The Advocate Magazine Jan 2015

70 Pages·2016·12.26 MB·English

by  Various

YEAR IN REVIEW: THE EVENTS THAT MADE 2014 REMARKABLE
SINCE 1967
PERSON OF
THE YEAR
WhatisSTRIBILD? •WorseningofhepatitisB(HBV) What should I tell my healthcare
infection.IfyoualsohaveHBVandstop providerbeforetakingSTRIBILD?
STRIBILDisaprescriptionmedicine takingSTRIBILD,yourhepatitismay
usedtotreatHIV-1inadultswhohave suddenlygetworse.Donotstoptaking • All your health problems. Be sure to
nevertakenHIV-1medicinesbefore.It STRIBILDwithoutfirsttalkingtoyour tell your healthcare provider if you have
combines4medicinesinto1pilltobe healthcareprovider,astheywillneedto or had any kidney, bone, or liver problems,
takenonceadaywithfood.STRIBILD monitoryourhealth.STRIBILDisnot including hepatitis virus infection.
isacompletesingle-tabletregimen approvedforthetreatmentofHBV. • All the medicines you take, including
andshouldnotbeusedwithother
prescription and nonprescription
HIV-1medicines. WhoshouldnottakeSTRIBILD?
medicines, vitamins, and herbal
STRIBILDdoesnotcureHIV-1 supplements. STRIBILD may affect the
DonottakeSTRIBILDifyou:
infectionorAIDS.TocontrolHIV-1 way other medicines work, and other
infectionanddecreaseHIV-related •Takeamedicinethatcontains: medicines may affect how STRIBILD
illnessesyoumustkeeptakingSTRIBILD. alfuzosin,dihydroergotamine,ergotamine, works. Keep a list of all your medicines
Askyourhealthcareproviderifyouhave methylergonovine,cisapride,lovastatin, and show it to your healthcare provider
questionsabouthowtoreducetheriskof simvastatin,pimozide,sildenafilwhen and pharmacist. Do not start any new
passingHIV-1toothers.Alwayspractice usedforlungproblems(Revatio®), medicines while taking STRIBILD
safersexandusecondomstolowerthe triazolam,oralmidazolam,rifampin without first talking with your
chanceofsexualcontactwithbodyfluids. ortheherbSt.John’swort. healthcare provider.
Neverreuseorshareneedlesorother •Foralistofbrandnamesforthese • If you take hormone-based birth
itemsthathavebodyfluidsonthem. medicines,pleaseseetheBrief control (pills, patches, rings, shots, etc).
Summaryonthefollowingpages.
• If you take antacids. Take antacids at
IMPORTANT SAFETY •Takeanyothermedicinestotreat least 2 hours before or after you take
INFORMATION HIV-1infection,orthemedicine STRIBILD.
adefovir(Hepsera®).
Whatisthemostimportant • If you are pregnant or plan
informationIshouldknow Whataretheotherpossibleside to become pregnant. It is not
aboutSTRIBILD? effectsofSTRIBILD? known if STRIBILD can harm
your unborn baby. Tell your
STRIBILD can cause serious Serious side effects of STRIBILD healthcare provider if you
side effects: may also include: become pregnant while
• Build-up of an acid in your blood • New or worse kidney problems, taking STRIBILD.
(lactic acidosis), which is a serious including kidney failure. Your • If you are breastfeeding
medical emergency. Symptoms of healthcare provider should do regular (nursing) or plan to breast-
lactic acidosis include feeling very blood and urine tests to check your feed. Do not breastfeed.
weak or tired, unusual (not normal) kidneys before and during treatment HIV-1 can be passed to
muscle pain, trouble breathing, with STRIBILD. If you develop kidney the baby in breast milk.
stomach pain with nausea or vomiting, problems, your healthcare provider Also, some medicines in
feeling cold especially in your arms may tell you to stop taking STRIBILD. STRIBILD can pass into
and legs, feeling dizzy or lightheaded, breast milk, and it is not
• Bone problems, including bone pain or
and/or a fast or irregular heartbeat. known if this can harm
bones getting soft or thin, which may lead
• Serious liver problems. The liver may to fractures. Your healthcare provider may the baby.
become large (hepatomegaly) and fatty do tests to check your bones. You are encouraged
(steatosis). Symptoms of liver problems
• Changes in body fat can happen in to report negative side
include your skin or the white part of
people taking HIV-1 medicines. effects of prescription
your eyes turns yellow (jaundice), dark
drugs to the FDA. Visit
“tea-colored” urine, light-colored bowel • Changes in your immune system.
www.fda.gov/medwatch,
movements (stools), loss of appetite for Your immune system may get stronger
or call 1-800-FDA-1088.
several days or longer, nausea, and/or andbegintofightinfections.Tellyour
stomach pain. healthcareproviderifyouhaveany
newsymptomsafteryoustarttaking
• You may be more likely to get lactic PleaseseeBriefSummaryoffull
STRIBILD.
acidosis or serious liver problems if PrescribingInformationwithimportant
you are female, very overweight (obese), The mostcommonsideeffectsof warningsonthefollowingpages.
or have been taking STRIBILD for a STRIBILDincludenauseaanddiarrhea.
long time. In some cases, these serious Tell yourhealthcareproviderifyouhave
conditions have led to death. Call your any sideeffectsthatbotheryouordon’t
healthcare provider right away if you go away.
have any symptoms of these conditions.
STRIBILD is a prescription medicine used as
a complete single-tablet regimen to treat HIV-1 in
adults who have never taken HIV-1 medicines
before. STRIBILD does not cure HIV-1 or AIDS.
I started my
personal revolution
Talk to your healthcare provider
about starting treatment.
STRIBILD is a complete HIV-1
treatment in 1 pill, once a day.
Ask if it’s right for you.
PatientInformation • D o not stop taking STRIBILD without first talking to your
healthcare provider
STRIBILD®(STRY-bild)
(elvitegravir150mg/cobicistat150mg/emtricitabine200mg/ • If you stop taking STRIBILD, your healthcare provider will need to
tenofovirdisoproxilfumarate300mg)tablets check your health often and do blood tests regularly for several
months to check your HBV infection. Tell your healthcare provider
BriefsummaryoffullPrescribingInformation.Formoreinformation,
about any new or unusual symptoms you may have after you stop
pleaseseethefullPrescribingInformation,includingPatientInformation.
taking STRIBILD
WhatisSTRIBILD?
WhoshouldnottakeSTRIBILD?
•STRIBILDisaprescriptionmedicineusedtotreatHIV-1inadultswho
Do not take STRIBILD if you also take a medicine that contains:
havenevertakenHIV-1medicinesbefore.STRIBILDisacomplete
regimenandshouldnotbeusedwithotherHIV-1medicines. • adefovir (Hepsera®)
•STRIBILDdoesnotcureHIV-1orAIDS.Youmuststayon • alfuzosin hydrochloride (Uroxatral®)
continuousHIV-1therapytocontrolHIV-1infectionanddecrease
• cisapride (Propulsid®, Propulsid Quicksolv®)
HIV-relatedillnesses.
• ergot-containing medicines, including: dihydroergotamine
•Askyourhealthcareproviderabouthowtopreventpassing
mesylate (D.H.E. 45®, Migranal®), ergotamine tartrate (Cafergot®,
HIV-1toothers.Donotshareorreuseneedles,injection
Migergot®, Ergostat®, Medihaler Ergotamine®, Wigraine®,
equipment,orpersonalitemsthatcanhavebloodorbodyfluids
Wigrettes®), and methylergonovine maleate (Ergotrate®, Methergine®)
onthem.Donothavesexwithoutprotection.Alwayspracticesafer
sexbyusingalatexorpolyurethanecondomtolowerthechance • lovastatin (Advicor®, Altoprev®, Mevacor®)
ofsexualcontactwithsemen,vaginalsecretions,orblood.
• oral midazolam
WhatisthemostimportantinformationIshouldknow • pimozide (Orap®)
aboutSTRIBILD? • rifampin (Rifadin®, Rifamate®, Rifater®, Rimactane®)
• sildenafil (Revatio®), when used for treating lung problems
STRIBILD can cause serious side effects, including:
1. Build-up of lactic acid in your blood (lactic acidosis). Lactic • simvastatin (Simcor®, Vytorin®, Zocor®)
acidosis can happen in some people who take STRIBILD or similar
• triazolam (Halcion®)
(nucleoside analogs) medicines. Lactic acidosis is a serious
medical emergency that can lead to death. Lactic acidosis can • the herb St. John’s wort
be hard to identify early, because the symptoms could seem
Do not take STRIBILD if you also take any other HIV-1
like symptoms of other health problems. Call your healthcare
medicines, including:
provider right away if you get any of the following symptoms
which could be signs of lactic acidosis: • Other medicines that contain tenofovir (Atripla®, Complera®,
Viread®, Truvada®)
• feel very weak or tired
• Other medicines that contain emtricitabine, lamivudine, or ritonavir
• have unusual (not normal) muscle pain
(Atripla®, Combivir®, Complera®, Emtriva®, Epivir® or Epivir-HBV®,
• have trouble breathing Epzicom®, Kaletra®, Norvir®, Trizivir®, Truvada®)
• have stomach pain with nausea or vomiting STRIBILD is not for use in people who are less than 18 years old.
• feel cold, especially in your arms and legs
WhatarethepossiblesideeffectsofSTRIBILD?
• feel dizzy or lightheaded
• have a fast or irregular heartbeat STRIBILD may cause the following serious side effects:
2. Severe liver problems. Severe liver problems can happen in • See “What is the most important information I should know
people who take STRIBILD. In some cases, these liver problems about STRIBILD?”
can lead to death. Your liver may become large (hepatomegaly) and
• New or worse kidney problems, including kidney failure. Your
you may develop fat in your liver (steatosis). Call your healthcare
healthcare provider should do blood and urine tests to check your
provider right away if you get any of the following symptoms
kidneys before you start and while you are taking STRIBILD. Your
of liver problems:
healthcare provider may tell you to stop taking STRIBILD if you
• your skin or the white part of your eyes turns yellow (jaundice) develop new or worse kidney problems.
• dark “tea-colored” urine • Bone problems can happen in some people who take STRIBILD.
Bone problems include bone pain, softening or thinning (which may
• light-colored bowel movements (stools)
lead to fractures). Your healthcare provider may need to do tests to
• loss of appetite for several days or longer check your bones.
• nausea • Changes in body fat can happen in people who take HIV-1
• stomach pain medicine. These changes may include increased amount of fat
in the upper back and neck (“buffalo hump”), breast, and around
You may be more likely to get lactic acidosis or severe liver
the middle of your body (trunk). Loss of fat from the legs, arms
problems if you are female, very overweight (obese), or have
and face may also happen. The exact cause and long-term health
been taking STRIBILD for a long time.
effects of these conditions are not known.
3. Worsening of Hepatitis B infection. If you have hepatitis B virus
• Changes in your immune system (Immune Reconstitution
(HBV) infection and take STRIBILD, your HBV may get worse
Syndrome) can happen when you start taking HIV-1 medicines. Your
(flare-up) if you stop taking STRIBILD. A “flare-up” is when your
immune system may get stronger and begin to fight infections that
HBV infection suddenly returns in a worse way than before.
have been hidden in your body for a long time. Tell your healthcare
• Do not run out of STRIBILD. Refill your prescription or talk to provider right away if you start having any new symptoms after
your healthcare provider before your STRIBILD is all gone starting your HIV-1 medicine.
ThemostcommonsideeffectsofSTRIBILDinclude: - digoxin (Lanoxin®)
•Nausea - disopyramide (Norpace®)
•Diarrhea - estazolam
Tellyourhealthcareproviderifyouhaveanysideeffectthat - ethosuximide (Zarontin®)
bothersyouorthatdoesnotgoaway.
- flecainide (Tambocor®)
•ThesearenotallthepossiblesideeffectsofSTRIBILD.Formore
- flurazepam
information,askyourhealthcareprovider.
- fluticasone (Flovent®, Flonase®, Flovent® Diskus®,
•Callyourhealthcareproviderformedicaladviceaboutsideeffects.
Flovent® HFA, Veramyst®)
YoumayreportsideeffectstoFDAat1-800-FDA-1088.
- itraconazole (Sporanox®)
WhatshouldItellmyhealthcareproviderbeforetakingSTRIBILD? - ketoconazole (Nizoral®)
- lidocaine (Xylocaine®)
Tell your healthcare provider about all your medical conditions,
including: - mexiletine
• If you have or had any kidney, bone, or liver problems, including - oxcarbazepine (Trileptal®)
hepatitis B infection
- perphenazine
• If you are pregnant or plan to become pregnant. It is not known if
- phenobarbital (Luminal®)
STRIBILD can harm your unborn baby. Tell your healthcare provider
if you become pregnant while taking STRIBILD. - phenytoin (Dilantin®, Phenytek®)
- There is a pregnancy registry for women who take antiviral - propafenone (Rythmol®)
medicines during pregnancy. The purpose of this registry is to - quinidine (Neudexta®)
collect information about the health of you and your baby. Talk
- rifabutin (Mycobutin®)
with your healthcare provider about how you can take part in
this registry. - rifapentine (Priftin®)
• If you are breastfeeding (nursing) or plan to breastfeed. Do not - risperidone (Risperdal®, Risperdal Consta®)
breastfeed if you take STRIBILD.
- salmeterol (Serevent®) or salmeterol when taken in combination
- You should not breastfeed if you have HIV-1 because of the risk with fluticasone (Advair Diskus®, Advair HFA®)
of passing HIV-1 to your baby.
- sildenafil (Viagra®), tadalafil (Cialis®) or vardenafil (Levitra®,
- Two of the medicines in STRIBILD can pass to your baby in your Staxyn®), for the treatment of erectile dysfunction (ED). If you get
breast milk. It is not known if the other medicines in STRIBILD can dizzy or faint (low blood pressure), have vision changes or have
pass into your breast milk. an erection that last longer than 4 hours, call your healthcare
- Talk with your healthcare provider about the best way to feed provider or get medical help right away.
your baby. - tadalafil (Adcirca®), for the treatment of pulmonary arterial
Tell your healthcare provider about all the medicines you take, hypertension
including prescription and nonprescription medicines, vitamins, - telithromycin (Ketek®)
and herbal supplements:
- thioridazine
• STRIBILD may affect the way other medicines work, and other
- voriconazole (Vfend®)
medicines may affect how STRIBILD works.
- warfarin (Coumadin®, Jantoven®)
• Be sure to tell your healthcare provider if you take any of the
following medicines: - zolpidem (Ambien®, Edlular®, Intermezzo®, Zolpimist®)
- Hormone-based birth control (pills, patches, rings, shots, etc) Know the medicines you take. Keep a list of all your medicines and
show it to your healthcare provider and pharmacist when you get a
- Antacid medicines that contain aluminum, magnesium hydroxide,
new medicine. Do not start any new medicines while you are taking
or calcium carbonate. Take antacids at least 2 hours before or
STRIBILD without first talking with your healthcare provider.
after you take STRIBILD
Keep STRIBILD and all medicines out of reach of children.
- Medicines to treat depression, organ transplant rejection, or high
blood pressure This Brief Summary summarizes the most important information
- amiodarone (Cordarone®, Pacerone®) about STRIBILD. If you would like more information, talk with your
healthcare provider. You can also ask your healthcare provider or
- atorvastatin (Lipitor®, Caduet®) pharmacist for information about STRIBILD that is written for health
- bepridil hydrochloride (Vascor®, Bepadin®) professionals, or call 1-800-445-3235 or go to www.STRIBILD.com.
- bosentan (Tracleer®) Issued: October 2013
- buspirone
- carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- clarithromycin (Biaxin®, Prevpac®)
- clonazepam (Klonopin®)
- clorazepate (Gen-xene®, Tranxene®) COMPLERA, EMTRIVA, GILEAD, the GILEAD Logo, GSI, HEPSERA, STRIBILD, the STRIBILD Logo,
TRUVADA, and VIREAD are trademarks of Gilead Sciences, Inc., or its related companies. ATRIPLA
- colchicine (Colcrys®) is a trademark of Bristol-Myers Squibb & Gilead Sciences, LLC. All other marks referenced herein
are the property of their respective owners.
- medicines that contain dexamethasone
- diazepam (Valium®) © 2014 Gilead Sciences, Inc. All rights reserved. STBC0108 10/14
43 48 52
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When different people come together,
it’s not just beautiful, it’s priceless.
At MasterCard Worldwide, we find value in diversity of background, experience and thought.
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By Matthew Breen OCK
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A
year-end issue is always an exer-
cise in nostalgia. We’re reminded
of the great and terrible events of
the previous year—and it’s a much
needed reality check for those of
us in magazines who are accus-
tomed to constantly looking sev-
eral months into the future. But the
week we put this issue to bed, the
news media were consumed with developments in
marriage equality cases. The week was a study not in
nostalgia, but in truly retrograde thinking.
The Supreme Court rejected the appeals of five states
(Virginia, Utah, Indiana, Wisconsin, and Oklahoma)
to keep their unconstitutional bans on same-sex mar-
riage, raising the number of marriage equality states
from 19 to a possible 30. I’m sure we’ll all have a better
handle on the precise number in a few days, but as I
write this, some states’ attorneys general are fighting
to keep the marriage equality bans that were deemed
unconstitutional—by rulings in 40 court cases.
As progress goes, this week’s was both speedy and
spasmodic. In Nevada, marriages were set to start,
then they were stopped, and then were set to start
up again—glitches attributed to clerical errors in the
order by Associate Justice Anthony Kennedy. More
malevolently, Florida’s Gov. Rick Scott said he’d stand
by Attorney General Pam Bondi’s vow to keep fight- scenarios. Nevertheless, my money is on (d) business as
ing for the ban despite having exhausted every sin- usual, apart from a lot of really great weddings.
gle one of their legal options. Kansas governor Sam But it’s Cruz, Brownback, Haley, and the rest, and
Brownback said he won’t follow the federal appeals all the people to whom they’re pandering, that are ter-
court rulings, and couples there are being deprived of minally caught in the past. And who is leaving them in
their lawful rights. In South Carolina, Attorney Gen- the dust? Estonia.
eral Alan Wilson and Gov. Nikki Haley are refusing, This same week, the Estonian parliament passed
too. Call it denial, or call it pandering to conservative legislation, which was signed into law by its president,
voters in the run-up to a midterm election. Is one any giving legal protections to cohabiting couples regard-
better than the other? less of gender as of 2016.
Ted Cruz, U.S. senator from Texas—the human To recap: Estonia, a former Soviet country, will
embodiment of a wrench in the works—has gone recognize same-sex unions. South Carolina, Kansas,
full-tilt Michele Bachmann and said he’ll introduce a and Florida won’t. If Estonia can figure it out and look
constitutional amendment barring the federal govern- toward the future, one with dignity and equality for
ment or the courts from overturning state marriage its citizens, why can’t Kansas?
laws. No word yet on his plans for forcing gays into
opposite-sex marriages or homo re-education camps.
Predictably, religious nuts said the action by SCOTUS
would (a) bring an end to Western civilization, (b) sub-
vert the laws of nature, (c) hasten the apocalypse. Can’t
argue with any of that, as those are clearly wait-and-see Matthew Breen, editor in chief
NE
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8 THE ADVOCATE december 2014 / january 2015