The Innate immune response to infection PDF
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The Innate Immune Response to Infection The Innate Immune Response to Infection Edited by Stefan H.E.Kaufmann Ruslan Medzhitov Siamon Gordon Washington, DC FM_Kaufmann_ASM_557014 5/7/04 1:49 PM Page iv Cover image:mycobacteria in a macrophage phagosome. Colorized transmission electron micrograph by Dr.Volker Brinkmann, Max Planck Institute for Infection Biology,Berlin,Germany. Copyright © 2004 ASM Press American Society for Microbiology 1752 N Street,N.W. Washington,DC 20036-2904 Library of Congress Cataloging-in-Publication Data The innate immune response to infection / edited by Stefan H.E.Kaufmann,Ruslan Medzhitov,Siamon Gordon. p.;cm. Includes bibliographical references and index. ISBN 1-55581-291-0 1. Natural immunity. [DNLM:1. Bacterial Infections--immunology.2. Immunity,Natural--physiology.3. Antibody Formation--physiology.4. Immunity,Cellular--physiology. QW 541 I575 2004] I.Kaufmann,S.H.E.(Stefan H.E.) II.Medzhitov,Ruslan.III.Gordon,Siamon. QR185.2.I486 2004 616.07'9--dc22 2004005850 All Rights Reserved Printed in the United States of America 10 9 8 7 6 5 4 3 2 1 Address editorial correspondence to:ASM Press,1752 N St.,N.W.,Washington,DC 20036-2904,U.S.A. Send orders to:ASM Press,P.O.Box 605,Herndon,VA 20172,U.S.A. Phone:800-546-2416;703-661-1593 Fax:703-661-1501 Email:[email protected] Online:www.asmpress.org FM_Kaufmann_ASM_557014 5/7/04 1:49 PM Page v CONTENTS Contributors vii Preface xi 1. Evolutionary Emergence and Interactions among Elements of the Innate and Combinatorial Responses John J.Marchalonis,G.Kerr Whitfield,and Samuel F.Schluter 1 2. Drosophila Responses to Microbial Infection:an Overview Jules A.Hoffmann and Petros Ligoxygakis 31 MAMMALIAN CELLS 3. Neutrophils:the Power Within Taco W.Kuijpers and Dirk Roos 47 4. The Biology of Macrophages R.Tedjo Sasmono and David A.Hume 71 5. The Regulatory Role of Dendritic Cells in the Innate Immune Response F.Granucci,S.Feau,I.Zanoni,G.Raimondi,N.Pavelka,C.Vizzardelli, and P.Ricciardi-Castagnoli 95 6. Roles of Mast Cells and Basophils in Innate Immunity Stephen J.Galli,Devavani Chatterjea,and Mindy Tsai 111 7. Innate Natural Killer Cell Responses to Infection Wayne M.Yokoyama 133 8. Urinary Tract Infection as a Model for Innate Mucosal Immunity M.Samuelsson,G.Bergsten,H.Fischer,D.Karpman,I.Leijonhufvud, A.C.Lundstedt,P.Samuelsson,M.L.Svensson,B.Wullt,and C.Svanborg 157 v FM_Kaufmann_ASM_557014 5/7/04 1:49 PM Page vi vi (cid:1) CONTENTS 9. Paneth Cells in Innate Immunity and Intestinal Inflammation Satish Keshav 171 HUMORAL FACTORS 10. Collectins and the Acute-Phase Response Howard Clark,Thilo Stehle,Alan Ezekowitz,and Kenneth Reid 199 11. Complement and Its Receptors in Infection Admar Verschoor and Michael C.Carroll 219 12. Coagulation and Innate Immunity Charles T.Esmon 241 RECEPTORS 13. Toll-Like Receptors:Ligands and Signaling Kiyoshi Takeda and Shizuo Akira 257 14. Toll-Like Receptors and Control of Adaptive Immunity Gregory M.Barton,Chandrashekhar Pasare,and Ruslan Medzhitov 271 15. Antigen-Presenting Cell Receptors and Innate Immunity: Diversity,Recognition,and Responses Siamon Gordon 287 16. The Function of Leukocyte Immunoglobulin-Like Receptors in Self-Tolerance,Viral Recognition,and Regulation of Adaptive Responses Marco Colonna and Winfried Barchet 301 EFFECTOR RESPONSES 17. Antimicrobial Peptides:Effectors of Innate Immunity Michael Zasloff 315 18. Antimicrobial Proteins Tomas Ganz and Robert I.Lehrer 345 19. Reactive Oxygen and Reactive Nitrogen Metabolites as Effector Molecules against Infectious Pathogens Christian Bogdan 357 20. Chemokines Bernhard Moser 397 21. Lipids K.Frank Austen and Yoshihide Kanaoka 417 22. Role of Innate Immunity in Bacterial Infection Peter Seiler,Ulrich Steinhoff,and Stefan H.E.Kaufmann 433 Index 455 FM_Kaufmann_ASM_557014 5/7/04 1:49 PM Page vii CONTRIBUTORS Shizuo Akira Department of Host Defense,Research Institute for Microbial Diseases,Osaka University,and SORST of Japan Science and Technology Corporation,3-1 Yamada-oka,Suita,Osaka 565-0871,Japan K.Frank Austen Department of Medicine,Harvard Medical School,and Division of Rheumatology,Immunology and Allergy,Brigham and Women's Hospital,Boston,MA 02115 Winfried Barchet Department of Pathology and Immunology,Washington University School of Medicine,Box 8118,660 South Euclid Ave.,St.Louis, MO 63110 Gregory M.Barton Howard Hughes Medical Institute,Yale University School of Medicine,300 Cedar St.,TAC S660,New Haven,CT 06520 G.Bergsten Department of Laboratory Medicine,Division of Microbiology, Immunology,and Glycobiology,Lund University,Sölvegatan 23,223 62 Lund,Sweden Christian Bogdan Institute of Medical Microbiology and Hygiene, Department of Medical Microbiology and Hygiene,University of Freiburg, Hermann-Herder-Strasse 11,D-79104 Freiburg,Germany Michael C.Carroll Departments of Pathology and Pediatrics,Harvard Medical School,The CBR Institute for Biomedical Research,800 Huntington Ave.,Boston,MA 02115-5701 Devavani Chatterjea Department of Pathology,Stanford University School of Medicine,300 Pasteur Dr.,L-235,Stanford,CA 94305-5324 Howard Clark MRC Immunochemistry Unit,Department of Biochemistry, University of Oxford,Oxford O1 3QU,United Kingdom Marco Colonna Department of Pathology and Immunology,Washington University School of Medicine,Box 8118,660 South Euclid Ave.,St.Louis, MO 63110 vii FM_Kaufmann_ASM_557014 5/7/04 1:49 PM Page viii viii (cid:1) CONTRIBUTORS Charles T.Esmon Cardiovascular Biology Research Program,Oklahoma Medical Research Foundation;Department of Pathology and Department of Biochemistry & Molecular Biology,University of Oklahoma Health Sciences Center;and Howard Hughes Medical Institute,Oklahoma City,OK 73104 Alan Ezekowitz Laboratory of Developmental Immunology,Harvard Department of Pediatrics,Massachusetts General Hospital,15 Parkman St., Boston,MA 02114 S.Feau University of Milano-Bicocca,Department of Biotechnology and Bioscience,Piazza della Scienza 2,20126 Milan,Italy H.Fischer Department of Laboratory Medicine,Division of Microbiology, Immunology,and Glycobiology,Lund University,Sölvegatan 23,223 62 Lund,Sweden Stephen J.Galli Departments of Pathology and Microbiology and Immunology,Stanford University School of Medicine,300 Pasteur Dr.,L- 235,Stanford,CA 94305-5324 Tomas Ganz CHS 37-055,Department of Medicine,David Geffen School of Medicine,University of California,Los Angeles,Los Angeles,CA 90095 Siamon Gordon Sir William Dunn School of Pathology,University of Oxford,South Parks Road,Oxford OX1 3RE,United Kingdom F.Granucci University of Milano-Bicocca,Department of Biotechnology and Bioscience,Piazza della Scienza 2,20126 Milan,Italy Jules A.Hoffmann Réponse Immunitaire et Développement chez les Insectes,Institut de Biologie Moleculaire et Cellulaire UPR9022 CNRS,15 rue René Descartes,67084 Strasbourg,France David A.Hume Institute for Molecular Bioscience,The University of Queensland,St.Lucia Q4072,Australia Yoshihide Kanaoka Department of Medicine,Harvard Medical School,and Division of Rheumatology,Immunology and Allergy,Brigham and Women's Hospital,Boston,MA 02115 D.Karpman Department of Pediatrics,Lund University Hospital,Lund, Sweden Stefan H.E.Kaufmann Max Planck Institute for Infection Biology, Schumannstr.21/22,D-10117 Berlin,Germany Satish Keshav Centre for Gastroenterology,Department of Medicine,Royal Free & University College Medical School,University College London, Upper 3rd Floor,Rowland Hill Street,London NW3 2PF,United Kingdom Taco W.Kuijpers Emma Children's Hospital,Academic Medical Centre, University of Amsterdam,1105 AZ Amsterdam,The Netherlands FM_Kaufmann_ASM_557014 5/7/04 1:49 PM Page ix CONTRIBUTORS (cid:1) ix Robert I.Lehrer CHS 37-055,Department of Medicine,David Geffen School of Medicine,University of California,Los Angeles,Los Angeles,CA 90095 I.Leijonhufvud Department of Laboratory Medicine,Division of Microbiology,Immunology,and Glycobiology,Lund University,Sölvegatan 23,223 62 Lund,Sweden Petros Ligoxygakis Genetics Unit,Department of Biochemistry,University of Oxford,South Parks Road,Oxford OX1 3QU,United Kingdom A.C.Lundstedt Department of Laboratory Medicine,Division of Microbiology,Immunology,and Glycobiology,Lund University,Sölvegatan 23,223 62 Lund,Sweden John J.Marchalonis Department of Microbiology and Immunology, University of Arizona,College of Medicine,P.O.Box 24-5049,Tucson,AZ 85724 Ruslan Medzhitov Howard Hughes Medical Institute,Yale University School of Medicine,300 Cedar St.,TAC S660,New Haven,CT 06520 Bernhard Moser Theodor-Kocher Institute,University of Bern,Freiestrasse 1,CH-3012 Bern,Switzerland Chandrashekhar Pasare Howard Hughes Medical Institute,Yale University School of Medicine,300 Cedar St.,TAC S660,New Haven,CT 06520 N.Pavelka University of Milano-Bicocca,Department of Biotechnology and Bioscience,Piazza della Scienza 2,20126 Milan,Italy G.Raimondi University of Milano-Bicocca,Department of Biotechnology and Bioscience,Piazza della Scienza 2,20126 Milan,Italy Kenneth Reid MRC Immunochemistry Unit,Department of Biochemistry, University of Oxford,Oxford O1 3QU,United Kingdom P.Ricciardi-Castagnoli University of Milano-Bicocca,Department of Biotechnology and Bioscience,Piazza della Scienza 2,20126 Milan,Italy Dirk Roos Sanquin Research at CLB,and Landsteiner Laboratory,Academic Medical Center,University of Amsterdam,1105 AZ Amsterdam,The Netherlands M.Samuelsson Department of Laboratory Medicine,Division of Microbiology,Immunology,and Glycobiology,Lund University,Sölvegatan 23,223 62 Lund,Sweden P.Samuelsson Department of Laboratory Medicine,Division of Microbiology,Immunology,and Glycobiology,Lund University,Sölvegatan 23,223 62 Lund,Sweden R.Tedjo Sasmono Institute for Molecular Bioscience,The University of Queensland,St.Lucia Q4072,Australia FM_Kaufmann_ASM_557014 5/7/04 1:49 PM Page x x (cid:1) CONTRIBUTORS Samuel F.Schluter Department of Biochemistry,University of Arizona, College of Medicine,P.O.Box 24-509,Tucson,AZ 85724 Peter Seiler Max Planck Institute for Infection Biology,Schumannstr.21/22, D-10117 Berlin,Germany Thilo Stehle Laboratory of Developmental Immunology,Harvard Department of Pediatrics,Massachusetts General Hospital,15 Parkman St., Boston,MA 02114 Ulrich Steinhoff Max Planck Institute for Infection Biology,Schumannstr. 21/22,D-10117 Berlin,Germany C.Svanborg Department of Laboratory Medicine,Division of Microbiology, Immunology,and Glycobiology,Lund University,Sölvegatan 23,223 62 Lund,Sweden M.L.Svensson Department of Laboratory Medicine,Division of Microbiology,Immunology,and Glycobiology,Lund University,Sölvegatan 23,223 62 Lund,Sweden Kiyoshi Takeda Department of Host Defense,Research Institute for Microbial Diseases,Osaka University,and SORST of Japan Science and Technology Corporation,3-1 Yamada-oka,Suita,Osaka 565-0871,Japan Mindy Tsai Department of Pathology,Stanford University School of Medicine,300 Pasteur Dr.,L-235,Stanford,CA 94305-5324 Admar Verschoor Departments of Pathology and Pediatrics,The CBR Institute for Biomedical Research,Harvard Medical School,800 Huntington Ave.,Boston,MA 02115-5701 C.Vizzardelli University of Milano-Bicocca,Department of Biotechnology and Bioscience,Piazza della Scienza 2,20126 Milan,Italy G.Kerr Whitfield Department of Biochemistry,University of Arizona, College of Medicine,Tucson,AZ 85724 B.Wullt Department of Urology,Lund University Hospital,223 62 Lund, Sweden Wayne M.Yokoyama Howard Hughes Medical Institute,Rheumatology Division,Box 8045,Washington University Medical Center,660 South Euclid Ave.,St.Louis,MO 63110 I.Zanoni University of Milano-Bicocca,Department of Biotechnology and Bioscience,Piazza della Scienza 2,20126 Milan,Italy Michael Zasloff Georgetown University Medical Center,3900 Reservoir Rd.,Washington,DC 20057
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