensaiend Parndeenes: aeruginosa we
H. Clausen, S.-i. Hakomori, and W. E. Stamm murine macrophages is a two-step process requiring glucose.
Association of amino acid sequences in the HLA-DQB! ‘first D. P. Speert and S. Gordon . ;
domain with the antitopoisomerase I autoantibody response Cell retargeting by bispecific aunetund oetien. Seite
in scleroderma (progressive systemic sclerosis). J. D. Reveille, of bypass of intratumor susceptibility to cell lysis in human
E. Durban, M. J. MacLeod-St. Clair, R. Goldstein, melanoma. P. Nisticd, R. Mortarini, L. B. De Monte,
R. Moreda, R. D. Altman, andF . C. Arnett A. Mazzocchi, M. Mariani, F. Malavasi, G. Parmiani,
Cultured human synovial fibroblasts rapidly metabolize kinins P. G. Natali, and A. Anichini
and neuropeptides. J. M. Bathon, D. Proud, Rapid Publications
S. Mizutani, and P. E. Ward
Molecular cloning and preliminary amasadauien ofa nove Lupus anticoagulant activity of autoimmune antiphospholipid
antibodies is dependent upon 8,-glycoprotein I. R. A. S.
cytoplasmic antigen recognized by myasthenia gravis sera.
T. Gordon, B. Grove, J. C. Loftus, T. O’Toole, R.M cMillan, Roubey, C. W. Pratt, J. P. Buyon,
and J. B. Winfield.
J. Lindstrom, and M. H. Ginsberg ;
Regulation of catalase in Neisseria iaiieene Effects of Induction of antiphospholipid eunemuiinedion vm
oxidant stress and exposure to human neutrophils. immunization with 82 glycoprotein I (apolipoprotein H).
H.-y. Zheng, D. J. Hassett, K. Bean, and M. S. Cohen A. E. Gharavi, L. R. Sammaritano, J. Wen, and K. B. Elkon
Synthesis and release of interleukin | by reoxygenated human Advanced glycosylation endproducts block the
mononuclear phagocytes. S. Koga, S.O gawa, K. Kuwabara, antiproliferative effect of nitric oxide. Role in the vascular and
J. Brett, J. A. Leavy, J. Ryan, Y. Koga, J. Plocinski, renal complications of diabetes mellitus. M. Hogan,
W. Benjamin, D. K. Burns, andD . Stern . A. Cerami, and R. Bucala
Expression and developmental regulation of Na’, K* Nitric oxide, an endothelial cell _w duster, inhibits
adenosine triphosphatase in the rat small intestine. neutrophil superoxide anion production via a direct action on
B. V. Zemelman, W. A. Walker, and S.-h. W. Chu the NADPH oxidase. R. M. Clancy, J. Leszczynska-Piziak,
andS . B. Abramson
Organ distribution of the three rat endothelin messenger
RNAs and the effects of ischemia on renal gene expression. Human pastatiebielfpessneability-Inessesing onde _ a
J. D. Firth andP . J. Ratcliffe recombinant NH,-terminal fragment cause killing of serum-
resistant Gram-negative bacteria in whole blood and inhibit
Genetic linkage of recessive dystrophic oituenies _—
tumor necrosis factor release induced by the bacteria. J. Weiss,
to the type VII collagen gene. A. Hovnanian, P. Duquesnoy,
P. Elsbach, C. Shu, J. Castillo, L. Grinna, A. Horwitz,
C. Blanchet-Bardon, R. G. Knowlton, S. Amselem,
and G. Theofan .
M. Lathrop, L. Dubertret, J. Uitto, and M. Goossens .
Inhibition of the oomsinent sates ~— conan he
Antibodies to T- and L-isoforms of the cytoskeletal protein,
the galactose-specific adhesin of Entamoeba histolytica.
fimbrin, in patients with systemic lupus erythematosus.
L. L. Braga, H. Ninomiya, J. J.M cCoy, S. Eacker, T. Wiedmer,
E. C. De Mendonca Neto, A. Kumar, N. A. Shadick,
C. Pham, S. Wood, P. J. Sims, and W. A. Petri, Jr.
A.-M. Michon, P. Matsudaira, R. B. Eaton, P. Kumar,
andP . H. Schur . Lysophosphatidylcholine, a component of atherogenic
lipoproteins, induces mononuclear leukocyte adhesion
Messenger RNA expression ond wares of endothelin-| l
molecules in cultured human and rabbit arterial endothelial
along rat nephron segments. K. Ujiie, Y. Terada,
cells. N. Kume, M. I. Cybulsky, amd M. A. Gimbrone, Jr.
H. Nonoguchi, M. Shinohara, K. Tomita, and F. Marumo
Endothelial production of C-type natriuretic peptide and its
Mucopolysaccharidosis type IVA. N-acetylgalactosamine-6-
marked augmentation by transforming growth factor-@.
sulfate sulfatase exonic point mutations in classical Morquio
Possible existence of “vascular natriuretic peptide system.”
and mild cases. S. Fukuda, S. Tomatsu, M. Masue, S. Suga, K. Nakao, H. Itoh, Y. Komatsu, YS. ean
K. Sukegawa, H. Iwata, T. Ogawa, Y. Nakashima, T. Hori,
N. Hama, and H. Imura .
A. Yamagishi, Y. Hanyu, K. Morooka, T. Kiman,
T. Hashimoto, and T. Orii . The serpin-enzyme complex (SEC) |re ceptor medians the
neutrophil chemotactic effect of a-, antitrypsin-elastase
Interleukin-7 is a growth factor for stew nshene. oie,
complexes and amyloid-f peptide. G. Joslin, G. L. Griffin,
A. Dalloul, L. Laroche, M. Bagot, M. D. Mossalayi,
A. M. August, S. Adams, R. J. Fallon, R. M. Senior,
C. Fourcade, D. J. Thacker, D. E. Hogge, H. Merle-Béral,
and D. H. Perlmutter . :
P. Debré, andC . Schmitt
Filamentous, helical, and winter microstructures s Gases
Purification and partial sequencing oft he uiiaree teutionn
cholesterol crystallization from hile. Evidence that cholesterol
RA33 shows that it is indistinguishable from the A2 protein
does not nucleate classic monohydrate plates. F. M. Konikoff,
of the heterogeneous nuclear ribonucleoprotein complex.
D. S. Chung, J. M. Donovan, D. M. Small, and M. C. Carey
G. Steiner, K. Hartmuth, K. Skriner, 1. Maurer-Fogy,
A. Sinski, E. Thalmann, W. Hassfeld, A. Barta, Hypertrophic gastropathy resembling Menetrier’s disease in
and J. Smolen transgenic mice overexpressing transforming growth factor a
in the stomach. H. Takagi, C. ate R. —
Enhanced membrane bindinn ofm nnsetthation'st o ames
and G. Merlino . ;
keratinocytes of systemic lupus erythematosus patients after
ultraviolet B/ultraviolet A irradiation. 7. D. Golan, Antiatherogenic effects fvL -arginine in the
K. B. Elkon, A. E. Gharavi, and J. G. Krueger . hypercholesterolemic rabbit. J. P. Cooke, A. H. Singer,
P. Tsao, P. Zera, R. A. Rowan, and M. E. Billingham
September Author Index .
Contents
The Journal of Clinical investigation
October 1992, Volume 90, Number 4
Presidential Address Dietary cholesterol increases transcription of the human
cholesteryl ester transfer protein gene in transgenic mice.
Presidential Address to the American Society for Clinical
Dependence on natural flanking sequences. X. C. Jiang,
Investigation, Baltimore, Maryland, 2-6 May 1992. E. Benz L. B. Agellon, A. Walsh, J. L. Breslow, and A. Tall
Regular Articles Modulation of airway inflammation in cystic fibrosis. In vivo
A unique recombination event resulting in a suppression of interleukin-8 levels on the respiratory epithelial
surface by aerosolization of recombinant secretory
C4A+Q0,C4B+Q0 double null haplotype. M. B. Fasano, J.
A. Winkelstein, T. LaRosa, W. B. Bias, and R. H. McLean leukoprotease inhibitor. N. G. McElvaney, H. Nakamura,
P. Birrer, C. A. Hébert, W. L. Wong, M. Alphonso,
Type 1 hereditary tyrosinemia. Evidence for molecular J. B. Baker, M. A. Catalano, and R. G. Crystal .
heterogeneity and identification of a causal mutation in a
French Canadian patient. D. Phaneuf, M. Lambert, Cellular basis for blunted volume expansion natriuresis in
R. Laframboise, G. Mitchell, F. Lettre, and R.M . Tanguay experimental nephrotic syndrome. J.-P. Valentin, C. Qiu,
W. P. Muldowney, W.-Z. Ying, D. G. Gardner,
Mitochondrial oxidative stress after carbon monoxide hypoxia and M. H. Humphreys
in the rat brain. J. Zhang and C. A. Piantadosi.
Degradation of endogenous eestestel cellw all eines byt he
Identification of a mutation in the coding sequence of the
muralytic enzyme mutanolysin prevents hepatobiliary injury
human thyroid peroxidase gene causing congenital goiter.
in genetically susceptible rats with experimental intestinal
M. J. Abramowicz, H. M. Targovnik, V. Varela, P. Cochaux, bacterial overgrowth. S. N. Lichtman, E. E. Okoruwa, J. Keku,
L. Krawiec, M. A. Pisarev, F. V. E. Propato, G. Juvenal, J. H. Schwab, and R. B. Sartor
H. A. Chester, andG . Vassart.
Increased rate of gluconeogenesis in type r diabetes mellitus.
Mannose-induced dysmorphogenesis ofm atneghate oiee. A °C nuclear magnetic resonance study. J. Magnusson,
Role of proteoglycans and adenosine triphosphate. Z. Z. Liu, D. L. Rothman, L. D. Katz, R. G. Shulman,
F. A. Carone, T. M. Dalecki, B. Lelongt, E. I. Wallner, and G.I. Shulman .
and Y. S. Kanwar ;
Inhibition of apical Na* chennete'i n rabbit cortical collecting
Combined enzyme defect of mnochontelel fatty acid tubules by basolateral prostaglandin E, is modulated by protein
oxidation. S. Jackson, R. Singh Kler, K. Bartlett, H. Briggs,
kinase C. B. N. Ling, K. E. Kokko, and D. C. Eaton . ;
L. A. Bindoff, M. Pourfarzam, D. Gardner-Medwin,
and D. M. Turnbull Neutrophil induced oxidative injury of cardiac myocytes.
A compartmented system requiring CD11b/CD18-ICAM-1
Augmented production of hepato uote sahagenis seenien adherence. M. L. Entman, K. Youker, T. Shoji, G. Kukielka,
by preadipocytes from massively obese persons.
S. B. Shappeill, A. A. Taylor, and C. W. Smith .
K. Teichert-Kuliszewska, B. S. Hamilton, M. Deitel,
and D. A. K. Roncari . Major histocompatibility complex haplotypes and
complement C4 alleles in systemic lupus erythematosus.
Mechanisms underlying Samenet trafficking of digas Results of a multicenter study. K. Hartung, M. P. Baur,
progenitors in chronic myelogenous leukemia. Decreased R. Coldewey, M. Fricke, J. R. Kalden, H. J. Lakomek,
adhesion to stroma and fibronectin but increased adhesion to H. H. Peter, D. Schendel, P. M. Schneider, S. A. Seuchter,
the basement membrane components laminin and collagen W. Stangel, and H. R. G. Deicher
type IV. C. M. Verfaillie, J. B.M cCarthy, and P. B. McGlave
Overexpression of the epidermal growth factor auaie in
Epidermal keratinocyte-derived basophil promoting activity. human pancreatic cancer is associated with concomitant
Role of interleukin 3 and soluble CD23. A. H. Dalloul, increases in the levels of epidermal growth factor and
M. Arock, C. Fourcade, J. Y. Béranger, P. Jaffray, P. Debré, transforming growth factor alpha. M. Korc, B. Chandrasekar,
and M. D. Mossalayi . Y. Yamanaka, H. Friess, M. Buchler, and H. G. Beger .
L-Arginine improves cndotialinen-depentess waseditetes in Influence of experimental hyperglycemia on microvascular
hypercholesterolemic humans. M. A. Creager, S. J. Gallagher, blood perfusion of paricreatic islet isografts. M. D. Menger,
X. J. Girerd, S. M. Coleman, V. J. Dzau, and J. P. Cooke .
P. Vajkoczy, R. Leiderer, S. Jager, and K. Messmer .
Effect of streptozotocin-induced diabetes on GLUT-4 Cellular responses to steroids in the enhancement of Na*
phosphorylation in rat adipocytes. N. Begum and B. Draznin transport by rat collecting duct cells in culture. Differences
Prolonged exposure of human pancreatic islets to high glucose between glucocorticoid and mineralocorticoid hormones.
concentrations in vitro impairs the 8-cell function. J. R. Laplace, R. F. Husted, and J. B. Stokes
D. L. Eizirik, G. S. Korbutt, and C. Hellerstrém Spontaneous production of transforming growth factor-82 ~
Human skin levels of retinoic acid and cytochrome P-450— primary cultures of bronchial epithelial cells. Effects on cell
derived 4-hydroxyretinoic acid after topical application of behavior in vitro. O. Sacco, D. Romberger, A. Rizzino,
retinoic acid in vivo compared to concentrations required to J. D. Beckmann, S. I. Rennard, and J. R. Spurzem
stimulate retinoic acid receptor—mediated transcription in Glucose transport in human skeletal muscle cells in culture.
vitro. E. A. Duell, A. Astrém, C. E. M.w n P. Chambon, Stimulation by insulin and metformin. V. Sarabia, L. Lam,
and J. J. Voorhees . E. Burdett, L. A. Leiter, and A. Klip ‘
Maturation of aldose ihe expression in the enents rat Evidence for defective transmembrane devdinn |in B cells
inner medulla. G. J. Schwartz, B. J. Zavilowitz, A. D. Radice, from patients with Wiskott—Aldrich syndrome. H.-U. Simon,
A. Garcia-Perez, and J.M . Sands G. B. Mills, S. Hashimoto, and K. A. Siminoviich . 3
Human intrahepatic biliary epithelial cells proliferate iin vitro Human melanoma cells derived from lymphatic metastases
in response to human hepatocyte growth factor. R. Joplin, use integrin a,8, to adhere to lymph node vitronectin. J. Nip,
T. Hishida, H. Tsubouchi, Y. Daikuhara, R. nie H. Shibata, D. J. Loskutoff, D. A. Cheresh, and P. Brodt
J. M. Neuberger, and A. J. Strain
Eosinophils express interleukin 5 and granulocyte On the interaction of IgG subclasses with the low affinity
macrophage-colony-stimulating factor mRNA at sites of FceyRIla (CD32) on human monocytes, neutrophils, and
allergic inflammation in asthmatics. D. H. Broide, platelets. Analysis of a functional polymorphism to human
M. M. Paine, andG . S. Firestein. IgG2. P. W. H. I. Parren, P. A. M. Warmerdam,
Renal tubular responsiveness to atrial natriuretic s peptide in L. C. M. Boeije, J. Arts, N. A. C. Westerdaal, A. Vlug,
sodium-retaining chronic caval dogs. A possible role for kinins P. J. A. Capel, L. A. Aarden, and J. G. J. van de Winkel
and luminal actions of the peptide. L. Legault, P. Cernacek, Effects of uninephrectomy on electrical properties of the
M. Levy, E. Maher, and D. Farber . cortical collecting duct from rabbit remnant kidneys. S. Ebata,
Modulation of cisplatin sensitivity and gua rate of an S. Muto, and Y. Asano
ovarian carcinoma cell line by bombesin and tumor necrosis Myasthenia gravis. CD4* T uhune on the euteyenie OYy
factor-a. S. Isonishi, A. P. Jekunen, D. K. Hom, A. Eastman, subunit of human muscle acetylcholine receptor. M. P. Protti,
P. S. Edelstein, F. B. Thiebaut, R. D. Christen, A. A. Manfredi, X. D. Wu, L. Moiola, M. W. M. Dalton,
andS . B. Howell J. F. Howard, Jr., andB . M. Conti-Tronconi
Chronic hyperkalemia impairs ammonium transport and Insulin resistance in obese Zucker rat (fa/fa) skeletal aundeii s
accumulation in the inner medulla of the rat. associated with a failure of glucose transporter translocation.
T. D. DuBose, Jr., andD . W. Good . P. A. King, E. D. Horton, M. F. Hirshman, and E. S. Horton
Rabbit aortic smooth muscle cells express inducible Differential expression of Op18 phosphoprotein during
macrophage scavenger receptor messenger RNA that is absent human thymocyte maturation. J. Gratiot-Deans, D. Keim,
from endothelial cells. P. E. Bickel and M. W. Freeman J. R. Strahler, L. A. Turka, and S.H anash :
Endothelin inhibits vasopressin-stimulated water permeability Expression of transforming growth factor-61 is inane in
in rat terminal inner medullary collecting duct. S. P. Nadler, human vascular restenosis lesions. S. Nikol, J. M. Isner,
J. A. Zimpelmann, and R. L. Hébert ‘ J. G. Pickering, M. Kearney, G. Leclerc, and L. Weir
Characterization of the cDNA of a broadly reactive Granulosa cell-derived insulin-like growth factor (IGF)
neutralizing human anti-gp!20 monoclonal antibody. binding proteins are inhibitory to IGF-I hormonal action.
W. A. Marasco, J. Bagley, C. Zani, M. Posner, L. Cavacini, Evidence derived from the use of a truncated IGF-I analogue.
W. A. Haseltine, and J. Sodroski . E. Y. Adashi, C. E. Resnick, E. Ricciarelli, A. Hurwitz,
Human fibroblasts synthesize elevated itll toni E. Kokia, C. Tedeschi, L. Botero, E. R. Hernandez,
matrix proteins in response to interleukin 4. R. G. Rosenfeld, C. Carlsson-Skwirut, and G. L. Francis
A. E. Postlethwaite, M. A. Holness, H. Katai, and R. Raghow
Rapid Publications
Activation of infectious virus from latent human
immunodeficiency virus infection of monocytes in vivo. Neutrophil-dependent acute lung injury. Requirement for
J. A. Mikovits, N. C. Lohrey, R. Schulof, J. Courtless P-selectin (GMP-140). M. S. Mulligan, M. J. Polley,
andF . W. Ruscetti . R. J. Bayer, M. F. Nunn, J. C. Paulson, and P. A. Ward
Cytokine regulation of benes — fibroblast Seiten Microfilament-dependent activation of Na*/K*/2CI-
(hyaluronic acid) production. Evidence for cytokine-regulated cotransport by cAMP in intestinal epithelial monolayers.
hyaluronan (hyaluronic acid) degradation and human lung J. B. Matthews, C. S. Awtrey, and J. L. Madara ‘
fibroblast-derived hyaluronidase. P. M. Sampson,
Thrombin receptor expression in normal and atherosclerotic
C. L. Rochester, B. Freundlich, andJ . A. Elias .
human arteries. N. A. Nelken, S. J. Soifer, J.O ’Keefe,
Lipoprotein lipase-mediated uptake and degradation of lew T.-K. H. Vu, I. F. Charo, andS . R. Coughlin ’
density lipoproteins by fibroblasts and macrophages.
Requirement of pp60°** expression for osteoclasts to fem
S. C. Rumsey, J. C. Obunike, Y. Arad, R. J. Deckelbaum,
ruffled borders and resorb bone in mice. B. F. Boyce,
and I. J. Goldberg . :
T. Yoneda, C. Lowe, P. Soriano, and G. R. Mundy
Thrombospondin cooperates with CD36 ont the vitronectin
Epiligrin, the major human keratinocyte integrin ligand, is a
receptor in macrophage recognition of neutrophils undergoing
target in both an acquired autoimmune and an inherited
apoptosis. J. Savill, N.H ogg, Y. Ren, and C. Haslett . subepidermal blistering skin disease. N. Domloge-Hultsch,
Evidence for tissue-specific activation of renal angiotensinogen W. R. Gammon, R. A. ae S. G. Gil, W. G. Carter,
mRNA expression in chronic stable experimental heart failure. and K. B. Yancey Sat its ae a
H. Schunkert, J. R. Ingelfinger, A. T. Hirsch, S.-S. Tang,
October Author Index .
S. E. Litwin, C. E. Talsness, andV . J. Dzau . ;
Correction .
Isolation and partial characterization of a specific hi
fetoprotein receptor on human monocytes. Y. Suzuki,
C. Q. Y. Zeng, and E. Alpert
Contents
The Journal of Clinical Investigation
November 1992, Volume 90, Number 5
Perspectives Importance of peripheral insulin levels for insulin-induced
suppression of glucose production in depancreatized dogs.
Cancer risks from germline P53 mutations. 7. Frebourg
and S. H. Friend p A. Giacca, S. J. Fisher, Z. Q. Shi, R. — H. L. A. Lickley,
and M. Vranic
Regular Articles Mesenchymal cells isolated hereasc ute tone iina jury manifest an
Cytomegalovirus induction of tumor necrosis factor-a by enhanced proliferative phenotype. B. Chen, V. Polunovsky,
human monocytes and mucosal macrophages. P. D. Smith, J. White, B. Blazar, R. Nakhleh, J. Jessurun, M. Peterson,
S. S. Saini, M. Raffeld, J. F. Manischewitz, and S. M. Wahl and P. Bitterman
Modulation of transforming growth factor-81 antiproliferative Effects of transforming one factor-8 on murine : astrocyte
effects on endothelial cells by cysteine, cystine, and N- glutamine synthetase activity. Implications in neuronal injury.
acetylcysteine. S. K. Das, A. C. White, and B. L. Fanburg . C. C. Chao, S. Hu, M. Tsang, J. Weatherbee, T. W. Molitor,
W. R. Anderson, and P. K. Peterson.
Paradoxical withdrawal of reflex vasoconstriction as a cause of
Cardiac contractile dysfunction during mild coronary tow
hemodialysis-induced hypotension. R. L. Converse, Jr.,
T. N. Jacobsen, C. M. T. Jost, R. D. Toto, P. A. Grayburn, reductions is due to an altered calcium-—pressure relationship
T. M. Obregon, F. Fouad-Tarazi, and R. G. Victor in rat hearts. V. M. Figueredo, R. Brandes, M. W. Weiner,
B. M. Massie, and S. A. Camacho
Sporadic hypertrophic cardiomyopathy due to de novo
Acquisition and synthesis of folates by obligateh eider
myosin mutations. H. Watkins, L. Thierfelder, D.-S. Hwang,
W. McKenna, J. G. Seidman, and C. E. Seidman . et bacteria of the genus Chlamydia. H. Fan,R . C. Brunham,
and G. McClarty
Regulation ofl ipoprotein lipase in the diabetic rat.
Inhibition of lung epithelial on suaitination _ inetuate,
K. Tavangar, Y. Murata, M. E. Pedersen, J. F. Goers,
A. R. Hoffman, andF . B. Kraemer . Posttranscriptional regulation of proliferation-related genes.
A. Clement, M. Edeas, K. Chadelat, and J. S. Brody .
Glutaric acidemia type II. Heterogeneity in p-oxidation a
Uptake of toxic silica particles by isolated rat liver
polypeptide synthesis, and complementary DNA mutations
macrophages (Kupffer cells) is receptor mediated and can be
in the a subunit of electron transfer flavoprotein in eight
blocked by competition. V. Kolb-Bachofen
patients. E. Freneaux, V. C. ceunenn L. Molin, A. Shires,
and W. J. Rhead New insights on the mechanism(s) of the dominant mate
Recruitment of CD1 ib/CD18 to the a utes _ effect of mutant thyroid hormone receptor in generalized
adherence-dependent cell locomotion. B. J. Hughes, resistance to thyroid hormone. P. M. Yen, A. Sugawara,
S. Refetoff, and W. W. Chin
J. C. Hollers, E. Crockett-Torabi, and C. W. Smith
High levels of circulating cytomegalovirus DNA reflect vinsund
Interleukin 4 inhibits in vitro proliferation of leukemic and
organ disease in viremic immunosuppressed patients other
— human Bc ell precursors. D. Pandrau, S. Saeland,
than marrow recipients. R. L. Saltzman, M. R. Quirk.
’. Duvert, I. Durand, A.-M. Manel, M.-T. Zabot, N. —
and M. C. Jordan
ply Banchereau .
Regulation of insulin receptor ry in — -_ emutte
Balloon angioplasty tease the expression of:m utstunte il
of animal models of insulin resistance. M. J. A. Saad,
AT, receptors in neointima of rat aorta. M. Viswanathan,
E. Araki, M. Miralpeix, P. L. a M. F. White,
Cc. Stromberg, A. Seltzer, and J. M. Saavedra
and C. R. Kahn .
Homozygous 4.1 (—) hereditary elliptocytosis associated _— a
point mutation in the downstream initiation codon of protein lon channels in human oust. Modulation by
4.1 gene. N. Dalla Venezia, F. Gilsanz, N. Alloisio, erythropoietin. J. Y. Cheung, M. Elensky, U. Brauneis,
M.-T. Ducluzeau, E. J. Benz, Jr., and J. Delaunay R. C. Scaduto, Jr., L. L. Bell, D. L. Tillotson, and B. A. Miller
Endogenously synthesized nitric oxide prevents endotoxin- Induction of thrombospondin | by retinoic acid is important
induced glomerular thrombosis. P. J. Shultz and L. Raij during differentiation of neuroblastoma cells. V. P. Castle,
X. Ou, S. O'Shea, and V. M. Dixit
Cloning, characterization, and expression of a human
calcitonin receptor from an ovarian carcinoma cell line. Animal cell mutants represent two comgtememtions groupss of
A. H. Gorn, H. Y. Lin, M. Yamin, P. E. Auron, M. R. Flannery, peroxisome-defective Zellweger syndrome. N. Shimozawa,
D. R. Tapp, C. A. Manning, H. F. Lodish, S. M. Krane, T. Tsukamoto, Y. Suzuki, T. Orii, and Y. Fujiki
and§ S. R. Goldring . Identification of Rifampin-inducible P450IIIA4 (CYP3A4) in
Neuroendocrine mechanism of o0n set of paibeate. ‘Sequential human small bowel enterocytes. J. C. Kolars, P. Schmiedlin-
reduction in activity of inhibitory and facilitatory N-methyl- Ren, J. D. Schuetz, C. Fang, andP . B. Watkins
D-aspartate receptors. J.-P. Bourguignon, A. Gérard, Structure-function relationships of interleukin-3. An analysis
M.-L. A. Gonzalez, andP . Franchimont : based on the function and binding characteristics of a series
Blood volume and body fluid compartments in lambs with of interspecies chimera of gibbon and murine interleukin-3.
aortopulmonary left-to-right shunts. J. W. C. Gratama, K. Kaushansky, S. G. Shoemaker, V. C. Broudy, N. L. Lin,
M. Dalinghaus, J. J. Meuzelaar, A. M. Gerding, J. H. Koers, J. V. Matous, E. M. Alderman, J. D. Aghajanian, P. J. Szklut,
W. G. Zijlstra, andJ . R. G. Kuipers. . R. E. VanDyke, M. K. Pearce, andJ . S. Abrams
Epitope regions on U1 small nuclear RNA a by Mechanism of hypertriglyceridemia in human uiieemenie
anti-U 1IRNA-specific autoantibodies. R. M. Hoet, (Apo) CIII transgenic mice. Diminished very low density
P. De Weerd, J. K. Gunnewiek, I. Koornneef, lipoprotein fractional catabolic rate associated with increased
and W. J. Van Venrooij . ; — Apo CII and reduced Apo E on the particles. K. Aalto-Setdld,
Pharmacological tolerance to ay-adrenergic smanen E. A. Fisher, X. Chen, T. Chajek-Shaul, T. Hayek, R. Zechner,
antagonism mediated by terazosin in humans. J. Vincent, A. Walsh, R. Ramakrishnan, H. N.s pace
W. Dachman, T. F. Blaschke, and B. B. Hoffman . and J. L. Breslow
Macrophages, T cell receptor usage, and endothelial cell Inhibition of smooth muscle cell proliferation in injured rat
activation in the pancreas at the onset of insulin-dependent arteries. Interaction of heparin with basic fibroblast growth
diabetes mellitus. A. Hdnninen, S. Jalkanen, M. Salmi, factor. V. Lindner, N. E. Olson, A. W. Clowes,
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t(1 1;22\(q24;q12) in small round cell tumors. M. Giovannini, rat hearts. A. Voogd, W. Sluiter, H. G. van ead
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Distinct sites of production _ dentin oft he nate cell function of cultured neonatal cardiac myocytes. Autocrine
death marker clusterin in the human thymus. L. E. French, action and reversal of damaging effects of interleukin-1.
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corticotrophic adenoma and murine pituitary cell cultures. erythematosus. In vivo imaging and clearance studies.
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Distinct localization of otenen aedt issue inhibitor of Plasma lipoprotein metielion in enbeniie mice
metalloproteinases expression in wound healing associated overexpressing apolipoprotein E. Accelerated clearance of
with ulcerative pyogenic granuloma. U. K. Saarialho-Kere, lipoproteins containing apolipoprotein B. H. Shimano,
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with lipoprotein lipase deficiency and with type III Rapid Publications
hyperlipoproteinemia. No evidence for a triglyceride-rich
precursor of lipoprotein(a). C. Sandholzer, G. Feussner, Molecular cloning and characterization of the constitutive
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Mutations in the ligand-- binding demain of the enteaen
for tracer kinetic analysis of myocardial glucose metabolism. receptor gene cluster in two regions of the gene.
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Novel Fey receptor I family gene sete tin hone
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Human milk mucin inhibits rotavirus senfieation ont spent
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system in human skin. N. Dovezenski, R. Billetta, and I. Gigli
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Lipoprotein lipase enhances binding of lipoproteins to heparan production in human whole blood. L. E. DeForge,
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Two distinct mechanisms for bilirubin glucuronide nennen
Verapamil ameliorates the clinical and pathological course of by rat bile canalicular membrane vesicles. Demonstration of
murine myocarditis. R. Dong, P. Liu, L. Wee, J.a ren defective ATP-dependent transport in rats (TR-) with
and M. J. Sole ; inherited conjugated hyperbilirubinemia. 7. Nishida,
Leukemia inhibitory factor nets: are » dretad in entie chock Z. Gatmaitan, J. Roy-Chowdhry, and I. M. Arias .
and various inflammatory body fluids. P. Waring, Cytomegalovirus immediate early genes prevent the inhibitory
K. Wycherley, D. Cary, N. Nicola, and D. Metcalf . effect of cyclosporin A on interleukin 2 gene transcription.
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for the formation of the Pen*/Pen” alloantigen system. November Author Index .
R. Wang, K. Furihata, J. G. McFarland, K. Friedman,
Addendum .
R. H. Aster, and P. J.N ewman