The Journal of Antimicrobial Chemotherapy (Volume 62, Number 6, 2008)

145 Pages·2008·13.57 MB·English

701 A VersatileAnalyticalExpression for the Inverse Abel TransformApplied to Experimental
Data with Noise
ShuiliangMa, HongmingGao, Guangjun Zhang, and Lin Wu
Spectroscopic Techniques
708 A Strategy to Prevent SignalLosses, Analyte Decomposition,and FluctuatingCarbon Contamination
Bands in Surface-EnhancedRaman Spectroscopy
Boon-Siang Yeo, Thomas Schmid,Weihua Zhang, and Renato Zenobi
Notes
714 Mid-InfraredLaser-Induced BreakdownSpectroscopy Emissionsfrom AlkaliMetal Halides
Clayton S.-C. Yang, E. Brown, Uwe Hommerich,SudhirB. Trivedi,Alan C. Samuels, and
A. Peter Snyder
716 Evaluation and Comparisonof TwoCombinationsof Pneumatic Nebulizersand Spray Chambersfor
Direct SlurryAspirationand MultielementAnalysis of Infant MilkPowders by Axial-Viewing
Inductively Coupled Plasma Atomic EmissionSpectrometry
G. A. Zachariadisand L. I. Valianou
Columns and Features
136A Cover Feature
140A Spectroscopists’Calendar
144A What’s New 2008 Buyer’s Guide
151A Applied Spectroscopy News
153A Book Reviews
Cover Feature
A confocal Raman microscope focuses a laser beam to a small diffraction-limited focal volume and
uses an aperture to block scattered light originating from outside this region, thereby improving the
spatial resolution. However, this attenuation is not 100% effective; there is an extended illumination
volume that can excite detectable Raman scatter on either side of the optimum focus. In a transparent
sample, every point in the extended volume can generate a few rays that pass through the focal point
and hence through the confocal aperture, and the summed out-of-focus contribution can be significant
compared to the signal from the optimum focus. The net result is that with transparent samples the
surface specificity of confocal Raman microscopy is significantly worse than one would imagineandthe
spectrum of a surface is overlaid by significant features from subsurface domains. This can have con-
fusing, counterintuitive ramifications, such as an increase in the signal from the substrate, relative tothe
surface, on moving the laser focus above the surface of a sample. These effects can be modeled using
a simple analytical treatment. For more information, please see the paper ‘‘The Influence of Out-of-
Focus Sample Regions on the Surface Specificity of Confocal Raman Microscopy’’, by Neil Everall.
136A Volume62,Number6,2008
Mary Carrabba, Editor
Spectroscopists’Calendarisaregularfeature Chemistry, The Ohio State University, 100 14th Biennial National Atomic Spectrosco-
in Applied Spectroscopy. Your cooperation West 18th Avenue, Columbus, OH 43210, py Symposium (14th BNASS), 7–9 July
insubmittingtimelyinformationforthecol- e-mail: [email protected]. 2008, Brighton, United Kingdom; 14th
umn is appreciated. For publication in one edu, world wide web: http://molspect. BNASS Secretariat, (cid:2) Dr Joanna Wragg,
issue of Applied Spectroscopy, send infor- chemistry.ohio-state.edu/symposium/, Ph: British Geological Society, Keyworth, Not-
mationnolessthanfourmonthsinadvance [phone],Fax:[phone]. tingham, NG12 5GG, United Kingdom;
of the actual event. Please send announce- e-mail: [email protected], world
ments of meetings and symposia of interest EXRS 2008—13th European Conference wideweb:http://www.bnass.org.
to spectroscopists to Mary Carrabba, De- on X-ray Spectrometry, 16–20 June 2008,
partment of Chemistry, Southern Oregon Cavtat,Dubrovnik,Croatia;EXRS-2008Sec- The Sixteenth Annual International Con-
University, 1250 Siskiyou Blvd., Ashland, retariat, Rudjer Boskovic Institute, P.O. Box ference on Composites/NANOEngineering
Oregon 97520, e-mail: carrabbam@sou. 180, 10002 Zagreb, Croatia, e-mail: (ICCE-16),20–26July2008,Kunming,Chi-
edu, Ph: [phone]. Announcementsof [email protected], world wide web: http:// na; Professor David Hui, Conference Chair,
short courses, schools, workshops, or other exrs2008.irb.hr/. Department of Mechanical Engineering, Uni-
versity of New Orleans, New Orleans, Loui-
educational activities should be sent to the
ISEAC 35—25th InternationalSymposium siana 70148, e-mail: [email protected], world
SAS webmaster, Stephen Bialkowski
on Environmental Analytical Chemistry, wide web: http://www.acad.polyu.edu.hk/
([email protected]).
22–26 June 2008, Gdansk, Poland; Interna- (cid:3)mmktlau/ICCE/ICCE(cid:3)Main.htm, Ph: (504)
tional Association of Environmental Analyti- 280-6652,Fax:[phone].
calChemistry(IAEAC),Attn:Mrs.Marianne
Frei,Postfach46,CH-4123Allschwil2,Swit- 50th Rocky Mountain ConferenceonAna-
CMA4CH Mediterranean Meeting: Multi- zerland,e-mail:[email protected],worldwide lytical Chemistry, 27–31 July 2008, Breck-
variateAnalysisandChemometricsapplied web: http://www.pg.gda.pl/chem/iaeac/index. enridge, Colorado; Milestone Presentations,
toCulturalHeritageandEnvironment,1–4 htm. LLC, 4255 S. Buckley Road, Suite 118, Au-
June 2008, Ventotene Island, Latium, Italy; rora, Colorado 80013, e-mail: info@
e-mail:[email protected],worldwide 21st International Conference on X-Ray rockychem.com, world wide web: http://
web:http://w3.uniroma1.it/cma4ch/. andInner-ShellProcesses,22–27June2008, www.rockychem.com, Ph: [phone] or
Paris, France; world wide web: http://x08. [phone], Fax: [phone] or
ASMS 2008—56th ASMS Conference on spectro.jussieu.fr. [phone].
MassSpectrometry,1–5June2008,Denver,
Colorado; American Society for Mass Spec- 11th Conference on Chemometrics in An- 14thInternationalDiffuseReflectanceCon-
trometry, 2019 Galisteo Street, Building I, alytical Chemistry (CAC 2008), 30 June–4 ference (IDRC 2008), 1–8 August 2008,
Santa Fe, New Mexico 87505 (USA), July 2008, Montpellier, France; CAC-2006, Chambersburg, Pennsylvania; Steve Del-
e-mail: offi[email protected], world wide web: Jean-Michel Roger, Cemagref, 361 rue JF wiche, General Chair, e-mail: stephen.
http://www.asms.org, Ph: [phone], Breton—BP 5095, 34196 MontpellierCedex, [email protected], world wide web:
Fax:[phone]. France, e-mail: [email protected], world http://www.idrc-chambersburg.org.
wide web: http://www.cac2008.org, Fax: 33
GeoRaman 08—8th International Confer- 467046306. Gordon Research Conference on Vibra-
enceonRamanSpectroscopyAppliedtothe tional Spectroscopy, 3–8 August 2008,
Earth Sciences, 2–6 June 2008, Ghent, Bel- 21st International Activated Carbon Con- South Hadley, Massachusetts; Chair: Philip
gium;PeterVandenabeele,DepartmentofAn- ference (IACC-21), 3–4 July 2008, Madrid, J. Reid, Chair, University of Washington,
alytical Chemistry, Proeftuinstraat 86, B-9000 Spain; Dr. Henry Nowicki, Conference Chair- Department of Chemistry, Box 351700,
Ghent, Belgium, e-mail: GeoRaman@UGent. man,PACS,Inc.,409MeadeDrive,Coraopolis, Seattle, Washington 98195-1700, e-mail:
be, world wide web: http://www.georaman. Pennsylvania 15108, e-mail: Henry@pacslabs. [email protected], world wide
ugent.be, Ph: 32 9 264 66 23, Fax: 32 9 264 com,worldwideweb:http://www.pacslabs.com, web: http://www.grc.org/programs.aspx?
6699. Ph: [phone] or [phone], Fax: year(cid:2)2008&program(cid:2)vibrspec.
[phone].
10th International Workshop on Physical ASTMInternationalConferenceonSurface
Characterization of Pharmaceutical Solids, CHIRALITY—2008: 20th International and Dermal Sampling, 4–8 August 2008,
8–13 June 2008, Bamberg, Germany; Sarah Symposium on Chirality (ISCD-20), 6–9 Boulder, Colorado; Dr. Kevin Ashley, Confer-
Passell,CommunicationsManager,AssaInter- July 2008, Geneva, Switzerland; Organizers ence Chairman,CDC/NIOSH,4676Columbia
national, 3B East Lake Road, Danbury, Con- Switzerland Ltd., (cid:2) Chirality 2008 Sympo- Parkway, Mail Stop R-7, Cincinnati, OH,
necticut 06811, e-mail: communications@ sium, Obere Egg 2, 4312 Magden, Switzer- 45226-1998;e-mail:[email protected],world
assainternational.com, world wide web: www. land, e-mail: offi[email protected], world wide web: http://www.astm.org/MEETINGS/
assainternational.com,Ph:[phone],Fax: wide web: https://asp.artegis.com/lp/CHI08/ COMMIT/d22boulder.html, Ph: (513)841-
[phone]. CHI08?1(cid:2)1,Ph:41618369876,Fax:[phone],Fax:[phone].
8369877.
63rd Ohio State University International DXC2008–57thAnnualDenverX-rayCon-
Symposium on Molecular Spectroscopy, EUROMAR 2008, 6–11 July 2008, St. Pe- ference,4–8August2008,Denver,Colorado;
16–20 June 2008, Columbus, Ohio; Terry A. tersburg, Russia; e-mail: hq@euromar2008. Denise Flaherty, DXC Conference Coordina-
Miller, Chair, International Symposium on com, world wide web: http://www. tor, 12 Campus Boulevard, NewtownSquare,
Molecular Spectroscopy, Department of euromar2008.com. Pennsylvania 19073-3273, e-mail: flahertyj@
140A Volume62,Number6,2008
(Continued)
icdd.com, world wide web: http://www. 20444267 or 420 2 66053635, Fax: 420 2 suga, Bunkyo-ku, Tokyo 112-8551, Japan,
dxcicdd.com. 86582307. e-mail: [email protected], world
wide web: http://envsun.chem.chuo-u.ac.jp/
AmericanChemicalSociety236thNational SMASH2008—SmallMoleculeNMRCon- plasma/2008apwccont.htm, Ph: 81 3 3817
Meeting & Exposition, 17–21 August 2008, ference,7–10September2008,SantaFe,New 1906,Fax:[phone].
Philadelphia, Pennsylvania; ACS Meetings, Mexico; Daneen Hadden, Conference Secre-
115516thSt.,N.W.,Washington,D.C.20036- tary, world wide web: http://www.smashnmr. Eastern Analytical Symposium & Exposi-
4899, e-mail: [email protected], world wide org/main.asp,Ph:[phone]. tion, 17–20 November 2008, Somerset, New
web:http://www.chemistry.org,Ph:(800)227- Jersey; EAS Executive Secretary and Retort
30th Annual Meeting of the British Mass
5558,Fax:[phone]. Editor, Eastern Analytical Symposium, Inc.,
Spectrometry Society (BMSS 2008), 7–10
P.O. Box 370, Walkersville, MD 21793,
21st International Conference on Raman September2008,York,UnitedKingdom;Dave
e-mail: [email protected], world wide web:
Spectroscopy (ICORS 2008), 17–22 August Collison, 68 Bathurst Road, Winnersh, Wok-
http://www.eas.org, Ph: [phone], Fax:
2008, London, United Kingdom; The Secre- ingham,BerkshireRG415JF,UnitedKingdom,
(301)6684312.
tariat, Hampton Medical Conferences Ltd., e-mail: [email protected], world
113-119 High Street, Hampton Hill, Middle- wide web: http://www.massspectrum.co.uk/ 7th Biennial Conference of the Australian
sex TW12 1NJ, UK, e-mail: ICORS@ york2008/, Ph: 44 0 118 961 9155, Fax: 44 andNewZealandSocietyforMagneticRes-
hamptonmedical.com, world wide web: 01189018359. onance (ANZMAG 2008), 6–11 December
www.icors2008.ukevents.org/contact. XIIIInternationalSymposiumonLumines- 2008,Queensland,Australia;worldwideweb:
ICMRBS 2008—23rd International Con- cence Spectrometry. Analytical lumines- http://www.anzmag.com.au/anzmag2008.html.
ference on Magnetic ResonanceinBiologi- cence: new diagnostic tools in life sciences,
calSystems,24–29August2008,SanDiego, food safety and cultural heritage (ISLS European Winter Conference on Plasma
California; world wide web: http://www. 2008), 7–11 September 2008, Bologna, Italy; Spectrochemistry, 15–20 February 2009,
icmrbs2008.org/. Professor Aldo Roda, Symposium President. Graz, Austria; Ms. Astrid Tuider, Conference
DepartmentofPharmaceuticalSciences,Uni- Secretary,Karl-FranzensUniversityGraz,In-
13th International Conference on Capture versityofBologna,ViaBelmeloro6,I-40126 stitute of Chemistry/Analytical Chemistry,
Gamma-Ray Spectroscopy and Related Bologna, Italy, e-mail: isls2008.bologna@ Universita¨tsplatz 1, A-8010 Graz, Austria,
Topics (CGS-13), 25–29 August 2008, Co- unibo.it, world wide web: http://www. e-mail: offi[email protected], world
logne, Germany; Prof. Jan Jolie, Institute for isls2008.unibo.it,Ph:39051343398,Fax:39 wide web: www.winterplasmagraz.at, Ph: 43
Nuclear Physics, University ofCologne,Zu¨l- 051343398. 3163805300,Fax:[phone].
picherstrasse 77, D-50937 Ko¨ln, Germany,
10thRioSymposiumonAtomicSpectrom- The Pittsburgh Conference on Analytical
e-mail: [email protected], world wide
web:http://www.ikp.uni-koeln.de/cgs13/,Fax: etry, 7–12 September 2008, Salvador, Bahia, Chemistry and Applied Spectroscopy
492214705168. Brazil; Dr. Bernhard Welz, Departamento de (PITTCON 2009), 8–13 March 2009, Chi-
Qu´ımica,UniversidadFederaldeSantaCatar- cago, Illinois; PITTCON, 300 Penn Center
5th International Conference on Broad- ina, 88040-900 Floriano´polis—SC, Brazil, Boulevard, Suite 332, Pittsburgh, Pennsylva-
band Dielectric Spectroscopy and Its Ap- e-mail: [email protected], world wide web: nia 15235, e-mail: [email protected], world
plications,Jointmeetingofthe5thConfer- http://www.10riosymposium.ufba.br, Ph: 55 wide web: http://www.pittcon.org, Ph: (412)
enceofthe‘‘InternationalDielectricSocie- 4837338876,Fax:[phone]-3220 or [phone], Fax: (412)825-
ty’’andthe10thConferenceon‘‘Dielectric 3224.
European Symposium on Atomic Spec-
and Related Phenomena’’, 26–29 August
2008, Lyon, France; BDS 2008 Secretariat, trometry, 28 September–1 October 2008, AmericanChemicalSociety235thNational
IMP/LMPB, UMR CNRS 5223, Universite´ Weimar, Germany; world wide web: http:// MeetingandExposition,22–26March2009,
Lyon 1, Baˆt. ISTIL, 43 Bd. du 11 Novembre www.esas-symposium.de. Salt Lake City, Utah; ACS Meetings, 1155
1918, 69622 Villeurbanne Cedex, France, Expoquimia,InternationalChemicalIndus- 16thSt.,N.W.,Washington,D.C.20036-4899,
e-mail: [email protected], world wide try Exhibition, 20–24 October 2008, Barce- e-mail: [email protected], world wide web:
web: http://bds2008.univ-lyon1.fr, Fax: 33 4 lona,Spain;FiraDeBarcelona,Av.ReinaM. http://www.chemistry.org,Ph:[phone],
78892583. Cristina, E-08004 Barcelona, Spain, e-mail: Fax:[phone].
expoquimia@firabon.es, world wide web:
8th Atmospheric SpectroscopyApplications ThirdInternationalCongressonOperando
www.expoquimia.com, Ph: 34 3 2332200,
Meeting, 27–30 August 2008, Reims, France; Spectroscopy (Operando—III):RecentDe-
Fax:[phone].
Ludovic Daumont, e-mail: ludovic.daumont@ velopments and Future Perspectives in
univ-reims.fr, world wide web: http://asa. 25thLC/MSMontreuxSymposiumonLC/ Spectroscopy of Working Catalysts, 19–23
univ-reims.fr. MS,12–14November2008,Montreux,Swit- April 2009, Rostock-Warnemu¨nde, Germany;
zerland; Secretary, Marianne Frei, Postfach Secretariat: Operando III, Leibniz-Institutfu¨r
The20thInternationalConferenceonHigh 46, CH-4123 Allschwil 2, Switzerland, Katalyse, an der Universitat Rostock, Albert-
Resolution Molecular Spectroscopy (PRA- e-mail: [email protected], world wide web: Einstein Straße 29 a, 18059 Rostock, Ger-
HA2008), 2–6 September 2008, Prague, http://www.iaeac.ch/lcms-montreux.html, Ph: many, e-mail: [email protected], world
CzechRepublic;ProfessorSˇte˘pa´nUrban,Lo- 41614812789,Fax:[phone]. wideweb:www.catalysis.de/operando,Ph:49
cal Organizing Committee Co-Chair, PRA- 3811281169;Fax:[phone].
HA2008, Academy of Sciences of the Czech Third Asia-Pacific Winter Conference on
Republic, J. Heyrovsky´ Institute of Physical Plasma Spectrochemistry, 16–21 November AmericanChemicalSociety236thNational
Chemistry, Dolejsˇkova3, CZ-18223 Praha8, 2008, Tsukuba, Japan; Naoki Furuta, Chuo MeetingandExposition,16–20August2009,
Czech Republic, e-mail: praha06@jh-inst. University, Faculty of Science and Engineer- Washington, D.C.; ACS Meetings,1155 16th
cas.cz, world wide web: http://www.chem. ing,DepartmentofAppliedChemistry,Envi- St., N.W., Washington, D.C. 20036-4899,
uni-wuppertal.de/conference/, Ph: 420 2 ronmentalChemistryLaboratory,1-13-27Ka- e-mail: [email protected], world wide web:
APPLIEDSPECTROSCOPY 141A
(Continued)
http://www.chemistry.org,Ph:[phone], chem.chuo-u.ac.jp/plasma/2008apwccont.htm, Boulevard, Suite 332, Pittsburgh, Pennsylva-
Fax:[phone]. Ph:81338171906,Fax:[phone]. nia 15235, e-mail: [email protected], world
wide web: http://www.pittcon.org, Ph:
14th International Conferenceon NearIn- 45th Eastern Analytical Symposium and [phone] or [phone], Fax:
frared Spectroscopy (ICNIRS 2009), 7–16 Exposition,17–20November2008,Somerset, [phone].
November2009,Bangkok,Thailand;Sirinna- New Jersey; Eastern Analytical Symposium
pa Saranwong, General Secretariat (Asian and Exposition, Inc., P.O. Box 633, Mont- ASMS 2009–57th ASMS Conference on
NIRConsortium),NationalFoodResearchIn- chanin, Delaware 19710, e-mail: easinfo@ Mass Spectrometry, 31 May–4 June 2009,
stitute, 2-1-12 Kannondai Tsukuba JAPAN aol.com, world wide web: http://www.eas. Philadelphia,Pennsylvania;AmericanSociety
305-8642, e-mail: [email protected], org,Ph:[phone],Fax:[phone]. for Mass Spectrometry, 2019 Galisteo Street,
Building I, Santa Fe, New Mexico 87505
worldwideweb:http://www.nir2009.com,Ph: 2008MaterialsResearchSocietyFallMeet- (USA), e-mail: offi[email protected], world wide
81298388088,Fax:[phone]. ing, 1–5 December 2008, Boston, Massachu- web: http://www.asms.org, Ph: (505)989-
setts; Materials Research Society, 506 Key- 4517,Fax:[phone].
Third Asia-Pacific Winter Conference on
stoneDrive,Warrendale,Pennsylvania15086-
Plasma Spectrochemistry (2008 APWC), 36th Annual Conference of the Federation
7573,e-mail:[email protected],worldwideweb:
16–21 November 2008, Tsukuba, Ibaraki, Ja- of Analytical Chemistry and Spectroscopy
http://www.mrs.org, Ph: [phone], Fax:
pan; Naoki Furuta, Chuo University, Faculty Societies (FACSS), 18–20 October 2009,
[phone].
of Science and Engineering, Department of Louisville, Kentucky; FACSS, P.O. Box
AppliedChemistry,EnvironmentalChemistry The Pittsburgh Conference on Analytical 24379, Santa Fe, New Mexico 87502,
Laboratory, 1-13-27 Kasuga,Bunkyo-ku,To- Chemistry and Applied Spectroscopy e-mail: [email protected], world wide web:
kyo 112-8551, Japan, e-mail: nfuruta@chem. (PITTCON 2009), 8–13 March 2009, Chi- www.facss.org, Ph: [phone], Fax:
chuo-u.ac.jp, world wide web: http://envibm. cago, Illinois; PITTCON, 300 Penn Center [phone].
142A Volume62,Number6,2008
Lee Craven, Editor
WHAT’S NEW is provided as a ser- tion,withPOFandCPLprovidinginsightsinto vestigative, such as forensic trace evidence
vice for our readers. It contains the thestructure,interactions,andenvironmentof analysis, to routine manufacturing trouble-
the emitting molecule. A recently introduced shooting,asinthepolymerindustry.TheDXR
latest news on the products, cata-
Olis upgrade accessory adds both CPL and Raman microscope brings the power of Ra-
logs, tips, and supplies that manu-
POF to any Olis CD or fluorescence spec- man microscopy to academic studies, for
facturers elect to highlight. Publica- trometer for kinetic or steady-state readings. characterization of geological specimens, for
tioninWHAT’SNEWdoesnotimply Singlepurposemodelsarealsoavailable.On- example; to routine product quality control;
recommendation or endorsement by LineInstrumentSystems,130ConwayDr., and to sample authentication in industries
Suites A and B, Bogart, GA 30622-1724, such as fine gemstones. This Raman micro-
theSocietyforAppliedSpectroscopy
Ph:706-353-6547,www.olisweb.com. scopeisdesignedfromthegroundupforrou-
orthecolumneditor.Contributionsto
(cid:2) tine analysis. In addition to the DXR Raman
WHAT’SNEWshouldbesenttoAp- microscope, Thermo Fisher Scientific is also
pliedSpectroscopy,What’sNewEd- launching its new DXR SmartRaman spec-
itor, 201B Broadway Street, Freder- trometer. It is a macro Ramananalyticaltool
designedspecificallytobringthepowerofRa-
ick, MD 21701-6501 (Fax 301-694-
man spectroscopy to busy multipurpose lab-
6860; e-mail offi[email protected]).
oratories. ThermoFisherScientific,81Wy-
Please note that only black-and- man Street, Waltham, MA 02454, Ph: 800-
white photos will be considered for 532-4752,www.thermo.com.
publication. Although there is no (cid:2)
charge to submit materials, prefer-
ence is given to Applied Spectros-
copy advertisers. Call 800-627-0932
for questions regarding advertising.
New DXR Raman Microscope
(cid:2)
ThermoFisherScientificInc.launchedits
new Thermo Scientific DXR Raman micro-
scope.Theinstrumentisdesignedspecifically
to help non-specialist users achieve rapid
sampling and analysis of particles, down to
one-micron spatial resolution. The novel mi-
croscope offers excellent spatial resolution,
superior performance, andunmatchedrepro-
ducibility in a package that anyone can use.
TheDXRRamanmicroscopeisequippedwith
fully integrated, pre-aligned components for
Probes of Molecular Chirality and fast and easy fieldinstallationandconfigura- New Ultra-Violet/Visible (UV/VIS)
(cid:2)
Structure tion. Interchangeable SMART components Spectrophotometers
require no operator adjustment and ensure
New accessories from Olis. Fluorescence automated system configuration. Patented PerkinElmer Life and AnalyticalScienc-
andcirculardichroism(CD)spectroscopyare autoalignmentandautocalibrationensurere- es announced the global introduction of the
well represented in the literature of macro- liableresults.Afiberprobeoptionisavailable LAMBDA(cid:3)XLS,aUV/Visspectrophotometer
molecular studies. Polarization of fluores- for remotesampling.Furthermore,themicro- for Quality Assurance/Quality Control (QA/
(cid:2)
cence(POF)andcircularlypolarizedlumines- scope utilizes theThermoScientificValPro QC)andteachinglaboratories,andtheLAMB-
cence(CPL)arelessutilizedhighlysensitive completesystemvalidationpackage,allowing DA(cid:3) Bio, a UV/Vis spectrophotometer de-
probesofmolecularinteractions(e.g.,protein forcompliancewithcGMPandFDAregulatory signed specifically for biological science lab-
folding, secondary structure formation). requirements. Thermo Fisher Scientific also oratories.BoththeLAMBDAXLSandLAMB-
Whereas CD involves the ground state of a offersalargecollectionofRamanspectralli- DA Bio are designed as low-cost, routine
chiral molecule, CPL is emitted by a fluoro- braries to aid in sample identification. The platforms with a number of pre-configured
phoreiftheexcitedstateoftheemittingspe- DXRRamanmicroscopeisdesignedtomake standard methods and the capability to add
ciesischiral.Fluorescenceoffersinsightsinto the Raman technique accessible to a much customized methods, addressing a wide
theenvironmentsurroundingtheemittingmol- wider audience by replacing manual adjust- rangeofapplications.TheLAMBDAXLSwas
ecule; anisotropy (POF) is sensitive to rota- ments with system intelligence and automa- designed with a focus on productivity and
tionalmotionofthefluorescentprobe.These tion. The newly designed instrument is ideal easeofuse.TheLAMBDAXLSandBiomod-
four probes provide complementary informa- forabroadrangeofapplications,fromthein- elsincludealarge,clearon-boarddisplayand
144A Volume62,Number6,2008
hanced return on investment over previous user input. Software packages include pro-
2008 technology.TheOptima7000Seriesreplaces teomics,polymerandcopolymeranalysis,LC-
theOptima2100,5100,5200,and5300mod- MALDI, biomarker discovery, and tissue im-
BUYER’S GUIDE
els. Perkin Elmer, Inc, 940 Winter Street, aging. Shimadzu designedtheAXIMAConfi-
Waltham, MA 02451, Ph: 781-663-6900, dence(cid:3) and Assurance(cid:3) instruments with
www.perkinelmer.com. generalanalyticalandlife-sciencelaboratories
in mind. Both systems are affordable,robust
(cid:2)
optionsforroutinesampleanalysisperformed
robustspill-resistantkeypad.Withitsintuitive manuallyorautomatically.Positive-andneg-
graphical interface and wide range of local ative-ionmodes arestandard,allowingusers
languageoptions,usersinmanufacturingQA/ full flexibility. Shimadzu also incorporated a
QC, environmental, teaching, and food anal- patented beam blanker to optionally remove
ysis laboratories are able to perform wave- unwantedlow-massionsandpreventdetector
length, scanning, concentration studies, and saturation.TheConfidenceMALDIMSoffers
biologicalassayswithease.TheLAMBDABio reliablemassinformationandMS/MS-derived
is pre-configured with standard methods for structural detail. A linear mode enables high
easeofaccess,includingDNA,RNA,andol- levels of analysis of high molecular weight
igonucleotideconcentrationandpurity,protein samples. The reflectron mode, incorporating
assays,andcelldensitymeasurements.Both the patented curved-field reflectron,provides
theLAMBDAXLSandLAMBDABiohaveno high resolution and mass accuracy. Confi-
movingpartsandfeatureanultra-long-lifetime dence software packages are available spe-
Xenon lamp, helping to ensure robustness, cificallyforproteomicsexperiments,LC-MAL-
maximumuptime,andlowcostofownership. DI,polymerandcopolymeranalysis,biomark-
Thehighqualitysplit-beamopticaldesignpro- er discovery, tissue imaging, and oligonucle-
vides high stability and run-to-run reproduc- otide/primer analysis. Shimadzu Scientific
ibility for added assurance of results. Perkin Instruments, 7102 Riverwood Drive, Co-
Elmer,Inc,940WinterStreet,Waltham,MA lumbia, MD 21046, Ph: 800-477-1227,
02451, Ph: 781-663-6900,www.perkinelmer. www.ssi.shimadzu.com.
com.
(cid:2)
(cid:2)
Optima(cid:3) 7000 Series ICP-OES
PerkinElmer Life and AnalyticalScienc-
eshasannouncedtheOptima(cid:3)7000Series
of Inductively Coupled Plasma-OpticalEmis-
sions Spectrometers(ICP-OES).TheOptima MALDI Mass Spectrometer
7000 family is designed for best-in-class in- Offering Enhanced Performance
organic analysis and is used in a variety of and Flexibility
markets, including environmental, geochemi-
cal,producttesting,andbiofuels.Thisnewest ShimadzuScientificInstrumentshasup-
generation in the Optima series includes a dated its line of AXIMA MALDI TOF mass
UniversalDataAcquisitionmodethatrecords spectrometers (MS) with three new systems
allofthespectraldataforeachsample.This tomeettheneedsofresearcherswithvarying
enables customers to retrieve data that was applicationsandbudgets.TheAXIMAPerfor-
notinitiallyreportedwithoutneedingtorunthe mance(cid:3)massspectrometerprovidesthepin-
sampleagain,savingthemtimeandincreas- nacleofperformanceforhigh-energyMS/MS
ingproductivity.TheOptima7000hasseveral interrogationofproteomicsandbiologicaland
time-savingenhancementsforlaboratoryper- organic samples. These include peptides,
sonnel.Forrapidreviewofresults,theOptima polymers, oligonucleotides, SNPs, metabo-
7000generatesanerrorflagifasampleresult lites,andcarbohydrates.Italsodemonstrates
fallsaboveorbelowauser-specifiedvalue.To performanceintheanalysisofhigh-massspe-
ensure a consistently high level of data and cies, such as intact proteins. In reflectron
withoutrequiringadditionalresources,thein- mode, high-resolution MS data is generated
strumentation can automatically generate for peptide mass fingerprinting and complex
QualityControl(QC)chartsthatshowresults mixture analysis. Full automation, advanced
for analyses run over a specified period of calibration algorithms, data-dependent work-
time. The addition of modern electronics ex- flows, and application-centric software help
tends the instrument’s lifetime, providing en- users achieve maximum resultswithminimal
APPLIEDSPECTROSCOPY 145A
folioforincreasingapplicationsinvolvingsmall trumfluorescentanalysiswithpatent-pending
2008 sample volumes. The Thermo Scientific technology that delivers a wide excitation
NanoDropinstrumentseliminatecuvettesand range without requiring filter changes or a
BUYER’S GUIDE
associateddilutions,resultinginmorereliable monochromator. Thermo Fisher Scientific,
measurements. An undiluted one-microliter 81WymanStreet,Waltham,MA02454,Ph:
sampleispipetteddirectlyontothemeasure- 800-532-4752,www.thermo.com.
ment surface. After a quick spectralreading,
(cid:2)
the sampleis simply wipedawayinprepara-
tionforthenextsample.Theinstrumentsare
usedtomeasurethequantityandpurityofnu-
cleicacidsandproteinsaswellasassociated
fluorescent labels. Such measurements are
routinely neededforqualitycontrolandsam-
ple preparation at multiple process points in
manyapplications,includingmicroarrayprobe
preparations, PCR template normalization,
small molecule crystallization, sequencing,
antibodies, microgenomics, proteomics, ge-
notyping,andFRET(fluorescenceresonance
NanoDrop Family of energytransfer).Theseapplicationsareused Advanced Series of
insuchdiversefieldsascancerresearch,mi-
Micro-volume Spectroscopy Monochromators and
crobiology, drug discovery, forensics, histo-
Instruments Spectrographs
compatibility, and diagnostics. The Thermo
Scientific NanoDroplineofproductsincludes
Thermo Fisher Scientific Inc.announces Princeton InstrumentsintroducestheAc-
the Thermo Scientific NanoDrop 1000 Spec-
the NanoDroplineofmicro-volumespectros- tonAdvancedSeriesofmonochromatorsand
trophotometer, which takes UV-Vis absor-
copy systems. These uniqueinstrumentsuti- spectrographs. Unlike the standard Acton
bance spectra of one-microliter samples;the
lize a patentedtechnologythatenableseasy spectrometers, the new ActonAdvancedSe-
Thermo Scientific NanoDrop 8000 Spectro-
measurement of UV-Vis and fluorescence ries combines high precision computer-con-
photometer, which takes UV-Vis absorbance
withouttheuseofcuvettes.TheThermoSci- trolled motorized slits, interchangeable triple
spectraofeightsamplessimultaneously;and
entific NanoDrop family of products extends gratingturrets,anddualentranceports.These
the Thermo Scientific NanoDrop 3300 Fluo-
the company’s molecular spectroscopy port- newfeaturesofferresearcherscompletesoft-
rospectrometer, which performs broad spec-
146A Volume62,Number6,2008
ionbatteryorfromACpower.Featuringinter- Technologies, 14 Commerce Drive, Dan-
2008 changeable internal reflection (ATR) and ex- bury, CT 06810, Ph: 203-312-1100, www.
ternalreflectionsamplinginterfaces,thissystem a2technologies.com.
BUYER’S GUIDE
isidealforsamplingawidevarietyofmateri-
(cid:2)
alsincludingsolids,pastes,gels,andliquids.
CoupledwiththeuniqueA2Technologiesdi-
amond internal reflection sampling system,
this system is also capable of large surface
warecontrolofincominglighttothespectrom- analysis. Controlled and operated via a PDA
eteraswellastheflexibilitytoconfiguresep- device, the A2 Technologies Exoscan spec-
arateexperimentsforeachentranceport.The trometer combines all the uniquecapabilities
ActonAdvancedSeriesisavailableinfourdif- of a laboratory-based FT-IR with the advan-
ferent focal lengths, 150 mm, 300 mm, 500 tages of a portable instrument that can be
mm, and 750mm, andishighlyconfigurable used in the field, ensuring real-time results.
for different types of detectors, grating com- Capable of nondestructive analysis,thisnew
binations, and light sources. The new Acton analyzerisidealforapplicationsforwhichthe
Advanced Series, like the previous sample is too largeto bringtothelaboratory New Fourier Transform Infrared
SpectraProseriesofspectrometers,continues ortoovaluabletorequireasmallportiontobe
Spectrophotometer Offers High
to provide high quality spectroscopy compo- removed for analysis. The optical system of
nents for researchers who demand the best theExoscanisamonolithic,highlyruggedin- Sensitivity
equipment for their experimental setup. For frared modulator that enables routine opera-
decades Actonproductshaveproduceddata tionofthesystemin non-routineapplications Shimadzu Scientific Instruments de-
for hundreds of posters, presentations, and and environments without sacrificing perfor- signed the IRAffinity-1 Fourier Transform In-
publications,makingActontheprovenchoice mance. This system operates in the 4000 to frared (FT-IR) spectrophotometer with high-
forspectroscopyrequirements.PrincetonIn- 650 wavenumber mid-infrared region and is throughput optics and a dynamic alignment
struments-Acton, 15 Discovery Way, Ac- capableof4cm(cid:3)1resolution.Additionally,the mechanism to increase sensitivity, stability,
ton, MA 01720, Ph: 978-263-3584, www. analyzerisequippedwiththree-levelsoftware andusability.TheIRAffinity-1isidealforhigh-
piacton.com. architecture,providingmethodsdevelopment, precisioninfraredanalysistoconfirm,identify,
(cid:2) supervisory, and operator functionality. A2 and detect foreign matter in raw materials,
Portable Exoscan FT-IR
Spectrometer for Surface
Analysis Applications
A2Technologiesannouncesthelaunchof
oneofthemostcompactFT-IRspectrometers
available,Exoscan(cid:3).Designedtomovespec-
troscopy out of the laboratory and into the
field,theanalyzerisdesignedfornondestruc-
tive on-site surface and bulk analysis appli-
cations. Weighing less than seven pounds,
the A2 Technologies Exoscan features ease
of use, coupled with analytical performance
that rivals far largerandmoreexpensivetra-
ditional analytical FT-IR spectrometers. Ex-
oscan is also capableofhandlingattenuated
totalreflection(ATR)applications.Exoscanis
poweredbyanon-boardrechargeablelithium
APPLIEDSPECTROSCOPY 147A
nents arehoused inoneconductivelycooled back-flushoptionoftheTRACEGCUltraen-
2008 enclosure.Theserobust,sealed,QCWdiode ables accurate detection of trace level com-
pumpedlasersareavailableat1064nm,532 ponentsincomplexmatrices.Thissystemen-
BUYER’S GUIDE (cid:4)m,355(cid:4)m,and1.57(cid:4)m.TheMiniisavail- ables users to perform routine full scan GC/
ablewithenergylevelsupto7mJat1.57(cid:4)m MS with greater analytical flexibility. Offering
and 20 mJ at 1064 nm with 5 to 8 ns pulse abroadselectionofinnovativefeaturesavail-
widthsatarepetitionrateupto50Hz.Ifyou ableforiontrapGC/MS,theThermoScientific
prefer,thesystemcomponentscanbehoused ITQ1100systemfeaturesnewadvancedMS/
medical products, packages, and coatings. in two enclosures. The Mini can be custom- MS(MSn)functions.Thesehigh-performance
TheIRAffinity-1offershighsignal-to-noisera- ized,forexample,4thand5thharmonicscan ion-trap-based GC/MS systems are ideal for
tio (sensitivity) at 30,000:1, with a maximum beoffered,aswellastheOPOidler(cid:5)3.1(cid:4)m laboratories seeking the most powerful GC/
resolutionof0.5cm(cid:3)1.Theunitachievesthis output. RPMC Lasers Inc., 203 Joseph MS platform and flexibility. For the first time,
levelofsensitivitybyusingahigh-energyce- Street, O’Fallon, MO 63366, Ph: 636-272- Thermo Scientific patented Pulsed Q Disso-
ramic light source, temperature-controlled, 7227ext.22,www.rpmclasers.com. ciationMode(PQD)isavailableonaGCion
high-sensitivity DLATGS detector, and high- trap system. PQD increases the number of
(cid:2)
throughputopticalelements.Also,theIRAffin- product ions formed during collision-induced
ity-1 includes optimized electrical andoptical disassociation (CID), yielding richer informa-
systemstominimizenoiselevels.TheIRAffin- tionforqualitativeMSnexperiments.TheITQ
ity-1includespatentedtechnologytoincrease 1100alsofeaturesa250L/sturbo-molecular
stabilityandprecision.Itsmovingmirrorisrun pump, the Thermo Scientific Vacuum Probe
smoothlyandpreciselybyaflexiblejointsys- Interlock, and Data Dependent(cid:3) Scanning.
tem patentedbyShimadzu.Theinterferome- Thisintegratedsystemprovidesanextended
ter is optimized and stabilized by a dynamic massrangeupto1100amu,considerablyin-
alignment mechanism on which Shimadzu creasing the number of compounds that can
hasapatentpending.Theinterferometer’sop- bedetectedandidentified.Inaddition,theITQ
ticalelementsareprotectedfromhumidityand Series of GC/MS systems can be fully up-
stabilized by a sealed interferometer,aswell gradedto maximize investmentandofferthe
asbycontinuouslyremovingmoisturebyare- flexibility to cater to each analytical require-
active polymeric desiccator and coating the ment. Detection capability can be improved
beam splitter with moisture-resistant protec- using the MS/MS upgrade, while adding
tivefilm.Toincreasereliability,theIRAffinity- chemicalionizationordirectsampleprobesal-
1 executes self-diagnosis at initializationand lowsincreasedflexibility.Injectionoptionscan
monitorsthestateoftheinstrumentduringop- alsobeexpandedbeyondsplit/splitlessinjec-
eration. Users can check basic performance tors to take advantage of advanced sample
using a standard-feature validation program. introduction techniques.ThermoFisherSci-
New ITQ Ion Trap GC/MS Series
IRsolutionsoftware,standardintheIRAffinity- entific, 81 Wyman Street, Waltham, MA
1, emphasizes operability and analysis sup- Thermo Fisher ScientificInc.announced 02454, Ph: 800-532-4752, www.thermo.
portprogramstoperformdataprocessingand thelaunchofits ThermoScientificITQ(cid:3)Se- com.
analysis.WithIRsolutionspecializedwindows,
riesofgaschromatography/massspectrome- (cid:2)
userscaneasilyperformstandardoperations,
try(GC/MS)iontrapinstruments,featuringex-
suchasmeasurement,display,dataprocess-
ternal ionization. The ITQ 700(cid:3), ITQ 900(cid:3),
ing,quantitativeanalysis,search,andprinting.
andITQ1100(cid:3)iontrapsystemsfeaturefully
A variety of optional programs andaccesso-
upgradeable systems designed to provide
ries, such as those facilitating PLS and mul-
highperformanceandhighspecificity.Devel-
tilinear regression, deconvolution, and map-
oped for a wide range of applications, from
ping measurement, are also available. Shi-
routineGC/MStoresearch-gradeiontrapMS,
madzu Scientific Instruments, 7102River-
these new systems address the analytical
wood Drive, Columbia, MD 21046, Ph:
needsoftheenvironmental,foodsafety,phar-
800-477-1227,www.ssi.shimadzu.com.
maceutical QA/QC, forensics, and toxicology
(cid:2) industries, as well as academic laboratories.
Designedforroutinefullscanquantitationand
general teaching applications, thecost-effec-
tive ITQ 700 GC/MS system combines full
scaniontrapsensitivitywithasmallfootprint Vacuum Ultraviolet Light Source,
for laboratories with limited space. The ITQ 30 nm(cid:2)
700 is capableofachievingamassrangeof
700 amu, suitable for most general GC/MS The McPherson, Inc. Model 629isawin-
applications,includingenvironmental,QA/QC, dowless hollow cathode source in which the
and forensics. The ITQ 900 incorporatesfull negative discharge glow is viewed directly.
scansensitivityofiontrapmassspectrometry Ionizedgasemissionlinesareproducedand
with the increased flexibility of the Thermo can be conveniently viewed with little or no
Scientific TRACE GC Ultra(cid:3) gas chromato- absorptionbyneutralgas.Thesource’swater-
graph.Combiningacompleterangeofinjector cooledanodeandcathodeareelectricallyiso-
options including true Cold-on-Column, Pro- lated.Adifferentialpumpingstageisavailable
Miniature Lasers grammable Temperature Vaporization (PTV) asanaccessorytoallowdirectconnectionto
andafullcomplementofadditionaldetectors, experimentalsystemsoperatingatlowervac-
RPMCintroducestheMiniseriesoflasers. theITQ900significantlyexpandstheworking uum pressures. The McPherson Model 629
TheMinilasersgettheirnamefromtheircom- massrangeofatypicalGC/MSsystemto900 maybeoperatedwithavarietyofinertgases.
pact size. All optical and electronic compo- amu. The large volume PTV injection with Helium (He) is amongthemostpopular.Op-
148A Volume62,Number6,2008
Road, Suite 335, Waltham, MA 02452, Ph: The Raman WorkStation(cid:3) incorporates Kai-
2008 781-478-0170,www.LambdaSolutions.com. ser’s PhAT technology intoa next-generation
(cid:2) macroRamananalyzer.PhATtechnologyrev-
BUYER’S GUIDE
olutionizes Raman sampling of solids and
crystals by eliminating sampling irreproduc-
ibility and focus sensitivity. PhAT technology
measures a representative sample volume,
whilereducinglocallaserpowerdensity,elim-
erating pressures of (cid:5)3 (cid:6) 10(cid:3)1 torranddis- inatingsampledamageconcerns.Theanalyz-
charge current of (cid:5)500 mA are optimum for er comes equipped for automated high-
emission of He II ion lines around 30.4 nm. throughput screening with varying spot sizes
With unchanged discharge current, higher available from 7 to 1 mm. One advantageis
pressure((cid:5)1torr)providesoptimumoutputat for analyzing well-plates in screeningexperi-
HeI,58.4nm.ArgonandNeonareotherpop- ments. Application needs and sampling ver-
ulargases.Thissourcemaybeuseddirectly satility have been designed into the Raman
for ultraviolet spectroscopy experiments WorkStation(cid:3) by incorporating Kaiser’s uni-
where unfiltered multi-line excitation is ac- versal fiber-optic sampling station interface.
ceptable.CombinetheModel629sourcewith This allows a basic Raman WorkStation(cid:3)to
a high throughput vacuum monochromator be expandedfor insitureactionanalysis,re-
likethe200mmfocallengthMcPhersonMod- motesolidssampling,ormicrometerlevelim-
el 234/302 to benefit applications requiring aging that extend the analyzer’s capability
greater specificity. This McPherson mono- fromthemillimetersamplingdomaintothemi-
chromator provides sub nanometer wave- Raman WorkStation(cid:3) Macro crometer sampling domain. The Raman
length resolution, easily discriminating be- Raman Analyzer WorkStation(cid:3) has capabilities for the tablet
tween multiple emission lines and rejecting and gelcap area by using a transmissionac-
outofbandenergy.Lineofsightopticalpath Kaiser Optical Systems Inc. (Kaiser) is cessory option. Kaiser Optical Systems,
is optionally availablefor theModel629light pleasedtoannouncethereleaseofthemost Inc., 371 Parkland Plaza, Ann Arbor, MI
source, simplifying alignment with optical or recent member of the RamanRxnSystems(cid:3) 48103,Ph:7346658083,www.kosi.com.
sampling systems. The Model 629 window- suiteofanalyzers;theRamanWorkStation(cid:3).
(cid:2)
lesshollowcathodesourceisusefulforwave-
length calibration and as a general emission
source for wavelengths 30 nm and longer.
McPherson,Inc.,7AStuartRoad,Chelms-
ford, MA 01824-4107, Ph: 978-256-4512,
www.McPhersonInc.com.
(cid:2)
High Performance Flow-Through
Raman System
TheLambdaSolutionsDimensionFT-ABS
represents a true high sensitivity on-lineRa-
manSystemforcriticalfluid-phasemonitoring.
The XL-FT featuresprovideexceptionalsen-
sitivityandstability.Thequartz-tefloncellde-
sign offers solvent/acid/base resistance and
LSIRealTimemonitoringsoftwareandoption-
al integrated UV-Vis absorption extend ana-
lytical capability. Wide ranging applications
maketheXL-FTidealforsemi-conductorwet
chemistry, petrochemical production and for-
mulation,fermentation,andchemicalreaction
monitoring. This flow-through system offers
high performance and robustness,withprov-
en24/7operation,coveragefrom50cm(cid:3)1to
3000cm(cid:3)1,andresolutionto1.5pixels/cm(cid:3)1.
LambdaSolutions,Inc.,411WaverleyOaks
APPLIEDSPECTROSCOPY 149A