The Aga Khan University 8th Health Sciences Research Assembly 2013

380 Pages·2013·3.08 MB·English

The Aga Khan University 8th Health Sciences Research Assembly 2013

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The Aga Khan University 8th Health Sciences Research Assembly 2013

8th Health Sciences Research Assembly
December 11 & 12, 2013

INAUGURAL SESSION
Wednesday, December 11, 2013 | 8:30 – 9:30

• Tilawat

• Introduction
Dr Hammad Ather, Chair Organising, Committee, 8th HSRA

• Remarks by
Dr Keith Cash, Dean, School of Nursing & Midwifery

• Remarks by
Dr Farhat Abbas, Dean, Medical College

• Remarks by
Dr El-Nasir Lalani, Dean of Research & Graduate Studies

• Vote of thanks
Shela Hirani, Co-Chair, 8th HSRA

• Inauguration of Scientific Exhibition (Posters)
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The Aga Khan University 8th Health Sciences Research Assembly 2013

Message from

Chair/Co-Chair, Organising Committee

Health Sciences Research Assembly is an essential milestone of Aga Khan University. It is an
avenue where faculty, fellows, residents, nurses, students, and alumni of Aga Khan University
unite at one platform. The gathering helps to disseminate research and share research ideas with
the interdisciplinary and multidisciplinary group of health care professionals.

HSRA not only plays a pivotal to promote research culture within the university but also
encourage the novice researchers to flourish their research career, come up with innovative
researches, and recognize the power of collaborative researches.

We are hopeful that in coming year we all will recognize the impact of such events beyond the
boundaries of AKU. Considering the impact of past years’ HSRAs, one can say it with
conviction that this platform will strengthen the research capacities of many novice researchers
to an extent that in coming years they can better serve this society and bring positive changes in
the health indicators worldwide.

We congratulate each one of you for your attendance and active participation in this year’s
research assembly.

Best wishes,

Dr Hammad Ather Shela Hirani
Chair, Organising Committee Co-Chair, Organising Committee
8th HSRA 8th HSRA

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The Aga Khan University 8th Health Sciences Research Assembly 2013

Message from

Dean, School of Nursing and Midwifery

These days knowledge is not confined to the narrow boundaries of individual disciplines. On the
contrary, for a university to be active in the creation of new knowledge and the application of
existing knowledge, we need cross-fertilization between disciplines. A good example is the
collaboration of a physicist and a biologist, using the findings of a crystallographer and
competing with a chemist, that lead to the modeling of DNA by Crick and Watson. This way of
working is not easy and needs structures that can support it, as well as the will to work in this
way.

One way of encouraging and supporting it comes from meetings like the 8th Health Sciences
Research Assembly, which lets faculty and students share their work and ideas in a collegial
environment where connections can be made and new ideas emerge. Collaboration needs the
opportunity to meet and talk.

The organizers of this celebration of the exciting research culture in AKU are to be congratulated
on their work and their initiative in creating this event.

Dr Keith Cash
Dean and Professor
School of Nursing and Midwifery
Aga Khan University

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The Aga Khan University 8th Health Sciences Research Assembly 2013

Message from

Dean, Medical College

As scholarship and discovery continue to take on increasing importance for all leading academic
institutions the world over, the Aga Khan University-in its pursuit of making AKU a truly
research-led institution of the 21st century-continues to foster and underpin its research culture
while forging new multi- and interdisciplinary collaborations.

AKU’s first Health Sciences Research Assembly was held in 2005 and was amongst the first
steps towards making research the cornerstone of AKU’s existence. Over the last eight years the
Health Sciences Research Assembly has become an integral component of AKU’s academic and
scholarly activities with abstract submission and participation surpassing expectations year after
year.

To continue this exchange and dissemination of learning, ideas and work, both completed and in
progress, to provide greater opportunities for collegial efforts across disciplines and specialties,
we announce the 8th Health Sciences Research Assembly, as a two-day event on December 11
and 12, 2013. I encourage all faculty, fellows, residents and students to actively participate in the
event, in an effort to make meaningful contributions to the contemporary knowledge-based
society and for making a sustainable impact on the intellectual landscape.
I take this opportunity to convey my appreciation to Dr. Hammad Ather and the Organizing
Committee of the 8th Health Sciences Research Assembly. I wish you all the best and hope the
event meets unprecedented success.

Dr Farhat Abbas
Dean, Medical College
Aga Khan University

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The Aga Khan University 8th Health Sciences Research Assembly 2013

Message from

Dean of Research and Graduate Studies

The Aga Khan University is committed to innovative trans/multi-disciplinary undergraduate and
postgraduate education, and research. The University aims to achieve this by offering students a
rich educational experience, an experience connecting individual curiosity, intellectual rigor and
trans-disciplinary breath. Research is an integral and essential part of this experience.

The thematic research focus of the Faculty of Health Sciences is “Social and Economic
Determinants of Health” with six sub-themes: a. Maternal, Newborn & Child Health;
b. Non-Communicable Diseases; c. Infection, Immunity and Inflammation; d. Human
Development; e. Neurosciences and f. Stem Cell Research.

These sub-themes are underpinned by the drive and intellectual inquisitiveness of individuals
who traverse departments, faculties and other AKU campuses. Their collective aim is to bring
forth new knowledge and solutions addressing local challenges and to inform regarding policy
and practices. AKU’s close collaborations with extraordinary external collaborators and
university partners offer an added wealth of research options. The University’s efforts are
supported through donations, gifts, extra and intramural competitive grants and international aid
agencies.

The concept of an annual research assembly was an important bold step that has become part of
the University’s calendar. The 8th Health Sciences Research Assembly provides a unique forum
for faculty, staff, and students at AKU to showcase their work, discuss ideas, and become
informed of the diverse activities and opportunities. AKU’s research is not only about new
knowledge or the application of it; but also about developing a steady stream of highly skilled
individuals.

It is a very tall order to organise an event on such a mammoth scale. The organisers have worked
tirelessly over many months to put together this year’s assembly. I take this opportunity to
recognise and thank them for their effort, creativity and passion. Congratulations.

Dr El-Nasir Lalani
Dean, Research & Graduate Studies and
Professor, Molecular and Cellular Pathology
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The Aga Khan University 8th Health Sciences Research Assembly 2013

TABLE OF CONTENTS

ID Theme Page
1.0 Bone and Joint Diseases/Orthopaedics 1
2.0 Cardiovascular Diseases 7
3.0 Clinical Trials 38
4.0 Dentistry/Orthodontics/Dental Surgery 42
5.0 Endocrinology/Diabetes 52
6.0 GI/Liver 64
7.0 Health Sciences Education 91
8.0 Hematologic and Oncologic Diseases 106
9.0 Infectious Diseases 156
10.0 Neurosciences/Mental Health 196
11.0 Miscellaneous Abstracts 215
12.0 Public Health 241
13.0 Renal/Urology 301
14.0 Techniques/Innovations 307
15.0 Women and Child Health 328

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The Aga Khan University 8th Health Sciences Research Assembly 2013

ABSTRACTS

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The Aga Khan University Bone & Joint Diseases
8th Health Sciences Research Assembly 2013 / Orthopaedics

Bone and Joint Diseases
/ Orthopaedics
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The Aga Khan University Bone & Joint Diseases
8th Health Sciences Research Assembly 2013 / Orthopaedics

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JUDET’S QUADRICEPSPLASTY FOR KNEE A CASE OF LOWER LIMB REPLANTATION
CONTRACTURES WITH A 12 YEARS FOLLOW UP

Akbar Jaleel Zubairi, Haroon ur Rashid Akbar Jaleel Zubairi, Pervaiz Hashmi
Department of Surgery, Aga Khan University, Department of Surgery, Aga Khan University,
Karachi Karachi

Background: Knee stiffness is seen after peri- Introduction: Replantation of the lower
articular knee fractures or Ilizarov application. extremity has limited indications because
Judet’s Quadricepsplasty has been used for over crushing and avulsion of the involved parts
half a century to manage this debilitating make the procedure difficult to perform and the
condition even so Literature from our region is results of modern prostheses are better than a
limited. poorly functional replanted limb. Nevertheless
Methods: We retrospectively reviewed the replantation may be considered in carefully
results of 22 cases of knee contractures managed selected patients like children with distal
with Judet’s quadricepsplasty during the last 5 amputations who make better functional
years having a mean follow up of 15.4 months. recoveries and in whom stump revision and
Degrees of flexion of the operated knees pre- frequent change of prosthesis is cumbersome.
operatively and at last follow up were recorded Here we present a successful replantation in a 3
along with quadriceps strength, presence of year old boy who has made excellent recovery
extension lag and complications. Outcomes were with no functional deficit evident at 12 years
classified according to Judet’s criteria. follow up.
Results: Ilizarov application was the cause of Case Description: A 3 year old boy, sustained a
contracture in 13 patients (59.1%) followed by traumatic amputation of his left lower limb at
internal fixation for peri-articular fractures in 5 the level of distal tibia when he fell of a ‘Qing
patients (22.7%). The degree of flexion Qi’ (Motorcycle Rickshaw). Replantation was
increased from 29 degrees (0-90 degrees) attempted at 8 hours cold ischemia time with the
preoperatively to 85.7 degrees (20-150 degrees) tibia shortened 4 cm and all tendons, vessels and
on last follow up showing a flexion gain of 56.6 nerves repaired. Patient required a second
degrees. Quadriceps strength at follow up was procedure during the same hospital stay for skin
4.5 with extension lag present in only 2 patients coverage. Patient made good recovery with
(9.1%). Superficial wound infection was seen in ambulation without support at 6 months, less
3 patients (13.6%) and 1 patient suffered from than 2 cm limb length discrepancy, plantar and
reflex sympathetic dystrophy. The outcome dorsiflexion power 4/5 and recovery of sensation
according to Judet’s criteria on last follow up over the foot. Now at 12 years of follow up
was excellent in 7 patients (31.8%), good in 10 patient has a normal gait with 5/5 power of
(45.5%), fair in 2 (9.1 %) and poor in 3 patients plantar and dorsiflexion and has integrated in to
(13.6%). Female gender was significantly society with no functional deficit. Considering
associated with a poor outcome (p value 0.039). the functional outcome of our case, replantation
Conclusion: Judet’s quadricepsplasty is a useful should be attempted where possible and feasible
procedure to increase the range of motion of especially in children.
rigid knees. Our results are comparable to what
have been reported in international literature. Keywords: Replantation, amputation, functional
outcome
Keywords: Judet's Quadricepsplasty, knee
contracture, functional outcome

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