Textbook of Structural Biology: 8

621 Pages·2017·53.543 MB·English

by  Anders Liljas, Lars Liljas, Miriam-rose Ash, Goran Lindblom, Poul Nissen

Textbook of
Structur al
Bi logy
Second Edition

10102_9789813142466_tp_Color.indd 1 19/9/16 11:47 AM
Series in Structural Biology
Series Editor: Anders Liljas (Lund University, Sweden)
Published
Vol. 1 Structural Aspects of Protein Synthesis (Second Edition)
by Anders Liljas and Måns Ehrenberg
Vol. 2 Found in Translation: Collection of Original Articles on Single-Particle
Reconstruction and the Structural Basis of Protein Synthesis
by Joachim Frank
Vol. 3 Selected Papers of Michael G. Rossmann with Commentaries:
The Development of Structural Biology
by Michael G. Rossmann
Vol. 4 From a Grain of Salt to the Ribosome: The History of Crystallography as seen Through
the Lens of the Nobel Prize
edited by Ivar Olovsson, Anders Liljas and Sven Lidin
Vol. 5 The Struggles and Dreams of Robert Langer
by Robert Langer
Vol. 6 Structure and Action of Molecular Chaperones:
Machines that Assist Protein Folding in the Cell
by Lila M. Gierasch, Arthur L. Horwich, Christine Slingsby, Sue Wickner and
David Agard
Vol. 7 Curiosity and Passion for Science and Art
by Uwe B. Sleytr

Vol. 8 Textbook of Structural Biology (Second Edition)
by Anders Liljas, Lars Liljas, Miriam-Rose Ash, Göran Lindblom, Poul Nissen and
Morten Kjeldgaard
SC - Textbook of Structural Biology.indd 1 19-09-16 10:11:21 AM
Series in Structural Biology – Vol. 8
Textbook of
Structur al
Bi logy
Second Edition
Anders Liljas
(Lund University, Sweden)
Lars Liljas
(Uppsala University, Sweden)
Miriam-Rose Ash
(The University of Sydney, Australia)
Göran Lindblom
(Umeå University, Sweden)

Poul Nissen
(Aarhus University, Denmark)
Morten Kjeldgaard
(Aarhus University, Denmark)
World Scientific
NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI • TOKYO
10102_9789813142466_tp_Color.indd 2 19/9/16 11:47 AM
Published by
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE
Library of Congress Cataloging-in-Publication Data
Names: Liljas, Anders, author.
Title: Textbook of structural biology / Anders Liljas, Lund University, Sweden [and five others].
Description: Second edition. | [Hackensack] New Jersey : World Scientific, 2017. |
Series: Series in structural biology ; vol. 8 | Includes bibliographical references and index.
Identifiers: LCCN 2016033861| ISBN 9789813142466 (hardcover : alk. paper) |
ISBN 9813142464 (hardcover : alk. paper) | ISBN 9789813142473 (pbk. : alk. paper) |
ISBN 9813142472 (pbk. : alk. paper)
Subjects: LCSH: Proteins--Structure. | Ultrastructure (Biology) | Protein folding. | Biomolecules--Structure.
Classification: LCC QP551 .T45 2017 | DDC 572/.633--dc23
LC record available at https://lccn.loc.gov/2016033861
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
Copyright © 2017 by World Scientific Publishing Co. Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic
or mechanical, including photocopying, recording or any information storage and retrieval system now known
or to be invented, without written permission from the publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center,
Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required
from the publisher.
Printed in Singapore
SC - Textbook of Structural Biology.indd 2 19-09-16 10:11:21 AM
“7.5x10.25” b2510 Textbook of Structural Biology, 2nd Edition
We dedicate this textbook to the memory
of our coauthor Jure Piskur.

bb22551100__FFMM..iinndddd vv 1100//2244//22001166 11::2277::2211 PPMM
b1754 Effective Anger Management for Children & Youth: A Training Manual
TTTThhhhiiiissss ppppaaaaggggeeee iiiinnnntttteeeennnnttttiiiioooonnnnaaaallllllllyyyy lllleeeefffftttt bbbbllllaaaannnnkkkk

bb11775544__FFMM..iinndddd iiii 99//33//22001144 77::3311::0044 PPMM
“7.5x10.25” b2510 Textbook of Structural Biology, 2nd Edition
Contents
Preface to the Second Edition ix
Chapter 1 I ntroduction 1
Chapter 2 B asics of Protein Structure 11
Chapter 3 T he Folding, Folds and Functions of Proteins 37
Chapter 4 B asics of Membrane Proteins 69
Chapter 5 B asics of Nucleic Acid Structure 105
Chapter 6 B asics of Lipids and Membrane Structure 161
Chapter 7 B asics of Carbohydrates 213
Chapter 8 E nzymes 227
Chapter 9 G enome Structure, DNA Replication and Recombination 269
Chapter 10 T ranscription 307

Chapter 11 P rotein Synthesis — Translation 351
Chapter 12 P rotein Folding and Degradation 385
Chapter 13 T ransmembrane Transport 425
Chapter 14 S ignal Transduction 451
Chapter 15 C ell Motility and Transport 481
Chapter 16 S tructural Aspects of Cell-Cell Interactions 507
Chapter 17 T he Immune System 521
bb22551100__FFMM..iinndddd vviiii 99//1199//22001166 1122::4400::1144 PPMM
b2510 Textbook of Structural Biology, 2nd Edition “7.5x10.25”
viii  Textbook of Structural Biology, 2nd Edition
Chapter 18 V irus Structure and Function 535
Chapter 19 B ioinformatics Tools in Structural Biology 553
Index 577

bb22551100__FFMM..iinndddd vviiiiii 99//1199//22001166 1122::4400::1144 PPMM
“7.5x10.25” b2510 Textbook of Structural Biology, 2nd Edition
Preface to the Second Edition
It is now over seven years ago since we published the first edition of our Textbook of
Structural Biology. Our coauthor of the first edition, Jure Piskur, died prematurely in 2014
due to cancer. We very much miss his insights and skills.
The field has made very rapid and extensive progress since the first edition was
released. In particular, it is becoming evident that many molecular systems are highly
integrated with each other and sometimes very large assemblies are formed. This com-
plexity is gradually emerging and accessible for structural investigations. The field of
membrane proteins is making remarkable progress and is more extensively covered in
this edition with its own dedicated chapter. Furthermore, we have added a chapter on
carbohydrates, which is an emerging area that is deeply integrated with protein and
cellular structure and function.
Given the impressive number of unique protein structures now available, it is of
course impossible to cover all of these in any single volume. We have therefore tried to
concentrate on the growing body of lasting knowledge of the structure and the roles of
macromolecular systems.
We have received help from many colleagues who have used the first edition of the
textbook for courses. In addition, we have had expert help in reviewing certain chapters.
We are indebted to Prof Ulf Lindahl for expert insight into carbohydrates. Furthermore,
we wish to express our thanks to Lars Erik Andreas Ehnbom and Saraboji Kadhirvel for
expert skills in producing parts of the illustrations. Many illustrations are produced using
the program Molscript by Per Kraulis.
bb22551100__FFMM..iinndddd iixx 99//1199//22001166 1122::4400::1144 PPMM