The Influence of Antibiotics on the Host-Parasite Relationship III

304 Pages·1989·6.375 MB·English

by  P. G. Quie (auth.), Professor Dr. Dr. Günther Gillissen, Professor Dr. Wolfgang Opferkuch, Professor Dr. Georg Peters, Professor Dr. Dr. h.c. Gerhard Pulverer (eds.)

The Influence
of Antibiotics
on the Host-Parasite
Relationship III
Edited by
G. Gillissen, W Opferkuch, G. Peters,
and G. Pulverer
With 84 Figures and 100 Tables
Springer-Verlag
Berlin Heidelberg New York
London Paris Tokyo
Professor Dr. Dr. GUNTHER GILLISSEN
Institut fUr Medizinische Mikrobiologie
der Medizinischen Fakultiit der RWTH Aachen
Pauwelsstrasse, D-5100 Aachen
Professor Dr. WOLFGANG QPFERKUCH
Abteilung fUr Theoretische und Klinische Medizin
Lehrstuhl fur Medizinische Mikrobiologie
Ruhr-Universitiit Bochum, Universitiitsstrasse 150
D-4630 Bochum
Professor Dr. GEORG PETERS
Professor Dr. Dr. h.c. GERHARD PULVERER
Hygiene-Institut der Universitiit zu Kaln
Goldenfelsstrasse 19-21, D-5000 Kaln 41
ISBN-13: 978-3-642-73655-1 e-ISBN-13: 978-3-642-73653-7
DOl: 10.1007/978-3-642-73653-7
Library of Congress Cataloging in Publication Data. The Influence of antibiotics on the host
parasite relationship III / edited by G. Gillissen ... ret al.]. p. cm. Papers from proceedings
of a conference. Includes bibliographies and index.
1. Host-bacteria relationships - Effect of drug on - Congresses. 2. Antibiotics - Side effects
Congresses. 3. Bacterial diseases-Chemotherapy - Complications and sequelae - Congresses.
I. Gillissen, G. [DNLM: 1. Antibiotics-immunology - congresses. 2. Antibiotics-pharma
cology - congresses. 3. Bacteria - physiology - congresses. 4. Host-Parasite Relations -
congresses. QV 350 143] QR201.B341755 1989 615'.329--{[c 19 DNLM/DLC for
Library of Congress 89-4293 CIP
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© Springer-Verlag Berlin Heidelberg 1989
Softcover reprint of the hardcover I st edition 1989
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2127/3130-543210 - Printed on acid-free paper
Preface
When comparing the number of contributions for the proceedings
of the third symposium on The Influence of Antibiotics on the
Host-Parasite Relationship with those of its two predecessors, one
becomes aware of the progress that has been made in this field.
It is obvious that the design of experiments has substantially refined
and therefore the clinical relevance of the results has gained in
significance.
The editors of this volume would like to thank all the colleagues
who contributed to this book. It is hoped that interest in this field
will develop further and that it will finally yield results which one
day may be the basis for an improvement of antibiotic therapy.
Bochum WOLFGANG OPFERKUCH
Contents
Opening Remarks
P. G. Quie ....
Interactions Between Antibiotics, Phagocytes, and Bacteria
W. L. Hand, N. L. King-Thompson, T. H. Steinberg, and
D. L. Hand. With 2 Figures and 5 Tables . . . . . . .. 4
Influence of Antibiotics on the Cell Surface of Escherichia coli
H. Leying, S. Suerbaum, H.-P. Kroll, J. Gmeiner, and
W. Opferkuch. With 2 Figures and 3 Tables . . . . . 17
Pseudomonas aeruginosa: Alterations Induced by Low
Concentrations of 4-Quinolones
M. T. Labro, A. Bryskier, C. Babin-Chevaye, and J. Hakim.
With 5 Figures and 6 Tables. . . . . . . . . . . . . . . 26
Interference of Tunicamycin-Induced Staphylococcal Lectin
Dysfunction with Specific Adherence Mechanisms and
Immune Responses
J. Beuth, H. L. Ko, R. Pfeiffer, A. Yassin, Y. Ohshima, and
G. Pulverer. With 1 Figure. . . . . . . . . . . . . .. 38
An In Vitro Model to Investigate the Influence of Antibiotics
on Bacterial Susceptibility to Surface Phagocytosis by Human
Polymorphonuclear Leukocytes
C. G. Gemmell. With 7 Tables . . . . . . . . . . . . . . 43
Growth Rate, Iron Depletion, and a Sub-Minimal Inhibitory
Concentration of Penicillin G Affect the Surface
Hydrophobicity of Staphylococcus aureus
P. A. G. Domingue, E. Schwarzinger, and M. R. W. Brown.
With 5 Figures and 3 Tables. . . . . . . . . . . . .. 50
Reduced Wall Degradation of Staphylococci After
Pretreatment with Bacteriostatic Antibiotics
J. Wecke, M. Lahav, P. Blumel, and P. Giesbrecht.
With 3 Figures. . . . . . . . . . . . . . . . . 63
Influence of Subinhibitory Concentrations of Ceftriaxone on
Opsonic Requirements of Pseudomonas aeruginosa
M. T. Labro, C. Babin-Chevaye, and J. Hakim.
With 3 Figures and 2 Tables. . . . . . . . . . . . . . . 71
VIII Contents
Traditional Chinese Medicines and Drugs in Relation to the
Host-Defense Mechanism
N. Satomi, A. Sakurai, R. Haranaka, and K. Haranaka.
With 7 Figures and 1 Table . . . . . . . . . . .. .. 77
Influence of Antibiotic Therapy of Mice on the Humoral
Immune Response Against Sheep Erythrocytes
K.-H. Buscher, G. Schwarz, B. Andres, S. Wendt, and
W. Opferkuch. With 6 Tables . . . . . . . .. .... 87
Influence of Ciprofloxacin Treatment In Vivo on
Cell-Mediated Immunity to Listeria monocytogenes
S. Ehlers and H. Hahn. With 4 Figures and 1 Table . . 94
Enzymatic Conversion of [3H]Clindamycin by the Human
Neutrophil
L. Amaral and V. Lorian. With 3 Tables. . . . . . .. 102
Antibiotic Modulation of Host Defense
B. P. Overbeek and J. Verhoef. With 3 Figures and 1 Table. 106
In Vitro and Ex Vivo Effect of Cefodizime on Phagocytosis
A. Fietta, C. Bersani, T. Santagada, F. M. Grassi, and
G. Gialdroni-Grassi. With 1 Figure and 2 Tables . . .. . 112
Antibacterial Substance(s) from Hypericum perforatum:
Influence on Phagocytosis of Escherichia coli by Human
Neutrophils
E. Lingaas and T. Midtvedt. With 4 Tables . . . . .. 116
Influence of the Tetrachlorodecaoxygen Anion Complex on
Phagocytosis of Peripheral Human Polymorphonuclear Cells
in Chemiluminescence Assays
G. Gillissen and H. Ostendorp. With 2 Figures . . . . 122
Influence of RO 236240 on Human Polymorphonuclear
Leukocytes In Vitro
P. vander Auwera and M. Husson. With 2 Tables. . . 128
Interactions Among Subinhibitory Antibiotics, Aerobic Gram
negative Rods, and Human Polymorphonuclear Neutrophils
L. A. Mandell and M. Afnan. With 5 Figures and 2 Tables. 133
Effects of Glycopeptide and Lipopeptide Antibiotics on
Granulocyte Function In Vitro
F. Schumacher-Perdreau, E. Schell-Frederick, G. Peters, and
G. Pulverer. With 3 Figures and 3 Tables . . . . .. . 144
Determination of Intracellular Antibacterial Activity of
Antibiotics by Means of a Fluorochrome Microassay
W. Horn, R. Jantzen, and J. Lucke.
With 3 Figures and 1 Table . . . . . . . . . . . . . . . 152
Contents IX
Effect of New Antibacterial Agents on Intracellular
Staphylococci and Mycobacteria
C. S. F. Easmon. With 7 Tables. . . . . . . . .. ... 160
Effects of Beta-Lactam Antibiotics on the Lymphocyte
Responses In Vitro and in Animals
E. A. Chaperon and A. C. Stonnington.
With 2 Figures and 6 Tables. . . . . . . . . . . . . . . 165
Effect of TrimethoprimjSulfamethoxazole on Human
Neutrophil Function and Survival of Mice Infected with Candida
T. N. Patselas, G. W. Sullivan, and G. L. Mandell.
With 6 Figures. . . . . . . . . . . . . . . . . . . . . 174
Effects of Selected Antibiotics on Experimental Candidiasis in
Cyclophosphamide-Treated Mice: An In Vivo Model to
Evaluate the Antibiotic Effect on Granulocytopoiesis
M. C. Escande, C. Poyart-Salmeron, and P. H. Lagrange.
With 6 Figures and 4 Tables. . . . . . . . . . . . . . . 184
Immunomodulating Effect of Fosfomycin
G. Gillissen, M. Breuer-Werle, B. Melzer, and H. Ostendorp.
With 5 Figures and 1 Table . . . . . . . . . . . .. . 196
Effects of Antibiotics on Resistance to Colonization with
Enteric Pathogens in Mice
D. J. Hentges, W. W. Marsh, S. H. Dougherty, W. R. ThaI, and
M. K. Adams. With 3 Tables. . . . . . . . . . . . . . . 204
Influence of Antibiotics on Biochemical Intestinal Microflora
Associated Characteristics in Man and Animals
T. Midtvedt. With 3 Tables . . . . . . . . . . . .. 209
Antibiotics and the Host-Parasite Relationship in Cystic
Fibrosis
J. A. Raeburn, R. Sutherland, R. T. Cullen, and A. Greening.
With 3 Figures and 4 Tables. . . . . . . . . . . . .. 216
Absence of a Postantibiotic Effect in Experimental Left-Sided
Streptococcus faecalis Endocarditis Treated with Penicillin Plus
Gentamycin
M. T. Hessen, P. G. Pitsakis, and M. E. Levison.
With 1 Figure . . . . . . . . . . . . . . . . . . . . . 222
Absence of a Postantibiotic Effect in Experimental Left-Sided
Pseudomonas aeruginosa Endocarditis Treated with Imipenem
with or Without Gentamicin
M. T. Hessen, P. G. Pitsakis, and M. E. Levison.
With 3 Figures. . . . . . . . . . . . . . . . . . . . . 226
X Contents
Influence of Mezlocillin Administration to Pregnant Mice on
the Immune System of Their Offspring
W. Roszkowski, B. Wesokowska, H. L. Ko, K. Roszkowski,
P. Ciborowski, J. Jeljaszewicz, and G. Pulverer.
With 6 Tables . . . . . . . . . . . . . . . . . . .. 231
Changes in the Immune Parameters of Antibiotic-Bacterial
Interactions Induced by Hypothalamic and Other Electrolytic
Brain Lesions Produced Through Stereotaxically Implanted
Depth Electrodes
J. Szentivanyi, A. Szentivanyi, P. Schultze, G. Filipp, and
o. Heim. With 1 Table . . . . . . . . . . . . . . . . . 237
In Vitro Effect of Different Antimicrobial Agents on 11-2
Production and 11-2 Receptor Expression of Human
Lymphocytes
S. Pusztai-Markos and K. Hauss. With 3 Figures and 1 Table. 245
Effect of 4-Quinolone Antibiotics on Cell Function, Cell
Growth, and Pyrimidine Nucleotide Biosynthesis in Human
Lymphocytes In Vitro
A. Forsgren. With 3 Figures and 2 Tables . . . . . . . . . 255
Enhancement by Ampicillin or Cyclacillin Pretreatment of
E. coli of Phagocytosis, Blastogenesis, and Production of
Lymphokines, Interferons, and Tumor Necrosis Factor
H. Friedman, A. Szentivanyi, T. W. Klein, and G. Warren.
With 8 Tables . . . . . . . . . . . . . . . . . . . . . 263
Effect of Beta-Lactam-Antibiotics on Eukaryotic DNA
Replication: Possible Impact on the Host-Parasite Relationship
K. A. Neftel, U. D. Huynh, and U. Hiibscher.
With 1 Figure and 1 Table . . . . . . . . . . . . . . . 274
Interaction Between the DNA-Gyrase Inhibitor Coumermycin
and the Membrane of Human Neutrophils
P. Van der Auwera, M. Husson, J. M. Ruysschaert, and
R. Brasseur. With 2 Figures and 1 Table. . . . . . . 281
Concluding Remarks
J. S. Remington 286
Subject Index . . . 289
List of Contributors
Adams, M. K., Lubbock, Texas, USA
Afnan, M., Hamilton, Ontario, Canada
Amaral, L., Bronx, New York, USA
Andres, B., Bochum, Federal Republic of Germany
Babin-Chevaye, C., Paris, France
Bersani, C., Pavia, Italy
Beuth, J., Cologne, Federal Republic of Germany
Blumel, P., Berlin, Federal Republic of Germany
Brasseur, R., Brussels, Belgium
Breuer-Werle, M., Aachen, Federal Republic of Germany
Brown, M. R. W., Birmingham, United Kingdom
Bryskier, A., CHG d'Argenteuil, France
Buscher, K.-H., Darmstadt, Federal Republic of Germany
Chaperon, E. A., Omaha, Nebraska, USA
Ciborowski, P., Warsaw, Poland
Cullen, R. T., Edinburgh, United Kingdom
Domingue, P. A. G., Calgary, Alberta, Canada
Dougherty, S. H., El Paso, Texas, USA
Easmon, C. S. F., London, United Kingdom
Ehlers, S., Berlin, Federal Republic of Germany
Escande, M. C., Paris, France
Fietta, A., Pavia, Italy
Filipp, G., Homburg, Federal Republic of Germany
Forsgren, A., Malmo, Sweden
Friedman, H., Tampa, Florida, USA
Gemmell, C. G., Glasgow, United Kingdom
XII List of Contributors
Gialdroni-Grassi, G., Pavia, Italy
Giesbrecht, P., Berlin, Federal Republic of Germany
Gillissen, G., Aachen, Federal Republic of Germany
Gmeiner, J., Darmstadt, Federal Republic of Germany
Grassi, F. M., Pavia, Italy
Greening, A., Edinburgh, United Kingdom
Hahn, H., Berlin, Federal Republic of Germany
Hakim, J., Paris, France
Hand, D. L., Atlanta, Georgia, USA
Hand, W. L., Atlanta, Georgia, USA
Haranaka, K., Tokyo, Japan
Haranaka, R., Tokyo, Japan
Hauss, K., Aachen, Federal Republic of Germany
Heim, 0., Homburg, , Federal Republic of Germany
Hentges, D. J., Lubbock, Texas, USA
Hessen, M. T., Philadelphia, Pennsylvania, USA
Horn, W., Giessen, Federal Republic of Germany
Hubscher, U., Zurich, Switzerland
Husson, M., Brussels, Belgium
Huynh, U. D., Zurich, Switzerland
Jantzen, R., Giessen, Federal Republic of Germany
Jeljaszewicz, J., Warsaw, Poland
King-Thompson, N. L., Atlanta, Georgia, USA
Klein, T. W., Tampa, Florida, USA
Ko, H. L., Cologne, Federal Republic of Germany
Kroll, H.-P., Wuppertal, Federal Republic of Germany
Labro, M. T., Paris, France
Lagrange, P. H., Paris, France
Lahav, M., Jerusalem, Israel
Levison, M. E., Philadelphia, Pennsylvania, USA
Leying, H., Bochum, Federal Republic of Germany
Lingaas, E., Oslo, Norway