The Chemokine Factsbook: Ligands and Receptors PDF
Preview The Chemokine Factsbook: Ligands and Receptors
THE CHEMOKINE FactsBook Other books in the FactsBook Series: A. Neil Barclay, Albertus D. Beyers, Marian L. Birkeland, Marion H. Brown, Simon J. Davis, Chamorro Somoza and Alan R Williams The Leucocyte Antigen FactsBook Robin Callard and Andy Gearing The Cytokine FactsBook Steve Watson and Steve Arkinstall The G-Protein Linked Receptor FactsBook Rod Pigott and Christine Power The Adhesion Molecule FactsBook Shirley Ayad, Ray Boot-Handford, Martin J. Humphries, Karl E. Kadler and C. Adrian Shuttleworth The Extracellular Matrix FactsBook Robin Hesketh The Oncogene FactsBook Grahame Hardie and Steven Hanks The Protein Kinase FactsBook Edward C. Conley The Ion Channel FactsBook I Extracellular Ligand-Gated Channels Edward C. Conley The Ion Channel FactsBook 11 Intracellular Ligand-Gated Channels Marion E. Reid and Christine Lomas-Francis The Blood Group Antigen FactsBook THE CHEMOKINE FactsBook Krishna Vaddi Genzyme Corporation Framingham, MA Margaret Keller duPont Hospital for Children Wilmington, DE Robert C. Newton The DuPont Merck Pharmaceutical Co Wilmington, DE Academic Press Harcourt Brace & Company, Publishers SAN DIEGO LONDON BOSTON NEW YORK SYDNEY TOKYO TORONTO This book is printed on acid-free paper Copyright © 1997 by ACADEMIC PRESS All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Academic Press, Inc. 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http://www.apnet.com Academic Press Limited 24-28 Oval Road, London NWl 7DX, UK http://wMrw.hbuk.co.uk/ap/ ISBN 0-12-709905-0 Library of Congress Cataloging-in-Publication Data Vaddi, Kris. The chemokine factsbook / by Kris Vaddi, Margaret Keller, Robert Newton. p. cm. ISBN 0-12-709905-0 (alk. paper) 1. Chemokines—Handbooks, manuals, etc. I. Keller, Margaret, n. Newton, Robert, 1952- . m. Title. [DNLM: 1. Chemokines—handbooks. QW 539 V122c 1996] QR185.8.C45V33 1996 616.07'9—dc21 DNLM/DLC for Library of Congress 96-44883 CIP A catalogue record for this book is available from the British Library Typeset in Great Britain by Alden, Oxford, Didcot and Northampton Printed in Great Britain by WBC, Bridgend, Mid Glamorgan 96 97 98 99 00 01 EB 9 8 7 6 5 4 3 2 1 Contents Preface vn Abbreviations DC Section I THE INTRODUCTORY CHAPTERS Chapter 1 Introduction Chapter 2 Organization of the data Chapter 3 Chemokines: an overview 10 Chapter 4 Chemokine receptors: an overview 18 Section II THE CHEMOKINES CXC or a family chemokines IL-8 23 MGSA _ 38 PF4 46 NAP-2 _ 53 IP-10 _ 60 MIP-2 _ 67 ENA-78 73 EMF-1 _ 76 GCP-2 _ 80 SDF-1 _ 82 MIG 84 CC or P family chemokines MCP-1 MCP-2 _ 99 MCP-3 _ 103 MlP-la _ 107 MIP-li5 _ 118 RANTES 124 1-309 131 Eotaxin _ 135 CIO 138 HCC-1 140 Contents C or 7 family chemokines Lymphotac tin 142 SCM-1 144 Section III THE CHEMOKINE RECEPTORS CXC or a chemokine receptors IL-8RA 149 IL-8RB 153 CC or j5 chemokine receptors CCCKR-1 158 CC CKR-2 162 CC CKR-3 164 CC CKR-4 165 Chemoattractant receptors C5aR 168 FPR/FMLPR 171 Miscellaneous receptors PAFR 175 DARC 178 Viral chemokine receptors US28 182 ECRF3 184 Orphan chemokine receptors LESTR 186 CMK-BRL-1 188 BLR-l/MDR-15 190 V28 193 EBIl 194 Index 197 Preface We would like to thank Tessa Picknett and Academic Press for their patience and encouragement during the compilation of this work. We would also like to thank our spouses, Lakshmi, Grant and Toni, for their understanding and support. Much appreciation goes to Dr David W. Martin, founder of the DuPont Merck Postdoctoral program which brought the authors together and supported our interest in chemokine biology. Left to right: Robert Newton, Margaret Keller, Krishna Vaddi This Page Intentionally Left Blank Abbreviations ADP Adrenaline activated platelets AIDS Acquired immune deficiency syndrome AML Acute myeloid leukemia AP-1 Activator protein-1 ARDS Adult respiratory distress syndrome BFU Burst-forming unit BLR-1 Burkitt's lymphoma receptor 1 Beta thromboglobulin C/EBP CCAAT/enhancer-binding protein C5a C5 anaphylatoxin C5aR C5 anaphylatoxin receptor cAMP cyclic adenosine monophosphate CCCKR CC chemokine receptor CEF Chick embryo fibroblasts CPU Colony-forming unit CIDNP Chemically-induced dynamic nuclear polarization CINC Cytokine-induced neutrophil chemoattractant CK Chemokine receptors CMK-BRL-1 Chemokine beta receptor-like 1 CMV Cytomegalovirus Con A Concanavalin A CP Capsular polysaccharide CTAP-m Connective-tissue activating peptide IE DARC Duffy antigen/chemokine receptor DMSO Dimethylsulfoxide DTH Delayed type hypersensitivity EAE Experimental autoimmune encephalomyelitis EBI-1 Epstein-Barr induced protein 1 EC50 50% effective concentration ECM Extracellular matrix ECRF3 An open reading frame of Herpes virus Saimiri gene sequence EDTA Ethylene diamine tetraacetic acid ELISA Enzyme-linked immunoabsorbent assay ELR Glutamic acid-leucine-arginine motif EMF-1 Embryo fibroblast protein 1 ENA-78 Epithelial derived neutrophil attractant 78 ERK-1 Extracellular signal regulated kinase 1 ESP MS Electron spray mass spectroscopy FGF Fibroblast growth factor FITC Fluoroscein isothiocyanate fMLP Formyl-methionyl-leucinyl-phenylalanine FMLPR N-formyl-methionyl-leucyl-phenylalanine receptor
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