The Big Book on Small Heat Shock Proteins

603 Pages·2015·11.42 MB·English

by  Robert M. Tanguay

Heat Shock Proteins 8
Series Editors
: Alexzander A.A. Asea · Stuart K. Calderwood
Robert M. Tanguay
Editors
Lawrence E. Hightower
The Big Book on
Small Heat Shock
Proteins
Heat Shock Proteins
Volume 8
Series editors
Alexzander A. A. Asea , Ph.D. , Professor and VD for Research Innovations,
Deanship for Scientifi c Research , University of Dammam ,
Dammam , Saudi Arabia
Stuart K. Calderwood , Department of Radiation Oncology, Molecular
& Cellular Radiation Oncology , Harvard Medical School, Beth Israel
Deaconess Medical Center , Boston , Massachusetts, USA
Heat Shock Proteins: key mediators of Health and Disease. Heat shock proteins
(HSP) are essential molecules conserved through cellular evolution required for
cells to survive the stresses encountered in the environment and in the tissues of the
developing and aging organism. These proteins play the essential roles in stress of
preventing the initiation of programmed cell death and repairing damage to the
proteome permitting resumption of normal metabolism. Loss of the HSP is lethal
either in the short-term in cases of acute stress or in the long-term when exposure to
stress is chronic. Cells appear to walk a fi ne line in terms of HSP expression. If
expression falls below a certain level, cells become sensitive to oxidative damage
that infl uences aging and protein aggregation disease. If HSP levels rise above the
normal range, infl ammatory and oncogenic changes occur. It is becoming clear that
HSP are emerging as remarkably versatile mediators of health and disease. The aim
of this series of volumes is to examine how HSP regulation and expression become
altered in pathological states and how this may be remedied by pharmacological and
other interventions.
More information about this series at h ttp://www.springer.com/series/7515
Robert M. Tanguay • Lawrence E. Hightower
Editors
The Big Book on Small
Heat Shock Proteins
Editors
Robert M. Tanguay Lawrence E. Hightower
Department of Molecular Biology, Medical Department of Molecular and Cell Biology
Biochemistry & Pathology Medical University of Connecticut
School Lab Cell & Developmental Storrs , CT , USA
Genetics IBIS
Université Laval
Québec , QC, Canada
ISSN 1877-1246 ISSN 1877-1254 (electronic)
Heat Shock Proteins
ISBN 978-3-319-16076-4 ISBN 978-3-319-16077-1 (eBook)
DOI 10.1007/978-3-319-16077-1
Library of Congress Control Number: 2015940537
Springer Cham Heidelberg New York Dordrecht London
© Springer International Publishing Switzerland 2015
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Preface
This book is based on a workshop entitled “The Small HSP World” and had the
mission to bring together investigators studying small heat shock proteins (sHSPs).
It was held at Le Bonne Entente in Quebec City (Quebec, Canada) from October 2
to October 5, 2014. Forty-four scientists from 14 different countries participated in
the workshop sponsored by the Cell Stress Society International (CSSI). The small
number of participants stimulated interesting discussions and the resulting informal
atmosphere was appreciated by everybody. A brief review of this meeting appeared
in Volume 20.2 of Cell Stress and Chaperones.
There are twenty-fi ve chapters in this book. The chapters are from the best
researchers working in this fi eld. These include AP Arrigo (Lyon), JLP Benesch
(Oxford), IJ Benjamin (Wisconsin), J Buchner-M Haslbeck- S Weinkauf (TUM,
Garching), R Benndorf (Ann Arbor), WC Boelens (Nijmegen), S Carra , Z Chang
(Beijing), RW Currie (Halifax), H Ecroyd (Wollongong), C Emanuelsson (Lund), X
Fu (Beijing), C Garrido (Dijon), N Golenhofen (Ulm), NB Gusev (Moscow), LE
Hightower (Storrs), HH Kampinga (Groningen), JN Lavoie (Québec), TH MacRae
(Halifax), RA Quinlan (Durham), RM Tanguay (Québec), E Vierling (Amherst), M
Toth-L Vigh (Szeged), SD Weeks (Leuven), T Wu (Wuhan), X Fu (Beijing) and
their collaborators and colleagues. Briefl y, the book starts with the structure and
dynamics of small heat shock proteins, moving to their molecular and cellular func-
tions as chaperones and regulators of cellular processes and fi nishing with their
involvement in diseases. Although this is quite broad, the structural aspects of sHSP
complexes are the unifying theme of the book.
Québec , QC , Canada Robert M. Tanguay
Storrs , CT , USA Lawrence E. Hightower
v

Contents
Part I General Introduction
1 The Multicolored World of the Human HSPB Family ........................ 3
Harm H. Kampinga , Romy de Boer , and Nico Beerstra
2 Immense Cellular Implications Associated to Small Stress
Proteins Expression: Impacts on Human Pathologies ......................... 27
André-Patrick Arrigo , Benjamin Ducarouge , Fabrice Lavial ,
and Benjamin Gibert
Part II Structure-Function
3 Dynamics-Function Relationships of the Small
Heat-Shock Proteins ............................................................................... 87
Georg K. A. Hochberg and Justin L. P. Benesch
4 Insights into How Small Heat Shock Proteins Bind a Great
Diversity of Substrate Proteins: A Super-Transformer Model ........... 101
Xinmiao Fu
5 Model Chaperones: Small Heat Shock Proteins from Plants ............. 119
Indu Santhanagopalan , Eman Basha , Keith N. Ballard ,
Nathen E. Bopp , and Elizabeth Vierling
6 Regulation of the Chaperone Function of Small Hsps ........................ 155
Martin Haslbeck , Sevil Weinkauf , and Johannes Buchner
7 Redefining the Chaperone Mechanism of sHsps:
Not Just Holdase Chaperones ................................................................ 179
Heath Ecroyd
8 Everything but the ACD, Functional Conservation
of the Non-conserved Terminal Regions in sHSPs ............................... 197
Michelle Heirbaut , Sergei V. Strelkov , and Stephen D. Weeks
vii
viii Contents
9 HSPB6 (Hsp20) as a Versatile Molecular Regulator ............................ 229
Maria V. Sudnitsyna , Nikolai N. Sluchanko , and Nikolai B. Gusev
10 The Chloroplast-Localized Plant sHsp in Arabidopsis
Thaliana: Role of Its Oligomeric Conformation
and Its Translocation into Membranes ................................................. 255
Katja Bernfur , Gudrun Rutsdottir , Cecilia Månsson ,
and Cecilia Emanuelsson
Part III sHsps in the Clinic
11 Multifunctional Roles of αB-Crystallin in Skeletal
and Cardiac Muscle Homeostasis and Disease ..................................... 269
Katie A. Mitzelfelt and Ivor J. Benjamin
12 Role of Small Heat Shock Protein HspB5 in Cancer ........................... 301
Wilbert C. Boelens
13 Small Heat Shock Proteins and Fibrosis ............................................... 315
Pierre-Simon Bellaye , Olivier Burgy , Julien Colas ,
Sebastien Causse , Carmen Garrido , and Philippe Bonniaud
14 Neurodegenerative Diseases, Sex Differences and the 27 kDa
Heat Shock Protein in the Nervous System .......................................... 335
Danielle A. Rioux , Kathleen Murphy , Michael J. Esser ,
and R. William Currie
15 HspB5/αB-Crystallin in the Brain ......................................................... 365
Nikola Golenhofen and Britta Bartelt-Kirbach
16 Small HSP Variants and Human Diseases ............................................ 383
Huan Guo and Tangchun Wu
Part IV sHsps Cellular and Molecular Mechanisms of Action
17 The Dynamic Duo of Small Heat Proteins and IFs Maintain
Cell Homeostasis, Resist Cellular Stress and Enable Evolution
in Cells and Tissues ................................................................................. 401
Ming Der Perng and Roy A. Quinlan
18 Regulation of Actin-Based Structure Dynamics by HspB
Proteins and Partners ............................................................................. 435
Solenn M. Guilbert , Alice-Anaïs Varlet , Margit Fuchs ,
Herman Lambert , Jacques Landry , and Josée N. Lavoie
19 Heat Shock Alters Keratocyte Movement and Morphology:
Exploring a Role for HSP27 (HSPB1) ................................................... 457
Bindi M. Doshi , Lawrence E. Hightower , and Juliet Lee
Contents ix
20 Reconsidering Old Data: Non-canonical HspB1 Species
and the Enigma of the Cytoskeletal Function of HspB1 ..................... 471
Rainer Benndorf and Peter R. Jungblut
21 Role of HSPB8 in the Proteostasis Network: From Protein
Synthesis to Protein Degradation and Beyond ..................................... 487
Angelo Poletti and Serena Carra
22 Understanding What Small Heat Shock Proteins Do
for Bacterial Cells.................................................................................... 511
Zengyi Chang
23 How to Stabilize Both the Proteins and the Membranes:
Diverse Effects of sHsps in Neuroprotection ........................................ 527
Melinda E. Tóth , Miklós Sántha , Botond Penke , and László Vígh
24 Small Heat Shock Proteins and Diapause
in the Crustacean, Artemia franciscana ................................................ 563
Thomas H. MacRae
25 Drosophila Small Heat Shock Proteins: An Update
on Their Features and Functions ........................................................... 579
Geneviève Morrow and Robert M. Tanguay
Index ................................................................................................................. 607