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GünterKahl DictionaryofGenomics, TranscriptomicsandProteomics RelatedTitles Hillenkamp,F.,Peter-Katalinic,J.(eds.) Korf,B.R.,Irons,M.B. MALDIMS HumanGeneticsand APracticalGuidetoInstrumentation, Genomics MethodsandApplications FourthEdition SecondEdition 2013 2014 ISBN:978-0-470-65447-7,alsoavailablein ISBN:978-3-527-33331-8,alsoavailablein digitalformats digitalformats Grotewold,E.,Chappell,J.,Kellogg,E. Meyers,R.A.(ed.) PlantGenes,Genomesand RNARegulation Genetics 2014 ISBN:978-3-527-33156-7,alsoavailablein 2015 ISBN:978-1-119-99887-7,alsoavailablein digitalformats digitalformats Meyers,R.A.(ed.) Weckwerth,W.,Kahl,G.(eds.) SyntheticBiology TheHandbookofPlant Metabolomics 2015 ISBN:978-3-527-33482-7,alsoavailablein digitalformats 2013 ISBN:978-3-527-32777-5,alsoavailablein digitalformats GünterKahl Dictionary of Genomics, Transcriptomics and Proteomics Fifth,GreatlyEnlargedEdition Volume1:A–D GünterKahl Dictionary of Genomics, Transcriptomics and Proteomics Fifth,GreatlyEnlargedEdition Volume2:E–L GünterKahl Dictionary of Genomics, Transcriptomics and Proteomics Fifth,GreatlyEnlargedEdition Volume3:M–R GünterKahl Dictionary of Genomics, Transcriptomics and Proteomics Fifth,GreatlyEnlargedEdition Volume4:S–Z TheAuthor AllbookspublishedbyWiley-VCHare carefullyproduced.Nevertheless,authors, ProfessorDr.GünterKahl editors,andpublisherdonotwarrantthe MolecularBioSciences,Biocenter informationcontainedinthesebooks, JohannWolfgangGoethe-University includingthisbook,tobefreeoferrors. Max-von-Laue-Straße9 Readersareadvisedtokeepinmindthat 60438FrankfurtamMain statements,data,illustrations,procedural Germany detailsorotheritemsmayinadvertently beinaccurate. and GenXProGmbH LibraryofCongressCardNo.:appliedfor FrankfurtInnovationCenter Biotechnology(FIZ) BritishLibraryCataloguing-in-Publication Altenhöferstraße3 Data 60438FrankfurtamMain Acataloguerecordforthisbookis Germany availablefromtheBritishLibrary. Cover Bibliographicinformationpublishedbythe Thetitlepageshowsathree-dimensional DeutscheNationalbibliothek modeloftheyeastDNA-dependent TheDeutscheNationalbiblio- RNApolymeraseII-Spt4/5elongation thekliststhispublicationinthe complex.Inthemodelthemajorityof DeutscheNationalbibliografie;detailed thepolymerasedomainsaredepicted bibliographicdataareavailableonthe ingray,thebridgehelixisshownin Internetathttp://dnb.d-nb.de. greenandtheclampdomainindarkred. Theactivesidemagnesiumisshownas apinksphereandtheDNAtemplate, ©2015Wiley-VCHVerlagGmbH&Co. DNAnon-templateandproductRNAare KGaA,Boschstr.12,69469Weinheim, showninblue,cyanandred,respectively. Germany ThetranscriptionfactorsSpt4(yellow) andSpt5(olivegreen)bindtotheclamp Allrightsreserved(includingthoseof domainofthepolymerase(darkred) translationintootherlanguages).Nopart andstayboundduringtranscription ofthisbookmaybereproducedinany elongation. form – byphotoprinting,microfilm, oranyothermeans – nortransmitted Themodelwasproducedasdescribed ortranslatedintoamachinelanguage inMartinez-Rucoboetal,EMBO withoutwrittenpermissionfromthe J.30(2011)andkindlyprovidedby publishers.Registerednames,trademarks, Dr.FuensantaMartinez-Rucoboand etc.usedinthisbook,evenwhennot ProfessorDr.PatrickCramer(Gene specificallymarkedassuch,arenottobe CenterandDepartmentofBiochemistry, consideredunprotectedbylaw. Ludwig-Maximilians-Universität München,Munich,Germany). PrintISBN:978-3-527-32852-9 ePDFISBN:978-3-527-67864-8 ePubISBN:978-3-527-67866-2 MobiISBN:978-3-527-67865-5 oBookISBN:978-3-527-67867-9 CoverDesign AdamDesign,Weinheim, Germany Typesetting LaserwordsPrivateLimited, Chennai,India PrintingandBinding MarkonoPrint MediaPteLtd,Singapore Printedonacid-freepaper To Marie, Michelle (“Mimi”) and Tanja, who reminded me of another beautiful world beyond Genomics, Transcriptomics and Proteomics