The Encyclopedia of Parkinson's Disease (Facts on File Library of Health and Living)

417 Pages·2004·2.21 MB·English

by  Anthony D. Mosley, Deborah S. Romaine

Parkinsons_FM-Print 4/25/05 11:40 AM Page i
THE ENCYCLOPEDIA OF
PARKINSON’S DISEASE
Anthony D. Mosley, M.D., M.S.
Medical Director
Booth Gardner Parkinson’s Care Center
and Deborah S. Romaine
An Amaranth Book
Parkinsons_FM-Print 4/25/05 11:40 AM Page ii
Disclaimer: This book contains the authors’ ideas and facts/knowledge accumulated. It is intended to provide helpful
information on the subject matter covered herein. It is sold with the understanding that the authors, book producer,
and the publisher are not engaged in rendering professional medical, health, or any other kind of personal professional
services via this book. If the reader wants or needs personal advice or guidance, he or she should seek an in-person
consultation with a competent medical professional. Furthermore, the reader should consult his or her medical, health,
or other competent professional before adopting any of the suggestions in the book or drawing inferences from infor-
mation that is included herein. This is a supplement, not a replacement, for medical advice from a reader’s personal
health care provider. Check with your doctor before following any suggestions in this book; consult your doctor before
using information on any condition that may require medical diagnosis or treatment.
The authors, book producer, and publisher specifically disclaim any responsibility for any liability, loss, or risk, whether
personal or otherwise, that someone may incur as a consequence, direct or indirect, of the use and application of any
contents of this book. In no way does reading this book replace the need for an evaluation by a physician. Also, the
full responsibility for any adverse effects that result from the use of information in this book rests solely with the reader.
The Encyclopedia of Parkinson’s Disease
Copyright © 2004 by Amaranth
All rights reserved. No part of this book may be reproduced or utilized in any form or by any means, elec-
tronic or mechanical, including photocopying, recording, or by any information storage or retrieval systems,
without permission in writing from the publisher. For information contact:
Facts On File, Inc.
132 West 31st Street
New York NY 10001
Library of Congress Cataloging-in-Publication Data
Romaine, Deborah S., 1956
The encyclopedia of Parkinson’s disease / Deborah S. Romaine ; Anthony D. Mosley.
p. cm.
“An Amaranth Book.”
Includes bibliographical references and index.
ISBN 0-8160-5032-5 (alk. paper)
1. Parkinson’s disease—Encyclopedias. I. Title.
RC382.R656 2004
616.8’33’003 dc21—2003052491
Facts On File books are available at special discounts when purchased in bulk quantities for businesses,
associations, institutions, or sales promotions. Please call our Special Sales Department in New York at
[phone] or [phone].
You can find Facts On File on the World Wide Web at http://www.factsonfile.com
Text and cover design by Cathy Rincon
Printed in the United States of America
VB FOF 10 9 8 7 6 5 4 3 2 1
This book is printed on acid-free paper.
Parkinsons_FM-Print 4/25/05 11:40 AM Page iii
For Gloria Shirley Chearneyi, with love;
may her journey through Parkinson’s bring healing and hope.
Parkinsons_FM-Print 4/25/05 11:40 AM Page iv
Parkinsons_FM-Print 4/25/05 11:40 AM Page v
CONTENTS
Foreword vii
Acknowledgments ix
Entries A–Z 1
Appendixes 355
Selected Bibliography and Further Reading 367
Index 369
Parkinsons_FM-Print 4/25/05 11:40 AM Page vi
Parkinsons_FM-Print 4/25/05 11:40 AM Page vii
FOREWORD
oday is a very exciting time for clinicians in the tual and technical information. First, most of the
Tfield of Parkinson’s disease. There has been a people with Parkinson’s disease are of a generation
recent explosion of information about the disease for whom the computer remains a foreboding and
from fields as diverse as genetics, epidemiology, unfamiliar object; a book is more familiar and
and toxicology. There are about 1.2 million people comfortable to such people. Also, the information
with Parkinson’s disease in the United States and available on the Web is diverse, with much of it of
Canada, roughly 3,500 people per million, with questionable validity as it has been posted by com-
approximately 480 per million people newly diag- mercial interests seeking to make a sale, or individ-
nosed each year. uals who may have their own motives other than
After decades of having only levodopa and anti- providing balanced and timely information. I daily
cholinergic agents available, a plethora of pharma- see patients who hunger for a comprehensive
cologic agents and the emergence of new surgical source of up-to-date information that is written for
techniques have revolutionized treatment of the a lay audience and vetted by a movement-disorders
disease. In just the decade since I began my med- physician as to clinical and scientific accuracy. I feel
ical education surgery options have exploded with that this encyclopedia more than fulfills both of the
the development of deep brain stimulation therapy above needs. It is among the most comprehensive
and investigations into dopaminergic cell replace- treatises on Parkinson’s disease for a lay audience
ment; dopamine agonist therapy has been revolu- that is currently available, and its encyclopedic for-
tionized with the introduction of three new mat makes it perfect for use as a reference for those
agonists (pergolide, pramipexole, and ropinerole) specific questions that patients and their family
that have made the side-effect-prone bromocrip- members often have. Entries are alphabetical, with
tine obsolete in the treatment of Parkinson’s dis- relevant topics cross-referenced. My coauthor, Deb
ease; and researchers have elucidated much more Romaine, and I have done our best to make this
information about the etiology and epidemiology book indispensable for the investigation of ques-
of Parkinson’s disease than was known before. tions related to Parkinson’s disease by students
Some may ask, in this age of the World Wide from advanced elementary school science buffs to
Web and the rapid changes in the field, why one social work, nursing, and premedical students.
would undertake the task of publishing an ency-
clopedia on Parkinson’s disease with so much fac- —Anthony D. Mosley, M.D., M.S.
vii
Parkinsons_FM-Print 4/25/05 11:40 AM Page viii
Parkinsons_FM-Print 4/25/05 11:40 AM Page ix
ACKNOWLEDGMENTS
wish to thank Deb Romaine, without whom this weekends working on this book. Most of all, I
Iwork would not have been conceivable. I also thank my patients, from whom I continue to learn
wish to thank my colleagues at the Evergreen more and more about Parkinson’s disease, and
Booth Gardner Parkinson’s Care Center, my men- from whose insightful questions this work springs
tors during my neurology residency at UCLA, and forth.
especially Dr. Bill Marks and Dr. Phil Starr who
honed my fledgling interest in movement disor- —Anthony D. Mosley, M.D., M.S.
ders into expertise during my fellowship at UCSF. Medical Director
I also thank my wife and two daughters for endur- Booth Gardner Parkinson’s Care Center
ing my absence from their lives during nights and Kirkland, Washington
ix