The Golden Guide to Oncologic Pharmacy Carolina Witchmichen Penteado Schmidt Kaléu Mormino Otoni Editors 123 The Golden Guide to Oncologic Pharmacy Carolina Witchmichen Penteado Schmidt • Kaléu Mormino Otoni Editors The Golden Guide to Oncologic Pharmacy Editors Carolina Witchmichen Penteado Kaléu Mormino Otoni Schmidt Jesus Maria José Maternity Pediatric Oncology Pharmacist & Hospital, Quixadá, Ceará, Brazil Writer, Curitiba, Paraná, Brazil Postgraduate Program in Integrated and Multidisciplinary Care for Women’s and Children’s Health, Federal University of Ceará, University Campus – Rectory, PICI, Fortaleza, CE, Brazil ISBN 978-3-030-98595-0 ISBN 978-3-030-98596-7 (eBook) https://doi.org/10.1007/978-3-030-98596-7 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface Oncology is an area of high complexity, where more and more specific knowledge is required. The time is short, the area is embracing and deep, and the books for pharmacists are few. The Golden Guide to Oncologic Pharmacy, edited by Carolina Witch- michen Penteado Schmidt and Kaléu Mormino Otoni, is a book by oncology pharmacists for oncology pharmacists. We, editors, have years of experience in the daily practice and teaching of oncology in postgraduate courses and publishing scientific knowl- edge to help professionals have the information we would like to have had when we started, and also years later, for quick search. So, we gathered a team of experienced pharmacists and other healthcare professionals who work in this area of high complex- ity. This book fills a gap, and it's the first one aimed at oncology pharmacists' daily practice. If you also work with pediatric patients, please check Pediatric Oncology Pharmacy: A Complete Guide to Practice as well. This essential guide will support oncologic pharmacists, clini- cal pharmacists, and hospital pharmacists in their daily practice with every area that involves chemotherapy, such as oncology, hematology, rheumatology, stem cell transplantation, ICU, and surgery center, as well as approaches without chemotherapy for cancer, such as CAR-T cells. The essential knowledge has been v vi Preface gathered in this volume, being essential also for postgraduate stu- dents, residents, and even undergraduate students. Curitiba, Brazil Carolina Witchmichen Penteado Schmidt Quixadá, Ceará, Brazil Kaléu Mormino Otoni Contents 1 The Pharmacist in Oncology and Hematology . . . . . . 1 Carolina Witchmichen Penteado Schmidt 2 Oncological Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Maria Inês Rodrigues Gato, Amanda Nascimento dos Reis, Flávio dos Santos Silvério, Fumiko Takahashi Ito, and Kathia Ferraro Lopes 3 Hematological Diseases . . . . . . . . . . . . . . . . . . . . . . . . . 73 Rafael Duarte Paes, Douglas Coutinho Ribeiro da Costa, Joyce Ferreira Viana, and Hebe Mizuno Watanabe 4 Drugs Used in Chemotherapy . . . . . . . . . . . . . . . . . . . 121 Samanta Oliveira da Silva and Ellen Mayara Corrêa 5 Protocols . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177 Kaléu Mormino Otoni, Karla Bruna Nogueira Torres Mormino, Sandna Larissa Freitas dos Santos, and Maria Liliane Luciano Pereira 6 Handling Chemotherapy . . . . . . . . . . . . . . . . . . . . . . . 207 Sandro Luis Ribeiro Ness and Laura Alegria Martins 7 Immunotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 Cristiane Souza de Agostinho, Flávia Mendes Leite, Marlize Brandão Ribeiro Cardoso, and Priscila Pinto Costa vii viii Contents 8 CAR-T Cells and Other Related Technologies . . . . . . 281 Marcus Rafael Lobo Bezerra, Larissa Queiroz Pontes, Igor Cabral Studart, Bruna de Sousa Lima, and Gilvan Pessoa Furtado 9 Intrathecal Chemotherapy . . . . . . . . . . . . . . . . . . . . . . 315 Breno Magalhães Gomes 10 Support Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 Gabriela Sandoval da Silva, Lygia Leão Fernandes, and Taynna Tatiane Pereira 11 Managing Issues: Tumor Lysis, Extravasation, Adverse Effects, and Others . . . . . . . . . . . . . . . . . . . . . . . . . . . . 371 Lucio Frigo, Guilherme Aparecido Monteiro Duque da Fonseca, Giovani Marino Favero, and Durvanei Augusto Maria 12 Administration of an Oncology Pharmacy . . . . . . . . . 399 Fred Soares dos Santos, Thais de Leles Balisa, Felipe de Souza Alves, and Wanessa Ferraz Neres 13 Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . 437 Fumiko Takahashi Ito, Cintia Vecchies Morassi, Gabriela Sandoval da Silva, Larissa Zuppardi Lacerda Sabino, and Mariana Perez Esteves Silva Motta 14 Oncology and Hematology in the ICU . . . . . . . . . . . . 473 Renan Gomes do Nascimento, Nataly Any Barros Garrido de Paula, MérciaPatrícia Ferreira Conceição, Daniel Rodrigues de Bastos, and Danilo de Oliveira Cerqueira 15 Chemotherapy for the Surgery Center . . . . . . . . . . . . 515 Alessandro Menegon 16 Chemotherapy for Rheumatology . . . . . . . . . . . . . . . . 539 Celina de Jesus Guimarães, Pedro Mikael da Silva Costa, José de Brito Vieira Neto, and Anderson Cavalcante Guimarães Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 569 Editors and Contributors About the Editors Carolina Witchmichen Penteado Schmidt Author of several Springer books in pediatric oncology. Editor of the book Chemo- therapy and Pharmacology for Leukemia in Pregnancy: Guide- lines and Strategies for Best Practices. Pediatric Oncology Pharmacist with extensive experience in chemotherapy for chil- dren. Oncological Hospital Pharmacy specialist with experience in chemotherapy for adults. MBA in Planning and Business Man- agement. Substantial experience at hospitals and clinics, with pharmacy, drug interactions, pediatrics, oncology, hematology, stem cell transplantation, neonatology, intensive health care and infectology. Academic experience in pharmacy, pediatrics, oncol- ogy and hematology; teaching for specialists including pharma- cists, physicians and nurses. Author of numerous children’s books about cancer, under the pen name Carola Schmidt, such as Chub- by’s Tale: The true story of a teddy bear who beat cancer, which was defined as “one of the best leukemia books of all time” by Book Authority, and Bald is Beautiful: A letter for a fabulous girl, which was featured by Crayola Education. Check out more about her work at kidscancerbooks.com Kaléu Mormino Otoni Oncology pharmacist with experience at major centers of excellence for cancer treatment, e.g., AC Camargo Cancer Center and Nove de Julho Hospital. Regional representative of the Brazilian Society of Pharmacists in Oncology ix x Editors and Contributors (SOBRAFO) for the State of São Paulo (2018-2019). Specialist in oncology hospital pharmacy at AC Camargo Cancer Center and MBA in Health Management from the University of São Paulo (USP) and Master's student in Women's and Children's Health at the Federal University of Ceará/Brazil Experience in chemother- apy manipulation, clinical oncology pharmacy, pediatric oncol- ogy and hematology, adult oncohematology, and intensive care unit oncology. He is currently the general director of Hospital Maternity Jesus Maria José and a professor of postgraduate courses in oncology pharmacy, and he offers training for health professionals. Contributors Marcus Rafael Lobo Bezerra Postgraduate Program in Bio- technology and Natural Resources, Federal University of Ceará, Fortaleza, Brazil Fiocruz Ceará, Precabura, Eusébio, Brazil Marlize Brandão Ribeiro Cardoso Salvador, Bahia, Brazil MérciaPatrícia Ferreira Conceição Translational Research Center in Oncology, ICESP – Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil FMUSP – Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil Ellen Mayara Corrêa São Caetano do Sul, SP, Brazil Priscila Pinto Costa Salvador, Bahia, Brazil Douglas Coutinho Ribeiro da Costa Hospital Samaritano, João Pessoa, PB, Brazil Guilherme Aparecido Monteiro Duque da Fonseca Periodon- tology Department, School of Dentistry, Universidade Guarulhos, São Paulo, Brazil