The Abdominal Centre

267 Pages·2013·2 MB·English

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RIGSHOSPITALET

Scientific Publications 2012
The Abdominal Centre .................................................................. 4

The Centre function ..................................................................................................................... 4
Department of Anaesthesiology ................................................................................................. 5
Department of Hepatology A ...................................................................................................... 7
Intensive Care Department ......................................................................................................... 9
Department of Vascular Surgery RK ........................................................................................ 12
Department of Surgical Gastroenterology C ........................................................................... 16
Department of Gastroenterology CA ....................................................................................... 19
Department of Nephrology P .................................................................................................... 20
Department of Endocrinological Medicine PE ........................................................................ 24
Department of Urology D .......................................................................................................... 32
Centre of Clinical Education (CEKU) ......................................... 35

The Nordic Cochrane Center ...................................................... 36

Copenhagen Trial Unit ............................................................................................................... 36
The Nordic Cochrane Center .................................................................................................... 40
The Centre of Diagnostic Investegation .................................... 45

Center of Genomic Medicine .................................................................................................... 45
Enfectious Hygiene Unit ............................................................................................................ 48
Department of Clinical Biochemistry ....................................................................................... 49
Department of Physiology, Nuclear Medicine & PET ............................................................. 57
Department of Clinical Immunology ........................................................................................ 67
Department of Clinical Microbiology ....................................................................................... 74
Department of Pathology .......................................................................................................... 79
Department of Diagnostic Radiology ....................................................................................... 88
The Executive Board ................................................................................................................. 94
The Finsen Centre ....................................................................... 96

The Muscle Research Centre .................................................................................................... 96
The Finsen Laboratory .............................................................................................................. 97
Department of Haematology ................................................................................................... 101
Department of Infectious Medicine and Rheumatology / Infectious Diseases .................. 109
Department of Infectious Medicine and Rheumatology / Rheumatology ........................... 127
Department of Infectious Medicine and Rheumatology / Centre of Inflammation and
Metabolism (CIM) ..................................................................................................................... 132
Department of Oncology ......................................................................................................... 136
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Department of Radiotherapy ................................................................................................... 145
The Heart Centre ........................................................................ 148

Department of Cardiology B ................................................................................................... 148
Department of Thoracic Surgery ............................................................................................ 169
Department of Thoracic Anaesthesia ANT ............................................................................ 175
The Centre of Head and Orthopaedics .................................... 177

Department of Anaesthesia and Operation ........................................................................... 177
Cochrane Anaesthesia Review Group, HOC ......................................................................... 183
Department of Ergotherapy and Physiotherapy ................................................................... 184
Department of Plastic Surgery, Breast Surgery and Burns Treatment .............................. 184
Department of Orthopaedic Surgery ...................................................................................... 187
Department of Dental, Oral and Maxillofacial Surgery ......................................................... 189
Trauma Centre and Acute Admissions .................................................................................. 192
Department of Otorhinolaryngology ...................................................................................... 193
The Juliane Marie Centre .......................................................... 199

Department of Anaesthesia and Operation ........................................................................... 199
Department of Paediatrics and Adolescent Medicine .......................................................... 200
Department of Surgical Pathophysiology ............................................................................. 207
Fertility Department ................................................................................................................. 212
Department of Gynaecology ................................................................................................... 216
Department of Clinical Genetics ............................................................................................. 222
Department of Kennedy Centre .............................................................................................. 228
Department of Psychology, Play Therapy and Social Counselling .................................... 231
Department of Growth and Reproduction ............................................................................. 231
Department of Neonatology .................................................................................................... 237
Department of Obstetrics ........................................................................................................ 239
The Neuroscience Centre ......................................................... 245

Department of Neuroanaesthesiology ................................................................................... 245
Department of Neurology ........................................................................................................ 248
The Danish Dementia Research Centre ................................................................................. 248
Danish Multiple Sclerosis Centre ........................................................................................... 252
Department of Epilepsy ........................................................................................................... 254
Department of Neuromuscular Diseases ............................................................................... 254
Department of Neurovascular Diseases ................................................................................ 256
Neurobiology Research Unit ................................................................................................... 256
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Department of Neurosurgery .................................................................................................. 259
Department of Clinical Neurophysiology .............................................................................. 262
The University Hospitals Center for Nursing and Care (UCSF)
..................................................................................................... 264

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The Abdominal Centre

The Centre function

Scientific publications

Greve I, Vasilevskis EE, Egerod I, Mortensen CB, Møller AM, Svenningsen H et al.
Interventions for preventing intensive care unit delirium (Protocol). Cochrane Database of
Systematic Reviews. 2012;8:1-21.

Herling SF, Møller A, Palle C, Thomsen T. Robotassisted laparoscpic hysterectomy-
Complications, quality of life and a health economic evaluation. 2012. Poster session
presented at forskningensdag, Herlev, Danmark.

Loving S, Nordling J, Jaszczak P, Thomsen T. Does evidence support physiotherapy
management of adult female chronic pelvic pain? A systematic review. Scandinavian
Journal of Pain. 2012 apr;3(2):70-81.

Loving S, Nordling J, Jaszczak P, Thomsen T. Does evidence support physiotherapy
management of adult female chronic pelvic pain? A systematic review. 2012. Poster
session presented at Danske Fysioterapeuters Fagfestival, Odense, Danmark.

Loving S, Thomsen T, Jaszczak P, Nordling J. Female Chronic Pelvic Pain is highly
prevalent in Denmark. A randomly selected crosssectional population study. 2012. Poster
session presented at Forskningensdag, Herlev, Danmark

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Department of Anaesthesiology

Scientific publications

Bada AA, Svendsen JH, Secher NH, Saltin B, Mortensen SP. Peripheral vasodilatation
determines cardiac output in exercising humans: insight from atrial pacing. Journal of
Physiology. 2012;590(Pt 8):2051-60.

Bjerring PN, Hauerberg J, Frederiksen H-J, Nielsen HMB, Clemmesen JO, Larsen FS. The
effect of fractionated plasma separation and adsorption on cerebral amino acid
metabolism and oxidative metabolism during acute liver failure. Journal of Hepatology.
2012;57(4):774-9.

Brassard P, Kim Y-S, van Lieshout J, Secher NH, Rosenmeier JB. Endotoxemia reduces
cerebral perfusion but enhances dynamic cerebrovascular autoregulation at reduced
arterial carbon dioxide tension*. The Open Critical Care Medicine Journal.
2012;40(6):1873-1878.

Christensen P, Nordsborg NB, Nybo L, Mortensen SP, Sander M, Secher NH et al. Thigh
oxygen uptake at the onset of intense exercise is not affected by a reduction in oxygen
delivery caused by hypoxia. American Journal of Physiology: Regulatory, Integrative and
Comparative Physiology. 2012;303(8):843-9.

Crandall CG, Wilson TE, Marving J, Bundgaard-Nielsen M, Seifert T, Klausen T et al.
Colloid volume loading does not mitigate decreases in central blood volume during
simulated hemorrhage while heat stressed. Journal of Physiology. 2012;1287-97.

Ganio MS, Overgaard M, Seifert T, Secher NH, Johansson PI, Meyer M et al. Effect of
heat stress on cardiac output and systemic vascular conductance during simulated
hemorrhage to presyncope in young men. American Journal of Physiology: Heart and
Circulatory Physiology. 2012;302(8):H1756-61.

Laughlin MH, Secher NH, Davis MJ, Van Lieshout JJ, Arce-Esquivel A, Simmons GH et al
Peripheral circulation: In Comprehensive Physiology, 2012; 321-447

Martusevicius R, Swiatek F, Joergensen LG, Nielsen HMB. Ultrasound-guided
locoregional anaesthesia for carotid endarterectomy: a prospective observational study.
European Journal of Vascular and Endovascular Surgery. 2012;44(1):27-30.

Overgaard M, Rasmussen P, Bohm AM, Seifert T, Brassard P, Zaar M et al. Hypoxia and
exercise provoke both lactate release and lactate oxidation by the human brain. F A S E B
Journal. 2012;3012-20.

Pearson J, Ganio MS, Seifert T, Overgaard M, Secher NH, Crandall CG. Pulmonary artery
and intestinal temperatures during heat stress and cooling. Medicine and Science in
Sports and Exercise. 2012;44(5):857-62.
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Rasmussen P, Kim Y-S, Krogh-Madsen R, Lundby C, Olsen NV, Secher NH et al. Both
acute and prolonged administration of EPO reduce cerebral and systemic vascular
conductance in humans. F A S E B Journal. 2012;26(3):1343-8.

Rasmussen P, Nordsborg NB, Taudorf S, Sørensen NHB, Berg RMG, Jacobs RA et al.
Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia
in humans. F A S E B Journal. 2012;26(5):1831-4.

Robach P, Siebenmann C, Jacobs RA, Rasmussen P, Nordsborg NB, Pesta D et al. The
role of haemoglobin mass on VO(2)max following normobaric 'live high-train low' in
endurance-trained athletes. British Journal of Sports Medicine. 2012;46(11):822-7.

Rud B, Foss O, Krustrup P, Secher NH, Hallén J. One-legged endurance training: leg
blood flow and oxygen extraction during cycling exercise. Acta Physiologica (Online).
2012;205(1):177-85.

Sato K, Fisher JP, Seifert T, Overgaard M, Secher NH, Ogoh S. Blood flow in internal
carotid and vertebral arteries during orthostatic stress. Experimental Physiology.
2012;97(12):1272-80.

Secher NH, Amann M. Human investigations into the exercise pressor reflex. Experimental
Physiology. 2012;97(1):59-69.

Secher NH, Rasmussen P. Food for thought. Journal of Physiology. 2012;590(Pt 5):1013.

Sørensen NHB, Secher NH, Siebenmann C, Nielsen HMB, Kohl-Bareis M, Lundby C et al.
Cutaneous vasoconstriction affects near-infrared spectroscopy determined cerebral
oxygen saturation during administration of norepinephrine. Anesthesiology News.
2012;117(2):263-70.

Toft BG, Federspiel BH, Sørensen SS, Bagi P, Nielsen HMB, Andersen CB. A
histopathological score on baseline biopsies from elderly donors predicts outcome 1 year
after renal transplantation. APMIS. 2012;120(3):182-6.

Truijen J, Kim YS, Krediet CTP, Stok WJ, Kölgen RS, Colier WN et al. Orthostatic leg
blood volume changes assessed by near-infrared spectroscopy. Experimental Physiology.
2012;97(3):353-61.

Volianitis S, Dawson EA, Dalsgaard M, Yoshiga C, Clemmesen J, Secher NH et al. Renal
lactate elimination is maintained during moderate exercise in humans.Journal of Sports
Sciences. 2012;30(2):149-53.

Wiis Vogelsang T, Marving J, G. Crandall C, Wilson C, C. Yoshiga C, Secher NH et al.
Atrial Natriuretic Peptide and Acute Changes in Central Blood Volume by Hyperthermia in
Healthy Humans. The Open Neuroendocrinology Journal. 2012;5:1-4.

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Department of Hepatology A

Doctoral thesis and PhD dissertations defended during the year

Bjerring PN. Cerebral metabolism during acute liver failure and the effect of treatment with
fractionated plasma separation and adsorption (Ph.D.). University of Copenhagen:
København: Eget forlag, 2012. 71 s.

Scientific publications

Allingstrup MJ, Esmailzadeh N, Wilkens Knudsen A, Espersen K, Hartvig Jensen T, Wiis J
et al. Provision of protein and energy in relation to measured requirements in intensive
care patients. Clinical Nutrition. 2012 aug;31(4):462-68.

Andersen IB, Ytting H. Oesophagussygdomme. Baslund B, Feldt-Rasmussen U, Kastrup
J, Soelberg Sørensen P, red. I: Medicin. 1 udg. København: FADL's Forlag. 2012. s. 133-
44.

Bendtsen F, Grønbæk H, Hansen JB, Aagaard NK, Schmidt L, Møller S. Treatment of
ascites and spontaneous bacterial peritonitis - Part I. Danish Medical Journal.
2012;59(1):C4371.

Berg RMG, Taudorf S, Bailey DM, Lundby C, Larsen FS, Pedersen BK et al. Effects of
lipopolysaccharide infusion on arterial levels and transcerebral exchange kinetics of
glutamate and glycine in healthy humans. APMIS. 2012;120(9):761-6.

Bjerring PN, Hauerberg J, Frederiksen H-J, Nielsen HMB, Clemmesen JO, Larsen FS. The
effect of fractionated plasma separation and adsorption on cerebral amino acid
metabolism and oxidative metabolism during acute liver failure. Journal of Hepatology.
2012;57(4):774-9.

Buchard A, Eefsen M, Semb S, Andersen SE, Morling N, Bendtsen F et al. The role of the
glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned
patients. Clinical Toxicology. 2012;50(1):27-33.

Christensen PB, Clausen MR, Krarup HB, Laursen AL, Schlichting P, Weis N. Treatment
for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection - Danish national
guidelines 2011. Danish Medical Journal. 2012;59(6):C4465.

Hartling HJ, Gaardbo JC, Ronit A, Knudsen LS, Ullum H, Vainer B et al. CD4(cid:0) and CD8(cid:0)
regulatory T cells (Tregs) are elevated and display an active phenotype in patients with
chronic HCV mono-infection and HIV/HCV co-infection. Scandinavian Journal of
Immunology. 2012;76(3):294-305.

Jie B, Jiang Z-M, Nolan MT, Zhu S-N, Yu K, Kondrup J. Impact of preoperative nutritional
support on clinical outcome in abdominal surgical patients at nutritional risk. Nutrition.
2012;28(10):1022-7.

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Kjær MS. Mave-tarmsygdomme. Bladbjerg EM, Sandbæk A, Stallknecht BM, red. I:
Sygdomslære for ikke-klinikere. 1 udg. København: Munksgård Danmark. 2012. s. 321-
355.

Larsen FS, Grønbæk H. Lever-galdevejssygdomme. Baslund B, Feldt-Rasmussen U,
Kastrup J, Soelberg Sørensen P, red. I: Medicin. 1 udg. København: FADL's Forlag. 2012.
s. 205-32.

Larsen FS, Schmidt L. Levererstatningsbehandling. Rubertsson, Larsson, red. I:
Intensivvård. 2 udg. Stockholm: Liber AB. 2012. s. 323-330.

Maibom MMM, Andersen JR. Forslag til ernæring ved hjerteinsufficiens. Ugeskrift for
Laeger. 2012;174(12):782.

Møller S, Aagaard NK, Schmidt L, Grønbæk H, Hansen JB, Bendtsen F. Treatment of the
hepatorenal syndrome and hyponatremia in cirrhosis - Part II. Danish Medical Journal.
2012;59(1):C4372.

Novovic S, Semb S, Olsen H, Moser C, Knudsen IJD, Homann C. First-line treatment with
cephalosporins in spontaneous bacterial peritonitis provides poor antibiotic coverage.
Scandinavian Journal of Gastroenterology. 2012;47(2):212-6.

Sorensen JM, Holm L, Frøst MB, Kondrup J. Food for patients at nutritional risk: a model
of food sensory quality to promote intake. Clinical Nutrition. 2012;31(5):637-46.

Volianitis S, Dawson EA, Dalsgaard M, Yoshiga C, Clemmesen J, Secher NH et al. Renal
lactate elimination is maintained during moderate exercise in humans. Journal of Sports
Sciences. 2012;30(2):149-53.

Weijs PJM, Sauerwein HP, Kondrup J. Protein recommendations in the ICU: g protein/kg
body weight - which body weight for underweight and obese patients?. Clinical Nutrition.
2012;31(5):774-5.

Weis N, Thomsen RW, DANHEP-styregruppen. Den Danske Database for Hepatitis B og
C. Ugeskrift for Laeger. 2012;174(42):2521.

Ytting H, Larsen FS. Karakteristik, diagnostik og behandling af patienter med autoimmun
hepatitis. Ugeskrift for Laeger. 2012;174(46):2859-63.

Ytting H, Andersen IB. Ventriklens og Duodenums sygdomme. I: Medicin. 1 udg.
København. 2012. s. 145-59.

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Intensive Care Department

Scientific publications

Allingstrup MJ, Esmailzadeh N, Wilkens Knudsen A, Espersen K, Hartvig Jensen T, Wiis J
et al. Provision of protein and energy in relation to measured requirements in intensive
care patients. Clinical Nutrition. 2012 aug;31(4):462-68.

Berg RMG, Plovsing RR, Ronit A, Bailey DM, Holstein-Rathlou N-H, Moller K.
Disassociation of Static and Dynamic Cerebral Autoregulatory Performance in Healthy
Volunteers After Lipopolysaccharide Infusion and in Patients with Sepsis. American
Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
2012;120/9:R1127-35.

Berg RMG, Taudorf S, Bailey DM, Lundby C, Larsen FS, Pedersen BK et al. Effects of
lipopolysaccharide infusion on arterial levels and transcerebral exchange kinetics of
glutamate and glycine in healthy humans. APMIS. 2012;120(9):761-6.

Berg RMG, Plovsing RR, Damgaard M. Teaching baroreflex physiology to medical
students: a comparison of quiz-based and conventional teaching strategies in a laboratory
exercise. Advances in Physiology Education. 2012;36(2):147-53.

Berg R, Møller K, Pedersen BK, Laye MJ, Mathur N, Pedersen M et al. Altered
Subcutaneous Adipose Tissue Response to Systemic LPS Administration in Patients with
Type 2 Diabetes. Journal of Diabetes & Metabolism. 2012;3(8):217.

Christiansen CB, Berg RMG, Plovsing RR, Møller K. Two cases of infectious purpura
fulminans and septic shock caused by Capnocytophaga canimorsus transmitted from
dogs. Scandinavian Journal of Infectious Diseases. 2012;44(8):635-9.

Grønlykke L, Brandstrup SLR, Perner A. Data from clinical database on septic shock are
valid. Danish Medical Journal. 2012;59(10):A4522.

Hvidt LN, Perner A. High dosage of dextran 70 is associated with severe bleeding in
patients admitted to the intensive care unit for septic shock. Danish Medical Journal.
2012;59(11):A4531.

Haase N, Perner A. Is hydroxyethyl starch 130/0.4 safe?. Critical Care (Online Edition).
2012;16(2):116.

Ibsen M, Wiis J, Waldau T, Perner A. Consecutive daily measurements of luminal
concentrations of lactate in the rectum in septic shock patients. Critical Care Research and
Practice. 2012;2012:504096.

Johansson PI, Sørensen AM, Perner A, Welling K-L, Wanscher M, Larsen CF et al. Elderly
trauma patients have high circulating noradrenaline levels but attenuated release of
adrenaline, platelets, and leukocytes in response to increasing injury severity. Critical Care
Medicine. 2012;40(6):1844-50.
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