The Carbonic Anhydrases: New Horizons

614 Pages·2000·18.17 MB·English

by  Robert E. Forster (auth.), Prof. Dr. W. Richard Chegwidden, Nicholas D. Carter, Yvonne H. Edwards (eds.)

EXS90
The Carbonic Anhydrases
New Horizons
Edited by WR. Chegwidden, N.D. Carter
and Y. H. Edwards
Springer Basel AG
Editor
Editor
Prof. Dr. W Richard Chegwidden
LakPer oEfr.i eD Cr. oWll eRgeic ohfa Ords tCehoepgawthiidcd Mene dicine
185L8a Wkee Estr Gier Canodllveigeew o Bfo Ouslteevoapradt hic Medicine
Erie1,8 P5A8 W16e5s0t 9G randview Boulevard
USAEr ie, PA 16509
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Library of Congress Cataloging-in-Publication Data
Library of Congress Cataloging-in-Publication Data
The carbonic anhydrases : new horizons I edited by W R. Chegwidden.
The carbonic anhydrases : new horizons / edited by W R. Chegwidden.
p. ; cm. --(EXS ; 90)
p. ; cm. --(EXS ; 90)
Includes bibliographical references and index.
Includes bibliographical references and index.
ISBN 3764356707 (alk. paper)
ISBN 3764356707 (alk. paper)
1. Carbonic anhydrase. 1. Chegwidden, WR. (W Richard), 1947-II. Series.
1. Carbonic anhydrase. I. Chegwidden, WR. (W Richard), 1947-II. Series.
[DNLM: 1. Carbonate Dehydratase. 2. Carbonic Anhydrase Inhibitors. QU 139 C2643 2000]
[DNLM: I. Carbonate Dehydratase. 2. Carbonic Anhydrase Inhibitors. QU 139 C2643 2000]
QP613.C37 C375 2000
QP613.C37 C375 2000
572'.79--dc21
572'.79--dc21
00-027796
00-027796
Deutsche Bibliothek Cataloging-in-Publication Data
Deutsche Bibliothek Cataloging-in-Publication Data
The carbonic anhydrases : new horizons I ed. by W R. Chegwidden. - Basel ; Boston; Berlin :
The carbonic anhydrases : new horizons / ed. by W R. Chegwidden. - Basel; Boston; Berlin:
Birkhiiuser, 2000
Birkhauser, 2000
(EXS; 90)
(EXS ; 90)
ISBN 3-7643-5670-7
ISBN 978-3-0348-9570-5 ISBN 978-3-0348-8446-4 (eBook)
DOI 10.1007/978-3-0348-8446-4
The publisher and editor can give no guarantee for the information on drug dosage and administra
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ISBN 3-7643-5670-7 Birkhauser Verlag, Basel-Boston - Berlin
This work is subject to copyright. All rights are reserved, whether the whole or part of the material
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Cov©e r2 i0ll0u0st rSatpiorinn: gTehre Bmaesmebl rAanGe- a2n0c0h0or ed human carbonic anhydrase IV (CA IV) isozyme
PriOnteridg oinn aalcliyd -pfruebe lpiaspheerd p broyd uBcierdk hfrioimus cehrl Voreinrel-afgre ien p u2l0p0. 0T CF 00
Cover illustration: The membrane-anchored human carbonic anhydrase IV (CA IV) isozyme
ISBN 3-7643-5670-7
Printed on acid-free paper produced from chlorine-free pulp. TCF
00
987654321
987654321
Contents
List of Contributors IX
Dedications XIII
Preface .. XVII
Robert E. Forster
Exordium: Remarks on the discovery of carbonic anhydrase I
*
W. Richard Chegwidden and Nicholas D. Carter
Introduction to the carbonic anhydrases ..... 13
David Hewett-Emmett
Evolution and distribution of the carbonic anhydrase gene families 29
Carbonic Anhydrase Isoforms and their Expression in Mammals
Seppo Parkkila
An overview of the distribution and function of carbonic anhydrase
isozymes in mammals ....................... 79
William S. Sly
The membrane carbonic anhydrases: from CO transport
2
to tumour markers . . . . . . . . . . . . . . . . . . . . . 95
*
Richard E. Tashian, David Hewett-Emmett, Nicholas D. Carter
and Nils C.H Bergenhem
Carbonic anhydrase (CA)-related proteins (CA-RPs),
and transmembrane proteins with CA or CA-RP domains . . . .. 105
Yvonne Edwards, Felicity Drummond and Jane Sowden
Regulation of the CA 1, CA 2 and CA 3 genes . . . 121
*
Yvonne Ridderstrdle, Per J. Wistrand, Lena Holm
and Nicholas D. Carter
Use of carbonic anhydrase II -deficient mice in uncovering
the cellular location of membrane-associated isoforms. . . 143
VI Contents
Structure and Mechanism
*
Travis Stams and David W. Christianson
X-ray crystallographic studies of mammalian carbonic anhydrase
isozymes 159
* Sven Lindskog and David N. Silverman
The catalytic mechanism of mammalian carbonic anhydrases 175
*Claudiu T. Supuran and Andrea Scozzafava
Activation of carbonic anhydrase isozymes 197
Jennifer A. Hunt, Charles A. Lesburg, David W. Christianson,
*
Richard B. Thompson and Carol A. Fierke
Active-site engineering of carbonic anhydrase and its application
to biosensors ........................... 221
*Uno Carlsson and Bengt-Harald Jonsson
Folding and stability of human carbonic anhydrase II 241
Physiology
*R obert E. Forster and Susanna J. Dodgson
Membrane transport and provision of substrates for carbonic
anhydrase in vertebrates ................... 263
Erik R. Swenson
Respiratory and renal roles of carbonic anhydrase in gas exchange
and acid-base regulation. . . . . . . . . . . . . . . . . . . . . .. 281
* W. Richard Chegwidden, Susanna J. Dodgson
and Ian M Spencer
The roles of carbonic anhydrase in metabolism,
cell growth and cancer in animals ...... . 343
Bruce P. Bryant
The roles of carbonic anhydrase in gustation, olefaction
and chemical irritation. . . . . . . . . . . . . . . . . . 365
Petra Wetzel and *GerolfGros
Carbonic anhydrases in striated muscle 375
Contents VII
Clinically Related Studies
Patrick J. Ttenta
Inherited deficiencies and activity variants of the mammalian
carbonic anhydrases . . . . . . . . . . . . . . . . . . . . . . 403
Per J. Wistrand
Carbonic anhydrase inhibition in ophthalmology: Carbonic
anhydrase in cornea, lens, retina and lacrimal gland 413
Thomas H Maren
Carbonic anhydrase inhibition in ophthalmology: Aqueous humour
secretion and development of sulphonamide inhibitors ..... 425
Umar F. Mansoor, Yiu-Rong Zhang and *G. Michael Blackburn
The design of new carbonic anhydrase inhibitors ........ 437
Seppo Parkkila
Roles of carbonic anhydrases in the alimentary tract . 461
* Wendy B. Cammer and Luc P. Brion
Carbonic anhydrases in the nervous system 475
Teuvo A. Hentunen, Pirkko L. Hiirkonen
*
and H Kalervo Viiiiniinen
Carbonic anhydrases in calcified tissues 491
Plant, Algal and Bacterial Carbonic Anhydrases
Jim N Burnell
Carbonic anhydrases of higher plants: an overview 501
Cecilia Forsman
Plant carbonic anhydrases: structure and mechanism 519
*H ideya Fukuzawa, Mikio Tsuzuki and Shigetoh Miyachi
Algal carbonic anhydrase ............... . 535
Evguenii 1. Kozliak, Michel B. Guilloton, James A. Fuchs
*
and Paul M. Anderson
Bacterial carbonic anhydrases 547
VIII Contents
Postscriptum
Richard E. Tashian
Keeping pace with a fast enzyme: steps and missteps 569
Per J. Wistrand
Carbonic anhydrase research: A clinical perspective,
past and future ................... . 597
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 611
* Author for correspondence
List of Contributors
Paul M. Anderson, Department of Biochemistry and Molecular Biology,
School of Medicine, University of Minnesota, Duluth, Duluth, MN
55812, USA; e-mail: [email protected]
Nils C. H. Bergenhem, Department of Biochemistry, University of
Michigan Medical School, Ann Arbor, MI 48109, USA, and Novo
Nordisk AlS, 2820 Gentofte, Denmark
Michael Blackburn, Krebs Institute, Department of Chemistry, University
of Sheffield, Sheffield S3 7HF, UK; e-mail: [email protected]
Luc P. Brion, Department of Pediatrics, Albert Einstein College
of Medicine, Weiler Hospital and Montefiore Medical Center, Bronx,
NY 10461, USA
Bruce P. Bryant, Monell Chemical Senses Center, 3500 Market St.,
Philadelphia, PA 19104, USA; e-mail: [email protected]
Jim N. Burnell, Department of Biochemistry and Molecular Biology,
James Cook University of North Queensland, Townsville, Queensland,
4811, Australia; e-mail: [email protected]
Wendy B. Cammer, Departments of Neurology and Neuroscience,
Albert Einstein College of Medicine, Bronx, NY 1046, USA
e-mail: [email protected]
Uno Carlsson, IFM-Department of Chemistry, Linkoping University,
S-58183 Linkoping, Sweden; e-mail: [email protected]
Nicholas D. Carter, Medical Genetics Unit, St George's Hospital Medical
School, London SW17 ORE, UK
W. Richard Chegwidden, Lake Erie College of Osteopathic Medicine,
1858 West Grandview Boulevard, Erie, PA 16509, USA;
e-mail: [email protected]
David W. Christianson, Department of Chemistry, University of
Pennsylvania, Philadelphia, PA 19104-6323, USA
Susanna J. Dodgson, Department of Physiology, University of
Pennsylvania School of Medicine, 37th & Hamilton Walk, A-200 Richards
Building, Philadelphia, Pennsylvania, 19104-6085, USA