The American Journal of Pathology 2001: Vol 159 Index

37 Pages·2001·10.8 MB·English

Index of Subjects
Volume 159, 2001
AAH. see Atypical adenomatous hyperplasia AB1—42 immunization and pathology associated with
Actin, a-smooth muscle, sarcomatoid variant of anaplas- (mouse), 439
tic large cell lymphoma (letter), 383 B-pleated sheets labeled by BSB, human postmortem
Activating transcription factor 3, in cardiac stress re- samples, 937
sponse (mouse), 639 cystatin C in neurons, 1061
Acute myelogenous leukemia, /V/L/-positive, granulo- PBP association with neurofibrillary alterations and tau
cytic sarcoma in, 2011 phosphorylation, 1597
AD. see Alzheimer's disease B-Amyloid, B-pleated sheets, BSB labeling of, neurode-
Adenocarcinomas generative disease brains (human and mouse), 937
invasiveness suppressed by synthetic tissue kallikrein Amyloid-B1-—42, immunization with, effect on Alzhei-
inhibitor, 1797 mer’s disease-associated pathology (mouse), 439
lung, LOH on 9q and 16p, 1941
Amyloid fibril proteins, MMP-1, MMP-2 and MMP-3 pro-
mammary implants, thrombosis of tumor vessels (rat), teolysis of, 561
245
Anaplastic large cell lymphoma
organ-specific gene expression profiles, 1231
ALK-negative, BCL-2 family proteins in, 527
Adenomatous polyposis coli, APC/B-catenin pathway
sarcomatoid variant (letter), 383
and 11p alterations, FAP-associated pancreatoblasto-
Anaplastic lymphoma kinase gene, fusion to CLIC,
mas, 1619
inflammatory myofibroblastic tumors, 411
Adenomyosis, disordered stromal differentiation and
Androgen receptors, ERs and, normal and diseased
(mouse), 623
prostate glands, 79
Adherens junction proteins, neutrophil! transmigration
Aneurysms, induced by Ang ll, ApoE-deficiency
in IBD and, 2001
(mouse), 1455
AFPs. see Amyloid fibril proteins
Angiogenesis
AIA. see Antigen-induced arthritis
after nephron reduction (mouse), 547
Airway hyperreactivity, Stat-4 and IL-2 in regulation of
altered, sponge granulomas of TSP2-null model
AHR and, RSV infection, 631
(mouse), 1255
Airways
fractalkine in RA, 1521
inflammation, Stat-4 and IL-2 in regulation of AHR and,
inhibition of, stromal keratitis controlled by, 1021
RSV infection, 631
PDGF in (mouse), 1869
paramyxoviral infection, effects on epithelial cell Foxj1
regulation in VPG melanomas, 223
expression (mouse), 2055
secretable endostatin gene therapy for CNV (mouse)
AKT1 kinase, in cancer, 431
313
Albumin, fractional clearance of, glomerulonephritis
tumor, GCP-2-induced, 1405
(rat), 1159
VEGF-C-induced, melanoma, 893
ALCL. see Anaplastic large cell lymphoma
ALK, cytoplasmic expression, sarcomatoid variant of VEGF-mediated, modulated by VEGFR-1 via NO, 993
anaplastic large cell lymphoma (letter), 383 VEGF-mediated autocrine stimulation, prostate tumor
ALK gene, see Anaplastic lymphoma kinase gene progression and, 651
Aikaline phosphatase, expression in human OA chon- in vivo imaging, immature to preovulatory ovarian folli-
drocytes, 1777 cles, 1661
Alport syndrome, X-linked, X-linked inner ear nephritis Angiolipomas, renal, telomerase to obtain stable cell
and (dog), 1097 populations, 483
Aluminum chloride, elastin pretreatment, inhibition of Angiopoietins, Angi responses and Ang2 expression,
MMP elastolysis and, 1981 hemangioma-derived cells, 2271
Alveolar soft part sarcomas, primary renal neoplasms Angiosarcomas, relation of FasL and TILs in, 963
with ASPL-TFE3 gene fusion, 179 Angiostatin, ADv expressing, inhibit breast cancer met-
Alzheimer’s disease astatic growth model, lung (mouse), 1137
2373
2374
1/P Decembe20r0 1, Vol. 159, No. 6
Angiotensin-converting enzyme, inhibition in PHN (rat), Arteries, injured, Jagged/Notch gene families in, 875
1743 Arthritis
Angiotensin Il experimental, effect of TSG-6 (mouse), 1711
type IA, deficiency, persistent proteinurea-induced tu- inflammatory joints, plasma Apo(a) co-deposits with
bulointerstitial damage (mouse), 1895 fibrin, 1445
uPA and, induction of aneurysms and, ApoE-defi- serum transfer model of, protection from bone erosion,
ciency (mouse), 1455 TRANCE/RANKL knockout model (mouse), 1689
Animal models ASPL-TFE3 gene, primary renal neoplasms, 179
altered type XIII collagen domains, progressive myop- ATF3. see Activating transcription factor 3
athy, (mouse model), 1581 Atherosclerosis
anorectal malformations, defects in Shh signaling coronary, protein C receptor and thrombomodulin, 797
(chick and mouse), 765 coronary piaques, natural anticoagulants and, 795
CDK4 and epidermal proliferation (mouse), 369 IL-15 expression in lesions (mouse and human), 417
cryoglobulinemic glomerulonephritis (thymic stromal Atypical adenomatous hyperplasia
lymphopoietin transgenic mouse), 2355 LOH on 9q and 16p, 1941
HIV-1 infection, small animal model (mouse), 2331
MMPs in invasive pulmonary adenocarcinoma with
prostate cancer, clinical and experimental progres-
bronchioalveolar component, 2125
sion, therapeutic approach in (mouse), 753
Autoimmune diseases
renal agenesis (mouse), 2347
EAM, IL-4 dependency of (mouse), 193
retinoic acid-induced caudal regression syndrome
myocarditis, Th1/Th2 paradigm, cardiac myosin (hu-
(mouse), 2321
man and mouse), 5
systemic autoimmunity, exposure to bovine thrombin
thyroid, functional germinal centers, 861
induced (mouse), 1957
Autoimmunity
Annexin 1, cytokine modulation, experimental endotox-
ectopic lymphoid organogenesis and, 787
emia, liver, 1435
systemic, induced by exposure to bovine thrombin
Annexin VI, expression in human OA chondrocytes,
(mouse), 1957
1777
Anoikis, apoptotic circulating breast cancer cells, 17
Anorectal malformations, anima! models, defects in
B-cell lymphomas, p53, p16 and p27 alterations and
Shh signaling (chick and mouse), 765
survival in, 205
Antigen-induced arthritis, experimental, role of Fe re-
B cells
ceptors in (mouse), 2309
IDC interactions with, human mesenteric lymph nodes,
Aortic stenosis, calcific, MMP-2 and TN-C in (sheep),
131
321
thyroid antigen-specific, chemokine-containing intra-
Aortic valve, TGF-B and in vitro EMT, 1335
thyroidal GCs, 861
APC. see Adenomatous polyposis colli
Basement membrane, fibrosis in kidney disease and,
APC gene, syndromic fundic gland polyps and neoplasia
1187
(letter)3,8 1
Bcl-2
Apolipoprotein (a), plasma, co-deposits with fibrin, in-
flammatory arthritic joints, 1445 family proteins in ALCL, 527
Apolipoprotein E, deficiency, Ang || increases uPA and role in MetAP2 and human mesothelioma cell survival,
induces aneurysms (mouse), 1455 721
Apoptosis Benign prostatic hyperplasia, FGF-2 induction by IL-8,
adult cardiomyocytes, videomicroscopy and electron 139
microscopy studies (rat), 683 B-Cells, death in response to dsRNA and IFN-y, 273
B-cell, response to dsRNA and IFN-y, 273 B-Pleated sheets, BSB labeling of, neurodegenerative
circulating breast cancer cells, 17 disease brains (human and mouse), 937
ethanol-induced, liver (mouse), 329 BE11 antibody, 4F2 in tumor-derived and vascular EC
human mesothelioma cells, MetAP2 and, 721 growth, 165
mitochondrial release of AIF and cyt c, SMCs, 305 Bladder cancer
NO-induced, galectin-3 and, breast cancer, 1055 E-cadherin gene methylation in, 831
SPARC induction of, ovarian cancer cells, 609 PPAR-y and its ligands, normal and neoplastic cells,
TNF-a-mediated hepatocyte, resistance to (cathepsin 591
B knockout mouse), 2045 Bob/GPR15, gp120-induced activation of, HIV enterop-
Apoptosis-inducing factor, SMC apoptosis and mito- athy and, 1933
chondrial release of, 305 Bone
2375
AJP December 2001, Vol. 159, No. 6
erosion of, serum transfer model of arthritis, TRANCE/ invasiveness, suppression by synthetic tissue kallikrein
RANKL knockout model (mouse), 1689 inhibitor, 1797
growth piate alterations in collagen type X mutation therapy, regulation of telomerase and, 405
(mouse), 2257 Carcinogenesis, SPARC induction of apoptosis, ovarian
Bone marrow cancer, 609
archival trephines, light chain restricted clonal B-lym- Carcinomas, with t(15;19) translocation, BRD4 gene re-
phoid infiltrates, PCR, 2023 arrangement in, 1987
infrequent neuroblastoma cells, GM2/GD2 synthetase Cardiomyocytes, adult, apoptosis studies by videomi-
mRNA and detection of, 493 croscopy and electron microscopy (rat), 683
Bone tumors, translocations and gene changes, 1979 Caspase-3, ethanol-induced apoptosis pathway, liver
BPH. see Benign prostatic hyperplasia (mouse), 329
Brain, neurodegenerative diseased, B-pleated sheets la- B-Catenin
beled by BSB (human and mouse), 937 APC/B-catenin pathway and 11p alterations, FAP-as-
BRD4 gene, rearrangement in aggressive carcinoma sociated pancreatoblastomas, 1619
with t(15;19) translocation, 1987 in CRC invasion front, 1613
Breast cancer neuroblastoma outcomes and plakoglobin expression,
angiostatin expressing ADv inhibits metastatic growth 43
model, lung (mouse), 1137 Cathepsin B, knockout model, resistance to TNF-a-me-
apoptotic circulating cells, 17 diated hepatocyte apoptosis (mouse), 2045
galectin-3 and NO-induced apoptosis, 1055 Cathepsin D, expression in breast cancer, 215
high-resolution 3p allelotyping, 119 Cathepsin K, in synovial fibroblast-mediated collagen
invasive, EBV and, 571 degradation, 2167
MT-3 overexpression and prognosis, 21 Caudal regression syndrome, retinoic acid-induced
TFF1 expression in, 215 (mouse), 2321
TMA links molecular changes and clinical endpoints, Caveolin-1 gene, down-regulation in ovarian cancer,
2249 1635
in vivo, interaction of uPAR and integrins in, 971 CChC. see Chagasic cardiomyopathy
Brinkhous, Kenneth Merle, in memoriam, 3 CD2AP, localization and binding of (mouse), 2303
(Trans, trans}-1-Bromo-2,5-bis-(3-hydroxycarbonyl-4- CD10, expression in HCCs, 1415
hydroxy)styrylbenzene, B-pleated sheet structures CD31. see Platelet/endothelial cell adhesion molecule-1
labeled by, neurodegenerative disease brains (human CD40, in severe malaria (mouse), 733
and mouse), 937 CD40 ligand, in severe malaria (mouse), 733
BSB, see (Trans,trans)-1—-Bromo-2,5—bis—(3—hydroxy- CD44, B1-integrin regulation of ovarian carcinoma sphe-
carbonyl-4—hydroxy)styryloenzene roids, 2071
Burns, healing (TGF-B transgenic mouse), 2147 CD154, see CD40 ligand
CDKN2A gene, alterations in atypical and anaplastic
meningiomas, 661
c-Met, EBV LPM-1 induction of, cervical lymph node NPC CDKN2B gene, alterations in atypical and anaplastic
metastases and, 27 meningiomas, 661
C5a receptor, receptor binding sites of RP S19 protein CDKN2C gene, alterations in atypical and anaplastic
dimer, 2293 meningiomas, 661
N-Cadherin, invasive epithelial cell tyoe expressing, cell CDX2, loss of expression in LCMDCs, 2239
culture endometriosis model, 1839 CEACAM1, cis interaction with B. integrin, 537
neuroblastoma outcomes and plakoglobin expression, Cell adhesion molecules, CEACAM1 cis interaction with
43 integrin Bz, 537
E-Cadherin gene Cell cycle, progression, mammary epithelial cells, a.B,
methylation in bladder neoplasia and normal urothelial integrin and, 983
epithelium, elderly individuals, 831 Central nervous system, cytokine contro! of 7. Cruzi
mutations in synovial sarcoma, 2117 (mouse), 1723
CAG repeat diseases, NI! interactions with coiled bodies Cerebral malaria, role of ischemia (mouse), 1105
(mouse and human), 1785 Cervical carcinomas, KA!1 down-regulation in, 1629
Calcium antagonists, ACE inhibition and, effects on Chagasic cardiomyopathy, |L-4 modulation of (mouse),
PHN (rat), 1743 703
CALLA. see CD10 Chemokine ligands, uterine expression of, pregnancy,
Cancer 2199
AKT1/PKBa kinase and, 431 Chemokine receptors
2376
AJP December 2001, Vol. 159, No. 6
CCR1* and CCR5* mononuclear phagocytes in CNS molecular defects in LCMDCs, 2239
of MS patients, 1701 primary adenocarcinomas, gene expression profiles,
uterine expression of, pregnancy, 2199 1231
Chemokines prognostic value of MSI and CTLs, 297
CXC, redundancy and neutrophil recruitment during Colorectal adenomas, CpG island methylation, 1129
inflammation (mouse), 1149 Colorectal cancer, adenocarcinomas, invasion front of,
wound healing and, MIP-1a and MCP-1 deficiency 1613
(mouse), 457 LAMPs associated with, 449
Chemotaxis MSI-H, characterization of, 2107
neutrophil recruitment and PGF.,, released hypoxia- Connective tissue growth factor, thrombin in pathogen-
activated ECs, 345 esis of pulmonary fibrosis, 1383
receptor binding sites of RP S19 protein dimer, 2293 Coronary arteries, atherosclerotic plaque, natural anti-
Chemotherapy, down-regulation of telomerase activity in coagulants and, 795
malignant lymphomas, 711 CpG islands, methylation, colorectal adenomas, 1129
Cholesterol, renal accumulation (mouse), 743 Crohn’s disease, |ymphotactin expression in, 1751
Chondrocytes Cryoglobulinemic glomerulonephritis, thymic stromal
human, early and late differentiation markers in OA, lymphopoietin transgenic model (mouse), 2355
1777 CTB. see Cytotrophoblasts
hypertrophic pericellular matrix, effect of collagen type Cyclin D1
X mutation (mouse), 2257 overexpression, RQ-PCR detection, MCLs, 425
Choroidal neovascularization, secretable endostatin polymorphism and expression, SCCHN, 1917
gene therapy for (mouse), 313 in CRC invasion front, 1613
Chromosome 11, APC/B-catenin pathway and 11p alter- Cyclin-dependent kinase 4, animal model, epidermal
ations, FAP-associated pancreatoblastomas, 1619 proliferation and (mouse), 369
Chromosome instability, in lung cancer, p53 and, 1345 Cyclin-dependent protein kinase inhibitors, B-cell lym-
Ciliogenesis, effects of paramyxoviral airway infection phoma survival and, 205
(mouse), 2055 Cystatin C, in AD neurons, 1061
CIN. see Chromosome instability Cytochrome c
Cirrhosis, liver ethanol-induced apoptosis pathway, liver (mouse), 329
ETBR expression, 1353 SMC apoptosis and mitochondrial release of, 305
p62 expression, 945 Cytokeratins, endothelial, MBL and LCP, oxidative
Cisplatin stress, 1045
down-regulation of telomerase activity in malignant Cytotoxic T lymphocytes
lymphomas, 711 prognostic value in colon cancer, 297
nephrotoxic effects of, resistance in GGT-deficiency transection of MHC class I-induced neurites by, 862
(mouse), 1889 Cytotrophoblasts, pY39FAK and invasion by, 93
Clathrin heavy chain gene, ALK gene fusion to, IMTs,
411
Clonality Demyelination, in vivo MHC expression in neurons and
B- and T-cell multiplex PCR in diagnosis of lymphopro- oligodendrocytes, viral infection, 1219
liferative disorders, 2031 Dendritic cells
light chain restricted B-lymphoid infiltrates, archival BM interdigitating, interactions with B and T cells, human
trephines, PCR, 2023 mesenteric lymph nodes, 131
CLTC ger. see Clathrin heavy chain gene plasmacytoid, DLE lesions, 237
CNV. see Choroidal neovascularization subsets in human tonsils, 285
Coiled bodies, NI! interactions with, CAG repeat dis- Dermal fibrosis, animal model, CDK4 and epidermal
eases (mouse and human), 1785 proliferation (mouse), 369
Collagen Dexamethasone, hepatocytes in organoid cultures,
synovial fibroblast-mediated degradation, cathepsin K 1877
in, 2167 Diabetes mellitus
thrombin in pathogenesis of pulmonary fibrosis, 1383 B-cell apoptosis in response to dsRNA and IFN-y, 273
type IV, EMT and, renal fibrosis, 1313 ILK distribution and regulation in kidneys, 1735
type X, mutation disrupts growth plate (mouse), 2257 nonhealing wounds, inflammation in, 399
type XIll, altered domains, progressive myopathy wound healing, RAGE blockade and (mouse), 513
(mouse model), 1581 Discoid lupus erythematosus, plasmacytoid DC accu-
Colon cancer mulation in lesions, 237
2377
AJP December 2001, Vol. 159, No. 6
DLE. see Discoid lupus erythematosus Epstein-Barr virus-induced gene 3, expression during
DNA human pregnancy, 1763
frozen tumor tissue, TMA analysis of RNA, proteins ER. see Estrogen receptors
and, 1645 Esophagus, MEN1 in multiple leiomyomas of, 1121
hypomethylated chromatin, 1q copy gain and, HCC, Estrogen receptors
465 ER-a and ER-B, AR and, normal and diseased prostate
mutations, detection of single-based alterations, SYBR glands, 79
and Tm analysis, 845 ER-B, prostate cancer, 13
cDNA arrays, CD10/CALLA expression in HCC, 1415 expression in breast cancer, 215
ETBR. see Endothelin B receptor
Ethanol, apoptosis induced by, liver (mouse), 329
EAM. see Experimental autoimmune myocarditis Experimental autoimmune encephalomyelitis, induc-
Editorial, editor for Centennial celebration of the Journal, tion of extracellular proteolysis during (mouse), 2227
1183 Experimental autoimmune myocarditis, |L-4 depen-
EIF3S3 gene, amplification in advanced prostate cancer, dency of (mouse), 193
2089 Extracellular matrix, altered remodeling, sponge gran-
Elastin, AICI, pretreatment, MMP elastolysis and, 1981 ulomas of TSP2-null model (mouse), 1255
Embryology
retinoic acid-induced caudal regression syndrome
(mouse), 2321 4F2, tumor-derived and vascular EC growth, 165
Shh signaling defects, anorectal malformations and Factor Xilla, |L-1-induced, 149
(chick and mouse), 765 Familial adenomatous polyposis, pancreatoblastomas
EMT. see Epithelial-mesenchymal transdifferentiation associated with, APC/B-catenin pathway and 11p al-
Endometriosis, cel! culture model, invasive N-cadherin- terations, 1619
expressing cell type in, 1839 Familial amyloidotic polyneuropathy, early, transthyre-
Endostatin, secretable, gene therapy for CNV (mouse), tin deposition in, 1993
313 FAP. see Familial adenomatous polyposis
Endothelial cells Fas
4F2 and growth derived by, 165 in anaplastic and atypical meningiomas, 1193
hypoxia-activated, PGF,, released by, neutrophil re- ethanol-induced apoptosis pathway, liver (mouse), 329
cruitment and, 345 Fas ligand
protein C receptor, thrombomodulin and, coronary ath- apoptosis and, anaplastic and atypical meningiomas,
erosclerosis, 797 1193
Endothelin B receptor, expression in cirrhotic liver, 1353 relation of TILs and, angiosarcomas, 963
Endotoxemia, experimental, cytokine modulation of an- FceyRI, in experimental AIA (mouse), 2309
nexin 1, liver, 1435 FeyRil, in experimental AIA (mouse), 2309
Enteropathies, HIV, gp120-induced Bob/GPR15 activa- FceyRIll, in experimental AIA (mouse), 2309
tion and, 1933 Fetal growth restriction, TGF-8 in placenta and placen-
Eosinophilia, airway, Stat-4 and IL-2 in regulation of AHR tal bed, 1827
and, RSV infection, 631 Fetal liver epithelial progenitor cells, liver repopulation
Epidermal growth factor, hepatocytes in organoid cul- by (rat), 1323
tures, 1877 Fibrin, plasma Apo(a) co-deposits with, inflammatory ar-
Epidermal hyperplasia, animal model, CDK4 and epi- thritic joints, 1445
dermal proliferation (mouse), 369 Fibroblast growth factor-2
Epithelial cells, mammary, cell-cycle progression, a.B, decreases hypoxia-induced photoreceptor cell death
integrin and, 983 (mouse), 1113
Epithelial-mesenchymal transdifferentiation IL-8 induction of, BPH, 139
aortic valve, TGF-B and, in vitro, 1335 Fibroblasts
fibrosis in kidney disease and, 1187 heterogeneity, human female reproductive tract, 925
key events in, renal interstitial fibrosis and, 1465 perifollicular and marginal zone of spleen, 501
type IV collagen and, renal fibrosis, 1313 Fibronectin, B1-integrin regulation of ovarian carcinoma
Epstein-Barr virus spheroids, 2071
in American HCC, 1287 FLEP. see Fetal liver epithelial progenitor cells
invasive breast cancer and, 571 Flow cytometry, rolling circle amplification, 63
LMP-1 induction of c-Met, lymph node NPC metasta- FLT-1, microvessel density and outcomes in VPG mela-
ses and, 27 nomas, 223
2378
AJP Decembe20r0 1, Vol. 159, No. 6
Focal adhesion kinases, CTB invasion and pY39FAK, Granulocytic sarcomas, in MLL-positive infant AML,
93 2011
Foxj1, airway epithelial cell expression, effects of Groa, neutralization attenuates renal ischemia/reperfu-
paramyxoviral infection (mouse), 2055 sion injury, 2137
Fractalkine, in RA, 1521 Growth, cellular, role of NF-«B, 387
Fundic gland polyps, syndromic, neoplasia and (letter), GSTP1, CpG island hypermethylation in prostate cancer
381 1815
Galectin-3, NO-induced apoptosis and, breast cancer, HaCaT/HaCaT-ras model, human skin carcinogenesis,
1055 tumor progression in vivo, 1567
Gastric mucosa, PLC62 and neoplastic transformation, HCC. see Hepatocellular carcinomas
803 Heart
GC-17 antibody, ER-a, ER-B and AR, normal and dis- adult, cardiomyocyte apoptosis studied by videomi-
eased prostate glands, 79 croscopy and electron microscopy (rat), 683
Gene therapy, secretable endostatin for CNV (mouse), autoimmune myocarditis, Th1/Th2 paradigm, cardiac
313 myosin (human and mouse), 5
Genes, human, stop codon assay, 1239 cytokine control of 7. Cruzi (mouse), 1723
Germ cells, RNF4 in, 1225 IL-4 modulation of CChC by (mouse), 703
Germinal centers, functional, AITD, 861 stress response, ATF3 in (mouse), 639
GGT. see y-Glutamy! transpeptidase toxicity of 3-NPA, compared with neurotoxicity, strain
Gliomas, classification, 779 differences (mouse), 1507
Gliomatosis peritonei, glial implants in, 51 Hemoglobin-vesicles, RES function and, 1079
Glomerular slit diaphragm, lipid rafts in nephrin phos- Hepatitis C virus, SS and (letter), 1593
phorylation and (rat), 1069 Hepatitis virus, murine, in vivo MHC expression in neu-
Glomerular-tubule disconnection, effect of ACE inhibi- rons and oligodendrocytes during infection, 1219
tion in PHN (rat), 1743 Hepatocellular carcinomas
Glomeruloid lesions, plexiform lesion in severe pulmo- American, lack of EBV association, 1287
nary hypertension and (letter), 382 CD10/CALLA expression in, 1415
Glomerulonephritis hypomethylated chromatin DNA and 1q copy gain, 465
experimental, glomerular capillary repair and VEGF, p62 expression, 945
599 Hepatocyte growth factor
fractional clearance of ablumin (rat), 1159 hepatocytes in organoid cultures, 1877
y-Glutamy! transpeptidase, deficiency, resistant to mesothelial cells and, peritonitis, 1275
nephrotoxic effects of cisplatin (mouse), 1889 response of prostate epithelial cells to, 579
Glycosaminoglycan, distribution of, effect of collagen Hepatocytes, organoid cultures, 1877
type X mutation (mouse), 2257 Hereditary leiomyomatosis and renal cel! cancer, fa-
GM2/GD2 synthetase, mRNA for, detection of infrequent milial MCL and RCC, 825
neuroblastoma cells in BM, 493 Herpes simplex virus, inhibition of neovascularization
GN. see Glomerulonephritis and control of stromal keratitis by, 1021
gp120, Bob/GPR15 activation induced by, HIV enterop- HGF/SF. see Hepatocyte growth factor/scatter factor
athy and, 1933 Histiocytes, MPO, Kikuchi and Kikuchi-like lymphade-
Granulation tissue, contractile activity of, contro! by me- nopathy, 915
chanical tension (rat), 1009 HIV-1, small animal model of infection (mouse), 2331
Granulocyte chemotactic protein-2, tumor angiogene- HIV enteropathy, gp 120-induced Bob/GPR15 activation
sis induced by, 1405 and, 1933
Granulocyte colony-stimulating factor HLA-G, psoriatic skin, 71
alveolar neutrophil survival and, BAC pulmonary ade- HLRCC. see Hereditary leiomyomatosis and renal cell
nocarcinoma, 1423 cancer
tumor progression and, HaCaT/HaCaT-ras model, skin Hodgkin’s disease, |ack of PU.1 expression, 1807
carcinoma cells, 1567 HRPE. see Human retinal pigment epithelial cells
Granulocyte-macrophage colony-stimulating factor Human leukocyte antigen G, HLA class | loss and IL-10
alveolar neutrophil survival and, BAC pulmonary ade- production and up-regulation of, lung cancer, 817
nocarcinoma, 1423 Human papillomavirus
tumor progression and, HaCaT/HaCaT-ras model, skin detection and genotyping, SybrGreen and molecular
carcinoma celis, 1567 beacon PCR, 1651
2379
AJP December 2001, Vol. 159. No. 6
DNA in penile carcinoma, 1211 Interferon-y
Human retinal pigment epithelial cells, thrombin in B-cell apoptosis in response to, 273
monocyte interaction with, 1171 control of T. Cruzi in heart and CNS (mouse), 1723
Hypertrophy, animal model, CDK4 and epidermal prolif- leukocyte transendothelial migration and, 2281
eration (mouse), 369 Interleukin 1, Factor Xilla and rlGase activity induced
Hypoxia ; by, 149
ECs activated by, PGF... release bly, neutrophil recruit- Interleukin 4
ment and, 345 dependency of EAM on (mouse), 193
photoreceptor cell death induced by, effect of FGF2 modulation of CChC by (mouse), 703
(mouse), 1113 Interleukin 6
annexin 1 modulation, experimental endotoxemia, liver,
1435
IDCs. see Dendritic cells, interdigitating in prostate cancer, 2159
IHC. see Immunohistochemistry Interleukin 8
ILK. see Integrin-linked kinase FGF-2 induction by, BPH, 139
immunodeficiency, SIV, strain dependence of dMAC redundancy and neutrophil recruitment during inflam-
induction (rhesus macaques), 693 mation (mouse), 1149
Immunoglobulin genes, usage of VH genes in NMZL, Interleukin 10, production of, HLA-G up-regulation-asso-
253 ciated HLA class | loss and, lung cancer, 817
Immunohistochemistry Interleukin 12
CD10/CALLA expression in HCC, 1415 control of 7. Cruzi in heart and CNS (mouse), 1723
rolling circle amplification, 63 role of Stat-4 and, regulation of airway inflammation
IMT. see Inflammatory myofibroblastic tumors and AHR in RSV infection, 631
In memoriam Interleukin 15, in atherosclerotic lesions (mouse and
Gary J. Miller, 775 human), 417
Kenneth Merle Brinkhous, M.D., 3 interstitial fibrosis, renal, EMT and, 1187
Infantile hemangiomas, Tie2 expression, Ang1 re- Intraductal papillary-mucinous neoplasms, S/K77/
sponses and Ang2 expression, hemangioma-derived LKB1 Peutz-Jeghers gene inactivation in, 2017
cells, 2271 IPMNs. see Intraductal papillary-mucinous neoplasms
inflammation, ischemia
arthritic joints, plasma Apo(a) co-deposits with fibrin, reactive oxygen intermediate-induced MCP-1, 1301
1445 role in CM (mouse), 1105
CXC chemokine redundancy and neutrophil recruit- ischemia/reperfusion injury
ment (mouse), 1149 attenuation of, neutralization of Groa and MIP-2 and,
molecular signatures of sepsis, 1199 2137
nonhealing DM wounds, 399 human placenta, model for oxidative stress, 1031
inflammatory bowel disease, neutrophil transmigration,
epithelial intercellular junction proteins and, 2001
Jagged/Notch gene families, injured arteries, 875
Inflammatory myofibroblastic tumors, ALK gene fusion
JPS. see Juvenile polyposis syndrome
to CLTC gene, 411
Junctional adhesion molecule, |eukocyte transendo-
Information management, management of high-density
thelial migration and, 2281
TMA data, prostate glands, 837
Juvenile polyposis syndrome, SIVAD4 mutations, pro-
Inner ear, x-linked nephritis and X-linked Alport syn-
tein expression in, 1293
drome (dog), 1097
Insulin, stimulation of renal proximal tumular epithelial
cell TGF-B1 (HK-2 cells), 1905 KAI1. down-regulation in cervical carcinoma, 1629
Integrin-linked kinase, distribution and regulation, nor- Kallikrein inhibitor, synthetic tissue, cancer invasive-
mal and diabetic kidneys, 1735 ness suppressed by, 1797
Integrins KDR, microvessel density and outcomes in VPG melano-
B1, ovarian carcinoma spheroids regulation by, 2071 mas, 223
Bs, Cis interaction of CEACAM1 with, 537 Keratin 6, animal model, CDK4 and epidermal! prolifera-
a5B,, Mammary epithelial cell-cycle progression via, tion (mouse), 369
983 Keratinocytes, norma! human, persistent p53 mutations
a,B,, in lymphocyte migration to inflamed lacrimal in single cells, 1247
glands (mouse), 671 Ki-67 antigen, in CRC invasion front, 1613
interaction of uPAR and, breast cancer, 971 Kidneys
2380
AJP December 2001, Vol. 159, No. 6
angiogenesis after nephron reduction (mouse), 547 cytokine-modulated annexin 1, experimental endotox-
cholesterol accumulation (mouse), 743 emia, 1435
fibrosis, EMT and, 1187 ethanol-induced apoptosis (mouse), 329
ischemia/reperfusion injury, neutralization of Groa and hepatocytes in organoid cultures, 1877
MIP-2 and, 2137 myeloperoxidase and oxidation products in Kupffer
normal and diabetic, ILK distribution and regulation, cells, 2081
1735 repopulation by FLEPs (rat), 1323
primary neoplasms, ASPL-TFE3 gene in, 179 TNF-a-mediated hepatocyte apoptosis, cathepsin B
renal fibrosis, type 4 collagen assembly and EMT, 1313 knockout model (mouse), 2045
TGF-B1 deregulation after ureteric obstruction (fetal LMP-1. see Latent membrane protein-1
sheep), 109 Loss of heterozygosity
tubulointerstitial damage, persistent proteinurea-in- high-resolution 3p allelotyping, breast cancer, 119
duced, AT1-deficiency (mouse), 1895 18q, serous ovarian carcinoma, 35
Kikuchi’s lymphadenopathies, MPO histiocytes in, 915 on 9q and 16p, AAH and adenocarcinoma of the lung,
1941
Killer cell immunoglobulin-like receptor, repertoire in
sinonasal lymphomas, 1671 Lung cancer
adenocarcinoma, BAC, GM-CSF and G-CSF prolong
KIRs. see Killer cell immunoglobulin-like receptor
alveolar neutrophil survival, 1423
Kupffer cells, human liver, myeloperoxidase and oxida-
adenocarcinomas with BAC and AAH, MMPs in, 2125
tion products in, 2081
chromosome instability in, 1345
HLA-G up-regulation-associated HLA class | loss and
IL-10 production, 817
Lacrimal glands, inflamed, lymphocyte migration to
primary adenocarcinoma, gene expression profiles,
(mouse), 671
1231
LAMPs. see Lysosome-associated membrane proteins
Lungs
Large cell minimally differentiated carcinomas of the
MEN1 in multiple leiomyomas of, 1121
colon, molecular defects in, 2239
thrombin in pathogenesis of pulmonary fibrosis, 1383
Large granular lymphocytes, !eukemia of, TCR-VB and
Lymph nodes
T-cell clonality in, 1861
cervical, NPC metastases, EBV LMP-1 induction of
Latent membrane protein-1, EBV, and cervical lymph
c-Met and, 27
node metastases, NPC, 27
mesenteric, IDC interactions with B and T cells, 131
LCMDCs. see Large cell minimally differentiated carcino-
Lymphangiogenesis, VEGF-C-induced, melanoma, 893
mas of the colon
Lymphocyte function-associated antigen-1, in |ympho-
LCP. see Lectin complement pathway
cyte migration to inflarred lacrimal glands (mouse),
Lectin complement pathway, activation mediated by
671
MBL and endothelial cytokeratins, oxidative stress,
Lymphocyte migration
1045
inflamed lacrimal glands (mouse), 671
Leiomyomas, multiple, in esophagus, lung and uterus,
perifollicular and marginal zone of spleen, 501
MEN1 in, 1121
Lymphoid tissues, ectopic organogenesis, 787
Leukemias. see a/so Specific leukemias
Lymphomas
LGL, TCR-VB and T-cell clonality in, 1861
malignant, down-regulation of telomerase activity in,
SHP-1 reduction in, 1495 711
Leukocytes, cytokines and transendothelial migration of, SHP-1 reduction in, 1495
2281 Lymphoproliferative disorders, B- and T-cell multiplex
Lewy bodies, torsinA association with a-synuclein, 339 PCR in diagnosis of, 2031
Lewy body diseases, human, a-synuclein solubility Lymphotactin, expression in Crohn’s disease, 1751
(transgenic mouse), 2215 Lysosome-associated membrane proteins, in colorec-
LFA-1. see Lymphocyte function-associated antigen-1 tal neoplasms and inflammatory diseases, 449
Lipid rafts, in nephrin phosphorylation and glomerular
slit diaphragm (rat), 1069
Lipoblastomas, PLAG/7 alterations in, 955 MAC. see Mycobacterium avium complex
Liver Macrophage inflammatory protein-1a, deficiency of,
cancer and cirrhosis, p62 expression, 945 wound healing (mouse), 457
chronic injury, effects of plasminogen deficiency Macrophage inflammatory protein-2, neutralization at-
(mouse), 2179 tenuates renal ischemia/reperfusion injury, 2137
cirrhotic, ETBR expression, 1353 Macrophages
2381
AJP December 2001, Vol. 159, No. 6
activated, killing of mesangial cells inhibited by apo- Nop5/Sik expression, melanoma, 1363
ptotic cell phagocytosis, 1397 role of galectin-3, breast cancer, 1055
endoneurial, response to nerve injury (rat), 2187 Methallothionein-3, and breast cancer prognosis, 21
VEGF-C-induced recruitment, melanoma, 893 Methionine aminopeptidase-2, human mesothelioma
Major histocompatibility complex class | molecules, cell survival and, 721
CTL transection of neurites induced by, 809 Microsatellite instability
Major histocompatibility complex class Il molecules, high-level, familial and sporadic colorectal carcino-
skeletal muscle fibers, inflammatory myopathies, 1263 mas, 2107
Major histocompatibility complex molecules, in vivo molecular defects in LCMDCs, 2239
expression in neurons and oligodendrocytes, viral in- prognostic value in colon cancer, 297
fection, 1219 Miller, Gary J., In memoriam, 775
Malaria MIP-1a@. see Macrophage inflammatory protein-1a
cerebral, role of ischemia (mouse), 1105 Mitochondria
severe, CD40-CD40L in (mouse), 733 AIF and cyt c release by, SMC apoptosis, 305
Malignant peripheral nerve sheath tumors, \/F7 dele- alterations in Zellweger syndrome model, PEX5 knock-
tions in PN and, 57 out model (mouse), 1477
Mammary gland, epithelial cell-cycle progression, a.B, MMP-2. see Matrix metalloproteinase-2
integrin and, 983
Molecular biology, new approaches, NIH Pathology B
Mantle cell lymphomas, detection of cyclin D1 overex-
Study Section meeting report, 1971
pression, RQ-PCR, 425
Monocyte chemoattractant proteins, deficiency in,
Matrix metalloproteinases
wound healing (mouse), 457
elastolysis by, elastin AICI, pretreatment and, 1981
Monocyte chemotactic protein-1, induction by reactive
extracellular proteolysis during EAE (mouse), 2227
oxygen intermediates, 1301
in invasive pulmonary adenocarcinoma with BAC and
Monocytes
AAH, 2125
receptor binding sites of RP S19 protein dimer, 2293
MMP-1, MMP-2 and MMP-3, proteolysis of AFPs, 561
thrombin in HRPE cell interaction with, 1171
MMP-2, calcific aortic stenosis and (sheep), 321
MPNST. see Malignant peripheral nerve sheath tumors
MMP-2sponge granulomas in TSP2-null model
MPO. see Myeloperoxidase
(mouse), 1255
MT-3. see Methallothionein-3
vitreo-retinal scar tissue Contraction and, 1555
Mucociliary function, effects of paramyxoviral airway
MCL. see Multiple cutaneous leiomyomatosis
infection (mouse), 2055
MCP. see Monocyte chemoattractant proteins
Multiple cutaneous leiomyomatosis, familial, RCC and,
Mechanical tension, contro! of myoblast differentiation
825
and granulation tissue contraction (rat), 1009
Multiple endocrine neoplasia type 1, multiple leiomyo-
Melanomas
mas in esophagus, lung and uterus, 1121
CEACAM1 cis interaction with integrin B3, 537
Multiple sclerosis, CCR1* and CCR5* mononuclear
metastatic cells, nop5/Sik expression, 1363
phagocytes in CNS, 1701
role of VEGF-C, 893
Mutations, chain-terminating, stop codon assay, human
VPG, regulation of angiogenesis in, 223
genes, 1239
Membrane proteins, trafficking in Purkinje cells, SCA7
Mycobacterium avium complex, disseminated, induc-
transgenic model (mouse), 905
MEN1. see Multiple endocrine neoplasia type 1 tion in SIV (rhesus macaques), 693
Meningiomas, anaplastic and atypical Myeloperoxidase
CDKN2A, p14*"", CDKN2B and CDKN2C gene alter- histiocyte expression of, Kikuchi’s and Kikuchi-like
ations, 661 lymphadenopathy, 915
Fas expression and apoptosis, 1193 oxidation products and, in human liver Kupffer cells,
Mesothelial cells, effect of peritonitis-released HGF/SF, 2081
1275 Myoblasts, differentiation of, contro! by mechanical ten-
Mesotheliomas, human cells, MetAP2 and survival of, sion (rat), 1009
721 Myocarditis, autoimmune, Th1/Th2 paradigm, cardiac
MetAP2. see Methionine aminopeptidase-2 myosin (human and mouse), 5
Metastasis Myofibroblasts
B1-integrin regulation of ovarian carcinoma spheroids, key events in EMT, renal interstitial fibrosis and, 1465
2071 TGF-B1 response and Smad3 signaling, skin fibrosis
lung, angiostatin expressing ADv inhibits breast can- (pig), 263
cer growth model (mouse), 1137 Myopathies
2382
1/P Decembe20r0 1, Vol. 159, No. 6
inflammatory, MHC class || antigen expression, skele- Neutrophils
tal muscle fibers, 1263 alveolar, GM-CSF and G-CSF prolong survival, BAC
progressive, altered type XIIl collagen domains pulmonary adenocarcinoma, 1423
(mouse model), 1581 CXC chemokine redundancy and recruitment during
Myopodin, deletions in invasive prostate cancers, 1603 inflammation (mouse), 1149
Myosin human, OSM-mediated recruitment, 1531
cardiac, Th1/Th2 paradigm in autoimmune myocarditis ischemia/reperfusion injury, neutralization of Groa and
(human and mouse), 5 MIP-2 and, 2137
XVA, in neuroendocrine tissues and tumors, 1375 method for isolation from blood, negative immunomag-
netic separation (mouse), 473
recruitment, PGF. released hypoxia-activated ECs
Nasopharyngeal carcinomas, EBV LIVP-1 induction of and, 345
c-Met, 27 transmigration in IBD, epithelial intercellular junction
National Institutes of Health Pathology B Study Sec- proteins and, 2001
tion, meeting report, 1971 NF1 gene, deletions in MPNST and PN, 57
Natural killer receptors, psoriatic skin, 71 Nils. see Neuronal intranuclear inclusions
Natural killer/T-cell lymphomas, nasa!, p53 mutations Nitric oxide
in, 2095 apoptosis induced by, galectin-3 and, breast cancer,
Necrosis, NO-dependent, B-cell apoptosis in response 1055
to dsRNA and IFN-y, 273 VEGF-mediated angiogenesis modulated by VEGFR-1
Neovascularization, inhibition of, stromal keratitis con- via, 993
trolled by, 1021 3-Nitropropionic acid, cardiac and neurotoxicity, strain
Nephrin differences in susceptibility (mouse), 1507
CD2AP binding to (mouse), 2303 NMZL. see Nodal marginal zone B-cell lymphomas
lipid rafts and phosphorylation, glomerular slit dia- Nodal marginal zone B-cell lymphomas, VH genes in,
phragm and (rat), 1069 253
Nephritis, X-linked inner ear, and X-linked Alport syn- Nop5/Sik, expression, melanoma metastatic cells, 1363
drome (dog), 1097 3-NPA, see 3—-Nitropropionic acid
Nephrons, reduction of, peritubular microcirculation Nuclear bodies, N!! interactions with, CAG repeat dis-
changes after (mouse), 547 eases (mouse and human), 1785
Nephrotoxicity, cisplatin, resistance in GGT-deficiency Nuclear factor-«B, role in regulation of cell growth, 387
(mouse), 1889 Nucleolus, Nop5/Sik expression, melanoma metastatic
Nerve sheath tumors, malignant peripheral, VF7 dele- cells, 1363
tions in, 57
Nervous system tumors, classification, NIH Pathology B
Study Section meeting report, 1971 ODC. see Ornithine decarboxylase
Neurites, MHC class |-induced, CTL transection of, 809 Oligodendrocytes, in vivo expression of MHC molecules,
Neuroblastomas viral infection, 1219
infrequent, GM2/GD2 synthetase mRNA and detection Oligodendrogliomas, anaplastic, PTEN target of 10q
of cells in BM, 493 LOH in, prognosis and, 359
outcomes and plakoglobin expression, 43 Oncogenesis
regulation of telomerase activity, 1925 AKT1/PKBa kinase and (NIH3T3 cells), 431
Neuroendocrine cells, myosin XVA in, 1375 PLAG?1 alterations in lipoblastomas, 955
Neuronal intranuclear inclusions, interactions with Oncostatin M, neutrophil recruitment, 1531
coiled bodies, CAG repeat diseases (mouse and hu- Organoid cultures, hepatocytes in, 1877
man), 1785 Ornithine decarboxylase, role in photocarcinogenesis,
Neurons 885
cystatin C in, AD, 1061 OSM. see Oncostatin M
injury to, response of endoneurial macrophages to Osteoarthritis, early and late differentiation markers in
(rat), 2187 human chondrocytes, 1777
toxicity of 3-NPA, cardiotoxicity and, strain differences Ovarian cancer
in susceptibility (mouse), 1507 Caveolin-1 down-regulation in, 1635
in vivo expression of MHC molecules, viral infection, primary adenocarcinomas, gene expression profiles,
1219 1231
Neurotrophins, expression, cortical tubers of tuberous serous, allelic loss at 18q, 35
sclerosis complex, 1541 SPARC induction of apoptosis, 609