Targeted Chemoprevention of Progressive Marrow Failure in Patients with Fanconi Anemia using ... PDF
Preview Targeted Chemoprevention of Progressive Marrow Failure in Patients with Fanconi Anemia using ...
Targeted Chemoprevention of Progressive Marrow Failure in Patients with Fanconi Anemia using Quercetin, a Pilot study Parinda Mehta, M.D. Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati Children’s Hospital Medical Center Treatment options for Fanconi Anemia Moderate End-stage Early marrow Diagnosis marrow failure Marrow failure failure Comprehensive Watchful waiting Newer Radiation-free Care Clinic Androgens Hematopoietic Transplantation Complementation Need for an effective novel therapy with a better toxicity profile Reactive Oxygen Species (ROS) in FA • Studies in both animals and human subjects indicate that high levels of and increased sensitivity to ROS plays an important role in pathogenesis of bone marrow failure in patients with FA ROS Reactive oxygen species (ROS) • Reactive oxygen species (ROS) refer to a variety of molecules and free radicals derived from molecular oxygen • The biologically relevant ROS, such as hydrogen peroxide (H2O2), superoxide (O2), and the hydroxyl radical (HO), are generated from the precursor superoxide anion Consequences of increased oxidative stress/ROS • Oxidative stress is detrimental to cells due to oxidative damage to lipids, proteins, and DNA • This leads to a cascade of events that leads to apoptosis (cell death) or uncontrolled proliferation Consequences of increased oxidative stress/ROS MDS/Leukemia/ Marrow Failure other cancers What can we do about this?
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