The Enteric Nervous System: 30 Years Later

236 Pages·2016·6.52 MB·English

by  Stuart Brierley

Advances in Experimental Medicine and Biology 891
Australian Neuroscience Society
Stuart Brierley
Marcello Costa Editors
The Enteric
Nervous
System
30 Years Later
Advances in Experimental Medicine and Biology
Australian Neuroscience Society
Volume 891
Editorial Board:
IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel
ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA
JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA
RODOLFO PAOLETTI, University of Milan, Milan, Italy
More information about this series at h ttp://www.springer.com/series/5584

Stuart Brierley • Marcello Costa
Editors
The Enteric Nervous System
30 Years Later
Editors
Stuart Brierley Marcello Costa
Discipline of Medicine Department of Human Physiology
University of Adelaide School of Medicine
Adelaide , SA , Australia Flinders University
Adelaide , SA , Australia
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-3-319-27590-1 ISBN 978-3-319-27592-5 (eBook)
DOI 10.1007/978-3-319-27592-5
Library of Congress Control Number: 2016935070
© Springer International Publishing Switzerland 2016
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Introduction to the ENS II 2014, 30 Years Later
Nearly 30 years ago a number of scientists working on the Enteric Nervous System
(ENS) gathered at Flinders to discuss the advances and future of their research.
A photograph (see below, Fig. 1) captured the friendly and stimulating meeting
attended by most of the major players in what was to become the new discipline of
‘neurogastroenterology’.
This fi rst meeting was small, but very successful, and involved all of the leading
researchers in the fi eld of enteric neuroscience from across the world. The reason
for the meeting’s success was that its entire purpose focused on discussing method-
ological strategies and unresolved issues in the fi eld.
At that time we had just started at Flinders a golden decade for the two organisers
John Furness and Marcello Costa, foundation lecturers at the newly established
School of Medicine at Flinders, John in anatomy and Marcello in physiology.
At that meeting they intended to look ahead for the next 10 years.
We are now looking back at more than 30 years, during which a second and a
third generation of researchers in the fi eld emerged, and many of the original
researchers are still active, and some have come to this meeting held again in
Adelaide (see Fig. 1 ).
I ndeed many of the second and third generation researchers have accepted the
invitation and contributed to the 2-day meeting in Adelaide. An extended audience
of selected active researchers in the ENS attended (see Fig. 2 ).
The main Australasian Neuroscience Society (ANS) meeting was held in Adelaide
30 years later, providing a perfect opportunity to recreate a similar follow- up ENS
meeting. As such the ENS II 2014 meeting aimed to identify how far we have come
in the fi eld of enteric neuroscience, where the future is heading and what technological
advances have been made to address current and future unresolved questions.
The local committee consisted of Marcello Costa, Simon Brookes, Nick Spencer,
Stuart Brierley and Phil Dinning, whilst Marcello Costa and John Furness, the
organisers of the 1983 meeting, were the ‘patrons’ of this meeting.
v
vi Introduction to the ENS II 2014, 30 Years Later

Fig. 1 A ttendees of the original ENS meeting held in 1983 at Flinders University, Adelaide,
Australia

Fig. 2 Attendees of the ENS II meeting held at the National Wine Centre, University of Adelaide,
Australia
Introduction to the ENS II 2014, 30 Years Later vii

Fig. 3 Speakers and chairs of the ENS II meeting
From around the world 30 speakers were invited to give talks to revisit the
original expectations, the advances made since and the future directions on ENS
research. This included three generations of investigators from seven different
countries (see Fig. 3 ).
This group included ‘historical’ speakers, those who signifi cantly contributed to
the advances on the ENS over the past two decades (some of whom attended the
fi rst meeting) and the new generation that will continue to contribute to advancing
our understanding of the ENS.
This publication represents the majority of the proceedings of the conference on
The Enteric Nervous System II 2014, a meeting held on February 1st to 2nd at the
National Wine Centre of Australia, Adelaide. It was an offi cial satellite meeting of
the 34th Annual Meeting of ANS, also held in Adelaide.
We thank all those who accepted the invitation to come, many from far away,
and recreate a friendly yet rigorous atmosphere.
Some colleagues could not attend but did send greetings, and their messages are
included in these proceedings (including letters from Joe Szurszewski and Michael
Schemann). We would like to thank our local organising committee and the spon-
sors that made this conference possible.
Adelaide, SA, Australia Stuart Brierley
Marcello Costa

Contents
1 Memories and Promises of the Enteric Nervous System
and Its Functions ..................................................................................... 1
Marcello C osta
2 A Personal Perspective on the Development
of Our Understanding of the Myogenic Control Mechanisms
of Gut Motor Function ........................................................................... 11
Jan D. Huizinga
3 Enteric Inhibitory Neurotransmission, Starting Down Under ........... 21
Kenton M. Sanders
4 Spatio-Temporal Mapping and the Enteric Nervous System ............. 31
Grant W. Hennig
5 Development of Neural Activity in the Enteric
Nervous System: Similarities and Differences
to Other Parts of the Nervous System ................................................... 43
Marlene M. Hao
6 ENS Development Research Since 1983:
Great Strides but Many Remaining Challenges ................................... 53
Heather M. Young , Lincon A. Stamp , and Sonja J. McKeown
7 Extrinsic Sensory Innervation of the Gut:
Structure and Function .......................................................................... 63
Simon Brookes , Nan Chen , Adam Humenick , Nick Spencer ,
and Marcello Costa
8 Ageing and Gastrointestinal Sensory Function .................................... 71
Christopher Keating and David Grundy
ix