The complete South African health guide

607 Pages·2013·16.46 MB·English

by  June Engel

Handbook of Parkinson’s
Disease
TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk
Handbook of Parkinson’s
Disease
Fifth Edition
Edited by
Rajesh Pahwa, MD
Laverne and Joyce Rider Professor of Neurology
Director, Parkinson’s Disease and Movement Disorder Center
University of Kansas Medical Center
Kansas City, Kansas, USA
Kelly E. Lyons, PhD
Research Professor of Neurology
Director of Research and Education
Parkinson’s Disease and Movement Disorder Center
University of Kansas Medical Center
Kansas City, Kansas, USA
Boca Raton London New York
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Version Date: 20130313
International Standard Book Number-13: 978-1-84184-909-6 (eBook - PDF)
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Contents
Contributors viii
Foreword Matthew B. Stern xiii
1. Early iconography of Parkinson’s disease 1
Christopher G. Goetz
2. Epidemiology 24
Raymond Y. Lo and Caroline M. Tanner
3. Differential diagnosis 40
John C. Morgan, Shyamal H. Mehta, and Kapil D. Sethi
4. Pathophysiology and clinical assessment 61
Joseph Jankovic and Raja Mehanna
5. Premotor symptoms 93
Arif Dalvi
6. Autonomic dysfunction and management 103
Richard B. Dewey Jr., Pravin Khemani,
Cherian Abraham Karunapuzha, and Shilpa Chitnis
7. Sleep dysfunction 120
Pouya Movahed, M. Tanya Mitra, and K. Ray Chaudhuri
8. Neuropsychological aspects 144
Julie A. Fields and Alexander I. Tröster
9. Management of anxiety and depression 171
Jack J. Chen
10. Management of psychosis and dementia 192
Thien Thien Lim, Kelvin L. Chou, and Hubert H. Fernandez
11. Neuroimaging 225
David J. Brooks
v
vi CONTENTS
12. Neuropathology of parkinsonism 239
Dennis W. Dickson
13. Neurophysiology 258
Erwin B. Montgomery Jr.
14. Animal models of Parkinson’s disease
and related disorders 281
Giselle M. Petzinger and Michael W. Jakowec
15. Genetics 317
Shinsuke Fujioka, Christina Sundal, Owen A. Ross,
and Zbigniew K. Wszolek
16. Environmental risk factors 341
Gill Nelson and Brad A. Racette
17. Disease modifi cation 358
Daniel E. Kremens
18. Amantadine and anticholinergics 373
Khashayar Dashtipour, Joseph S. Chung, Allan D. Wu,
and Mark F. Lew
19. Levodopa 389
David Salat and Eduardo Tolosa
20. Dopamine agonists 414
Valerie Suski and Mark Stacy
21. Monoamine oxidase inhibitors 430
Alex Rajput, Theresa Zesiewicz, and Robert A. Hauser
22. Catechol-O-methyltransferase inhibitors 448
Ronald F. Pfeiffer
23. Investigational pharmacological treatments 466
Fernando L. Pagan and Jill Giordano Farmer
24. Deep brain stimulation 478
Kelly E. Lyons, Jules M. Nazzaro, and Rajesh Pahwa
25. Investigational surgical therapies 496
Neil M. Issar and Joseph S. Neimat
26. Physical and occupational therapy 520
Ingrid H.W.M. Sturkenboom, Samyra H.J. Keus,
Marten Munneke, and Bastiaan R. Bloem
CONTENTS vii
27. Voice, speech, and swallowing disorders 539
Shimon Sapir, Lorraine Olson Ramig, and Cynthia Fox
28. Complementary and alternative medicine
in Parkinson’s disease 570
Louis C.S. Tan and Kulthida Methawasin
Index 591
Contributors
Bastiaan R. Bloem Donders Institute of Brain & Cognition, Department of
Neurology, Radboud University Nijmegen Medical Centre, Nijmegen,
the Netherlands
David J. Brooks Hartnett Professor of Neurology, Hammersmith Hospital,
Imperial College London, London, UK
K. Ray Chaudhuri National Parkinson Foundation International Centre of
Excellence, Centre Principal Investigator, MRC Centre of Neurodegeneration
Research, King’s College London, Kings College Hospital and University Hospital
Lewisham, London, UK
Jack J. Chen Movement Disorders Center, Schools of Medicine and Pharmacy,
Loma Linda University, Loma Linda, California, USA
Shilpa Chitnis Department of Neurology and Neurotherapeutics,
UT Southwestern Medical Center, Dallas, Texas, USA
Kelvin L. Chou Departments of Neurology and Neurosurgery, University of
Michigan, Ann Arbor, Michigan, USA
Joseph S. Chung Department of Neurology, Southern California Kaiser
Permanente, Los Angeles, California, USA
Arif Dalvi Department of Neurology, NorthShore University Health System,
Glenview, Illinois, USA
Khashayar Dashtipour Division of Movement Disorders, Department of
Neurology, Loma Linda University School of Medicine, Loma Linda,
California, USA
Richard B. Dewey Jr. Department of Neurology and Neurotherapeutics,
UT Southwestern Medical Center, Dallas, Texas, USA
Dennis W. Dickson Robert E. Jacoby Professor of Alzheimer’s Research,
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
Jill Giordano Farmer Capital Institute for Neuroscience, Pennington,
New Jersey, USA
viii
CONTRIBUTORS ix
Hubert H. Fernandez Center of Neurological Restoration, Cleveland Clinic
Foundation, Cleveland, Ohio, USA
Julie A. Fields Department of Psychiatry and Psychology, Mayo Clinic College
of Medicine, Rochester, Minnesota, USA
Cynthia Fox National Center for Voice and Speech, Denver, Colorado, USA
Shinsuke Fujioka Department of Neurology, Mayo Clinic, Jacksonville, Florida,
USA
Christopher G. Goetz Professor of Neurological Sciences, Rush University
Medical Center, Chicago, Illinois, USA
Robert A. Hauser Parkinson’s Disease and Movement Disorders Center,
National Parkinson Foundation Center of Excellence, Byrd Institute,
University of South Florida, Tampa, Florida, USA
Neil M. Issar School of Medicine, Vanderbilt University, Nashville,
Tennessee, USA
Michael W. Jakowec Department of Neurology, Keck School of Medicine,
University of Southern California, Los Angeles, California, USA
Joseph Jankovic Parkinson’s Disease Center and Movement Disorders Clinic,
Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
Cherian Abraham Karunapuzha Department of Neurology, The University of
Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Samyra H.J. Keus Department of Neurology, Nijmegen Centre for Evidence
Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen,
the Netherlands
Pravin Khemani Department of Neurology and Neurotherapeutics,
UT Southwestern Medical Center, Dallas, Texas, USA
Daniel E. Kremens Department of Neurology, Jefferson Medical College of
Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Mark F. Lew Division of Movement Disorders, Keck School of Medicine,
University of Southern California, Los Angeles, California, USA
Thien Thien Lim Center of Neurological Restoration, Cleveland Clinic
Foundation, Cleveland, Ohio, USA
Raymond Y. Lo Buddhist Tzu Chi General Hospital, Department of Neurology,
Hualien, Taiwan