The Handbook of Alzheimer's Disease and Other Dementias

664 Pages·2011·1.38 MB·English

by  Andrew E. Budson

The Handbook of Alzheimer’s Disease and
Other Dementias
Wiley - Blackwell Handbooks of Behavioral Neuroscience
The rapidly expanding fi eld of behavioral neuroscience examines neurobiological
aspects of behavior, utilizing techniques from molecular biology, neuropsychol-
ogy, and psychology. This series of handbooks provides a cutting - edge overview
of classic research, current scholarship, and future trends in behavioral neuro-
science. The series provides a survey of representative topics in this fi eld, suggest-
ing implications for basic research and clinical applications.
Series editor: David Mostofsky, Boston University
The Handbook of Stress: Neuropsychological Effects on the Brain
Edited by Cheryl D. Conrad
The Handbook of Alzheimer ’ s Disease and Other Dementias
Edited by Andrew E. Budson and Neil W. Kowall
The Handbook of the Neuropsychology of Language (2 Volumes)
Edited by Miriam Faust
The Handbook of
Alzheimer’s
Disease and Other
Dementias
Edited by Andrew E. Budson and
Neil W. Kowall
A John Wiley & Sons, Ltd., Publication
This edition fi rst published 2011
© 2011 Blackwell Publishing Ltd.
Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing program
has been merged with Wiley’s global Scientifi c, Technical, and Medical business to form Wiley-Blackwell.
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The right of Andrew E. Budson and Neil W. Kowall to be identifi ed as the editors of the editorial material
in this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988.
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Library of Congress Cataloging-in-Publication Data
The handbook of Alzheimer’s disease and other dementias / edited by Andrew E.
Budson and Neil W. Kowall.
p. ; cm. – (Wiley-Blackwell handbooks of behavioral neuroscience)
Includes bibliographical references and index.
ISBN 978-1-4051-6828-1 (hardcover : alk. paper)
1. Dementia. I. Budson, Andrew E. II. Kowall, Neil W. III. Series:
Wiley-Blackwell handbooks of behavioral neuroscience.
[DNLM: 1. Dementia. WM 220]
RC521.H34 2011
616.8'3–dc22
2011010575
A catalogue record for this book is available from the British Library.
This book is published in the following electronic formats: ePDFs 9781444344080;
Wiley Online Library 9781444344103; ePub 9781444344097
Set in 10.5/13 pt Minion by Toppan Best-set Premedia Limited
1 2011
We wish to dedicate this book to our families:
Amy, Leah, and Danny
And
Miriam, Elisheva, Charlotte, Jenny, Mischa, and Jonah

Contents
Contributors ix
Foreword xii
Preface xv
Part I Common Dementias 1
1 Alzheimer’s Disease 3
Alan M. Mandell and Robert C. Green
2 Vascular Dementia 92
Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon
3 Dementia with Lewy Bodies 131
Tamara G. Fong and Daniel Z. Press
4 Frontotemporal Dementia 145
Adam L. Boxer
5 Other Dementias 179
Peter Morin
Part II Pathogenesis and Disease Mechanisms 195
6 Genetic Risk Factors for Dementia 197
Paul Hollingworth and Julie Williams
7 The Neuropathology of the Dementing Disorders 235
Ann C. McKee and Brandon E. Gavett
8 Amyloid Beta Peptide and the Amyloid Cascade Hypothesis 262
Carmela R. Abraham
viii Contents
9 Other Mechanisms of Neurodegeneration 277
Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki
10 Rational Therapeutics for Alzheimer’s Disease and Other Dementias 301
Neil W. Kowall
Part III Cognitive and Behavioral Dysfunction 313
11 Memory Dysfunction in Dementia 315
Andrew E. Budson
12 Language Processing in Dementia 336
Jamie Reilly, Joshua Troche, and Murray Grossman
13 Executive Functioning 369
Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett
14 Emotion and Behavior in Alzheimer’s Disease and Other Dementias 416
Christopher I. Wright
15 Visuospatial Function in Alzheimer’s Disease and Related Disorders 457
Alice Cronin-Golomb
16 Sleep and Circadian Rhythms in Dementia 483
David G. Harper
Part IV Neuroimaging in Dementia 505
17 Glimpses of the Living Brain with Alzheimer’s Disease 507
Ronald J. Killiany
18 Functional MRI in Alzheimer’s Disease and Other Dementias 535
Maija Pihlajamäki and Reisa A. Sperling
19 Molecular Neuroimaging of the Dementias 557
Bradford C. Dickerson
20 Using EEG and MEG to Understand Brain Physiology in
Alzheimer’s Disease and Related Dementias 575
Brandon A. Ally
Index 604