The American Journal of Pathology 2002: Vol 161 Index

37 Pages·2002·10.7 MB·English

Index of Subjects
Volume 161, 2002
AAA. see Abdominal aortic aneurysms intraneuronal AB42 accumulation in MBVs and synap-
AB42, intraneuronal accumulation in MBVs and synaptic tic pathology (mouse), 1869
pathology (mouse), 1869 AMACR. see a-Methylacyl-CoA racemase
Abdominal aortic aneurysms, 1,2 predominant im- AMD. see Macular degeneration, age-related
mune responses, 499 Amniochorion membranes, LIGHT and LIGHT recep-
ABPP gene, Down syndrome model, lens defects and tors in human placental villi and, 2011
age-related fiber cell degeneration (mouse), 1985 Anaplastic large cell lymphomas, pediatric, c-Myc in-
ABX-IL8, inhibits angiogenesis, tumor growth and me- duced by NPM-ALK fusion protein, 875
tastasis, human melanoma, 125 Androgen receptor gene, human, clonality analysis,
Acid sphingomyelinase, deficiency, reproductive pa- PCR, 807
thology and sperm physiology (mouse), 1061 Androgen receptors, co-factors, primary prostate can-
Actin cytoskeleton, co-localization of nephrin, podocin cer, 1467
and, 1459 Aneurysms, aortic, mural thrombus, MMP-9 release and
Activator protein-1, activation in acute lung injury (rat), activation, 1701
275 Angiogenesis
Acute respiratory distress syndrome, Fas and FasL accelerated by nicotine (mouse), 97
regulation in pulmonary edema fluid and lung, 1783 esophageal ulceration, HIF-1a@ and activation of VEGF
AD. see Alzheimer's disease gene (rat), 1449
ADAM12, skeletal muscle pathology and, max dystrophy FGF2 glycation reduces angiogenic activity (mouse),
(mouse), 1535 531
Adenocarcinomas, gastric, APC mutations and devel- gut mucosal healing, 1101
opment from adenoma, 611 inhibited by HoxD10, 2099
Adenomas, gastric, APC mutations and progression to inhibited by humanized neutralizing IL-8 Ab, human
adenocarcinoma, 611 melanoma, 125
Adenomatous polyposis coli gene MMP-9 and choroidal neovascularization (mouse),
FGPs with epithelial dysplasia, 1735 1247
mutations and gastric adenoma progression to adeno- molecular profiling of markers, commentary, 7
carcinoma, 611 molecular profiling of markers (mouse), 35
AGD. see Argyrophilic grain disease regulation by VEGF and Ang-1, aorta (rat), 823
Aging retina, MMP-9-dependent exposure of cryptic migra-
endotoxin-induced thrombosis and (mouse), 1805 tory control site in collagen (mouse), 1429
fiber cell degeneration related to, Down syndrome vascular architecture and, pheochromocytomas, 1235
model (mouse), 1985 Angiopoietin-1
AIDS, diffuse large-cell lymphomas related to, abnormal uterine bleeding and, progestin-only contra-
p27*"?'and EBV-encoded LMP1, 163 ception, 979
Airway hyperresponsiveness, allergen-induced, angiogenesis regulation by VEGF and, aorta model
MMP-9 impairs cellular infiltration (mouse), 491 (rat), 823
ALDO. see Aldosterone Angiostatin, gene transfer, in endometriosis model
Aldosterone, inflammation induced by, heart (rat), 1773 (mouse), 909
Alzheimer’s disease Angiotensin Il, renal damage induced by, protection by
biochemical analysis of tau proteins in AGD, PiD and, immunosuppressive treatment (rat), 1679
1135 Animal models
Down syndrome model, ABPP gene dosage and fiber acute lung injury, shock-induced PMN _ priming
cell degeneration (mouse), 1985 (mouse), 2283
Flemish variant, vasocentric dense-core_ senile AMD, progressive age-related changes (transgenic
plaques, 507 mouse), 1515
2311
2312
AJP December 2002, Vol. 161, No. 12
cardiac disease in transgenic model expressing HIV-1 regulation of TRAIL-induced, thyroid carcinoma, 643
Nef (mouse), 321 TNF-a— and Fas-mediated, liver susceptibility to
cdk4 inhibits skin tumor development (mouse), 405 (SMP30 knockout mouse), 1273
colitis, effects of GALT deficiency (mouse), 2273 Archival tissues, microdissected, DNA amplification,
Down syndrome, ABPP gene dosage, lens defects and SCOMP, 43
age-related fiber cell degeneration (mouse), 1985 Argyrophilic grain disease, biochemical analysis of tau
Duchenne muscular dystrophy, IFG-| improves con- proteins in AD, PiD and, 1135
tractile function of mdx diaphragm muscle (mouse), Arteritis, necrotizing, thymus in development of, env-pxX
2263 gene of human TCLV type 1 (transgenic rat), 755
EGF reduces |/R intestinal damage (rat), 373 Arthritis, collagen-induced, osteoprotegerin and oste-
FAP, human _transthyretin Leu55Pro_ transgenic oclasts in bone erosion (rat), 1419
(mouse), 1935 Astrocytomas, classification by fibronectin ED-B domain
FGF2 glycation reduces angiogenic activity (mouse), antibody, 1695
531 Atherosclerosis, cysteine and aspartic proteases during
hair follicle morphogenesis and cycling impaired progression (ApoE deficient mouse), 939
(nackt mouse), 693
Autoantibodies, to type VI! collagen mediate Fcy-de-
host-virus interactions, IHC FIV localization using na-
pendent neutrophil activation and dermal-epidermal
tive species antibcdies (cat), 1143
separation, 301
a, integrin subunit deficiency (mouse), 337
Autoimmune diseases, DAF deletion and development
LuCaP 49, prostate carcinoma xenograft (nude
of (mouse), 1077
mouse), 705
mammary tumors, ErobB/Ras and Wnt pathway pathol-
ogy (transgenic mouse), 1087
B-Catenin, expression patterns in NSLC, proliferation
MMP-9 impairs cellular infiltration and AHR (mouse),
and, 1619
491
B-Catenin gene, mutations in adamantinomatous type
ovarian carcinoma, effects of VEGF (mouse), 2295
craniopharyngiomas, 1997
preconditioning increases fatty liver tolerance in he-
B-cell chronic lymphocytic leukemias, genetic imbal-
patic I/R injury (rat), 587
ances in, CGH, 957
prostatic intraepithelial neoplasias (mouse), 727
B-cell non-Hodgkin’s lymphomas, DNA polymerase yu
pulmonary fibrogenesis susceptibilty, COX-2 defi-
gene expression, 1349
ciency and (mouse), 459
B-cells, origins of SMZLs, 81
renin in large arteries outside kidney (nNREN promoter/
bcr-abi tyrosine kinase, functional! profiling, 781
LacZ transgenic mouse), 717
Bile acid, MB formation induced by, in drug-primed liver
SLE, DAF deletion and autoimmune disease develop-
(mouse), 2019
ment (mouse), 1077
Bladder cancers, loss of p63 expression, tumor progres-
T. cruzi infection induces infertility and fetal loss
sion and, 1199
(mouse), 673
Blood vessels, intracranial, prion proteins in walls, 1979
vagal nerve stimulates HPCs via M3 receptor (rat), 521
XLH and rickets, ethyl-nitrosourea-induced point muta- Bone
tion in Phex and (mouse), 1925 erosion of, effect of osteoprotegerin and osteoclast,
Anogenital modeling, female urogenital tract develop- CIA (rat), 1419
ment, role of p63 (mouse), 1111 human fetal growth plates, FGFR type 3 activating
Anti-thrombin, in prostatic epithelium and prostatic can- mutations, PTHR1/IHH in, 1325
cer, 2053 Bone marrow, transplants, liver repopulation after, 565
Aorta, aneurysms, mural thrombus, MMP-9 release and Brain
activation, 1701 developing, evasion of innate immune responses by
Aortic valve, serotonin mechanisms in heart valve dis- CMV infected neurons (mouse), 919
ease, 2111, 2209 elderly, isolation of living neurons from, immunomag-
APC gene. see Adenomatous polyposis coli gene netic sorting DNA-linker system, 1567
Apo2. see Tumor necrosis factor-related apoptosis-in- human, NSGP levels in PD and DLB, 885
ducing ligand Breast cancers
Apoptosis caveolin-1 mutations P132L and null in pathogenesis
caspase-dependent, cathepsin D microinjection in- (mouse), 1357
duced, fibroblasts, 89 chromosomal instability and defective mitotic spindle
development of, changes in tissular nucleotides during checkpoints, 391
\/R of small bowel (rat), 1839 CK 17 and CK 5/6 related to poor outcomes, 1991
2313
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DNA hypomethylation, chromosomal abnormalities, cathepsin-L deficiency, pathogenesis of gingival over-
859 growth and (mouse), 2047
genes involved in progression, 1973 progression of atherosclerosis (ApoE-deficient
HER2/neu expression patterns, 1171 mouse), 939
inflammatory, sLe”’* and E-cadherin in lymphovascular CAV. see Cardiac allograft vasculopathy
embolus, 619 Caveolin-1
intravascular location of cells after spontaneous metas- filopodia formation and, lung adenocarcinoma cell
tasis to lung (mouse), 749 lines, 1647
LOH in normal and carcinogenic epithelium, 283 mutations P132L and null, breast cancer pathogenesis
markers for, tissue and DNA microarrays, 1223 and (mouse), 1357
TMA copy number analysis of 17q23 by FISH, 73 CCSP. see Clara cell secretory proteins
Bronchoalveolar ducts, CCSP-expressing stem cells lo- CD24, prognosis in ovarian cancer and, 1215
calized to (mouse), 173 CD44, deficiency of, neutrophil migration and lung injury,
E. coli pneumonia (mouse), 2219
CD55. see Decay-accelerating factor
C5a, generation by phagocytic cells (rat), 1849 CD95, IFN-y, pro-caspase-8 and, vascular EC sensitiza-
E-Cadherin, sLe*“* and, in lymphovascular embolus, tion to CD95-mediated apoptosis, 1485
IBC, 619 CD97, in colorectal carcinomas, 1657
E-Cadherin promoter, methylation status, nonneoplastic CD106. see Vascular cell adhesion molecule-1
gastric epithelia, 399 CD200, constitutive retinal, role during EAU (mouse),
Cadherins 1669
E-cadherin and sLe”* in lymphovascular embolus, CDH1 gene, real-time-PCR method for promoter methyl-
IBC, 619 ation, 629
molecular profiling of angiogenesis markers (mouse), cdk4, deficiency inhibits skin tumor development
35 (mouse), 405
Calcification, ectopic, OPN in mineral deposition and CDKN2A promoter, hypermethylation and polymor-
regression of (mouse), 2035 phism, vertical growth phase meianoma, 229
Calcium/calmodulin-dependent protein kinase Il, ef- CD200 receptor, constitutive retina CD200 and, during
fect of heparin on, VSMCs, 1893 EAU (mouse), 1669
Carbon tetrachloride, liver injury induced by, fibrosis Central nervous system, CXCR4 and CCRS5 tropic vi-
and, FGFR4-deficiency (mouse), 2003 ruses and IL-4 in MCP-1 production by macrophages
Carcinogenesis (macaques), 813
B-catenin in NSCLC and, 1619 Cervical cancers, TAMs expression of lymphatic growth
telomere shortening in PanIN, 1541 factors, 947
Carcinoma in situ, urinary bladder, chromosome 9 al- Cervical tissue, cultured explants, susceptibility to HIV
terations and p53 accumulation, 1119 infection, 867
Cardiac allograft vasculopathy, Mig/CXCL9 in (mouse), Chemokine receptors, CXCR4 and CCR8 tropic viruses
1307 and IL-4 in MCP-1 production by macrophages (ma-
Cardiac myxomas, cardiomyogenic differentiation and caques), 813
transcription factors, 381 Chemokines, keratinocyte production of, suppressed by
Cardiomyopathies NO donors, 1409
dilated, role of complement, 449 Cholangiocarcinomas, intrahepatic, aberrant CpG is-
linked to complement activation, 351 land methylation, 1015
Caspases Cholestasis, chronic, bile acid-induced MB formation in
1 and 3, in pathology of EAE (ABH mouse and Lewis drug-primed liver (mouse), 2019
rat), 1577 Cholesterol, accumulation and mevalonate pathway,
apoptosis dependent on, cathepsin D microinjection acute tubular injury, 681
induced, fibroblasts, 89 Chromosomes
caspase-8, IFN-y, and CD95, vascular EC sensitization 1, DNA hypomethylation, breast cancer, 859
to CD95-mediated apoptosis, 1485 6, aberrations in thymomas, 1507
Cataracts, early-onset, murine Down syndrome model, 9, alterations, p53 accumulation and, CIS lesions, 1119
ABPP gene dosage and (mouse), 1985 16, DNA hypomethylation, breast cancer, 859
Cathepsins instability, breast cancer, 391
capthesin-D microinjection induces caspase-depen- Clara cell secretory proteins, stem cells expressing,
dent apoptosis, fibroblasts, 89 localized to bronchoalveolar duct (mouse), 173
2314
JP Decembe20r0 2, Vol. 161, No. 12
Class Il transactivator, transcription deficiency, SCLC Decay-accelerating factor, deletion of, and autoimmune
and NB, 291 disease and (mouse), 1077
CLIC4, in TNF-81-mediated fibroblast to myofibroblast Decidua, human, 1a-hydroxylase in, 105
conversion, 471 Deleted in malignant brain tumor 1, heterogeneity of
Clonality analysis, human androgen receptor gene ductular reactions in adult liver (rat and human), 1187
PCR, 807 Dementia with Lewy bodies, NSGP levels in, 885
CMN. see Congenital melanocytic nevi Demyelination, virus-induced, mediation by yé T cells
c-Myc, induced by NPM-ALK fusion protein, pediatric (nude mouse), 1255
ALCLs, 875 Dendritic cells
Colitis, anima! models, GALT deficiency and (mouse), misdirected, trapping in granulomatous lesions of
2273 GCA, 1815
Collagen, autoantibodies to type Vil, mediate Fcy-de- TDLN sampling for analysis of, 19
pendent neutrophil activation and dermal-epidermal Dense-core senile plaques, vasocentric, Flemish variant
separation, 301 AD, 507
Colorectal carcinomas Dexamethasone, Ang]ll-induced damage, protection by
CD97 in, 1657 immunosuppressive treatment (rat), 1679
PTEN expression levels, 439 Diabetes mellitus
Comparative genomic hybridization insulin-regulated increase in sVAP-1, 2255
genetic imbalances in CLL and RS, 957 MMP-9 and choroidal neovascularization (mouse),
genomic imbalances define groups of intracranial 1247
ependymomas, pediatric patients, 2133 Diffuse large-cell lymphomas, A!DS-related, p27?’
T-cell/histiocyte-rich B-cell lymphoma, Hodgkin's lym- and EBV-encoded LMP1, 163
phoma and, 1861 DLB. see Dementia with Lewy bodies
thyroid cancer progression, genome-wide appraisal DMBT1. see Deleted in malignant brain tumor 1
1549 DNA
Complement amplification microdissected archival tissues,
activation linked to cardiomyopathy, 351 SCOMP, 43
C5b-9, role in cardiomyopathy, 449 multi-site and PCR/sequencing in single reactions, 27
Congenital melanocytic nevi, genetic changes in neo- DNA-linker system, immunomagnetic, isolation of living
lasms arising from, 1163 neurons from elderly brains, 1567
Connexin43, response to injury, glomerular podocytes DNA methylation
(rat), 1597 aberrant, genes in intrahepatic cholangiocarcinoma,
Coronary arteries, NO in dilation of, HHcy (rat), 145 1015
Craniopharyngiomas, adamantinomatous type, B-cate- hypomethylation, chromosomal abnormalities, breast
nin gene mutations in, 1997 cancer, 859
Creutzfeidt-Jakob disease p15INK4b and p16/NK4a promoters, hypermethylation
immunization and delayed onset of prion disease HLs and CD30-positive NHLs, 1007
(mouse), 13 DNA microarrays
prion proteins in vessel walls, 1979 effect of fixatives and tissue processing on nucleic
Cyclooxygenase-2, deficiency, susceptibilty to pulmo- acids, 1961
nary fibrogenesis (mouse), 459 expression profiling of synovial sarcoma by, 1597
Cytochrome P450 2E1, CCL.-induced liver injury and TMA and, breast cancer markers, 1223
fibrosis, FGFR4-deficiency (mouse), 2003 warm ischemia time and gene expression, radical
Cytokeratins, CK 17 and CK 5/6, breast cancer out- prostatectomy specimens, 1743
comes and, 1991 DNA polymerase ju gene, expression, B-NHLs, 1349
Cytomegalovirus Down syndrome, ABPP gene dosage, lens defects and
evasion of innate immune responses by infected neu- age-related fiber cell degeneration in (mouse), 1985
rons (mouse), 919 Duchenne muscular dystrophy, mode! of, IGF-! im-
human, placental trophoblast damage caused by, IE proves contractile function of max diaphragm muscle
gene-induced TNF-a mediation of, 1371 (mouse), 2263
Cytotoxic T cells, in acute generalized exanthematous
pustulosis, 2079
EGF. see Epidermal growth factor
eHAND, in cardiac myxomas, 381
Data analysis, TMA, software tools for analysis and ar- Encephalitis, Nipah virus pathology and pathogenesis,
chiving, 1557 2153
2315
AJP December 2002, Vol. 161, No. 12
Endometriosis, mode! of, effect of angiostatin gene Experimental allergic encephalomyelitis, caspases-1
transfer (mouse), 909 and -3 in pathology of (ABH mouse and Lewis rat)
Endothelial cells 1577
CD95-mediated apoptosis, IFN-y, pro-caspase-8 and Experimental autoimmune uveoretinitis, constitutive
CD95, 1485 retinal CD200 in (mouse), 1669
selective induction of GBP-1 during inflammatory dis- Extracellular signal-regulated protein kinases, phos-
eases, 1749 phorylated, cytoplasmic aggregates, Lewy body dis-
tumor-associated, blockade of EGF-R signaling, hu- eases, 2087
man carcinoma therapy, 929
vascular, PDGFR-8 pathway blockade induces apo-
ptosis (mouse), 135 Factor H, in porcine MPGN I! (pig), 2027
Endotoxin-induced thrombosis, aging and (mouse), Familial amyloidotic polyneuropathy, human transthy-
1805 retin Leu55Pro transgenic model (mouse), 1935
Enteropathy-type T cell lymphomas FAP. See Familial amyloidotic polyneuropathy
gains at 9q, 1635 Fas
genotyping, 1527 liver susceptibility to apoptosis mediated by (SMP30
env-pX gene, human TCLV type 1, development of ne- knockout mouse), 1273
crotizing arteritis (transgenic rat), 755 regulation in pulmonary edema fluid and tissue, ALI
Eosinophils, MCP-3 and recruitment of, type-2 hyper-
and ARDS, 1783
sensitivity pulmonary granulomas (mouse), 257
Fas gene
Ependymomas, intracranial, groups defined by genomic
deletions in nasal NK/T-cell lymphoma, 2123
imbalances, pediatric patients, 2133
mutations, testicular germ cell tumors, 635
Epidermal growth factor, reduces |/R intestinal damage
Fas ligand, regulation in pulmonary edema fluid and
(rat), 373
tissue, ALI and ARDS, 1783
Epidermal growth factor receptor, bDiockade of signal-
Feline immunodeficiency virus, |HC localization using
ing by, human carcinoma therapy, 929
native species antibodies (cat), 1143
Epithelial cells
Fetuses, human, FGFR type 3 activating mutations
biliary, LPS-induced MUC2 and MUCS5AC overexpres-
PTHR1/IHH in growth plates and, 1325
sion, 1475
Fibroblast growth factor 2, glycation reduces angio-
female urogenital tract development, role of p63
genic activity (mouse), 531
(mouse), 1111
Fibroblast growth factor receptors
gastric nonneoplastic, promoter methylation of E-cad-
type 3, mutations activating, PTHR1/IHH in human fetal
herin, AMLH1 and p16, 399
growth plates, 1325
guanylin gene inactivation (mouse), 2169
type 4, deficiency, CCL,-induced liver and fibrosis
intestinal, hyperosmotic stress-induced NF-«B activa-
(mouse), 2003
tion and IL-8 production, 987
Fibroblasts
renal glomerular, HIV-1 Tat induces hyperproliferation
cathepsin D microinjection-induced caspase-depen-
and dysregulation, 53
dent apoptosis, 89
Epithelial-mesenchymal transition, Twist, S!P-1, and
conversion to myofibroblasts, role of CLIC4 and TNF-
Snail differential expression, gastric cancer, 1881
1p, 471
Epitheloid trophoblastic tumors, molecular genetic
Fibronectin, ED-B domain, recombinant human antibody
analysis, 1033
EP. receptor, loss in immortalized human keratinocytes, to, astrocytoma classification, 1695
2065 Fibrosis, myofibroblast differentiation, injured skeletal
Epstein-Barr virus muscle (SCID mouse), 895
gastric cancer positive for, pattern of allelic loss, p53 Fibrous cap, PDGF blockade delays formation (ApoE
tumor suppressor pathway and, 1207 null mouse), 1395
LMP-1, p27“'"' and, AlDS-related DLCLs, 163 Filopodia, caveolin-1 and formation of, lung adenocarci-
ERBB2, expression profiling by cDNA microarray, syno- noma, 1647
vial sarcomas, 1597 Fixatives, tissue processing and, effect on nucleic acids,
ErbB/Ras pathway, Wnt pathway and, pathology, mam- 1961
mary tumors (transgenic mouse), 1087 Fixed drug eruption, |FN-y production by effector-mem-
Esophagus, ulceration, HIF-1a@ and activation of VEGF ory-type intraepidermal T cells, 1337
gene (rat), 1449 Fit-1, molecular profiling of angiogenesis markers
Exanthematous pustulosis, acute generalized, 2079 (mouse), 35
2316
AJP December 2002 Vol. 161, No. 12
Fluorescence immunophenotyping and interphase Granulomas
cytogenetics, multicolor, genetic single cell analyses, pulmonary, S. mansoni egg-induced formation of, IL-
lymphomas, 413 13-PE and (mouse), 1283
Fluorescence in situ hybridization, [MA copy number type-2 hypersensitivity pulmonary, MCP-3 in eosinophil
analysis of 17q23, 73 recruitment (mouse), 257
Foreskin, cultured explants, susceptibility to HIV infec- Graves’ disease, recent onset, |P-10/CXCL10 and Mig/
tion, 867 CXCLY9 in thyroid and serum, 195
FPG. see Fundic gland polyps Growth plates, human fetal, FGFR3 activating mutations,
Frozen cell arrays, high-throughput approach for cell- PTHR1/IHH in, 1325
based analysis, 787 Guanylate-binding protein-1, selective induction by in-
Fundic gland polyps, gastric, epithelial dysplasia in, flammatory cytokines, 1749
1735 Guanylin, salivary glands and gland tumors, 655
Guanylin gene, inactivation of, colonic epithelial prolifer-
ation and (mouse), 2169
Gastric cancers Gut-associated lymphatic tissues, deficiency of, colitis
EBV-positive, pattern of allelic loss, p53 tumor sup- models (mouse), 2273
pressor pathway and, 1207
Twist, SIP-1, and Snail differential expression, 1881
Gastric epithelia, nonneoplastic,promoter methylation of Hair follicles, morphogenesis and cycling impaired
E-cadherin, hMLH1 and p16, 399 (nackt mouse), 693
Gastrointestinal stromal tumors, K/7 gene mutations Head and neck squamous cell carcinomas, multiple,
(letter), 737 origin of, 1051
GATA-4, in cardiac myxomas, 381 Heart
GBP-1. see Guanylate-binding protein-1 ALDO-induced inflammation (rat), 1773
GCA. see Giant cell arteritis cardiac disease in transgenic model expressing HIV-1
Geminin, marker of cell proliferation, 267 Nef (mouse), 321
Gene expression studies Mig/CXCL9 in CAV (mouse), 1307
meningiomas, high-density ODN microarrays, 665 NO in coronary dilation, HHcy (rat), 145
soft tissue tumors, 1531 serotonin mechanisms in heart valve disease, 2111,
Gene therapy, endometriosis model, angiostatin gene 2209
transfer (mouse), 909 Heparin, effect on Ca®*/CaM kinase II, VSMCs, 1893
Gene transfer, by Sendai virus coated liposomes, HGF Hepatic progenitor cells, stimulated by vagal nerve via
into skin wounds (rat), 1761 M3 receptor (rat), 521
Giant cell arteritis Hepatitis virus, murine, demyelination induced by, me-
reactive nitrogen intermediates (mouse), 115 diation by yé T cells (nude mouse), 1255
trapping of misdirected DCs in granulomatous lesions, Hepatocellular carcinomas, invasiveness triagered by
1815 TGF-B1 via a3B1 integrin, 183
Gingivae, overgrowth, cathepsin-L in pathogenesis of Hepatocyte growth factor, gene transfer into skin
(mouse), 2047 wounds by Sendai virus coated liposomes (rat), 1761
Glomeruli, !arge scale isolation of (mouse), 799 Hepatocytes
Glomerulonephritis bone marrow-derived, 349
crescentic, glomerular and tubulointerstitial scarring generation, regulation of, adults (rat), 1107
reduced by anti-VLA-1 (rat), 1265 Hepatolithiasis, LPS-induced MUC2 and MUCS5AC over-
immune, NF-«B inhibitors as anti-inflammatory agents expression, cultured BECs, 1475
(rat), 1497 Hereditary nonpolyposis colon cancers, P7TEN expres-
Glucose, TGF-81 regulation by PDGF and, 1039 sion levels, 439
y—Glutamy! leukotrienase, role in leukotriene D,, forma- HER2/neu gene, expression patterns, breast cancer,
tion, 481 1171
Goblet cells, MUC2-expressing, pseudomyxoma perito- HHcy. see Hyperhomocysteinemia
nei, 551 HIV-1
gp340/DMBT1 gene, regulation of hepatocyte genera- cardiac disease in transgenic model expressing Nef
tion, adults (rat), 1107 (mouse), 321
G proteins, serotonin mechanisms in heart valve disease susceptibility of foreskin and cervical tissue explant
1, 2111 cultures to infection, 867
Graft-versus-host disease, experimental, VCAM-1 ex- Tat induces hyperproliferation and dysregulation, renal
pression by squamous epithelium (mouse), 763 glomerular epithelial cells, 53
2317
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hMLH1 promoter, methylation status, nonneoplastic a7B1, splicing variants, skeletal muscle regeneration
gastric epithelia, 399 (rat), 1023
Hodgkin’s disease a, Subunit deficiency (mouse), 337
nodular lymphocyte predominance in, T/HRBCL and, a,B,, enteric MCP-1 in nematode-induced mucosal
CGH, 1861 mast cell hyperplasia (mouse), 771
p15INK4b and pi6INK4a promoters, hypermethylation, intercellular adhesion molecule-1, L-selectin and, reg-
CD30-positive NHLs and, 1007 ulation of bleomycin-induced lung injury (mouse), 1607
Homeobox D10 gene, inhibits angiogenesis, 2099 Interferon-a, cutaneous T-cell lymphoma genes in resis-
Host-virus interactions, |HC FIV localization using na- tance to, 1825
tive species antibodies (cat), 1143 interferon-y
HPC. see Hepatic progenitor cells CD95, pro-caspase-8 and, vascular EC sensitization to
Human papillomavirus type 16, £6 and £7, |IGFBP-3 CD95-mediated apoptosis, 1485
during keratinocyte immortalization by, 603 production by effector-memory-type intraepidermal T
Hyaluronan cells, 1337
in subcutaneous growth and vascularization, prostate
Interferon-inducible protein-10, in thyroid and serum,
cancer (mouse), 849
recent onset Graves’ disease, 195
tumor growth and, 745
Interleukin 1, in hepatic neutrophil recruitment after |/R
1a-Hydroxylase, in human placenta and decidua, 105
(mouse), 1797
Hyperhomocysteinemia, role of NO in coronary dilation
Interleukin 4, CXCR4 and CCR5 tropic viruses and, in
(rat), 145
MCP-1 production by macrophages (macaques), 813
Hyperosmotic stress, NF-«B activation and IL-8 produc-
interleukin 8
tion induced by, human IECs, 987
humanized neutralizing Ab, inhibits angiogenesis, tu-
Hyperoxia, lung injury by, p21°'°'“"S9"" and normal
mor growth and metastasis, human melanoma, 125
remodeling of (mouse), 1383
hyperosmotic stress-induced production of, human
Hypoxia, Ang-1and abnormal uterine bleeding, LTPOC-
IECs, 987
treated patients, 979
interleukin-13-PE fusion protein, S. mansoni egg-in-
Hypoxia-inducible factor-1a, esophageal ulceration
duced pulmonary granuloma formation and (mouse),
and (rat), 1449
1283
Intermediate-early genes, TNF-a-induced by, HCMV
caused placental trophoblast damage and, 1371
IBC. see Breast cancers, inflammatory
Invasiveness
1 cell disease, cathepsin-L in gingival overgrowth
EP. receptor loss and, immortalized human keratino-
(mouse), 2047
cytes, 2065
immune privilege, tumor, Fas gene deletions in nasal NL
loss of p63 expression, tumor progression, bladder
and, 2123
cancer, 1199
Indian hedgehog, PTHR1/!HH human fetal growth plates
TGF-B1 triggers, via a3B1 integrin, HCC, 183
with FGFR3 activating mutations, 1325
ischemia/reperfusion injuries
Infections, iNOS and bacterial colonization of wounds
(mouse), 2143 EGF reduces intestinal damage (rat), 373
Inflammation, ALDO-induced, heart (rat), 1773 ischemic preconditioning increases fatty liver tolerance
inflammatory cytokines, selective induction of GBP-1, (rat), 587
ECs, 1749 neutrophil recruitment after, IL-1 in (mouse), 1797
inflammatory diseases, glycosylation zip codes for or- tissular nucleotide changes during, apoptosis and,
gan-specific leukocyte trafficking, 543 small bowel (rat), 1839
Innate immune responses, CMV infection in developing ischemia time, warm, gene expression and, radical
brain, virus-infected neuron evasion (mouse), 919 prostatectomy specimens, 1743
Insulin, increase in sVAP-1 regulated by, DM, 2255
Insulin-like growth factor-1, improved contractile func-
tion, max dystrophic diaphragm muscle (mouse), 2263 Kallikrein 2, human glandular, anti-thrombin complex
Insulin-like growth factor-binding protein 3, during with, 2053
HPV-16 E6/E7 keratinocyte immortalization, 603 KDR, molecular profiling of angiogenesis markers
Integrins (mouse), 35
a 2, roles of, commentary (knockout mouse), 3 Keratinocytes
a1B1, antibody reduces scarring, crescentic glomeru- HPV-16 E6/E7 immortalization of, |GFBP-3 and, 603
lonephritis modei (rat), 1265 immortalized human, EP. receptor loss, 2065
a3B1, invasiveness triggered by TGF-B1 via, HCC, 183 NO donors suppress chemokine production by, 1409
2318
AJP December 2002, Vol. 161, No. 12
Keratins, CK 17 and CK 5/6, breast cancer outcomes drug-primed, bile acid-induced MB formation in
and, 1991 (mouse), 2019
Kidneys fatty, STAT3 and p21 in impaired regeneration
Angll-induced damage, protection by immunosup- (mouse), 155
pressive treatment (rat), 1679 repopulation after bone marrow transplants, 565
glomerular and tubulointerstitial scarring reduced by susceptibility to TNF-a— and Fas-mediated apoptosis
anti-VLA-1, crescentic GN model (rat), 1265 (SMP30 knockout mouse), 1273
glomerular podocyte injury, connexin43 regulation in LMP-1, EBV-encoded, p27“'®' and, AlDS-related DLCLs,
response to (rat), 1597 163
HIV-1 Tat induces hyperproliferation and dysregula- Loss of heterozygosity, normal and carcinogenic
tion, renal glomerular epithelial cells, 53 breast epithelium, 283
large scale isolation of glomeruli (mouse), 799 5-LOX. see 5-Lipoxygenase
mevalonate pathway during acute tubular injury, 681 LTB, receptor. see Leukotriene B,, receptor
molecular basis of porcine MPGN I! (pig), 2027 LuCaP 49, prostate carcinoma xenograft (nude mouse),
PDGFR-B blockade induces vascular EC apoptosis 705
and glomerular capillary disruption (mouse), 135 Lung adenocarcinomas, cell lines, caveolin-1 and
podocyte up-regulation of TGF-B1 in response to pro- filopoda formation, 1647
tein overload, 2179 Lungs
remnant, NO modulation of vascular disease in model acute injury, AP-1 activation in (rat), 275
of (rat), 239 acute injury, Fas and FasL regulation, 1783
sporadic PRCC, distinguishing type 1 from type 2, 997 acute injury, shock-induced PMN priming (mouse),
uranyl acetate-induced acute renal failure, MMF inhib- 2283
its repair (rat), 217 bleomycin-induced injury, L-selectin and ICAM-1 in
KIT gene, mutations, GISTs (letter), 737 regulation (mouse), 1607
injury, CD44 deficiency and, E. coli pneumonia
(mouse), 2219
Leishmania donovani, infection, TNF-a and splenic oxygen-injured, p21°'°“4FS'1 and normal remodel-
marginal zone remodeling (mouse), 429 ing of (mouse), 1383
Lens, defects in, murine Down syndrome model, ABPP restricted SIV replication during acute infection (rhesus
gene dosage and (mouse), 1985 macaques), 969
Lentiviral infections, neuropathogenesis (macaques), spontaneous metastasis to, intravascular location of
813 breast cancer cell after (mouse), 749
Leukocytes, glycolysation zip codes for organ-specific Lymphangiogenesis, TAMs expression of lymphatic
trafficking, 543 growth factors, 947
Leukotriene B,, role of y—glutamy! leukotrienase in for- Lymph nodes
mation, 481 mesenteric, GALT deficiency and, colitis model
Leukotriene B, receptor, 5-LOX and, in pancreatic can- (mouse), 2273
cers, 421 sentinel, molecular lymphatic mapping (rat), 1153
Lewy bodies, diseases of, cytoplasmic aggregates of tumor-draining, sampling for analysis of DCs and T
phosphorylated ERKs, 2087 cells, 19
Leydig cells, hyperplasia, Smad4 overexpression and Lymphomas. see a/so Specific lymphomas
(mouse), 1723 B-NHL, DNA polymerase jm gene expression, 1349
LIGHT, LIGHT receptors and, in human placental villi and cutaneous T-cell, genes in resistance to IFN-a, 1825
amniochorion membranes, 2011 enteropathy-type T cell, gains at 9q, 1635
Lipopolysaccharide enteropathy-type T cell, genotyping, 1527
MUC2 and MUCS5AC overexpression induced by, cul- M-FICTION single cell analyses, 413
tured biliary epithelial cells, 1475 splenic marginal zone, B cell origins, 81
shock-induced PMN priming and, acute lung injury
model (mouse), 2283
5-Lipoxygenase, LTB. receptor and, in pancreatic can- M3. see Muscarinic acetylcholine receptor type 3
cers, 421 Macrophages
Liver perivascular, PCNA marker of, SIV encephalitis, 575
adult, heterogeneity of ductular reactions, DMBT1 and tumor-associated, expression of lymphatic growth fac-
(rat and human), 1187 tors, 947
CCL,-induced injury, fibrosis and, FGFR4-deficiency Macrosialin, progression of atherosclerosis (ApoE-defi-
(mouse), 2003 cient mouse), 939
2319
AJP December 2002, Vol. 161, No. 12
Macular degeneration, age-related, model for, progres- Microglia, CD200 in EAU (mouse), 1669
sive age-related changes (transgenic mouse), 1515 Mig
MAL gene, resistance to IFN-a and, cutaneous T-cell in CAV (mouse), 1307
lymphoma, 1825 in thyroid and serum, recent onset Graves’ disease,
Mallory bodies, bile acid-induced formation drug- 195
primed liver (mouse), 2019 Mitotic spindles, checkpoint defects, breast cancer, 391
Mammary glands Monocyte chemoattractant proteins
lesions, strain background and lesion phenotype MCP-1, macrophage production, CXCR4 and CCR5
(TGF-a transgenic mouse), 1439 tropic viruses and IL-1 in (macaques), 813
p53'’24 transgene acceleration of MMTV-induced tu- MCP-3, eosinophil recruitment, type-2 hypersensitivity
morigenesis (mouse), 2241 pulmonary granulomas (mouse), 257
tumors, ErbB/Ras and Wnt pathway pathology (trans- Mouse mammary tumor virus, mammary tumorigenesis
genic mouse), 1087 induced by, p53'7*" transgene acceleration of
Marginal zone, splenic, TNF-a and remodeling, L. dono- (mouse), 2241
vani infection (mouse), 429
MPGN Il. see Membranoproliferative glomerulonephritis
Mast cell protease-1, enteric a,B, integrin in mucosal
type Il
mast cell hyperplasia and (mouse), 771
MUC2
Mast cells, hyperplasia, enteric a,B, integrin in MCP-1
goblet cells expressing, pseudomyxoma peritonei, 551
expression (mouse), 771
LPS-induced overexpression, cultured BECs, 1475
Matrix metalloproteinase-9
MUCSAC, LPS-induced overexpression, cultured BECs,
and choroidal neovascularization (mouse), 1247
1475
cryptic sites and retinal angiogenesis (mouse), 1429
Mucosa, gut, healing of, 1101
impairs cellular infiltration and AHR (mouse), 491
Mucosa-associated tissue lymphomas, with t(11;
progression of atherosclerosis (ApoE-deficient
18)(q21\1) and MALT with aneuploidy, pathogenetic
mouse), 939
pathways, 63
release and activation in aortic aneurysms, mural
Multiple endocrine neoplasias, types 2A and 2B, RET
thrombus, 1701
point mutations responsible for, 249
MBs. see Mallory bodies
Multivesicular bodies, intraneuronal AB42 accumulation
MEF2, in cardiac myxomas, 381
in, and synaptic pathology (mouse), 1869
Melanomas
Muscarinic acetylcholine receptor type 3, vagal nerve
CMN, genetic changes in neolasms arising from, 1163
stimulates HPC via (rat), 521
human, ABX-IL8 inhibits angiogenesis, tumor growth
Muscle. see Skeletal muscles; Vascular smooth muscle
and metastasis, 125
cells
new approaches to biology of, NIH pathology B study
Muscular dystrophy
section, 1949
mdx, ADAM12 alleviates skeletal muscle pathology
vertical growth phase, CDKN2A promoter hypermeth-
(mouse), 1535
ylation and polymorphism, 229
model of, IGF-I improves contractile function of max
Membranoproliferative glomerulonephritis type Il,
diaphragm muscle (mouse), 2263
porcine, molecular basis (pig), 2027
Musculoskeletal cells, embryonic, RB7CC7 expression,
Meningiomas, gene expression profiling by high-density
ODN microarrays, 665 359
Metastasis MVBs. see Multivesicular bodies
caveolin-1 and filopodia formation, lung adenocarci- Mycophenylate mofetil, inhibits repair, urany! acetate-
noma cell lines, 1647 induced acute renal failure (rat), 217
intravascular breast cancer cells, after spontaneous Myofibrobiasts, differentiation of, injured skeletal muscle
metastasis to lung (mouse), 749 (SCID mouse), 895
TAMs expression of lymphatic growth factors, 947
a-Methylacyl-CoA racemase, tumor differentiation and,
841 Natural killer/T-cell lymphomas, nasal, Fas gene dele-
Mevalonate pathway, effect of acute tubular injury, 681 tions in, 2123
M-FICTION. see Fluorescence immunophenotyping and Nef, HIV-1, cardiac disease in transgenic model express-
interphase cytogenetics, multicolor ing (mouse), 321
Microarrays. see also DNA microarrays; Tissue microar- Neovascularization
rays choroidal, MMP-9 and (mouse), 1247
high-density ODN microarrays, meningioma gene pro- retinal, MMP-9-dependent exposure of cryptic migra-
filing, 665 tory control site in collagen (mouse), 1429
2320
AJP December 2002, Vol. 161, No. 12
Nephrin, co-localization of podocin, actin cytoskeleton inhibitors, as anti-inflammatory agents, immune GN
and, 1459 (rat), 1497
Nephropathies, Tat induces hyperproliferation and dys- Nucleic acids, effect of fixatives and tissue processing
regulation, renal glomerular epithelial cells, 53 on, 1961
Neuroblastomas, CI/TA transcription deficiency, SCLCs Nucleophosmin-anaplastic lymphoma kinase fusion
and, 291 protein, c-Myc induced by, pediatric ALCLs, 875
Neurons, living, isolation from elderly brains, immuno-
magnetic sorting DNA-linker system, 1567
Oligoastrocytomas, genetic signatures denote distinct
Neutrophils
subsets, 313
acute lung injury, shock-induced PMN _ priming
Osteoclasts, osteoprotegerin and numbers of, bone ero-
(mouse), 2283 sion and, CIA (rat), 1419
Fcey-dependent activation, mediated by autoantibodies Osteopontin, in mineral deposition and regression of
to type Vil collagen, human skin, 301 ectopic calcification (mouse), 2035
migration, CD44 deficiency and, E. coli pneumonia Osteoprotegerin, osteoclast numbers and, in bone ero-
(mouse), 2219 sion, CIA (rat), 1419
recruitment after I/R, IL-1 in (mouse), 1797 Ovarian cancers
Nevi, CMN, genetic changes in neolasms arising from, animal models, VEGF and (mouse), 2295
1163 paclitaxel and VEGF antibody on (mouse), 1917
Nicotine, accelerates angiogenesis and wound healing prognosis, CD24 and, 1215
(mouse), 97 Oxidative stress, ALDO-induced inflammation in heart
Niemann-Pick disease, acid sphingomyelinase defi- (rat), 1773
ciency, reproductive pathology and sperm physiology
(mouse), 1061
p15INK4b promoter, 076/NK4a promoter and, hyper-
Nipah virus, pathology and pathogenesis, 2153
methylation, HLs and CD30-positive NHLs, 1007
Nippostrongylus brasiliensis, enteric a,B, integrin in
p16INK4a promoters, 075/NK4b promoter and, hyper-
MCP-1 expression and mast cell hyperplasia (mouse),
methylation, HLs and CD30-positive NHLs, 1007
771
p21, STAT3 and, impaired fatty liver regeneration
Nitric oxide
(mouse), 155
in coronary dilation, HHcy (rat), 145
p21ciPwAFivsait normal remodeling of oxygen-injured
donors suppress chemokine production by keratino-
lung and (mouse), 1383
cytes, 1409
p27*'"', EBV-encoded LMPiand, AlDS-related diffuse
modulates vascular disease in remnant kidney model
large-cell lymphomas, 163
(rat), 239
p53
Nitric oxide synthase, inducible, bacterial colonization
accumulation and chromosome 9 alterations, urinary
of wounds and (mouse), 2143
bladder CIS lesions, 1119
Nitrogen, reactive intermediates in GCA (mouse), 115
tumor suppressor pathway, allelic loss in EBV-positive
S-Nitrosoglutathione, keratinocyte chemokine produc-
gastric cancer and, 1207
tion suppressed by, 1409
p53"”2" transgene, acceleration of MMTV-induced
Nkx2.5/Csx, in cardiac myxomas, 381
mammary tumorigenesis (mouse), 2241
NL. see Natural killer/T-cell lymphomas Paclitaxel, VEGF antibody and, ovarian cancer (mouse),
Non-Hodgkin’s lymphomas 1917
AIDS-related, p27*'°' and EBV-encoded LMP1, 163 Pancreatic cancers, 5-LOX and LTB, receptor, 421
CD30-positive, p75INK4b and p16INK4a promoters, Pancreatic intraepithelial neoplasias, telomere short-
hypermethylation, HLs and, 1007 ening in, 1541
Nonselenium glutathione peroxidase, human brain, PK Panin. see Pancreatic intraepithelial neoplasias
and DLB, 885 Papillary renal cell carcinomas, sporadic, distinguish
Non-small-cell lung carcinomas, B-catenin and prolif- ing type 1 from type 2, 997
eration, 1619 Paramyxoviruses, Nipah virus pathology and pathogen-
NOR-1, keratinocyte chemokine production suppressed esis, 2153
by, 1409 Parathyroid tumors, multiple, development of, PHPT pa-
NSGP. see Nonselenium glutathione peroxidase tients, 1299
Nuclear factor-«B Parkinson’s disease
human Rb cell viability and, 2229 cytoplasmic aggregates of phosphorylated ERKs,
hyperosmotic stress-induced activation of, human 2087
IECs, 987 NSGP levels in, 885