Kewal K. Jain Textbook of Personalized Medicine Second Edition Universal Free E-Book Store Donate Us, In order to keep our Service Alive, We have to pay for placing files (Abstracts, Books, Literature & Software) on File Hosting Servers, Your donations will make our process of payment a bit easier, Please use any one of the Payment Gateway for Donation. Never matter what amount you donate (10’s or 100’s or 1000’s). Universal Free E-Book Store T extbook of Personalized Medicine Universal Free E-Book Store Universal Free E-Book Store T extbook of Personalized Medicine Second Edition Kewal K. Jain, MD, FRACS, FFPM Jain PharmaBiotech, Basel, Switzerland Universal Free E-Book Store K ewal K . J ain J ain PharmaBiotech B asel, S witzerland I SBN 978-1-4939-2552-0 ISBN 978-1-4939-2553-7 (eBook) D OI 10.1007/978-1-4939-2553-7 L ibrary of Congress Control Number: 2015934582 S pringer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2 014, 2015 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. P rinted on acid-free paper H umana Press is a brand of Springer S pringer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com) Universal Free E-Book Store “ Tonight, I’m launching a new Precision Medicine Initiative to bring us closer to curing diseases like cancer and diabetes — and to give all of us access to the personalized information we need to keep ourselves and our families healthier.” —President Barack Obama, State of the Union Address, 20 January 2015, USA Universal Free E-Book Store Universal Free E-Book Store P reface to the S econd Edition Considerable advances have taken place in technologies used for advancing person- alized medicine, and it is increasingly applied in clinical use. This has required expansion and revision of some parts of the fi rst edition published in 2009. The style has been maintained due to the positive feedback of readers, including scientists, pharmacists, physicians, and lay persons interested in this topic. The book provides a concise and comprehensive source of reference for those involved in healthcare management, planning, and politics. As a single author book, it avoids the overlaps and missing areas frequently found in multiauthor books. Moreover, the time to publication is reduced by avoiding the long delays of numerous authors who do not keep the deadlines. The book includes 700 references selected from thousands of publications during the past decade and appended at the end of each chapter. Some of the references included were prepublication versions at the end of 2014 that will not be formally published until 2015. The text is supplemented by 31 illustrations and 56 tables. Algorithms are included as a guide to those involved in the management of important diseases where decision making is involved due to the multiple choices available. Finally, I thank the editorial staff of Springer, particularly Patrick Marton and David Casey, for their help and encouragement in this project. B asel, Switzerland K ewal K . J ain vii Universal Free E-Book Store Universal Free E-Book Store