The Cytokine Factsbook and Webfacts PDF
Preview The Cytokine Factsbook and Webfacts
THE CYTOKINE FactsBook Second Edition Other books in the FactsBook Series: Robin Callard and Andy Gearing The Cytokine FactsBook Steve Watson and Steve Arkinstall The G-Protein Linked Receptor FactsBook Shirley Ayad, Ray-Boot Handford, Martin J. Humphries, Karl E. Adler and C. Adrian Shuttleworth The Extracellular Matrix FactsBook^ 2nd edn Grahame Hardie and Steven Hanks The Protein Kinase FactsBook The Protein Kinase FactsBook CD-Rom Edward C. Conley The Ion Channel FactsBook I: Extracellular Ligand-Gated Channels Edward C. Conley The Ion Channel FactsBook II: Intracellular Ligand-Gated Channels Edward C. Conley and William J. Brammar The Ion Channel FactsBook IV: Voltage-Gated Channels Kris Vaddi, Margaret Keller and Robert Newton The Chemokine FactsBook Marion E. Reid and CHristine Lomas-Francis The Blood Group Antigen FactsBook A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson and P. Anton van der Merwe The Leucocyte Antigen Facts Book ^ 2nd edn Robin Hesketh The Oncogene and Tumour Suppressor Gene FactsBook, 2nd edn Jeffrey K. Griffith and Clare E. Sansom The Transporter FactsBook lak W. Mak, Josef Penninger, John Rader, Janet Rossant and Mary Saunders The Gene Knockout FactsBook Bernard J. Morley and Mark J. Walport The Complement FactsBook Steven G.E. Marsh, Peter Parham and Linda Barber The HLA FactsBook Hans G. Drexler The Leukemia-Lymphoma Cell Line FactsBook Clare M. Isacke and Michael A. Horton The Adhesion Molecule FactsBook, 2nd edn Marie-Paule Lefranc and Gerard Lefranc The Immunoglobulin FactsBook Marie-Paule Lefranc and Gerard Lefranc The T Cell Receptor FactsBook Vincent Laudet and Hinrich Gronemeyer The Nuclear Receptor FactsBook THE CYTOKINE FactsBook Second Edition Katherine A. Fitzgerald Department of Biochemistry & Biotechnology Institute, Trinity College, Dublin, Ireland Luke A.J. O'Neill Department of Biochemistry & Biotechnology Institute, Trinity College, Dublin, Ireland Andy J.H. Gearing Biocomm International, Melbourne, Australia Robin E. Callard Institute of Child Health, University College London, London, UK ACADEMIC PRESS A Harcourt Science and Technology Company San diego San Francisco New York Boston London Sydney Tokyo This book is printed on acid-free paper. Copyright g 2001 by ACADEMIC PRESS All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the pubhsher. Academic Press A Harcourt Science and Technology Company Harcourt Place, 32 Jamestown Road, London NWl 7BY, UK http://www.academicpress.com Academic Press A Harcourt Science and Technology Company 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http://www.academicpress.com ISBN 0-12-155142-3 Library of Congress Catalog Number: 2001092474 A catalogue record for this book is available from the British Library INSTRUCTIONS ON GAINING ACCESS TO THE ON-LINE VERSION OF THE CYTOKINE FACTSBOOK, SECOND EDITION Access for a limited period to an on-line version of The Cytokine FactsBook, Second Edition is included in the purchase price of the print edition. The on-Hne version has been uniquely and persistently identified by the Digital Object Identifier (DOI) doi: 10.1006/bkcf2001 By following the Hnk http://dx.doi.org/10.1006/bkcf2001 from any Web Browser, buyers of the Cytokine FactsBook, Second edition will find instructions on how to register for access. If you have any problems with accessing the on-line version, e-mail tscap(a hbtechsupport.com Typeset by Bibliocraft, Dundee, Scotland Printed and bound in Great Britain by Bookcraft, Bath, Somerset. 01 02 03 04 05 06 07 BC 9 8 7 6 5 4 3 2 1 Contents Preface Abbreviations Section I THE INTRODUCTORY CHAPTERS Chapter 1 Introduction Chapter 2 Organization of the Data_ Chapter 3 The Cytokine Network 12 Chapter 4 Cytokine Receptor Superfamihes 20 Section II THE CYTOKINES AND THEIR RECEPTORS Interleukins IL-1 35 IL-10_ _90 IL-2 44 IL-11_ _95 IL-3 51 IL-12_ _99 IL-4 58 IL-13_ 105 IL-5 64 IL-14_ 111 IL-6 69 IL-15_ 113 IL-7 75 IL-16_ 116 IL-8 80 IL-17 119 IL-9 85 IL-18 123 Other Cytokines and Chemokines (in alph Activin 129 CTACK _ .200 Amphiregulin 136 EGF 203 Angiostatin 139 ELC 209 Apo2L 142 ENA-78 _ 211 APRIL 148 Eotaxin 1 .213 BAFF 150 Eotaxin 2 .217 4-lBBL 153 Eotaxin 3 219 BCA-1 157 Epo .221 BDNF 160 Fas ligand_ .225 Betacellulin 166 FGF .230 BMPs 168 Flt3 Hgand _ .244 CD27L 174 Fractalkine_ .249 CD30L 178 GCP-2 .253 CD40L 183 G-CSF .255 6Ckine 188 GDNF .260 CNTF 192 GITRL .267 CT-1 197 GM-CSF 270 Contents GROa, p and Y (MIP-2) 275 MlP-la 384 Growth hormone 278 MIP-13 389 HB-EGF 283 MSP 392 HCC-1 286 NGF 397 HCC-4 288 NT-3 405 HGF 290 NT-4 412 1-309 297 OSM 415 IGF I and II _301 OX-40L 420 IFNa and IFNco 311 PBP, CTAP-III, NAP-2 and PTG 424 I F N p 319 PDGF (AA, AB , BB) _426 I F N Y 322 PF-4 436 yIP-10 328 Prolactin 439 ISG-15 332 RANTES 444 ITAC 335 SCF 448 LARC 337 SDF-1 453 Leptin 340 TARC 457 LIF 346 TECK 460 LIGHT 351 TGFa 464 Lptn _ 3 5 4 TGFP _467 LT (TNFp) _ 357 TNFot _474 MCP-1,-2,-3 , -4 and -5 361 Tpo 481 M-CSF 367 TRANCE 486 MDC 373 TSLP 490 MFC 377 TWEAK 493 MIF 379 VEGF 498 MIG _ 3 8 2 Appendix I: CC ytokine Standards_ 505 Appendix II: WWW Sites for DN.\ and Protein Databases _507 Appendix III: Internet Resources for Transgenic and Targeted Mutation Research_ _508 Index 509 Preface The updating of the Cytokine FactsBook was started by Robin Callard in 1998. Given the rate at which new cytokines were being discovered and characterized, the work was then shared out, with Kate Fitzgerald, Luke O'Neill and Andy Gearing contributing. Kate Fitzgerald in particular did much of the work on novel cytokines. There are many people who have helped with advice and information during the writing of this book. In particular, we would Uke to mention Ewan Robson (Dept. of Pathology, University of Cambridge) and Eleanor Dunn (Trinity College Dublin) for help with database searches and structural models respectively. We also wish to thank Tessa Picknett, Margaret MacDonald and Emma Parkinson for their patience and hard work in getting tlie manuscript into press. R.E.C. also wishes to acknowledge funding from Action Research, the Leukaemia Research Fund, the Medical Research Council, and the Wellcome Trust. A.J.H.G. wishes to thank Kate Owen for cheery help, British Biotech for employment, Academic Press for very nearly understanding I had a day job (sorry Tessa!) and finally Frances, Jamie and Catherine. K.F. wishes to acknowledge funding from Enterprise Ireland and the European Union and members (both past and present) of the Inflammation Group, Trinity College Dublin (in particular Ewan Robson and Eleanor Dunne) for much appreciated help. L.O.N, wishes to acknowledge funding from the Health Research Board, Enterprise Ireland, Bioresearch Ireland, the European Union and finally Margaret, Stevie and Sam. There will undoubtedly be some omissions and errors in this volume although we hope they will be infrequent. We would greatly appreciate being informed of any inaccuracies by wridng to the Editor, Cytokine FactsBook, Academic Press, Harcourt Place, 32 Jamestown Road, London, NWl 7BY, UK, so that these can be rectified in future edifions. Katherine Fitzgerald Luke O'Neill Andy Gearing Robin Callard Abbreviations CSF Colony-stimulating factor DAG 1,2-Diacylglycerol EBV Epstein-Barr virus FADD Fas-associated death domain FNIII Fibronectin type III domain GAG Glycosaminoglycan GAP GTPase-activating protein GF Growth factor GPI Glycosyl-phosphatidylinositol IFN Interferon Ig Immunoglobulin IL Interleukin IP3 Inositol 1,4,5-trisphosphate IRAK IL-1 receptor associated kinase JAK Janus kinase LAK Lymphokine-activated killer LPS Lipopolysaccharide LRR Leucine-rich region LTR Long terminal repeat Mr Molecular ratio NK Natural killer ORF Open reading frame PGE2 Prostaglandin E2 PHA Phytohaemagglutinin PI Phosphatidylinositol PIP2 Phosphatidylinositol bisphosphate PKC Protein kinase C PLC Phospholipase C PLD Phospholipase D PTK Protein tyrosine kinase SCID Severe combined immunodeficiency STAT Signal transducer of activated transcription TCR T-cell receptor TIR Toll/IL-1 receptor TLR Toll-like receptor TRADD TNF receptor-associated death domain TRAF TNF receptor-associated factor 4PS IL-4 induced phosphotyrosine substrate Abbreviations for all the cytokines are not included here as the abbreviation and full name appears at the beginning of each entry. 'Now what I want is, Facts. Teach these boys and girls nothing but Facts. Facts alone are wanted in Ufe. Plant nothing else, and root out everything else. You can only form the minds of reasoning animals upon Facts: nothing else will ever be of any service to them.' From Hard Times, by Charles Dickens
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