THE ECONOMICS OF THE PHARMACEUTICAL INDUSTRY By the same author ADVERTISING: ITS PLACE IN POLITICAL AND MANAGERIAL ECONOMICS MANAGEMENT IN THE SOCIAL AND SAFETY SERVICES (with N. C. Hunt) THE ECONOMICS OF THE PHARMACEUTICAL INDUSTRY w. Duncan Reekie © W. Duncan Reekie 1975 Softcover reprint of the hardcover 15t edition 1975 All rights reserved. No part of this publication may be reproduced or transmitted, in any form or by any means, without permission. First published 7975 by THE MACMILLAN PRESS LTD London and Basingstoke Associated companies in New York Dublin Melbourne Johannesburg and Madras SBN 333 166906 ISBN 978-1-349-02258-8 ISBN 978-1-349-02256-4 (eBook) D00O1I 1100..11000077//997788--11--334499--0022225566--44 Typeset in Great Britain by PREFACE LIMITED Salisbury, Wilts For Basil But know also, man has an inborn craving for medicine ... the desire to take medicine is one feature which distinguishes man the animal, from his fellow creatures. It is really one of the most serious difficulties with which we have to contend. William Osler, 1894 Contents A cknowledgemen ts ix 'Introduction Definition -- origins and history - recent growth - benefits produced by the industry - the costs of the pharmaceutical industry 2 Structure and Morphology 19 Market concentration and firm size - the sub-market concept- ownership patterns - exports and imports - industry entry - diversification out of pharmaceuticals 3 Patterns of Competition 35 Price competition - promotional competition - competition by innovation - diversification within pharmaceuticals - entry barriers 4 Research and Development 50 Medical and pharmaceutical R&D statistics - nature and performance of pharmaceutical R&D - the direction of pharmaceutical R&D - trends and patterns in pharmaceutical innovation 5 Marketing 71 The nature of pharmaceutical promotion - branding - the evidence of econometrics - some recent trends 6 Patents 84 The rationale for patents - patent monopoly in the pharmaceutical industry - provisions to counter abuse - evaluation vii viii Contents 7 Relationships with the State 100 Historical development - invoking countervailing power - price control - influencing prescribing patterns - control of quality and safety - another view 8 Current Areas of Controversy 113 Market structure - profits and prices - state participation in R&D 9 Summary and Conclusions 126 Background - market structure - profit levels - product differentiation - legislative control - where the future may lead References 137 Index 143 Acknowledgements Past experience had forewarned me that in writing a book of this sort I would be indebted to literally dozens of individuals. This book would not have been possible without the assistance of the many executives of pharmaceutical firms who so willingly gave me their aid. In particular, I spent many hours scanning the library and records of the Association of the British Pharmaceutical Industry and the files of Intercontinental Medical Statistics Limited. It would be remiss of me, however, not to mention two individuals by name. My interest in the industry was first aroused by Professor K. J. W. Alexander of the University of Strathclyde. His frequent counsel and interested advice proved an unfailing source of stimulus. Second, George Teeling-Smith, Director of the Office of Health Economics, read and commented on an early manuscript of this book. My own fascination with the pharmaceutical industry springs to no small degree from the infectious enthusiasm held for the subject by the Director of the OHE. Finally, my thanks to my typists for transforming the manuscript into a readable whole. The responsibility for the opinions expressed in the following chapters is exclusively my own. W. DUNCAN REEKIE ix 1 Introduction 1 Definition No two firms in the British pharmaceutical industry are alike. Their products range from fertilisers to antibiotics; from emulsion paints to tranquilisers. Many are subsidiaries of overseas parents, principally American, but also German, Swiss, Italian, Dutch and French. Only a few are quoted on the London Stock Exchange and one of these, lei Ltd, has barely 2~ per cent of its turnover in pharmaceuticals. A precise definition of the 'pharmaceutical industry' is obviously necessary in order to isolate it conceptually from the wide variety of company types which participate in it. Economists usually define an industry from one of two viewpoints; that of the producer or that of the consumer. From the producer's position, industry boundaries are indicated by the immobility of productive resources. If the same productive resources can be easily used to manufacture two or more distinct products, then the products come from the same industry. From the consumer's position, if two or more products are regarded as acceptable substitutes for one another then they are produced in the same industry. The pharmaceutical industry as seen by the consumer is the group of firms manufacturing and distributing medicines in finished forms such as ointments, capsules, tablets and syrups. The industry as seen by the producer performs the following manufacturing and processing activi ties: 1. bulk manufacture of synthetic organic chemicals, such as vita mins, antihistamines, diuretics and sulphonamides. These, often complex, substances include many different classes of drugs; 2. bulk manufacture by fermentation, synthesis, or both of anti biotics, such as penicillin and streptomycin, which are normally