HOW A POTENTIAL CURE FOR ALS WAS FOUND IN JUST 2 WEEKS USING FREE & PUBLICLY AVAILABLE INFORMATION ON THE INTERNET AND THE “TOP-DOWN” RESEARCH TECHNIQUE Jeff T. Bowles Warning: This book is not yet really a book, and it is not yet finished. But my father, a Stanford-educated MD, urged me to get the word out as soon as possible about my discovery of a hormonal treatment that should CURE ALS--or at least stop further progression. He liked the theory so much and believed it was so compelling that anyone with ALS should learn how two harmless hormones-- melatonin and progesterone, taken in high doses--should CURE or at least HALT ALS! In this book, I reveal the big clues and the logic that led to this new theory, as well as a protocol that has been helping an ALS sufferer to stop its progression. I am quite sure it will work. I believe it would be unethical to sit on this potentially life-saving information while continuing to research and edit this book. YOU WILL WANT TO BUY THIS BOOK-IN-PROGRESS IF YOU OR A LOVED ONE HAS ALS . IF YOU JUST HAVE A GENERAL INTEREST IN THE TOPIC, PLEASE WAIT FOR ANOTHER MONTH OR TWO FOR THE FINISHED PRODUCT. If you do jump the gun and buy this unfinished book, I include my email address at the end, and if you contact me I will send you a finished version of the book for free when it is done. Date of this draft- September 15, 2015. Introduction I recently published a little e-Book on Amazon.com with a long crazy title. ”The Miraculous Results of extremely high doses of the sunshine hormone vitamin D3.” In it I detailed my year-long experiment taking “dangerously” high doses of Vitamin D3 and how it dramatically improved my health and well-being. In the D3 book I discussed the miracle of the medical database called Pub Med. This is a database that contains abstracts (abstracts are basically just short summaries) of all the medical and science experiments that have been published since 1967. It is kind of like the Google of studies of diseases and experiments which are generally correct and devoid of most of the flotsam and jetsam you get from the unfiltered internet. I also bragged in that book, that almost anyone could find the cure for almost any disease with at most 30 days of research using Pub Med, even without knowing much about science! An outrageous claim! But I believe it to be true. After the publication of my Vitamin D3 book I was surprised that it became kind of a minor best seller in the e-book world. I had included my email address in the book so readers could tell me things that happened to them with their own experiments with extremely high dose Vitamin D3 therapy. I was a bit surprised by some of the responses. Some said super-high doses cured their asthma, psoriasis, chronic wounds, and all sorts of things. You can get a feel for the curative powers of Vitamin D3 by reading the book reviews of the book at Amazon at the link: http://www.amazon.com/dp/B005FCKN2S One of the readers contacted me and told me she had recently been diagnosed with ALS (Amyotrophic Lateral Sclerosis), also known as Lou Gehrig’s disease. She was hoping that high dose D3 might be useful in treating her fatal condition. She told me her doctors told her she had only about 2 to 4 years left to live! I told her I would look into it. After an initial peak into the data, what I found was very depressing. About 90% of ALS victims are dead and gone in 2 to 4 years. They gradually lose control of their nerves and suffer from involuntary movements all the time, and eventually the nerves in their breathing muscles get affected and they often die of suffocation. Before this happens, doctors often extend their lives a short time by giving them a tracheotomy--which is cutting a hole in their throat so they don’t have to try and breathe through their mouths. Not a nice way to go! There is only one drug approved by the FDA to treat ALS, called Riluzole (Rilutek). It only extends their lives about 5 months, and costs $1,400 a month! What a racket! Based on the prior boast in my book that a cure for any disease, if it exists, could be found in 30 days or less of research on Pub Med. I told her, “Don’t worry, I’ll find you a cure.” I think she believed me! And I think I believed me! So just like that, I decided to start reading all 11,200 abstracts in Pub Med that included a reference to ALS. To me it just seemed like a big jigsaw puzzle, which my mother had me work on a lot as a child. Nothing more than a 500 piece puzzle as a kid--but after years of working them as a child, I eventually came up with a simple strategy for puzzles, and I developed quite a bit of enjoyment from seeing the puzzle slowly come together. It was especially rewarding at the end, when everything was becoming clear and the pieces were getting easier and easier to put in their proper places. That was the best part. Putting in the last puzzle piece was anticlimactic. The best part was when you were still a bit confused--then all of a sudden, you saw how everything was supposed to fit together. The Eureka moment! In retrospect, that’s when I could have quit the puzzle unfinished, since my brain knew how it could be completed. I didn’t have to go through the extra motions. Completion of the puzzle was not the reward--just figuring out how it should be completed was the reward. But I always finished them just to prove the case that I had figured it out. What follows is the step-by-step process that I used to develop a protocol that I believe will stop ALS in its tracks (and can, I believe, be used for any disease). Chapter 1—December 18th, 2012 It was December 18th 2012 when I was first contacted by Denise with this email: Hi Jeff! I am reading your book about D3, love it! I am more hopeful now, thank you! I was diagnosed with ALS recently, such a shock because my health is good, weight is low, have exercised since 4 years old when put in a ballet class. Cholesterol is low, blood pressure is low, have not had any sweets/sugar for years, my skin at 63 is line free, my friends all ask if I found the fountain of youth. Not quite-first Neurologist said I will die in 2 to 4 years. So what is the problem? One is that I never go out in the sun, had limited sun exposure for 20 years. I am on a mission to fight the ALS progression and started seeing an acupuncturist twice a week, and met with a NaturoPath Practitioner in October and she has me on Adrenal drops, supplements-C, E, B and Enzymes. Only last week she started me on D3-3 drops of 2000 IU so 6000 IUs a day. Could be because I asked her about Vitamin D supplements recently, and she said "you don't need that you get it from the sun--"! Glad she changed her mind. Do you have any other suggestions for me about getting on the healing path? Thank you! Denise I started working on the problem at this point, using the Pub Med database, not working all that hard, and I took a few days off. On the morning of January 8th I believe I had solved the problem of finding an extremely promising cure for ALS. A total of 21 days! But only 14, if you take out my few days off. So I guess it might be true. Anyone can probably find a cure for any disease using the Pub Med database with the “top-down” approach, which is basically using jigsaw puzzle solving logic to complete the puzzle. (Of course I am assuming that the “cure” I have found will work, but I am pretty confident, and have been successful at these things before.) The process of completing a Pub Med disease puzzle is simple and it depends on a few simple assumptions. The first assumption is that all the studies needed to find a cure for a disease have been done and are sitting there in the Pub Med database. The second assumption is that research scientists are basically like semi-autistic children who are hyper-focused on their little specialties, and are churning out excellent puzzle pieces, doing a lot of repetitive work, and are experts in their small fields specific to their puzzle pieces. But they don’t often try to look at the bigger picture. The third assumption is that even without any specific knowledge in the field, anyone of above- average IQ can start looking at all these puzzle pieces and try to put them together by looking for patterns and using common sense in creating questions produced from working with the puzzle pieces. The questions created keep you on the lookout for even more telling puzzle pieces. Acting upon these assumptions, I have come up with what I call the top-down research technique. It is the opposite of the way most scientists work. Most scientists spend years and years on the basics, learning more and more about more and more specific things. Eventually they find themselves complete experts on very narrow fields of science. The bottom-up approach I call it. The top-down approach is the exact opposite. In the past I had spent years and years studying all sorts of things related to a problem that I did not fully understand at a deep level (aging)--but instead I tried to organize a huge number of small facts to see how they related to each other. I studied the top of accumulated knowledge--not the bottom. And I worked my way down, not up. From this I developed a unified theory of aging and published my first paper on it in 1998. What does this mean? It means I was always looking for puzzle pieces to fill in the picture, and when I came across a puzzle piece that seemed like it was important but I had no idea what it meant--I then went down--and did some research to try to understand the basics of the puzzle piece. For example, with respect to ALS, I kept seeing IG popping up in ALS studies. I had only a vague idea of what it meant--so I got on google and googled “IG” and found this: Immunoglobulin superfamily The immunoglobulin superfamily (IgSF) is a large group of cell surface and soluble proteins that are involved in the recognition, binding, or adhesion processes of cells. Molecules are categorized as members of this superfamily based on shared structural features with immunoglobulins (also known as antibodies); they all possess a domain known as an immunoglobulin domain or fold. Members of the IgSF include cell surface antigen receptors, co- receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins. They are commonly associated with roles in the immune system. The sperm-specific protein Izumo, a member of the immunoglobulin superfamily, has also been identified as the only sperm membrane protein essential for sperm-egg fusion. Immunoglobulin domains Proteins of the IgSF possess a structural domain known as an immunoglobulin (Ig) domain. Ig domains re named after the immunoglobulin molecules. They contain about 70-110 amino acids and are categorised according to their size and function.[2] Ig-domains possess a characteristic Ig-fold, which has a sandwich- like structure formed by two sheets of antiparallel beta strands. Interactions between hydrophobic amino acids on the inner side of the sandwich and highly conserved disulfide bonds formed between cysteine residues in the B and F strands, stabilize the Ig-fold. One end of the Ig domain has a section called the complementarity determining region that is important for the specificity of