The Bethesda Handbook of Clinical Oncology

757 Pages·2014·7.917 MB·English

by  Jame Abraham, James L. Gulley, Carmen J. Allegra

T H E b E T H E s d a
H a n d b o o k
o F C L I n I C a L
o n C o L o g y
FourTH EdITIon
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T H E b E T H E s d a
H a n d b o o k
o F C L I n I C a L
o n C o L o g y
FourTH EdITIon
eDitors
Jame abraham, mD, FaCP
Director, Breast Oncology Program
Taussig Cancer Institute, Cleveland Clinic
Cleveland, Ohio
James L. GuLLey, mD, PhD, FaCP
Chief, Medical Oncology Service
Center for Cancer Research
National Cancer Institute
National Institutes of Health
Bethesda, Maryland
Formerly of Emory University School of Medicine
And Loma Linda University School of Medicine
Carmen J. aLLeGra, mD
Professor and Chief, Division of Hematology and Oncology
Associate Director for Clinical and Translational Research
Shands/University of Florida Cancer Center
University of Florida
Gainesville, Florida
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Senior Executive Editor: Jonathan W. Pine
Senior Product Manager: Emilie Moyer
Director of Medicine Marketing: Lisa Zoks
Manufacturing Manager: Beth Welsh
Production Project Manager: Alicia Jackson
Designer: Teresa Mallon
Production Service: Integra Software Services Pvt. Ltd
Printer: R.R. Donnelley
Fourth Edition
© 2014 by Lippincott Williams & Wilkins, a Wolters Kluwer business
Two Commerce Square,
2001 Market Street
Philadelphia, PA 19103
LWW.com
1st edition copyright 2000; 2nd edition copyright 2005; 3rd edition copyright 2010 by Lippincott Williams &
Wilkins
All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form
or by any means, including photocopying, or utilized by any information storage and retrieval system without
written permission from the copyright owner, except for brief quotations embodied in critical articles and
reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. govern-
ment employees are not covered by the above-mentioned copyright.
Printed in China
Library of Congress Cataloging-in-Publication Data
Bethesda handbook of clinical oncology / editors, Jame Abraham, James L. Gulley, Carmen J. Allegra. —
Fourth edition.
p. ; cm.
Handbook of clinical oncology
Includes bibliographical references and index.
ISBN 978-1-4511-8758-8
I. Abraham, Jame, editor of compilation. II. Gulley, James L. (James Leonard), 1964- editor of compilation.
III. Allegra, Carmen J., editor of compilation. IV. Title: Handbook of clinical oncology.
[DNLM: 1. Neoplasms—therapy—Handbooks. QZ 39]
RC262.5
616.99'4—dc23
2013039691
Care has been taken to confirm the accuracy of the information presented and to describe generally accepted
practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any
consequences from application of the information in this book and make no warranty, expressed or implied,
with respect to the currency, completeness, or accuracy of the contents of the publication. Application of this
information in a particular situation remains the professional responsibility of the practitioner.
The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set
forth in this text are in accordance with current recommendations and practice at the time of publication.
However, in view of ongoing research, changes in government regulations, and the constant flow of informa-
tion relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug
for any change in indications and dosage and for added warnings and precautions. This is particularly impor-
tant when the recommended agent is a new or infrequently employed drug.
Some drugs and medical devices presented in this publication have Food and Drug Administration (FDA)
clearance for limited use in restricted research settings. It is the responsibility of the healthcare provider to
ascertain the FDA status of each drug or device planned for use in their clinical practice.
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We dedicate this book to those lives
that are touched by cancer and to their
caregivers who spend endless hours
taking care of them.
“May I never forget that the patient is
a fellow creature in pain.
May I never consider him merely a
vessel of disease.”
—Maimonides
(Twelfth-century
philosopher and physician)
n
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c o n t r i b u t o r s
Jame Abraham, MD, FACP Director, Breast Oscar S. Breathnach, MB, FRCPI
Oncology Program Taussig Cancer Institute, Cleveland Consultant Medical Oncologist, Clinical
Clinic Cleveland, Ohio Investigator, Beaumont Hospital, Connolly
Hospital, Royal College of Surgeons, ICORG
Bamidele A. Adesunloye, MD, MS Senior
Clinical Fellow, Medical Oncology Service, National Dublin, Ireland
Cancer Institute, National Institutes of Health, Christina Brzezniak, DO Clinical Fellow,
Bethesda, Maryland Hematology and Oncology, Walter Reed National
Sanjiv S. Agarwala, MD Professor of Medicine, Military Medical Center, Bethesda, Maryland
Temple University; Chief, Oncology and Hematology, Mauricio E. Burotto Pichún, MD Senior
St. Luke’s Cancer Center, Bethlehem, Pennsylvania Clinical Fellow, Medical Oncology Service,
Sairah Ahmed, MD Assistant Professor of National Cancer Institute, National Institutes of
Medicine, Division of Cancer Medicine, Department Health, Bethesda, Maryland
of Stem Cell Transplantation and Cellular Therapy, Eric G. Bush, MD, MBA, RPh Medical
The University of Texas M.D. Anderson Cancer Director, Frederick Memorial Hospital Pain and
Center, Houston, Texas Palliative Care Service; Medical Director, Hospice
Carmen J. Allegra, MD Professor and Chief, of Frederick County; Chairman, Ethics Committee,
Division of Hematology and Oncology, Associate Frederick Memorial Hospital, Frederick, Maryland
Director for Clinical and Translational Research, Jon Cardinal, MD Assistant Professor of
Shands/University of Florida Cancer Center, Surgery, West Virginia University Hospital,
University of Florida, Gainesville, Florida Morgantown,West Virginia
Lukas C. Amler, PhD Director, Oncology George L. Carter, MMS, PA-C Physician
Biomarker Development, Genentech, Inc., South San Assistant Medical Oncology Service, National
Francisco, California
Cancer Institute, National Institutes of Health,
Christina M. Annunziata, MD, PhD Bethesda, Maryland
Investigator, Medical Oncology Branch, National Ellie E. Chan, MD Assistant Professor of
Cancer Institute, National Institutes of Health,
Medicine, Division of Hematology and Oncology,
Bethesda, Maryland
University of California, San Francisco, Fresno
Andrea B. Apolo, MD Assistant Clinical Medical Education, California
Investigator, Head, Bladder Cancer Research
Bruce D. Cheson, MD Professor of Medicine,
Program, Medical Oncology Branch, Center for
Head of Hematology; Deputy Chief, Division of
Cancer Research, National Cancer Institute, National
Hematology-Oncology, Georgetown University
Institutes of Health, Bethesda, Maryland
Hospital, Lombardi Comprehensive Cancer Center,
Philip M. Arlen, MD Attending Physician, Washington, DC
Medical Oncology Branch, Center for Cancer
Richard W. Childs , MD Senior Investigator,
Research, National Cancer Institute, National
Hematology Branch, National Heart Blood and
Institutes of Health, Bethesda, Maryland
Lung Institute, National Institutes of Health,
Anne Berger, MSN, MD Senior Clinician, Pain Bethesda, Maryland
and Palliative Care Service, National Institute of
Deborah Citrin, MD Investigator, Radiation
Health Clinical Center, National Institutes of Health,
Oncology Service, Center for Cancer Research,
Bethesda, Maryland
National Cancer Institute, National Institutes of
Philippe C. Bishop, MD Vice President, Product Health, Bethesda, Maryland
Development Oncology, Angiogenesis Franchise Head
Barbara A. Conley, MD Associate Director,
Genentech, Inc,. South San Francisco, California
Cancer Diagnosis Program, Division of Cancer
Christopher Bowden, MD Vice President, Treatment and Diagnosis, Department of Health
Global Signing Franchise Head, Product Development, and Human Services, National Cancer Institute,
Oncology, Genentech, South San Francisco, California National Institutes of Health, Rockville, Maryland
vi
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Contributors vii
David P. Cosgrove, MB, BCh Assistant Professor, Juan C. Gea-Banacloche, MD Staff Clinician, Infectious
Department of Medical Oncology, Sidney Kimmel Diseases, Experimental Transplantation and Immunology
Comprehensive Cancer Center, Johns Hopkins University, Branch, National Cancer Institute, National Institutes of
Baltimore, Maryland Health, Bethesda, Maryland
Michael Craig, MD Associate Professor of Medicine, Thomas J. George, Jr., MD, FACP Associate Professor,
Osborn Hematopoietic Malignancy and Transplantation Director, Gastrointestinal Oncology Program, Division of
Program, West Virginia University, Morgantown, West Hematology and Oncology, University of Florida Health
Virginia Cancer Center, Gainesville, Florida
Aaron Cumpston, PharmD Pharmacy Clinical Giuseppe Giaccone, MD, PhD Chief, Medical
Specialist, Osborn Hematopoietic Malignancy and Oncology Branch; Head, Thoracic Oncology Section,
Transplantation Program, West Virginia University, National Cancer Institute, National Institutes of Health,
Morgantown, West Virginia Bethesda, Maryland
Brendan Curley, DO, MPH Fellow, Section of Govardhanan Nagaiah, MD Attending, Medical
Hematology/Oncology, Mary Babb Randolph Cancer Center, Oncology/Hematology New Mexico Cancer Center,
West Virginia University, Morgantown, West Virginia Albuquerque, New Mexico
William L. Dahut, MD Clinical Director, Center for Ann W. Gramza, MD Medical Oncologist, Endocrine
Cancer Research, National Cancer Institute, National Oncology Branch, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland Institutes of Health, Bethesda, Maryland
Alexandre Buckley de Meritens, MD Senior Fellow Tim F. Greten, MD Chief, Gastrointestinal Cancer
Molecular Signaling Section, Medical Oncology Branch, Section, Medical Oncology Branch, National Cancer Institute,
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
National Institutes of Health, Bethesda, Maryland
James L. Gulley, MD, PHD, FACP Chief, Medical
Suzanne G. Demko, PA-C Clinical Team Leader, Oncology Service, Center for Cancer Research,
Neuro-Oncology, Pediatric Oncology and Rare Tumors Group, National Cancer Institute, National Institutes of Health
Division of Oncology Products 2, Office of Hematology and Bethesda, Maryland, Formerly of Emory University School of
Oncology Products, Center for Drug Evaluation and Research, Medicine, And Loma Linda University School of Medicine
U.S. Food and Drug Administration, Silver Spring, Maryland
Karl E. Haglund, MD, PhD Assistant Clinical
Marnie G. Dobbin, MS, RD Clinical Research Dietitian, Investigator, Radiation Oncology Branch, National Cancer
Clinical Research Center, National Institutes of Health, Institute, National Institutes of Health, Bethesda, Maryland
Bethesda, Maryland
Mehdi Hamadani, MD Associate Professor of Medicine,
Mark K. Doherty, MB BCh BAO Consultant, Division of Hematology & Oncology, Medical College of
University College Hospital Galway, Galway, Ireland Wisconsin & CIBMTR, Milwaukee, Wisconsin
Jennifer M. Duff, MD Fellow, Division of Hematology Chad A. Hamilton, MD, Lt Col, USAF, MC
and Oncology, University of Florida Health Cancer Center, Chief, Gynecologic Oncology Service; Co-Director, DOD
Gainesville, Florida Gynecologic Cancer Translational Research Center, Walter
Reed National Military Medical Center, Bethesda, Maryland
Austin Duffy, MB, MRCPI Staff Clinican,
Gastrointestinal Malignancies Section, Medical Oncology Garrett M. Hampton, PhD Senior Director, Oncology
Branch, National Cancer Institute, National Institutes of Biomarker Development, Genentech, Inc., South San
Health, Bethesda, Maryland Francisco, California
Kieron Dunleavy, MD Staff Clinican, National Cancer Hannah W. Hazard, MD, FACS Assistant Professor
Institute, National Institutes of Health, Bethesda, Maryland of Surgery, Chief of Surgical Oncology, Assistant Dean for
Daniel E. Elswick, MD Assistant Professor, Director, Admissions, West Virginia University School of Medicine,
West Virginia
Psychosocial Oncology Services, Department of Behavioral
Medicine and Psychiatry, West Virginia University, Christopher Ryan Heery, MD Staff Clinician, Laboratory
Morgantown, West Virginia of Tumor Immunology and Biology, National Cancer Institute,
Sharon Romano Fitzgerald, MD Fellow, Gynecologic National Institutes of Health, Bethesda, Maryland
Oncology, Walter Reed National Military Medical Center Upendra P. Hegde, MD Associate Professor of
and Medical Oncology Branch, Center for Cancer Research, Medicine, Associate Director of Cutaneous Melanoma
National Cancer Institute, National Institutes of Health, Program, University of Connecticut Health Center, Neag
Bethesda, Maryland Comprehensive Cancer Center, Farmington, Connecticut
Sheryl B. Fleisch, MD Psychosomatic Medicine Fellow, Lee J. Helman, MD Scientific Director for Clinical
Department of Psychiatry, University of North Carolina, Research, Center for Cancer Research, National Cancer
Chapel Hill, North Carolina Institute, National Institutes of Health, Bethesda, Maryland
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viii cONTRIBUTORS
Joleen M. Hubbard, MD Assistant Professor, Department Midhun Malla, MD, MBBS Internal Medicine, St.
of Medical Oncology, Mayo Clinic, Rochester, Minnesota Joseph Hospital and Medical Center, Phoenix, Arizona
Thomas E. Hughes, PharmD, BCOP Clinical Patrick J. Mansky, MD Medical Oncologist, Medical
Pharmacy Specialist, Pharmacy Department, Clinical Research Director, Clinical Research, The Cancer Team at Bellin
Center, National Institutes of Health, Bethesda, Maryland Health, Green Bay, Wisconson
Geraldine Jacobson, MD, MPH, MBA, FACR Clifton Mo, MD Hematology/Oncology Staff Physician,
Chair, Professor, Department of Radiation Oncology, West Department of Medicine, Walter Reed National Military
Virginia University School of Medicine, WVU Healthcare, Medical Center, Bethesda, Maryland
Morgantown, West Virginia
Manish Monga, MD Assistant Professor of Medicine,
Elaine S. Jaffe, MD Chief, Hematopathology Section Section of Hematology/Oncology; Medical Director, Clinical
Laboratory of Pathology, Center for Cancer Research, Trial Research Unit, Mary Babb Randolph Cancer Center,
National Cancer Institute, National Institutes of Health, West Virginia University Hospital, Morgantown, West
Bethesda, Maryland Virginia
Abraham S. Kanate, MD Assistant Professor of Dominic H. Moon, MD, MBBS National Institutes of
Medicine, Section of Hematology/Oncology, Marry Babb Health, Medical Research Scholar Program Fellow, National
Randolph Cancer Center, Morgantown, West Virginia Institutes of Health, Bethesda, Maryland
Uzer Khan, MD Academic Chief Resident, Department Jarushka Naidoo, MB BCH BAO MRCPI Medical
of Surgery, West Virginia University Hospitals, Morgantown, Oncology Specialist Registrar, Beaumont Hospital, Connolly
West Virginia Hospital, Royal College of Surgeons, ICORG, Dublin, Ireland
Hung T. Khong, MD Associate Professor, Division of Julie Nangia, MD Assistant Professor, Lester and Sue Smith
Oncology, Huntsman Cancer Institute, University of Utah, Breast Center, Baylor College of Medicine, Houston, Texas
Salt Lake City, Utah
Anne M. Noonan, MB BCh BAO, MSc, MRCPI
Joseph Woong Kim, MD Senior Clinical Fellow, Medical Investigator, Medical Oncology Branch, National Cancer
Oncology Service, National Cancer Institute, National Institute, National Institutes of Health, Bethesda, Maryland
Institutes of Health, Bethesda, Maryland
Maryland Pao, MD Clinical Director, National Institute
Stephen Ko, MD Instructor, Department of Radiation of Mental Health, National Institutes of Health, Bethesda,
Oncology, Mayo Clinic Florida, Jacksonville, Florida Maryland
David R. Kohler, PharmD Staff Scientist, Clinical Muzaffar H. Qazilbash, MD Professor of Medicine,
Center Pharmacy Department, National Institutes of Health, Department of Stem Cell Transplantation and Cellular
Bethesda, Maryland Therapy, Division of Cancer Medicine, The University of
Elise C. Kohn, MD Head, Women’s Cancers Clinic; Head, Texas M.D. Anderson Cancer Center, Houston, Texas
Molecular Signaling Section; Senior Investigator, Medical Sarah Read, MD, MHS Director, Therapeutics Research
Oncology Branch, Center for Cancer Research, National Cancer Program, Division of AIDS, National Institute of Allergy and
Institute, National Institutes of Health, Bethesda, Maryland Infections Diseases, National Institutes of Health, Bethesda,
Teri Kreisl, MD Staff Clinician, Neuro-Oncology Branch, Maryland
National Cancer Institute, National Institutes of Health, Mark Roschewski, MD Staff Clinician, Lymphoma
Bethesda, Maryland Therapeutics Section, Metabolism Branch, Center for Cancer
Shaji K. Kumar, MD Professor of Medicine, Consultant, Research, National Cancer Institute, National Institutes of
Division of Hematology, Department of Internal Medicine, Health, Bethesda, Maryland
Mayo Clinic, Rochester, Minnesota Donald L. Rosenstein, MD Professor, Departments of
Jung-min Lee, MD Assistant Clinical Investigator, Psychiatry and Medicine; Director, Comprehensive Cancer
Women’s Cancers Clinic, Medical Oncology Branch, Center Support Program, University of North Carolina at Chapel
for Cancer Research, National Cancer Institute, National Hill, Chapel Hill, North Carolina
Institutes of Health, Bethesda, Maryland Inger Lerra Rosner, MD Director, Urology Oncology;
Gregory D. Leonard Consultant, University College Associate Director, Center for Prostate Disease Research;
Hospital Galway, Galway, Ireland Assistant Professor of Surgery, USUHS, Walter Reed National
Military Medical Center, Bethesda, Maryland
W. Marston Linehan, MD Chief, Urologic Oncology
Branch, Center for Cancer Research, National Cancer Kerry Ryan, MPH, MS, PA-C Physician Assistant,
Institute, National Institutes of Health, Bethesda, Maryland Medical Oncology Branch, National Cancer Institute,
National Institutes of Health, Bethesda, Maryland
Ravi A. Madan, MD Assistant Clinical Investigator,
Laboratory of Tumor Immunology and Biology, Medical Yogen Saunthararajah, MD Staff, Hematologic
Oncology Branch, National Cancer Institute, National Malignancies and Blood Disorders, Taussig Cancer Institute,
Institutes of Health, Bethesda, Maryland Cleveland Clinic, Cleveland, Ohio
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Contributors ix
Nilay A. Shah, MD Fellow, Section of Hematology/ Quoc Truong, MD Clinical Assistant Professor of
Oncology, Department of Medicine, West Virginia University Hematology/Oncology, Cancer Center of Kansas, University
Hospital, Morgantown, West Virginia of Kansas Medical Center, Wichita, Kansas
Nishith K. Singh, MD Clinical Fellow, Laboratory of Chaitra S. Ujjani, MD Assistant Professor of Medicine,
Tumor Immunology and Biology, National Cancer Institute, Division of Hematology-Oncology, Lombardi Comprehensive
National Institutes of Health, Bethesda, Maryland Cancer Center, Georgetown University Hospital,
Washington, DC
Preet Paul Singh, MBBS Fellow in Hematology/
Oncology, Mayo Clinic, Rochester, Minnesota Carter Van Waes, MD, PhD Chief, Head and Neck
Surgery Branch; Clinical Director, National Institute on
Ramaprasad Srinivasan, MD, PhD Head, Molecular
Deafness and Other Communication Disorders; Senior
Cancer Section, Urologic Oncology Branch, Center for Cancer
Investigator, Radiation Oncology Branch, National
Research, National Cancer Institute, National Institutes of
Cancer Institute, National Institutes of Health, Bethesda,
Health, Bethesda, Maryland
Maryland
Lindsay C. Stansfield, PharmD, BCPS Oncology
Wyndham Wilson, MD, PhD Chief, Lymphoma
Pharmacy Resident, Pharmacy Department, National
Therapeutics Section, Metabolism Branch, Center for Cancer
Institutes of Health Clinical Center, Bethesda, Maryland
Research, National Cancer Institute, National Institutes of
Michael P. Stany, MD Assistant Professor, Uniformed Health, Bethesda, Maryland
Services University of the Health Sciences, Bethesda, Maryland
Sarah Zentack, ScM, CGC Instructor, Lester and Sue
Annie Su, MD Fellow, Hematology/Oncology, Baylor Smith Breast Center, Baylor College of Medicine, Houston, Texas
College of Medicine, Houston, Texas
Anish Thomas, MBBS, MD Senior Clinical Fellow,
Medical Oncology Service, National Cancer Institute,
National Institutes of Health, Bethesda, Maryland
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