Table Of Content

TAILOR-MADE POLYSACCHARIDES IN DRUG DELIVERY This page intentionally left blank TAILOR-MADE POLYSACCHARIDES IN DRUG DELIVERY Edited by Amit Kumar Nayak Professor, Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj, Odisha, India Md Saquib Hasnain Professor, Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India Academic Press is an imprint of Elsevier 125 London Wall, London EC2Y 5AS, United Kingdom 525 B Street, Suite 1650, San Diego, CA 92101, United States 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom Copyright © 2023 Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. ISBN 978-0-12-821286-8 For information on all Academic Press publications visit our website at https://www.elsevier.com/books-and-journals Publisher: Stacy Masucci Acquisitions Editor: Andre G. Wolff Editorial Project Manager: Kristi L. Anderson Production Project Manager: Omer Mukthar Cover Designer: Greg Harris Typeset by STRAIVE, India Contents Contributors xi About the editors xiii Preface xv 1. Synthesis of tailor-made polysaccharides: An overview Muhanna K. Al-Muhanna, Naushad Anwar, Md Saquib Hasnain, and Amit Kumar Nayak 1 Introduction 1 2 Syntheses of tailor-made polysaccharides 2 3 Conclusion 18 References 20 2. Drug delivery dosage forms made of tailor-made natural polysaccharides Md Saquib Hasnain, Muhanna K. Al-Muhanna, Naushad Anwar, Mohd Usman Mohd Siddique, Mohd Neyaz Ahsan, Syed Anees Ahmed, Mohammed Tahir Ansari, and Amit Kumar Nayak 1 Introduction 29 2 Tablets made of tailor-made natural polysaccharides 30 3 Nanoparticles made of tailor-made natural polysaccharides 34 4 Microparticles made of tailor-made natural polysaccharides 37 5 Beads made of tailor-made natural polysaccharides 40 6 Hydrogels made of tailor-made natural polysaccharides 44 7 Miscellaneous 46 8 Conclusion 48 References 50 Further reading 61 3. Carboxymethylated polysaccharides in drug delivery Payam Zarrintaj, Mohammad Reza Ganjali, Azam Salmankhani, Amin Hamed Mashhadzadeh, Muhammad Tajammal Munir, Foad Salehnia, Morteza Rezapour, Sajjad Habibzadeh, and Mohammad Reza Saeb 1 Introduction 63 2 Carboxymethylation process 68 v vi Contents 3 Carboxymethyl polysaccharides in drug delivery 70 4 Conclusion 74 References 75 4. Thiolated polysaccharides in drug delivery Pranab Kumar Bandyopadhyay, Md Saquib Hasnain, and Amit Kumar Nayak 1 Introduction 83 2 Various thiolated polysaccharides used in drug delivery formulations 85 3 Conclusion 102 References 102 5. Cross-linked polysaccharides in drug delivery Mohsen Khodadadi Yazdi, Ali Khodadadi, Payam Zarrintaj, Mohammad Reza Ganjali, Foad Salehnia, Morteza Rezapour, Sajjad Habibzadeh, and Mohammad Reza Saeb 1 Introduction 107 2 Cross-linking of and the cross-linked polysaccharides 110 3 Cross-linked polysaccharides applied in DDSs 114 4 Smart cross-linking strategies 118 5 Conclusion 120 References 121 6. Graft copolymers of polysaccharides: Synthesis techniques and pharmaceutical applications Sudipta Das, Rimi Dey, Md Saquib Hasnain, and Amit Kumar Nayak 1 Introduction 129 2 Polysaccharides 130 3 Graft copolymers and different techniques of polymer grafting 131 4 Properties of graft copolymers 136 5 Pharmaceutical applications of polysaccharide graft copolymers 137 6 Conclusion 152 References 152 7. Grafted polysaccharides in drug delivery Mohsen Khodadadi Yazdi, Payam Zarrintaj, Mohammad Reza Ganjali, Foad Salehnia, Morteza Rezapour, Farzad Seidi, and Mohammad Reza Saeb 1 Introduction 157 2 Polysaccharide-based graft copolymers 160 3 Grafted polysaccharides in DDSs 160 4 Conclusion 168 References 170 Contents vii 8. Polysaccharide-based polyelectrolyte complex systems in drug delivery Gouranga Nandi, Md Saquib Hasnain, and Amit Kumar Nayak 1 Introduction 177 2 What is a polyelectrolyte complex? 178 3 Advantages of PECs 178 4 Factors affecting the formation and stability of PECs 179 5 Polysaccharides used to fabricate polyelectrolyte complexes (PECs) 180 6 Various dosage forms fabricated by polyelectrolyte complexation 189 7 Conclusion 202 References 202 9. Polysaccharide-based interpenetrating polymeric network systems in drug delivery Sudipta Das, Arnab Samanta, Md Saquib Hasnain, and Amit Kumar Nayak 1 Introduction 211 2 IPNs: Definition, properties, and classifications 212 3 Chitosan-based IPN systems in drug delivery 215 4 Alginate-based IPN systems in drug delivery 218 5 Pectin-based IPN systems in drug delivery 223 6 Gellan gum-based IPN systems in drug delivery 225 7 Locust bean gum-based IPN systems in drug delivery 225 8 Xanthan gum-based IPN systems in drug delivery 227 9 Carrageenan-based IPN systems in drug delivery 228 10 Conclusion 228 References 229 10. Polysaccharide nanoconjugates in drug delivery Mohammed Tahir Ansari, Farheen Sami, Md Saquib Hasnain, Mohd Usman Mohd Siddique, and Amit Kumar Nayak, 1 Introduction 237 2 Polysaccharide nanoconjugates 238 3 Advantages of polysaccharide nanoconjugates in drug delivery 239 4 Polysaccharide used for nanoconjugation 239 5 Recent progress 249 6 Conclusion 250 References 250 viii Contents 11. Functionalized chitosan in drug delivery Zahra Shariatinia 1 Introduction 257 2 Functionalized chitosan derivatives as drug delivery systems 258 3 Conclusion 284 Acknowledgments 285 References 285 12. Modified alginates in drug delivery Nandan Sarkar and Arindam Maity 1 Introduction 291 2 Alginate biopolymer 292 3 Physicochemical heterogeneity toward drug delivery 295 4 Biological synergistic attributes toward drug delivery 299 5 Modification of alginate 301 6 Application of modified alginate in drug delivery 313 7 Concluding remarks 319 8 Future directions 320 References 320 13. Uses of tailor-made plant starches in drug delivery Md Saquib Hasnain, Mohd Usman Mohd Siddique, Manoj M. Gadewar, Mohammed Tahir Ansari, Mohd Neyaz Ahsan, Gouranga Nandi, and Amit Kumar Nayak 1 Introduction 327 2 Starch: Basic chemistry and properties 328 3 Plant-derived starches as pharmaceutical excipients in drug delivery 330 4 Synthesis of tailor-made plant starches and their uses in drug delivery 331 5 Clinical potential of tailor-made starches 338 6 Conclusion 338 References 339 14. Cancer targeting by tailor-made polysaccharides Azim Ansari, Abdullah Sheriker, Mohd Usman Mohd Siddique, Mrunali Patil, Sameer N. Goyal, Sheikh Murtuja, Mohd Neyaz Ahsan, Md Saquib Hasnain, and Amit Kumar Nayak 1 Introduction 347 2 Polysaccharides and their importance 348 3 Tailor-made chitosan-based systems for cancer-targeting applications 349 4 Tailor-made hyaluronic acid-based systems for cancer-targeting applications 351 5 Tailor-made pectin-based systems for cancer-targeting applications 354 6 Tailor-made heparin-based systems for cancer-targeting applications 356 7 Tailor-made dextran-based systems for cancer-targeting applications 360 Contents ix 8 Tailor-made chondroitin sulfate-based systems for cancer-targeting applications 362 9 Tailor-made cyclodextrin-based systems for cancer-targeting applications 362 10 Tailor-made pullulan-based systems for cancer-targeting applications 363 11 Tailor-made alginate-based systems for cancer-targeting applications 365 12 Tailor-made amylose-based systems for cancer-targeting applications 366 13 Conclusion 368 References 368 15. Delivery of genes and growth factors using tailor-made polysaccharides Mrunali Patil, Mohd Usman Mohd Siddique, Abdullah Sheriker, Azim Ansari, Sameer N. Goyal, Md Saquib Hasnain, and Amit Kumar Nayak 1 Introduction 377 2 Polysaccharides 378 3 Gene therapy and applications of tailor-made polysaccharides for gene delivery 382 4 Growth factors and applications of tailor-made polysaccharides for growth delivery 386 5 Conclusion 386 References 387 Index 391