The Human T-Cell Receptor Repertoire and Transplantation PDF
Preview The Human T-Cell Receptor Repertoire and Transplantation
MoLEcULAR BIOLOGY INTELLIGENCE UNIT HuMAN THE T-CELL RECEPTOR REPERTOIRE AND TRANSPLANTATION Peter J. van den Elsen, Ph.D. Department of Immunohematology and Blood Bank University Hospital Leiden Leiden, The Netherlands Springer-Verlag Berlin Heidelberg GmbH RG.LANms CoMPANY AUSTIN MoLECULAR BIOLOGY INTElLIGENCE UNIT THE HUMAN T-CELL RECEPTOR REPERTOIRE AND TRANSPLANTATION R.G. LANDES COMPANY Austin, Texas, U.S.A. Submitted: May 1995 Published: July 1995 International Copyright© 1995 Springer-Verlag Berlin Heidelberg Originally published by Springer-Verlag, Heidelberg, Germany in 1995 Softcover reprint of the hardcover 1st edition 1995 All rights reserved. International ISBN 978-3-662-22496-0 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage ofe quipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time ofp ublication, they make no warranty, expressed or implied, with respect to material described in this book. In view oft he ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Library of Congress Cataloging-in-Publicatiuon Data Van den Elsen, Peter J., 1951- The human T -cell receptor repertoire and transplantation I by Peter J. van den Elsen p. em. -(Molecular biology intelligence unit) Includes bibliographical reference and index. ISBN 978-3-662-22496-0 ISBN 978-3-662-22494-6 (eBook) DOI 10.1007/978-3-662-22494-6 1. Graft rejection. 2. T-cells-Receptors. 3. Transplantation immunology. I. Title. II. Series. [DNLM: 1. Receptors, Aruigen, T -Cell-immunology. 2. Graft Rejection immunology. 3. T-lymphocytes-immunology. QW 573 V227h 1995] QR188.8.V361995 616.07'9---dc20 DNLMIDNLC for Library of Congress 95-14122 CIP PuBLISHER's NoTE R.G. Landes Company publishes five book series: Medical Intelligence Unit, Molecular Biology Intelligence Unit, Neuroscience Intelligence Unit, Tissue Engineering Intelligence Unit and Biotech nology Intelligence Unit. The authors of our books are acknowl edged leaders in their fields and the topics are unique. Almost without exception, no other similar books exist on these topics. Our goal is to publish books in important and rapidly changing areas of medicine for sophisticated researchers and clinicians. To achieve this goal, we have accelerated our publish ing program to conform to the fast pace in which information grows in biomedical science. Most of our books are published within 90 to 120 days of receipt of the manuscript. We would like to thank our readers for their continuing interest and wel come any comments or suggestions they may have for future books. Deborah Muir Molsberry Publications Director R.G. Landes Company CONTE NT S r;:::::=:=================== ====================::::;-] 1. General Introduction .................................................................. 1 Peter J van den Elsen 1. Introduction .................................................................................... 1 2. The Circulating Human Peripheral T -Cell Repertoire ............. 29 Linda Struyk, Gail E. Hawes, Frank Raaphorst, Marja van Eggermond, Barbara Godthelp and Peter J van den Elsen 2. Abstract ......................................................................................... 29 2.1 Introduction .................................................................................. 30 2.2 Results ........................................................................................... 31 2.3 Discussion ..................................................................................... 54 3. T Cell Receptor Usage in Alloreactivity .................................... 63 Gail E. Hawes and Peter J van den Elsen 3. Summary ........................................................................................ 63 4. T -Cell Receptor Usage Among Graft Infiltrating T Lymphocytes ................................. 85 fames T. Kurnick, Makiko Kumagai-Braesch, Carol P. Leary, Richard Waitkis, Lenora A. Boyle, Peter J van den Elsen and David M Andrews 4. Introduction .................................................................................. 85 5. T-Cell Receptor V-Gene Usage in T-Cell Lines Propagated from Graft-Infiltrating T Lymphocytes in Needle Biopsies of Rejecting Renal Allografts ................................................... 101 Benito A. Yard, Thomas Reterink, Peter J van den Elsen, ME. Paape, fan Antony Bruijn, Leendeert A. van Es, Mohammed R. Daha and Fokko J van der Woude 5. Abstract ....................................................................................... 101 5.1 Introduction ................................................................................ 102 5.2 Materials and Methods ................................................................ 103 5.3 Results ......................................................................................... 106 5.4 Discussion ................................................................................... 109 6. Structure ofT Cell Receptor Va. and V~ Chains Expressed by T-Lymphocytes in Cardiac Allograft Derived Cell Lines .... 117 Gert Datema, Len Vaessen, Rene Daane, Carla Baan, Willem Weimar, Frans J Claas and Peter J van den Elsen 6. Summary ..................................................................................... 117 6.1 Introduction ................................................................................ 118 6.2 Materials and Methods ................................................................ 119 6.3 Results ......................................................................................... 124 6.4 Discussion ................................................................................... 140 7. Involvement of Minor Histocompatability Antigens in the Rejection of an HIA Identical Renal Transplant from a Living Related Donor .................................................. 149 Benito A. Yard Thomas Reterink, fan Antony Bruijn, Peter f. van den Elsen, Frans f. Claas, Mohamed R Daha, Leendert A. van Es and Fokko]. van der Woude 7. Abstract ....................................................................................... 149 7.1 Introduction ................................................................................ 150 7.2 Materials and Methods ................................................................ 151 7.3 Results ......................................................................................... 154 7.4 Discussion ................................................................................... 157 8. Concluding Remarks .............................................................. 163 Peter f. van den Elsen Index .............................................................................................. 169 r.===================== ED IT O R=========================::::;-J J. Peter van den Elsen Department of Immunohematology and Blood Bank University Hospital Leiden Leiden, The Netherlands Chapters J-8 CO NTRI BU TO RS ======================! ~======================= David M. Andrews Rene Daane Department of Pathology Department oflnternal Medicine Massachusetts General Hospital University Hospital Dykzigt- Boston, Massachusetts, U.S.A Rotterdam Chapter4 Rotterdam, The Netherl ands Chapter6 CarlaBaan Department of Internal Medicine Mohamed R. Daha University Hospital Dykzigt- Department of Nephrology Rotterdam University Hospital Leiden Rotterdam, The Netherlands Leiden, The Netherlands Chapter6 Chapters 5, 7 Lenora A Boyle GertDatema Department of Pathology Department of Immunohematology Massachusetts General Hospital and Blood Bank Boston, Massachusetts, U.S.A. University Hospital Leiden Chapter4 Leiden, The Netherlands Chapter6 Jan Antony Bruijn Department of Pathology Marja van Eggermond University Hospital Leiden Department of Immunohematology Leiden, The Netherlands and Blood Bank Chapters 5, 7 University Hospital Leiden Leiden, The Netherlands Frans J. Claas Chapter2 Department of Immunohematology and Blood Bank University Hospital Leiden Leiden, The Netherlands Chapters 6, 7 CO NTRI BU TO RS r.================ ================il Leendert A. van Es M.E. Paape Department of Nephrology Department of Nephrology University Hospital Leiden University Hospital Leiden Leiden, The Netherlands Leiden, The Netherlands Chapters 5, 7 Chapter 5 Barbara Godthelp Frank Raaphorst Department of Immunohematology Department of Immunohematology and Blood Bank and Blood Bank University Hospital Leiden University Hospital Leiden Leiden, The Netherlands Leiden, The Netherlands Chapter2 Chapter2 Gail E. Hawes Thomas Reterink Department oflmmunohematology Department of Immunohematology and Blood Bank and Blood Bank University Hospital Leiden University Hospital Leiden Leiden, The Netherlands Leiden, The Netherlands Chapters 2, 3 Chapters 5, 7 Makiko Kumagai-Braesch Linda Struyk Department of Pathology Department of Immunohematology Massachusetts General Hospital and Blood Bank Boston, Massachusetts, U.S.A. University Hospital Leiden Chapter4 Leiden, The Netherlands Chapter2 James T. Kurnick Department of Pathology Richard Waitkus Massachusetts General Hospital Department of Pathology Boston, Massachusetts, U.S.A. Massachusetts General Hospital Chapter4 Boston, Massachusetts, U.S.A. Chapter4 Carol P. Leary Department of Pathology Willem Weimar Massachusetts General Hospital Department of Internal Medicine Boston, Massachusetts, U.S.A. University Hospital Dykzigt- Chapter4 Rotterdam' Rotterdam, The Netherlands Chapter6 r.================CO NTRI BU TO RS============~ Len Vaessen Fokko J. van der Woude Department oflnternal Medicine Department of Nephrology University Hospital Dykzigt- University Hospital Leiden Rotterdam Leiden, The Netherlands Rotterdam, The Netherlands Chapters 5, 7 Chapter6 Benito A. Yard Department ofNephrology University Hospital Leiden Lei den, The Netherlands Chapters 5, 7 AcKNOWLEDGMENTS I would like to thank the publishers of Human Immunol ogy; the Journal of Immunology; International Immunology; Immunogenetics, Kidney International and Transplantation for granting permission to use some of the figures and tables presented in chapters 2, 5 and 6 which were previously pub lished in these journals. Special thanks also to my other collabo rators Jeroen van Bergen, Jan Bruining, Eric Kaijzel, Maarten van der Keur, Ronald de Krijger, Renee Langlois-van den Berg, Maarten van Tol and Jaak Vossen for their contributions and support, Sam Gobin for his art-work and Karin Vlasveld for endless editing sessions of the manuscripts presented in this overvtew.
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