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The Enteric Nervous System: 30 Years Later PDF

236 Pages·2016·6.52 MB·English
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Advances in Experimental Medicine and Biology 891 Australian Neuroscience Society Stuart Brierley Marcello Costa Editors The Enteric Nervous System 30 Years Later Advances in Experimental Medicine and Biology Australian Neuroscience Society Volume 891 Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy More information about this series at h ttp://www.springer.com/series/5584 Stuart Brierley • Marcello Costa Editors The Enteric Nervous System 30 Years Later Editors Stuart Brierley Marcello Costa Discipline of Medicine Department of Human Physiology University of Adelaide School of Medicine Adelaide , SA , Australia Flinders University Adelaide , SA , Australia ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-319-27590-1 ISBN 978-3-319-27592-5 (eBook) DOI 10.1007/978-3-319-27592-5 Library of Congress Control Number: 2016935070 © Springer International Publishing Switzerland 2016 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland Introduction to the ENS II 2014, 30 Years Later Nearly 30 years ago a number of scientists working on the Enteric Nervous System (ENS) gathered at Flinders to discuss the advances and future of their research. A photograph (see below, Fig. 1) captured the friendly and stimulating meeting attended by most of the major players in what was to become the new discipline of ‘neurogastroenterology’. This fi rst meeting was small, but very successful, and involved all of the leading researchers in the fi eld of enteric neuroscience from across the world. The reason for the meeting’s success was that its entire purpose focused on discussing method- ological strategies and unresolved issues in the fi eld. At that time we had just started at Flinders a golden decade for the two organisers John Furness and Marcello Costa, foundation lecturers at the newly established School of Medicine at Flinders, John in anatomy and Marcello in physiology. At that meeting they intended to look ahead for the next 10 years. We are now looking back at more than 30 years, during which a second and a third generation of researchers in the fi eld emerged, and many of the original researchers are still active, and some have come to this meeting held again in Adelaide (see Fig. 1 ). I ndeed many of the second and third generation researchers have accepted the invitation and contributed to the 2-day meeting in Adelaide. An extended audience of selected active researchers in the ENS attended (see Fig. 2 ). The main Australasian Neuroscience Society (ANS) meeting was held in Adelaide 30 years later, providing a perfect opportunity to recreate a similar follow- up ENS meeting. As such the ENS II 2014 meeting aimed to identify how far we have come in the fi eld of enteric neuroscience, where the future is heading and what technological advances have been made to address current and future unresolved questions. The local committee consisted of Marcello Costa, Simon Brookes, Nick Spencer, Stuart Brierley and Phil Dinning, whilst Marcello Costa and John Furness, the organisers of the 1983 meeting, were the ‘patrons’ of this meeting. v vi Introduction to the ENS II 2014, 30 Years Later Fig. 1 A ttendees of the original ENS meeting held in 1983 at Flinders University, Adelaide, Australia Fig. 2 Attendees of the ENS II meeting held at the National Wine Centre, University of Adelaide, Australia Introduction to the ENS II 2014, 30 Years Later vii Fig. 3 Speakers and chairs of the ENS II meeting From around the world 30 speakers were invited to give talks to revisit the original expectations, the advances made since and the future directions on ENS research. This included three generations of investigators from seven different countries (see Fig. 3 ). This group included ‘historical’ speakers, those who signifi cantly contributed to the advances on the ENS over the past two decades (some of whom attended the fi rst meeting) and the new generation that will continue to contribute to advancing our understanding of the ENS. This publication represents the majority of the proceedings of the conference on The Enteric Nervous System II 2014, a meeting held on February 1st to 2nd at the National Wine Centre of Australia, Adelaide. It was an offi cial satellite meeting of the 34th Annual Meeting of ANS, also held in Adelaide. We thank all those who accepted the invitation to come, many from far away, and recreate a friendly yet rigorous atmosphere. Some colleagues could not attend but did send greetings, and their messages are included in these proceedings (including letters from Joe Szurszewski and Michael Schemann). We would like to thank our local organising committee and the spon- sors that made this conference possible. Adelaide, SA, Australia Stuart Brierley Marcello Costa Contents 1 Memories and Promises of the Enteric Nervous System and Its Functions ..................................................................................... 1 Marcello C osta 2 A Personal Perspective on the Development of Our Understanding of the Myogenic Control Mechanisms of Gut Motor Function ........................................................................... 11 Jan D. Huizinga 3 Enteric Inhibitory Neurotransmission, Starting Down Under ........... 21 Kenton M. Sanders 4 Spatio-Temporal Mapping and the Enteric Nervous System ............. 31 Grant W. Hennig 5 Development of Neural Activity in the Enteric Nervous System: Similarities and Differences to Other Parts of the Nervous System ................................................... 43 Marlene M. Hao 6 ENS Development Research Since 1983: Great Strides but Many Remaining Challenges ................................... 53 Heather M. Young , Lincon A. Stamp , and Sonja J. McKeown 7 Extrinsic Sensory Innervation of the Gut: Structure and Function .......................................................................... 63 Simon Brookes , Nan Chen , Adam Humenick , Nick Spencer , and Marcello Costa 8 Ageing and Gastrointestinal Sensory Function .................................... 71 Christopher Keating and David Grundy ix

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Nearly 30 years ago, a number of scientists working on the Enteric Nervous System (ENS) gathered at Flinders University, in Adelaide, Australia to discuss the advances and future of their research. It was a friendly and stimulating meeting, attended by most of the major players, in what was to becom
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