Table Of Content

SUPPLEMENT CONTENTS The | American Journal of Medicine. PROCEEDINGS OF A SYMPOSIUM HYPERTENSION, LIPIDS, AND CARDIOVASCULAR DISEASE: IS INSULIN THE MISSING LINK? VOLUME 90 (2A) FEBRUARY 21, 1991 2A-1S Introduction James A. Schoenberger HYPERTENSION AS A RISK FACTOR Section Editor: Norman M. Kaplan 2A-2S Management of Hypertension and Cardiovascular Risk Norman K. Hollenberg 2A-78 Insulin Resistance, Hyperinsulinemia, and Hypertriglyceridemia in the Etiology and Clinical Course of Hypertension Gerald M. Reaven 2A-13S Hypertension, Endothelium, and Cardiovascular Risk Factors Leopoldo Raij 2A-19S Cardiovascular Risk Reduction: The Role of Antihypertensive Treatment Norman M. Kaplan 2A-21S Workshop I—Fifth Joint National Committee Report: How Should It Differ from the 1988 Report? Jerome G. Porush, Myron Weinberger 786 June 1991 The American Journal of Medicine Volume 90 SUPPLEMENT CONTENTS The | American Journal of Medicine. PROCEEDINGS OF A SYMPOSIUM HYPERTENSION, LIPIDS, AND CARDIOVASCULAR DISEASE: IS INSULIN THE MISSING LINK? VOLUME 90 (2A) FEBRUARY 21, 1991 2A-1S Introduction James A. Schoenberger HYPERTENSION AS A RISK FACTOR Section Editor: Norman M. Kaplan 2A-2S Management of Hypertension and Cardiovascular Risk Norman K. Hollenberg 2A-78 Insulin Resistance, Hyperinsulinemia, and Hypertriglyceridemia in the Etiology and Clinical Course of Hypertension Gerald M. Reaven 2A-13S Hypertension, Endothelium, and Cardiovascular Risk Factors Leopoldo Raij 2A-19S Cardiovascular Risk Reduction: The Role of Antihypertensive Treatment Norman M. Kaplan 2A-21S Workshop I—Fifth Joint National Committee Report: How Should It Differ from the 1988 Report? Jerome G. Porush, Myron Weinberger 786 June 1991 The American Journal of Medicine Volume 90 SUPPLEMENT CONTENTS 2A-248S Workshop IIl—Hypertension Trials and Meta-Analyses: Is There Any Value for Further Studies? Richard H. Grimm, Jr., Henry Black 2A-26S Workshop IlI—Insulin Resistance: Is It Truly the Link? Joseph L. Izzo, Jr., Arthur L. M. Swislocki LIPIDS AS A RISK FACTOR Section Editor: Antonio M. Gotto 2A-32S The National Cholesterol Education Program: Guidelines, Status, and Issues DeWitt S. Goodman 2A-36S The Tangled Web of Coronary Risk Factors Ronald M. Krauss 2A-42S Regression of Atherosclerosis: What Does It Mean? David H. Blankenhorn 2A-48S Workshop IV—National Cholesterol Education Program Guidelines: Are They Clinically Relevant? Donald Hunninghake 2A-50S Workshop V—What Is a Risk Factor and What Is Not— Theoretical and Practical Implications Thomas A. Pearson 2A-53S Workshop VI—Regression of Atherosclerosis: What Does It Mean? B. Greg Brown INSULIN AS A RISK FACTOR Section Editor: Ralph A. DeFronzo 2A-56S Evolving Natural History of Coronary Artery Disease in Diabetes Mellitus Andrzej S. Krolewski, James H. Warram, Paola Valsania, Blaise C. Martin, Lori M. B. Laffel, A. Richard Christlieb 2A-62S Insulin as a Mitogenic Factor: Role in the Pathogenesis of Cardiovascular Disease Robert W. Stout 2A-66S Diabetic Retinopathy: Can We Modify Its Course? Lawrence |. Rand June 1991 The American Journal of Medicine Volume 90 787 SUPPLEMENT CONTENTS 2A-70S Diabetic Nephropathy: Can the Natural History Be Modified? Robert G. Narins 2A-76S Workshop VII—Patient Population and Genetics: Role in Diabetes Peter H. Bennett, Michael P. Stern 2A-80S Workshop VIII—Retinopathy, Nephropathy, Neuropathy, and Tight Control Harold E. Lebovitz, Aaron |. Vinik 2A-85S Workshop IX—Lipids, Insulin, Diabetes Donald C. Simonson, Victor J. Dzau 2A-87S Concluding Remarks James A. Schoenberger PROCEEDINGS OF A SYMPOSIUM THE EUROPEAN WORKING PARTY ON HIGH BLOOD PRESSURE IN THE ELDERLY VOLUME 90 (3A) MARCH 25, 1991 3A-1S INTRODUCTION The European Working Party on High Blood Pressure in the Elderly* Antoon Amery, M.D., André De Schaepdryver, M.D. ("See Appendix, page 3A-3S) 3A-5S Trends in Systolic Blood Pressure, 24-Hour Sodium Excretion, and Stroke Mortality in the Elderly in Belgium Jozef V. Joossens, M.D., Hugo Kesteloot, M.D., Ph.D. 3A-12S Treatment of Hypertension in the Elderly: Effects on Blood Pressure, Heart Rate, and Physical Fitness Gastone Leonetti, M.D., Carlo Mazzola, M.D., Carlo Pasotti, M.D., Laura Angioni, M.D., Alvaro Vaccarella, M.D., Alberto Capra, M.D., Gianfranco Botta, M.D., Alberto Zanchetti, M.D. 3A-14S Hypertension and the Risk of Dementia in the Elderly Francoise Forette, M.D., Francois Boller, M.D., Ph.D. 3A-20S Veterans Administration Cooperative Study Group on Hypertensive Agents: Effects of Age on Treatment Results Edward D. Freis, M.D., for the Veterans Administration Cooperative Study Group on Antihypertensive Agents 788 June 1991 The American Journal of Medicine Volume 90 SUPPLEMENT CONTENTS 3A-24S Age-Related Hypotensive Effects of Placebo and Active Treatment in Patients Older Than 60 Years Lutgarde Thijs, B.Sc., for the European Working Party on High Blood Pressure in the Elderly* (‘See Appendix, page 3A-3S) 3A-278 Choice of Drug Treatment for Elderly Hypertensive Patients Kevin O'Malley, M.D., John P. Cox, M.B., Eoin O’Brien, M.D. 3A-34S Body Mass Index and Prognosis in Elderly Hypertensive Patients: A Report from the European Working Party on High Blood Pressure in the Elderly Jaakko Tuomilehot, M.D., for the European Working Party on High Blood Pressure in the Elderly* ("See Appendix, page 3A-3S.) 3A-42S Adverse Treatment Effects in the Trial of the European Working Party on High Blood Pressure in the Elderly Astrid E. Fletcher, Ph.D., for the European Working Party on High Blood Pressure in the Elderly* ("See Appendix, page 3A-3S.) 3A-45S Renal Function in the Elderly: Results from the European Working Party on High Blood Pressure in the Elderly Trial Peter W. de Leeuw, M.D., for the European Working Party on High Blood Pressure in the Elderly* (“See Appendix, page 3A-3S.) 3A-50S The Determinants and Prognostic Significance of Serum Uric Acid in Elderly Patients of the European Working Party on High Blood Pressure in the Elderly Trial Jan Staessen, M.D., Ph.D., for the European Wurking Party on High Blood Pressure in the Elderly* ("See Appendix, page 3A-3S.) 3A-55S Left Ventricular Hypertrophy in Elderly Hypertensive Patients: A Report from the European Working Party on High Blood Pressure in the Elderly Trial Roger Van Hoof, M.D., for the European Working Party on High Blood Pressure in the Elderly* (“See Appendix, page 3A-3S.) 3A-60S Mortality and Treated Blood Pressure in Patients of the European Working Party on High Blood Pressure in the Elderly Jan Staessen, M.D., Ph.D., for the European Working Party on High Blood Pressure in the Elderly* ("See Appendix, page 3A-3S.) 3A-62S Serum Cholesterol Levels and Survival in Elderly Hypertensive Patients: Analysis of Data from the European Working Party on High Blood Pressure in the Elderly Robert Fagard, M.D., for the European Working Party on High Blood Pressure in the Elderly’ ("See Appendix, page 3A-3S.) 3A-648 Isolated Systolic Hypertension in the Elderly: An Epidemiologic Review Antoon Amery, M.D., Robert Fagard, M.D., C. Guo, M.D., Jan Staessen, M.D., Ph.D., Lutgarde Thijs, B.Sc. June 1991 The American Journal of Medicine Volume90 789 SUPPLEMENT CONTENTS ADDENDA The European Working Party on High Blood Pressure in the Elderly (EWPHE): An International Trial of Antihypertensive Therapy in Elderly Patients. Objectives, Protocol and Organization (Reprinted with permission from Arch Int Pharmacodyn Ther 1985; 275: 300-334) Mortality and Morbidity Results from the European Working Party on High Blood Pressure in the Elderly Trial Antoon Amery, M.D., Willem H. Birkenhager, M.D., Peter Brixko, M.D., et a/. (Reprinted with permission from Lancet 1985; 1: 1349-1354) Efficacy of Antihypertensive Drug Treatment According to Age, Sex, Blood Pressure, and Previous Cardiovascular Disease in Patients Over the Age of 60 Antoon Amery, M.D., Willem H. Birkenhager, M.D., Peter Brixko, M.D., et a/. (Reprinted with permission from Lancet 1986; 2: 589-592) PROCEEDINGS OF A SYMPOSIUM THE CHALI.ENGE OF COMBINATION ANTIRETROVIRAL THERAPY VOLUME 90 (4A) APRIL 10, 1991 4A-1S8 The Challenge of Combination Antiretroviral Therapy for AIDS: An Introduction Jerome E. Groopman 4A-28 Antiretroviral Therapy in Combination with Interferon for AIDS-Related Kaposi’s Sarcoma Margaret A. Fischl 4A-8S Treatment of AIDS with Combinations of Antiretroviral Agents Thomas C. Merigan 4A-18S Antiretroviral Therapy and Immunomodulators in Patients with AIDS Jerome E. Groopman 4A-22S Relative Resistance of Primary HIV-1 Isolates to Neutralization by Soluble CD4 Eric S. Daar, David D. Ho 4A-27S Treatment of AIDS with Combinations of Antiretroviral Agents: A Summary Jerome E. Groopman 790 June 1991 The American Journal of Medicine Volume 90 SUPPLEMENT CONTENTS PROCEEDINGS OF A SYMPOSIUM HYPERTENSION IN AN AGING POPULATION: PROBLEMS AND OPPORTUNITIES VOLUME 90 (4B) APRIL 25, 1991 4B-1S Hypertension in an Aging Population: Problems and Opportunities Norman K. Hollenberg 4B-3S Epidemiology and Evaluation: Steps Toward Hypertension Treatment in the 1990s James A. Schoenberger 4B-8S ; Vascular Injury: Mechanisms and Manifestations Winifred G. Nayler 4B-14S Epidemiology, Pathophysiology, and Management of Isolated Systolic Hypertension in the Elderly William H. Frishman 4B-21S The Aging Hypertensive Kidney: Pathophysiology and Therapeutic Options John H. Bauer, Garry P. Reams, Zhen Wu 4B-28S Practical Considerations in Treating the Elderly Hypertensive Patient James F. Burris PROCEEDINGS OF A SYMPOSIUM CALCIUM ANTAGONISTS: CURRENT USE AND FUTURE IMPLICATIONS VOLUME 90 (5A) MAY 17, 1991 5A-1S Introduction Franz H. Messerli 5A-3S Impact of Age, Race, and Obesity on Hypertensive Mechanisms and Therapy Matthew R. Weir June 1991 The American Journal of Medicine Yolume 30 791 SUPPLEMENT CONTENTS 5A-15S The Relationship of Sodium Balance and Concomitant Diuretic Therapy to Blood Pressure Response with Calcium Channel Entry Blockers Myron H. Weinberger 5A-21S Role of Caicium Channel Blockers in Protection Against Experimental Renal Injury Robert W. Schrier 5A-27S Left Ventricular Hypertrophy: Impact of Calcium Channel Blocker Therapy Franz H. Messerli 5A-32S Therapeutic Benefits of Calcium Channel Blockers in Cyclosporine-Treated Organ Transplant Recipients: Blood Pressure Control and Immunosuppression Matthew R. Weir 5A-37S Improvement of Cadaver Renal Transplantation Outcomes with Verapamil: A Review Ingemar Dawidson, Pal Rooth 5A-42S Nonsteroidal Anti-Inflammatory Drugs and Antihypertensives Mark C. Houston 5A-48S Verapamil and Migraine Prophylaxis: Mechanisms and Efficacy Herbert G. Markley 792 June 1991 The American Journal of Medicine Volume 90 de rn Ra mente paoyeets Py