The Hippocampus: Volume 2: Neurophysiology and Behavior

450 Pages·1976·12.122 MB·English

by  O. S. Vinogradova (auth.), Robert L. Isaacson, Karl H. Pribram (eds.)

The Hippocampus
Volume 2: Neurophysiology and Behavior
THE HIPPOCAMPUS
Volume 1: Structure and Development
Volume 2: Neurophysiology and Behavior
The Hippocampus
Volume 2: Neurophysiology and Behavior
Edited by
Robert L. Isaacson
Department of Psychology
University of Florida
and
Karl H. Pribram
Department of Psychology
Stanford University
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
Main entry under title:
The Hippocampus.
Includes bibliographies and index.
CONTENTS: v. 1. Structure and development.-v. 2. Neurophysiology and be.
havior.
1. Hippocampus (Brain) I. Isaacson, Robert Lee, 1928- II. Pribram, Karl
H., 1919- [DNlM: 1. Hippocampus. WL300H667]
QP381.H53 612'.825 75-28121
ISBN-13: 978-1-4684-2981-7 e-ISBN-13: 978-1-4684-2979-4
DOl: 10.1007/978-1-4684-2979-4
© 1975 Plenum Press, New York
Softcover reprint of the hardcover 1s t edition 1975
A Division of Plenum Publishing Corporation
227 West 17th Street, New York, N.Y. 10011
United Kingdom edition published by Plenum Press, London
A Division of Plenum Publishing Company, Ltd.
Davis House (4th Floor), 8 Scrubs Lane, Harlesden, London, NWI0 6SE, England
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording or otherwise, without written permission from the Publisher
Contributors
to this volume
A. H. BLACK, McMaster University, Hamilton, Ontario, Canada
B. H. BLAND, Department of Psychology, University of Calgary, Calgary, Alberta,
Canada
THOMAS L. BENNETT, Departments of Psychology, Physiology, and Biophysics,
Colorado State University, Fort Collins, Colorado
NELSON BUTTERS, Psychology Service, Boston Veterans Administration Hospital,
Boston, Massachusetts
LAIRD CERMAK, Aphasia Research Unit, Neurology Department, Boston University
School of Medicine, Boston, Massachusetts
DOUGLAS P. CROWNE, Department of Psychology, University of Waterloo, Waterloo,
Ontario, Canada
ROBERT J. DOUGLAS, University of Washington, Seattle, Washington
L. A. GILLESPIE, Department of Psychology, University of Western Ontario,
London, Ontario, Canada
DANIEL PORTER KIMBLE, University of Oregon, Eugene, Oregon
R. KRAMIS, Department of Psychology, University of Western Ontario, London,
Ontario, Canada
DONALD B. LINDSLEY, Departments of Psychology, Physiology, and Psychiatry, and
Brain Research Institute, University of California, Los Angeles, California
P. J. LIVESEY, Department of Psychology, University of Western Australia, Ned
lands, Western Australia
DOLORES D. RADCUFFE, Department of Psychology, University of Waterloo,
Waterloo, Ontario, Canada
JAMES B. RANCK, JR., Department of Physiology, University of Michigan, Ann
Arbor, Michigan
E. A. SERAFETINIDES, Brentwood Veterans Administration Hospital and Department
of Psychiatry, University of California Center for the Health Sciences, Los
Angeles, California
C. H. VANDERWOLF, Department of Psychology, University of Western Ontario,
London, Ontario, Canada
O. S. VINOGRADOVA, Department of Memory Problems, Institute of Biophysics, The
U.S.S.R. Academy of Sciences Biological Center, Puschino-on-Oka, U.S.S.R.
v
VI Contributors
R. D. WALTER, Department of Neurology, University of California Center for the
Health Sciences, Los Angeles, California
EUZABETH K. WARRINGTON, The National Hospital, Queen Square, London,
England
L. WEISKRANTZ, Department of Experimental Psychology, University of Oxford,
Oxford, England
CHARLES L. WILSON, Departments of Psychology, Physiology, and Psychiatry, and
Brain Research Institute, University of California, Los Angeles, California
JONATHAN WINSON, The Rockefeller University, New York, New York
Preface
These books are the result of a conviction held by the editors, authors, and publisher
that the time is appropriate for assembling in one place information about functions of
the hippocampus derived from many varied lines of research. Because of the explosion
of research into the anatomy, physiology, chemistry, and behavioral aspects of the hip
pocampus, some means of synthesis of the results from these lines of research was
called for. We first thought of a conference. In fact, officials in the National Institute of
Mental Health suggested we organize such a conference on the hippocampus, but after
a few tentative steps in this direction, interest at the federal level waned, probably due
to the decreases in federal support for research in the basic health sciences so keenly felt
in recent years. However, the editors also had come to the view that conferences are
mainly valuable to the participants. The broad range of students (of all ages) of brain
behavior relations do not profit from conference proceedings unless the proceedings are
subsequently published. Furthermore, conferences dealing with the functional
character of organ systems approached from many points of view are most successful
after participants have become acquainted with each other's work. Therefore, we
believe that a book is the best format for disseminating information, and that its
publication can be the stimulus for many future conferences.
As editors we would like to thank those authors whose contributions appear in
these books for their efforts and for sharing our belief in the timeliness of such a
publication. We also would like to thank Mr. Seymour Weingarten and Plenum
Publishing Corporation for their help and encouragement. They share our hopes and
beliefs.
Robert L. Isaacson
Karl H. Pribram
Vll
Contents
Contents of Volume 1 .................................... XVII
III. Electrical Activity
1. Functional Organization of the Limbic System in the Process of
Registration of Information: Facts and Hypotheses
O. S. VINOGRADOVA
1. Introduction............................................. 3
2. Methods................................................ 7
3. Basic Results and Hypotheses. . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... 8
3.1. Hippocampus Regio Inferior (Field CA3), Dorsal Part ..... 8
3.2. Hippocampus Regio Inferior (Field CA3), Ventral Part. . . .. 11
3.3. Hippocampus Regio Superior (Field CAl) ............... 12
3.4. Mammillary Bodies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 17
3.5. Anteroventral Thalamic Nucleus ....................... 19
3.6. Limbic (Cingulate) Cortex ............................ 21
3.7. Entorhinal Cortex. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 26
3.8. Dentate Fascia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 28
3.9. Medial and Lateral Septal Nuclei ...................... 32
3.10. Reticular Formation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 35
3.11. Descending Influences of the Hippocampus on RF . . . . . . . .. 37
3.12. Descending Influences of the Hippocampus on
Septum (Stimulation) . . . . . . . . . . . . . . . . . . . . . . . . . . .. 39
3.13. Descending Influence of the Hippocampus on
Septum (Disconnection) . . . . . . . . . . . . . . . . . . . . . . . . .. 40
3.14. Interaction Among Inputs to the Field CA3 .............. 43
3.15. Effects of Disconnection of Reticuloseptal Input ........... 48
3.16. DF Influences onCA3 ............................... 51
3.17. Influence ofCA3 on CAl............................. 57
3.18. General Assumptions About the Mode of Action of
the Limbic System in the Process of Registration
of Information ................................. 60
4. References.............................................. 64
ix
X Contents
2. The Electrical Activity of the Hippocampus and Processes of
Attention
THOMAS L. BENNETT
1. Introduction............................................. 71
2. Behavior Correlates of (J • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • •• 72
2.1. An Attempt to Resolve the Adey-Grastyan Controversy. . . .. 73
2.2. Hippocampal (J and Response Inhibition. . . . . . . . . . . . . . . .. 75
2.3. HIppocampal (J and the Attention Component of
Discrimination Learning. . . . . . . . . . . . . . . . . . . . . . . .. 79
2.4. Hippocampal (J and Voluntary Movement ............... 82
2.5. Species Differences in the Behavior Correlates of
Hippocampal (J •••. • • • • • • • • • • • • • • • • • • • • • • • • • • •• 83
3. Is (J Necessary? .......................................... 87
4. Summary and Conclusions ................................. 96
5. References.............................................. 97
3. Hippocampal Rhythmic Slow Activity and Neocortical Low
Voltage Fast Activity: Relations to Behavior
C. H. VANDERWOLF, R. KRAMIS, L. A. GILLESPIE,
AND B. H. BLAND
1. Introduction ......... ,................................... 101
2. Hippocampal Slow-Wave Activity and Behavior in Rats ......... 102
3. Two Types of Rhythmic Slow Activity in Hippocampus ......... 106
4. Two Neocortical Activating Systems ......................... 114
5. Selective Effects of Anesthetics .............................. 116
6. Problems of Interpretation of Behavior-Related Brain Activity .... 119
7. Implications ............................................. 123
8. References .............................................. 125
4. Hippocampal Electrical Activity and Behavior
A. H. BLACK
1. Introduction ............................................. 129
2. The Relationship Between Hippocampal EEG and Behavior ..... 130
2.1. Experiments Which Vary Movement .................... 132
2.2. Experiments Which Vary EEG ........................ 141
2.3. Experiments Which Attempt to Dissociate Hippocampal
RSA and Responding ........................... 145
2.4. Experiments Which Vary Other Behavioral Processes ...... 148
2.5. Discussion of the Data ............................... 152
3. Implications for Theories of Hippocampal Function ........... " 156
4. References .............................................. 163
Contents xi
5. The (J Mode of Hippocampal Function
JONATHAN WINSON
1. Introduction......... ................................... 169
2. Behavioral Correlates of () Activity. . . . . . . . . . . . . . . . . . . . . . . . . .. 170
3. Neurophysiological Basis of the () Rhythm .................... 172
4. Patterns of () Rhythm in the Freely Moving Rat . . . . . . . . . . . . . . .. 172
4.1. Methods ........................................... 173
4.2. Results ............................................ 174
4.3. Discussion ......................................... 181
5. References.............................................. 182
6. Some Characteristics and Functional Relations of the Electrical
Activity of the Primate Hippocampus and Hypotheses of
Hippocampal Function
DOUGLAS P. CROWNE AND DOLORES D. RADCUFFE
1. Introduction............................................. 185
1.1. Anatomy .......................................... 185
1.2. Connections........................................ 186
1.3. Electrical Activity 186
o' ••••••••••••••••••••••••••••••••••
2. The Behavioral Effects of Hippocampal Lesions ................ 187
3. The Electrical Activity of the Monkey Hippocampus ............ 189
4. Some Characteristics of the Electrical Activity of the
Monkey Hippocampus .......................... 191
4.1. Functional Significance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 192
4.2. A Hypothesis of Hippocampal Function ................. 199
5. References.............................................. 203
7. Behavioral Correlates and Firing Repertoires of Neurons in the
Dorsal Hippocampal Formation and Septum of Unrestrained
Rats
JAMES B. RANCK, JR.
1. Introduction............................................. 207
2. Methods ................................................ 209
3. Results................................................. 209
3.1. () Cells and Complex Spike Cells ....................... 209
3.2. Behavioral Correlates of () Cells ........................ 212
3.3. Behavioral Correlates of Complex Spike Cells ............ 220
3.4. Distribution of the Behavioral Types .................... 227
3.5. Preliminary Results on Related Structures ............... 229