The Adverse Chemical Influences of Clostridia Bacterial Toxins and Chronic Health Problems

112 Pages·2015·4.7 MB·English

The Adverse Chemical Influences of Clostridia
Bacterial Toxins and Chronic Health Problems –
Beyond Common GI Issues
Copyright© 2015, Kurt N. Woeller, D.O., Tracy Tranchitella, N.D., and
Educational Resource Association. This material may not be reprinted,
distributed or used without permission.
Support Documents For Module #5
• Clostridia Antibiotic Protocol – examples (pdf)
• Clostridia Natural Remedy Protocol – examples (pdf)
• Clostridia Treatment Program – patient handout
• General Considerations for Organic Acids Testing for
Clostridia Related Problems (pdf).
• Overview of Common Probiotics (pdf)
• Taking Probiotic Suggestions (pdf)
• Fecal Transplant Donor Test Recommendations (pdf)
• Lecture slides (pdf) + Lecture slides - note taking (pdf)
Lecture Overview
• Clostridia bacteria and various health problems, including
the pathogenicity of C. difficile.
• Clostridia bacteria toxins and how they negatively effect
the brain and nervous system.
• HPHPA & 4-cresol (and potentially others) as the main
culprits for dopamine converting enzyme inhibition.
• The toxic problems of excess dopamine
• A deeper understanding of probiotics – specific to
clostridia bacteria (helpful against candida too).
• Various treatment options:
• Antibiotic and botanical remedies
• Fecal Microbiota Transplant (FMT) information
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Clinical Usefulness of Clostridia Treatments
• Schizophrenia
• Autoimmune, i.e. RA
• Psychosis
• Obsessive compulsive
• Depression disorder.
• Chronic fatigue • Seizure disorders
• Tics, Tourette’s • Gastrointestinal
disorders, diarrhea,
• Autism, ADD/ADHD
constipation.
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Nutritional Neuroscience 2010 Vol 13 No 3: 1-10
Great Plains Laboratory – ‘Resource’ section, Articles
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Effect of anti-Clostridia therapy
on urine excretion of HPHPA* in
young woman with acute
psychosis-auditory
hallucinations

patient normals
During acute 7489 0-150
psychosis

After treatment 673 0-150
( depressed but no
psychosis)

*mmol/mol creatinine

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Clostridium difficile
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Lessa FC, Mu Y, Bamberg WM, et al. Burden of
Clostridium difficile infection in the United States. N
Engl J Med. 2015;372:825-834
• The Centers for Disease Control estimates that there
were 453,000 documented cases of Clostridium
difficile infection (CDI) in the United States in 2011
leading to 29,300 deaths.
• Between 10% and 30% of people who have an initial
episode of CDI will develop at least one recurrence.
NOTE: Approximately 20% recurrence rate.
• On the basis of the number of incident cases found in
2011, 45,300-135,900 people developed recurrent
CDI.
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Prevalence of Clostridium difficile in the gastrointestinal tract
of hospitalized children under two years of age. Med Dosw
Mikrobiol; 2010;62(1):77-84 (Poland)
• 178 fecal samples of children aged 2 months to 2
years, hospitalized in 2003-2006, were examined for
the presence of toxin A/B of C. difficile.
• Toxigenicity of strains was confirmed using PCR
• Susceptibility to antimicrobials was determined
• The percentage of children infected with C.
difficile was 68.6%.
• All strains were susceptible to Vancomycin and
Metronidazole (Flagyl).
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Inflammatory Bowel Secondary to C. Difficile
• In 1977, it was established that Pseudomembranous colitis
was caused by toxins produced from Clostridium difficile.
• Toxin A (enterotoxin) and toxin B (cytotoxin) are produced
by C. difficile and are involved in the disease process.
• Pseudomembranous colitis is frequently nosocomial with
an increased risk of spread among hospitalized patients.
• The C. difficile spores contaminate the patient's immediate
environment and are spread to other patients on the hands of
healthcare workers and medical equipment brought into the room.
• All groups of antibiotics like cephalosporin, penicillin,
clindamycin and ampicillin are commonly associated with
pseudomembranous colitis.
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