Testicular Cancer and Other Tumors of the Genitourinary Tract

518 Pages·1985·19.44 MB·English

by  A. Milani, M. Pasi (auth.), M. Pavone-Macaluso, P. H. Smith, M. A. Bagshaw (eds.)

Testicular Cancer
and Other Tumors of the
Genitourinary Tract
Ettore Majorana International Science Series
Series Editor
Antonino Zichichi
European Physical Society,
Geneva, Switzerland
(LIFE SCIENCES)
Recent volumes in the series
Volume 8 THE IMMUNOLOGY OF INFANT FEEDING
Edited by A. W. Wilkinson
Volume 9 ADVANCES IN NEPHROUROLOGY
Edited by M. Pavone-Macaluso and P.H. Smith
Volume 10 CELLULAR BIOLOGY OF THE LUNG
Edited by G. Cumming and G. BonSignore
Volume 11 BIOELECTROCHEMISTRY I: Biological Redox Reactions
Edited by G. Milazzo and M. Blank
Volume 12 SELECTED TOPICS IN PREVENTIVE CARDIOLOGY
Edited by A. Raineri and J. J. Kellermann
Volume 13 THE BEHAVIOR OF HUMAN INFANTS
Edited by A. Oliverio and M. Zappella
Volume 14 DRUGS AND THE LUNG
Edited by G. Cumming and G. Bonsignore
Volume 15 AGING AND DRUG THERAPY
Edited by G. Barbagallo-Sangiorgi and A. N. Exton-Smith
Volume 16 MULTIPLE SCLEROSIS: Present and Future
Edited by G.Scarlato and W. B. Matthews
Volume 17 SMOKING AND THE LUNG
Edited by G. Cumming and G. Bonsignore
Volume 18 TESTICULAR CANCER AND OTHER TUMORS OF THE
GENITOURINARY TRACT
Edited by M. Pavone-Macaluso, P. H. Smith, and M. A. Bagshaw
A Continuation Order Plan is available for this series. A continuation order will bring delivery of
each new volume immediately upon publication. Volumes are billed only upon actual shipment.
For further information please contact the publisher.
Testicular Cancer
and Other Tumors of the
Genitourinary Tract
Edited by
M. Pavone-Macaluso
University Po!yclinic Hospital
Palermo. Italy
P. H. Smith
St. James's University Hospital
Leeds, England
and
M. A. Bagshaw
Stanford University
Stanford. California
Plenum Press • New York and London
Library of Congress Cataloging in Publication Data
International School of Urology and Nephrology. Course (5th: 1983: Erice. Italy)
Testicular cancer and other tumors of the genitourinary tract.
(Ettore Maiorana international science series. Life sciences; 18)
"Proceedings of the Fifth Course of the International School of Urology and
Nephrology. held July 16-24. 1983. at the Ettore Maiorana Center for Scientific
Culture. Erice. Sicily. Italy"-T.p. verso.
Includes bibliographies and index.
1. Testis-Cancer-Congresses. 2. Urinary organs-Cancer-Congresses. I.
Pavone-Macaluso. Michele. II. Smith. P. H. (Philip Henry) III. Bagshaw. Malcolm A ..
1925- . IV. Title. V. Series. [DNLM: 1. Testicular Neoplasms-congresses. 2. Uro-
genital Neoplasms-congresses. W1 ET712M v.18 / WJ 160161 1983t]
RC280.T4158 1983 616.99 1463 84-26493
ISBN-13: 978-1-4612-9490-0 e-ISBN-13: 978-1-4613-2453-9
001: 10.1007/978-1-4613-2453-9
Proceedings of the Fifth Course of the International School of Urology and
Nephrology. held July 16-24. 1983, at the Ettore Maiorana Center for
Scientific Culture, Erice, Sicily, Italy
©1985 Plenum Press, New York
Softcoverreprintofthe hardcover 1st edition 1985
A Division of Plenum Publishing Corporation
233 Spring Street. New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted.
in any form or by any means, electronic, mechanical. photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
PREFACE
The proceedings of this volume represent a record of a meeting
in the Ettore Majorana center in Erice, Sicily from 16-24 July, 1983.
This was the fifth course of the International School of Urology and
Nephrology, the fourth in a series of meetings devoted to different
aspects of Urological Oncology. Speakers and delegates came from
nearly every part of the world and contributed to a detailed analysis
of the current state of knowledge of tumors of the testicle and to
the development of knowledge of cancer of the bladder, prostate and
kidney.
Previous volumes resulting from this series of meetings have
been well received and the Editors hope that the reader may find the
record of this meeting equally attractive.
We are indebted to the Department of Medical Illustration, St.
James's University Hospital, for their kindness in producing several
of the illustrations in this book.
The editors are very grateful to Dr. Cavallo of Palermo for the
major part which he has played in preparing the index.
M. Pavone-Macaluso
P.H. Smith
M.A. Bagshaw
v
CONTENTS
I TUMORS OF THE TESTIS
CLASSIFICATION, PATHOLOGY, AETIOLOGY, RESEARCH
Pre-treatment Classification of Tumors of the Testis 1
G. Pizzocaro, A. Milani and M. Pasi
Histopathological Classification of Testicular Tumors 9
F. Mostofi and I.A. Sesterhenn
Rare Tumors of Testes and Adnexal Tumors 29
F. Mostofi and C.J. Davis, Jr.
Tumors of the Testis - Aetiology, Epidemiology and
Animal Models 41
W.G. Jones
Cell Kinetics in Human Germ Cell Tumors of the Testis 55
R. Silvestrini, A. Costa, S. Pilotti and G. Pizzocaro
MARKERS, DIAGNOSIS, PROGNOSIS
Tumor Markers in Testicular Cancer - A Review of 12 Years
Experience at the NCI 63
N. Javadpour
Placental-like Alkaline Phosphatase as a Tumor Marker
in Seminoma 89
L. Andersson, F. Edsmyr and A. Jeppsson
Tumors of the Testicle: Recent Advances in Diagnosis 95
J.P. Blandy, R.T.D. Oliver, R.C. Tiptoft and W. Hately
vii
viii CONTENTS
Tumors of the Testis: Lymphography and Other Imaging
Techniques 99
R. Musumeci, J.D. Tesoro-Tess, A, Milani, E. Ceglia,
F. Zanoni and G. Pizzocaro
The Role of the CT-scan in Diagnosis and Follow-up in
Patients with Metastatic Testicular Cancer 109
K. Scheiber, D. zur Nedden and G. Jakse
Tumors of the Testis - Prognostic Factors 115
G. Stoter
Age -Adjusted Mortality Rates for Testicular Neoplasm in
Italy Between 1969 and 1978 119
F. Di Silverio and G. La Pera
TREATMENT
GENERAL CONSIDERATIONS
Tumors of the Testis - the Basic Concept of Therapy 125
G. Stoter
Current Controversies in the Management of Testicular
Germ Cell Tumors 131
R.T.D. Oliver, J.P. Blandy and H.F. Hope-Stone
SURGERY
Surveillance After Orchidectomy for Clinical Stage 1
Testicular Non-seminoma 141
M. J. Peckham
Unilateral Versus Bilateral Lymph Node Dissection
in Non-seminomatous Testicular Germ Cell Tumors 149
S.D. Foss~, S. Ous, H. H. Lien and A. E. Stenwig
Tumors of the Testis - the Role of Surgery After
Chemotherapy 157
G. Stoter
Combined Chemotherapy and Surgery in Treatment of
Bulky Germ Cell Tumors: Comparison of Two
Induction Regimens and Evaluation of Poor
Prognostic Factors 161
J.E. Al twe in , E. Kreuser, N. Jaeger, L. Weissbach
and W. Schreml
CONTENTS ix
The Role of Cytoreductive Surgery and Chemotherapy
in Advanced Disseminated Nonseminomatous
Testicular Cancer - A Randomized Study 171
N. Javadpour
Round Table: Surgery of Testis Tumors:
Controversial Aspects 179
J.P. Blandy, N. Vahlensieck, A. Jardin,
P. Scardino, G. Pizzocaro and S.D. Foss!
RADIOTHERAPY
Radiation Therapy of Testicular Germinomas,
Stanford University Series (1956-1980) 183
M.A. Bagshaw and L.D. Graham
Irradiation of Seminoma 197
S.D. Foss! and J.F. Evensen
CHEMOTHERAPY AND IMMUNOTHERAPY
Tumors of the Testis - New Drugs and Drug Combinations 209
G. Stoter
Tumors of the Testis - Induction and Maintenance
Chemotherapy for Disseminated Non-Seminomas:
the EORTC Experience 215
G. Stoter, W.W. ten Bokkel Huinink, C.P.J. Vendrik,
A.T. van Oosterom, W.G. Jones, S.B. Kaye and
D.Th. Sleyfer for the EORTC Genito-Urinary Group
Management of Bulky Advanced Disseminated Testicular
Cancer 219
N. Javadpour
Effect of Combination Chemotherapy Related to the
Size of Retroperitoneal Lymph Node Metastases
in Non Seminomatous Germ Cell Tumors: A
Preliminary Report 231
S. Guazzieri, G. Ferro, A. Lembo, C. Vergani,
P. Sperandio and F. Pagnano
Round Table: Chemotherapy of Testis Tumors 237
G. Stoter
x CONTENTS
FERTILITY IN PATIENTS WITH TESTIS TUMORS
Testicular Function and Hormone Status in Patients
with Malignant Germ Tumors Before and
After Treatment 241
S.D. Fossg
Fertility in Patients with Cancer of the Testis Before
and After Treatment! Fertility After Surgery 253
A. Jardin
HOW TO TREAT TESTIS TUMORS
Treatment of Teratoma and Embryonal Cell Carcinoma 257
E.W. Vahlensieck
Experience with Treatment of Non Seminomatous Germ
Cell Tumors of Testis in Turkey 263
A. Akdas, D. Remzi, A. Ergen, Z. Kirkali and
Y. Ilker
Treatment of Male Choriocarcinoma 269
S.D. Fossg
The Treatment of Choriocarcinoma: Discussion 277
J.P. Blandy
II ADVANCES IN RENAL CANCER
Natural History of Renal Cell Carcinoma: Aspects
of Tumor Morphology, Lymphatic and
Haematogenous Metastatic Spread 279
S. Hellsten, T. Berge, F. Linell and L. Wehlin
Advances in Renal Cancer: Advances in Diagnosis 281
R. Musumeci and J.D. Tesoro Tess
Advanced Renal Cell Carcinoma: Natural History and
Response to Chemotherapy 287
F. M. Torti
Treatment of Renal Cancer Invading Vena Cava and
Right Atrium 303
A. Jardin
Vindesine in Renal Cancer: An EORTC Study 307
S.D. Fossg, L. Denis, A.T. van Oosterom,
M. de Pauw and G. Stoter