Terpenoids Against Human Diseases

269 Pages·2019·12.579 MB·English

by  Roy, Dijendra Nath

Terpenoids Against Human
Diseases

Terpenoids Against Human
Diseases
Edited by
Dijendra Nath Roy
CRC Press
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Dedicated to the Next Generation
Mr. Diptesh Roy
Ms. Diyasnita Roy
Ms. Samriddhi Roy

Contents
Preface ......................................................................................................................................................ix
Acknowledgements ...................................................................................................................................xi
Editor ......................................................................................................................................................xiii
Contributors .............................................................................................................................................xv
1. A Brief History of Terpenoids .........................................................................................................1
Milena Campelo Freitas de Lima, Larissa Sousa da Silva, Larissa Silveira
Moreira Wiedemann and Valdir F. da Veiga Jr.
2. Bioengineering Approach on Terpenoids Production .................................................................17
Niha Dhar and Sarojam Rajani
3. Terpenoids: The Biological Key Molecules ..................................................................................39
Moumita Majumdar and Dijendra Nath Roy
4. Terpenoids in Treatment of Liver Disease ....................................................................................61
Sujan Chatterjee, Debajyoti Patra, Pujita Ghosh, Akash Prasad
and Kaustav Dutta Chowdhury
5. Terpenoids in Treatment of Neurodegenerative Disease ...........................................................95
Ayantika Pal and Sumantra Das
6. Terpenoids in Treatment of Immunological Disease .................................................................119
Avik Sarkar and Surajit Bhattacharjee
7. Terpenoids in Cancer Treatment ................................................................................................177
Arghya Adhikary, Shaswati Das and Mousumi Bhattacharjee
8. Terpenoids Against Infectious Diseases ......................................................................................187
Sanhita Ghosh, Kamalika Roy and Chiranjib Pal
9. Terpenoids Against Cardiovascular Diseases ...........................................................................209
F. Mahomoodally and P. Ramjuttun
10. Toxicity of Terpenoids in Human Health ..................................................................................233
Ritobrata Goswami and Dijendra Nath Roy
Index ......................................................................................................................................................247
vii

Preface
Terpenoids are a group of metabolites showing much functional diversity in the treatment of human dis-
ease. Over the last few decades, a huge volume of work has been reported in the medical literature, but no
such book has been published with a complete compilation of all the recent important works in a single
volume to date. A book such as Terpenoids Against Human Disease is highly required at this stage.
Interestingly, terpenoids have a role in treating some important human diseases—including liver dis-
ease, neurodegenerative disease, cancer, infectious diseases, cardiovascular disease, and inflammatory
disease—that are addressed in detail in this book. This book is a valuable resource for its classification
of terpenoids and their chemical properties and for its logical representation of the metabolic engineering
approaches to terpenoid production, the toxicity of terpenoids in living systems, and terpenoid molecules
as biological messengers leading to therapeutic efficacy against human disease. Moreover, applications
of terpenoids in disease models are noted and thoroughly discussed in reference to in vitro studies as well
as in vivo studies with clinical trials.
This book can be referred to as a knowledge resource for academic institutions and the pharmaceutical
industry. In addition, it may be an interesting asset to researchers in the fields of medicinal chemistry,
pharmaceutical chemistry, natural products, and remedial biotechnology of pathological disease.
This book is composed of chapters written by multiple authors—including myself—all of whom are
experts in their respective fields and ultimately compiled and edited by me. I hope that the readers of
this book will become aware of the enormous potential of terpenoids and will try to discover a few novel
applications. I also hope this book will serve to stimulate multidisciplinary studies on terpenoids, result-
ing in an optimal utilization of this “green” chemical in the near future.
Dr. Dijendra Nath Roy
Editor
Agartala, India
ix