The Cell Surface in Development and Cancer PDF
Preview The Cell Surface in Development and Cancer
Developmental Biology A COMPREHENSIVE SYNTHESIS Volume 3 The Cell Surface in Development and Cancer Developmental Biology A COMPREHENSIVE SYNTHESIS Editor LEON W. BROWDER University of Calgary Calgary, Alberta, Canada Editorial Board EVERETT ANDERSON ELIZABETH D. HAY Harvard Medical School Harvard Medical School JOSEPH T. BAGNARA RALPH S. QUATRANO The University of Arizona Oregon State University SAMUEL H. BARONDES RUDOLF A. RAFF University of California at San Diego Indiana University ANTONIE W. BLACKLER L. DENNIS SMITH Cornell University Purdue University MARIE A. DiBERARDINO IAN M. SUSSEX The Medical College of Pennsylvania Yale University RALPH B. L. GWATKIN The Cleveland Clinic Foundation Volume 1 OOGENESIS Edited by Leon W. Browder Volume 2 THE CELLULAR BASIS OF MORPHOGENESIS Edited by Leon W. Browder Volume 3 THE CELL SURFACE IN DEVELOPMENT AND CANCER Edited by Malcolm S. Steinberg Volume 4 MANIPULA TION OF MAMMALIAN DEVELOPMENT Edited by Ralph B. 1. Gwatkin Developmental Biology A COMPREHENSIVE SYNTHESIS Volume 3 The Cell Surface in Development and Cancer Edited by MALCOLM S. STEINBERG Princeton University Princeton, New. Jersey PLENUM PRESS • NEW YORK AND LONDON Library of Congress Cataloging in Publication Data (Revised for vols. 3 & 4) Developmental biology. Includes bibliographies and index. Contents: v. 1. Oogenesis- -v. 3. The cell surface in development and cancer- v. 4. Manipulation of mammalian development. 1. Developmental biology-Collected works. I. Browder, Leon W. QH491.D426 1985 574.3 85-3406 ISBN 978-1-4684-5052-1 ISBN 978-1-4684-5050-7 (eBook) DOl 10.1007/ 978-1-4684-5050-7 Cover illustrotion: Whole-mount immunofluorescence histochemistry of a chicken embryo. Only the myocytes of myotome and heart show positive staining; if there are any terminally differentiated myocytes in the wing bud at this stage, they cannot be detected. (From Chapter 11 by David C. Turner.) © 1986 Plenum Press, New York Softcover reprint ofthe hardcover 1st edition 1986 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher Contributors Kenneth E. Bassett Division of Biology, Kansas State University, Manhattan, Kansas 66506 Michael J. Bastiani Department of Biological Sciences, Stanford University, Stanford, California 94305 Paul Henry Black Department of Microbiology and Hubert H. Humphrey Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118 Daniel F. Bowen-Pope Department of Pathology, University of Washington, Seattle, Washington 98195 Marianne Bronner-Fraser Developmental Biology Center, University of Cal ifornia- Irvine, Irvine, California 9271 5 Peter Devreotes Department of Biological Chemistry, Johns Hopkins Univer sity School of Medicine, Baltimore, Maryland 21205 Chris Q. Doe Department of Biological Sciences, Stanford University, Stan ford, California 94305 Sascha duLac Department of Biological Sciences, Stanford University, Stan ford, California 94305 Edward G. Fey Department of Biology, Massachusetts Institute of Tech nology, Cambridge, Massachusetts 02139 Judah Folkman Department of Surgery, Children's Hospital, and Department of Surgery, Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115 Donna Fontana Department of Biological Chemistry, Johns Hopkins Univer sity School of Medicine, Baltimore, Maryland 21205. Present address: Department of Microbiology, University of Minnesota, Minneapolis, Min nesota 55455. Corey S. Goodman Department of Biological Sciences, Stanford University, Stanford, California 94305 v VI Contributors Gary Gorbsky High Voltage Electron Microscopy Laboratory and Department of Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin 53706 Russell Greig Smith Kline and French Laboratories, Philadelphia, Pennsylva nia 19101. Albert K. Harris Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27514 William J. Lennarz The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Department of Biochemistry and Molecular Biology, Houston, Texas 77030 Sheldon Penman Department of Biology, Massachusetts Institute of Tech nology, Cambridge, Massachusetts 02139 George Poste Smith Kline and French Laboratories, Philadelphia, Pennsylva nia 19101 Jean-Paul Revel Division of Biology, California Institute of Technology, Pas adena, California 91125 Brian S. Spooner Division of Biology, Kansas State University, Manhattan, Kansas 66506 Malcolm S. Steinberg Department of Biology, Princeton University, Princeton, New Jersey 08544 Brad Stokes Division of Biology, Kansas State University, Manhattan, Kansas 66506 Douglas Dillon Taylor Department of Microbiology and Hubert H. Humphrey Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118 Anne Theibert Department of Biological Chemistry, Johns Hopkins Univer sity School of Medicine, Baltimore, Maryland 21205 William A. Thomas Department of Biology, Wake Forest University, Winston Salem, North Carolina 27109 Holly A. Thompson-Pletscher Department of Chemistry, University of Mon tana, Missoula, Montana 59812 David C. Turner Department of Biochemistry, State University of New York Upstate Medical Center, Syracuse, New York 13210 Tit-Yee Wong Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218 Preface This series was established to create comprehensive treatises on specific topics in developmental biology. Such volumes serve a useful role in developmental biology, since it is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting-ground for the various practi tioners of this science, facilitating an integration of heterogeneous information on specific topics. Each volume is intended to provide the conceptual basis for a comprehen sive understanding of its topic as well as an analysis of the key experiments upon which that understanding is based. The specialist in any aspect of devel opmental biology should understand the experimental background of the field and be able to place that body of information in context to ascertain where additional research would be fruitful. At that point, the creative process gener ates new experiments. This series is intended to be a vital link in that ongoing process of learning and discovery. In no other aspect of developmental biology is its multidisciplinary char acter more evident than in the study of growth control, which involves embryologists, cell biologists, molecular biologists, biochemists, and clinical scientists. Orderly cell division is a prerequisite to conversion of the zygote into a highly organized multicellular adult organism. Cancer, on the other hand, is characterized by faulty growth control. The cell surface plays a central role in regulating many of the cellular functions related to growth control in normal development. The cell surface is also involved in mediating cell-cell interactions, which are important in morphogenesis and which may be highly 'lbnormal in malignancy. Clearly, the study of cell surface properties in devel uping cells and malignant cells is complementary; an understanding of either field improves our understanding of the other. An improved understanding of the cell biology of malignancy is the key to control of this deadly disease. This volume is a chronicle of our current understanding of the properties of the cell surface relating to development and cancer. It is a companion to Volume 2 of this series. That book (The Cellular Basis of Morphogenesis, edited by Leon W. Browder) considers the role of cellular and extracellular compo nents in the assembly of multicellular embryos. The functions of the vii viii Preface cytoskeleton, cell surface, and extracellular matrix molecules in cellular shape changes, cellular interactions, and cell motility in development are discussed in detail. Together, these two volumes are intended to provide the basis for understanding the cellular events underlying morphogenesis and contributing to the abnormal behavior of malignant cells. Leon w. Browder Introduction to the Volume Cells are the "atoms" of the metazoan organism. They are the subunits that multiply, differentiate, lay down extracellular scaffoldings, organize them selves into tissues and organs and-when the normal programs of differentia tion and morphogenesis go awry-metastasize to foreign sites and invade, multiply, and destroy the tissues of the host and ultimately the host itself. Growth, differentiation, and morphogenesis must all be regulated in rela tionship to demand, requiring the exchange of information between the cell and its environment. All such information must be delivered either to or through the cell surface. It is not surprising, then, that as cell regulatory pro cesses have come to be better understood, our perception of the cell envelope has changed dramatically. Whereas once it was thought of as not much more than the "bag" preventing the escape of all those interesting enzymes, today the cell membrane is recognized as a complex and heterogeneous structure with specialized domains dynamically regulating the passage of molecules of many kinds and bearing specific receptors relaying signals between the worlds with out and within. Just as the envelopes of normal cells have a crucial role in interpreting and relaying signals essential to normal cell functions, so have the envelopes of cancer cells been implicated in their refractoriness to control by those instruc tions to which normal cells submit. The concept of a volume bringing together accounts of contributions to our knowledge of cell-surface-related phenomena of importance to our understanding of both development and cancer arose from a symposium of like purpose sponsored by the Division of Developmental and Cell Biology of the American Society of Zoologists and generously supported by grants from NSF and NIH and by a contribution from Smith Kline and French Laboratories. This volume was assembled subsequently and addresses itself to the normal processes of controlled growth, guided cell locomotion, se lective cell association and assembly, and cell communication, as well as aber rations in these processes and in the underlying mechanisms in malignant cells. Malcolm S. Steinberg ix Contents Chapter 1 • Cell Surfaces in the Control of Growth and Morphogenesis Malcolm S. Steinberg 1. Introduction.................................................. 1 2. Cell Surfaces in the Control of Cell Proliferation ................ 1 3. Cell Surfaces and the Control of Multicellular Assembly ......... 4 4. Adhesive Specification of Pronephric Duct Segregation and Migration .................................................... 7 References ................................................... 12 Chapter 2 • The Cell Surface and Cancer Metastasis George Poste and Russell Greig 1. Introduction.................................................. 15 2. Tumor Models. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 3. Tumor Cell Heterogeneity and Correlation of Cell Surface Changes with Metastatic Behavior. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 4. Obligatory and Nonobligatory Phenotypes: Demonstrating Causality between Phenotypic Change and Metastatic Behavior. . . 23 5. Experimental Manipulation of the Metastatic Properties of Tumor Cells: Fulfilling Koch's Postulates at the Molecular Level ........ 27 References ................................................... 30 Chapter 3 • Shedding of Plasma Membrane Fragments: Neoplastic and Developmental Importance Douglas Dillon Taylor and Paul Henry Black 1. Introduction.................................................. 33 2. Historical Background. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 3. Membrane Structure .......................................... 37 xi
The list of books you might like
