The Complement System: Novel Roles in Health and Disease

565 Pages·2004·11.164 MB·English

by  Tibor Borsos (auth.), Janos Szebeni (eds.)

THE COMPLEMENT SYSTEM:
Novel Roles in Health and Disease
THE COMPLEMENT SYSTEM:
Novel Roles in Health and Disease
Edited by
Janos Szebeni
Walter Reed Army Institute of Research
Silver Spring, MD
KLUWER ACADEMIC PUBLISHERS
NEW YORK,BOSTON, DORDRECHT, LONDON, MOSCOW
eBookISBN: 1-4020-8056-5
Print ISBN: 1-4020-8055-7
©2004 Springer Science + Business Media, Inc.
Print ©2004 Kluwer Academic Publishers
Boston
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This book may provide relief for those
“hopelessly infected with the C bug”
Tibor Borsos, Chapter 1
CONTENTS
Dedication v
Contents vii
List of Contributors xi
Foreword Otto Götze xvii
Preface Janos Szebeni xix
THE COMPLEMENT SYSTEM
NOVELROLES IN HEALTH AND DISEASE
PART1. A PIECE OF COMPLEMENT HISTORY 1
1. The Development of the “One-Hit” or “Single Site”
Theory of Complement Mediated Immune Hemolysis
A Personal Account
T. Borsos 3
PART2.PATHWAYS,GENETICS AND GENEREGULATION OF
COMPLEMENT 17
2. The Initiation Complexes of the Classical and Lectin
Pathways
P. Gál, G. Ambrus, and P. Závodszky 19
3. Complement Genetics
Gy. Ábel and V. Agnello 45
4. Regulation of Complement Receptor Gene Expression:
Regulators and Inhibitors
M. Tolnay and G. C. Tsokos 61
viii Complement in Health and Disease
PART3.NOVELREGULATORYROLES OF COMPLEMENT IN
HEALTH AND DISEASE 75
5. Coordination of AdaptiveImmune Responses by C3
A. Erdei, E. Molnár, E. Csomor, Zs. Bajtay and J. Prechl 77
6. Terminal Complement Complex: Regulation of Formation
and Pathophysiological Functions
F. Tedesco, R. Bulla and F. Fischetti 97
7. The Many Faces of the Membrane Regulators of
Complement
C. L. Harris and B. P. Morgan 129
8. New Insights Into the Regulation of Complement
Activation by Decay Accelerating Factor
L.Kuttner-Kondo and E. M. Medof 167
9. The Role of Complement in Pregnancy and Fetal Loss
G. Girardi and J. E. Salmon 187
10. Complement Deficiencies: a 2004 Update
Gy. Ábel and V. Agnello 201
PART4.EXPLOITATION OF COMPLEMENTPROTEINS IN
INFECTION AND CANCER 229
11. Microbial Evasion Mechanisms Against Human
Complement
R. Würzner and P. F. Zipfel 231
12. Complement-Mediated Antibody-Dependent
Enhancement of Viral Infections
Z. Prohászka, F.D. Tóth, D. Bánhegyi and G. Füst 249
13. Tumor Cell Resistance to Complement-Mediated Lysis
M. Kirschfink and Z. Fishelson 265
Contents ix
PART5.ROLE OF COMPLEMENT IN AUTOIMMUNE
DISEASES,ALLERGY AND TRANSPLANTATION 305
14. Complement and Autoimmunity
G. C. Tsokos and M. Tolnay 307
15. The Complex Roles of Anaphylatoxins in Allergic Asthma
and Autoimmune Diseases
H. Hawlisch, M. Wills-Karp, C.L. Karp, and J. Köhl 315
16. Role of Complement in Allergy
L. Varga, H. Farkas and G. Füst 345
17. Complement Activation-Related Pseudoallergy:
Mechanism of Anaphylactoid Reactions to Radiocontrast
Media and Drug Carrier Liposomes and Micelles
J. Szebeni 361
18. The Role of Complement in Transplantation
M. Kirschfink and T.E. Mollnes 397
PART6.ROLE OF COMPLEMENT IN ACUTECATASTROPHIC
ILLNESSES 419
19. Role of Complement in Myocardial Ischemia and Infarction
M.C. Walsh, M.L. Hart, T.M. Bourcier, D. Bhole,
M. Takahashi and G.L. Stahl 421
20. Role of Complement in Intestinal Ischemia/Reperfusion
Induced Injury
S. D. Fleming and G. Tsokos 437
21. Role of C5a and C5a Receptor in Sepsis
F.S. Zetoune, P.A. Ward and M. S. Huber-Lang 451
22. Role of Complement in Multi-Organ Dysfunction Syndrome
M. S. Huber-Lang, J. V. Sarma, F. S. Zetoune and P.A. Ward 465
x Complement in Health and Disease
PART7.THECOMPLEMENTSYSTEM AS THERAPEUTICAL
TARGET 481
23. Therapeutic Manipulation of the Complement System
T. E. Mollnes 483
24. Activation and Inhibition of Complement by
Immunoglobulins
M. Basta 517
25. Engineering Control of Complement Inhibition at the
Cell Surface
R.A.G. Smith, D. Esser, S. H. Ridley and R. Bradford 531
INDEX 547
CONTRIBUTORS Basta,Milan,M.D., Ph.D.
National Institute for
Ábel, György, M.D. Ph.D. Neurological Disorders and
Medical Director, Department of Stroke; National Institutes of
LaboratoryMedicine,Lahey Health, Bethesda, Maryland, U.S.
Clinic Medical Center, [email protected]
Burlington, MA, and Department
of Pathology, Harvard Medical Bhole, Deepak
School, Boston, MA, Postdoctoral fellow
[email protected] Center for Experimental
Therapeutics and Reperfusion
Ambrus, Géza, Ph.D. Injury, Department of
Postdoctoral Fellow Anesthesiology, Perioperative
Institute of Enzymology and Pain Medicine
Biological Research Center Brigham and Women’s Hospital,
Hungarian Academy of Sciences Harvard Medical School,
Budapest,Hungary Boston, MA,
[email protected]
Borsos, Tibor, Sc.D.
Angello, Vincent, M.D. Scientist Emeritus
Director, Immunology Research, 4620 N Park Ave Apt. 608E
Department of Laboratory Chevy Chase, MD 20815,
Medicine, Lahey Clinic Medical [email protected]
Center, Burlington, MA,
and Edith Nourse Rogers Bourcier, Todd M.
VeteransAffairs Hospital Instructor, Center for
Bedford, MA, Experimental Therapeutics and
[email protected] Reperfusion Injury,
Brigham and Women’s Hospital,
Bajtay, Zsuzsa, Ph.D. Harvard Medical School,
Res. Assoc..Prof. Boston, MA,
Department of Immunology,
Eötvös Loránd University, Bradford, Roberta, B.Sc., DIBT
Budapest, Hungary Head of Pharmacology and
Toxicology, Adprotech Ltd.
Bánhegyi, Dénes, M.D. Cambridge, UK
Head, Department of [email protected]
Immunology, St László Hospital
Budapest Bulla, Roberta, Ph.D.
[email protected] Postdoctoral Fellow, Department
of Physiology and Pathology
University of Trieste, Italy
xii Complement in Health and Disease
Csomor, Eszter Fleming, Sherry, D.
Department of Immunology, ResearchAss. Professor, Dept. of
Eötvös Loránd University, Cellular Injury, Walter Reed
Budapest, Hungary Army Inst. of Research and Dept.
[email protected] of Medicine, Uniformed Services
University of the HealthSciences,
Erdei, Anna, Ph.D., D.Sc. Bethesda, MD,
Professor, Head of Department [email protected].
and Research Group of the mil
Hungarian Academy of
Sciences, Eötvös Loránd Füst, George, M.D., Ph.D., D.Sc.
University, Budapest,Hungary Professor, Chief, Research
Anna.Erdei @ freemail.hu Laboratory, Third Department of
Medicine, Faculty of Medicine
Esser, Dirk, Ph.D. Semmelweis University, Budapest
Senior Scientific Investigator Hungary
AdprotechLtd., Cambridge, UK [email protected]
[email protected]
Gál, Péter, Ph.D.
Farkas, Henriette, M.D., PhD Senior Scientist, Institute of
Head, Angoedema and Allergy Enzymology, Biological Research
Center, Semmelweis University, Center Hungarian Academy of
Budapest, Hungary Sciences, Budapest, Hungary
[email protected] [email protected]
Fischetti, Fabio, M.D. Girardi, Guillermina, Ph.D.
SeniorScientific Investigator Department of Medicine
Department of Medicine and Hospital for Special Surgery
Neurology, University of Trieste Weill Medical College of Cornell
Trieste,Italy University, New York, N.Y.
[email protected]
Fishelson, Zvi, Ph.D.
Professor, Department of Cell and Götze, Otto, M.D.
Developmental Biology, Sackler Emeritus Professor of
School of Medicine, Tel Aviv Immunology
University, Tel Aviv, Israel Bodelschwingh Str. 20,
[email protected] D 37075 Göttingen
Ogoetze @ gwdg.de