T Regulatory Cells in Human Health and Diseases PDF
Preview T Regulatory Cells in Human Health and Diseases
Advances in Experimental Medicine and Biology 1278 Song-Guo Zheng Editor T Regulatory Cells in Human Health and Diseases Advances in Experimental Medicine and Biology Volume 1278 SeriesEditors WimE.Crusio,InstitutdeNeurosciencesCognitivesetIntégratives d’Aquitaine,CNRSandUniversityofBordeaux,PessacCedex,France HaidongDong,DepartmentsofUrologyandImmunology,MayoClinic, Rochester,MN,USA HeinfriedH.Radeke,InstituteofPharmacology&Toxicology,Clinicofthe GoetheUniversityFrankfurtMain,FrankfurtamMain,Hessen,Germany NimaRezaei,ResearchCenterforImmunodeficiencies,Children’sMedical Center,TehranUniversityofMedicalSciences,Tehran,Iran JunjieXiao,CardiacRegenerationandAgeingLab,InstituteofCardiovascular Sciences,SchoolofLifeScience,ShanghaiUniversity,Shanghai,China Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary researchintheareasofmicrobiology,immunology,neurosciences,biochem- istry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it bringstogethercliniciansandresearchersfromvariousfields. Advances in Experimental Medicine and Biology has been publishing exceptionalworksinthefieldforover40years,andisindexedinSCOPUS, Medline (PubMed), Journal Citation Reports/Science Edition, Science Cita- tion Index Expanded (SciSearch, Web of Science), EMBASE, BIOSIS, Reaxys, EMBiology, the Chemical Abstracts Service (CAS), and Pathway Studio. 2019ImpactFactor:2.450 5YearImpactFactor:2.324 Moreinformationaboutthisseriesathttp://www.springer.com/series/5584 Song-Guo Zheng Editor T Regulatory Cells in Human Health and Diseases Editor Song-GuoZheng DepartmentofInternalMedicine OhioStateUniversityCollegeofMedicineandWexnerMedicalCenter Columbus,OH,USA ISSN0065-2598 ISSN2214-8019 (electronic) AdvancesinExperimentalMedicineandBiology ISBN978-981-15-6406-2 ISBN978-981-15-6407-9 (eBook) https://doi.org/10.1007/978-981-15-6407-9 #SpringerNatureSingaporePteLtd.2021 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeor part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations,recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway, andtransmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,or bysimilarordissimilarmethodologynowknownorhereafterdeveloped. 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The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721,Singapore Contents 1 RegulatoryTCells:Concept,Classification,Phenotype, andBiologicalCharacteristics. . . . . . . . . . . . . . . . . . . . . . 1 YangDu,QiannanFang,andSong-GuoZheng 2 AStructure-GuidedDelineationofFOXP3Regulation MechanisminIPEX. . . . . . . . . . . . . . . . .. . . . . . . . . . . . . 33 TengyunMa,XiaominSong,CiriacoA.Piccirillo, GuopingDeng,andMarkI.Greene 3 RegulationofTregFunctionsbytheUbiquitinPathway. . 47 ElenaMontautiandDeyuFang 4 Ubiquitin-DependentRegulationofTregFunction andPlasticity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 YiDongandFanPan 5 MetabolicChoiceTunesFoxp3+RegulatoryTCell Function. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 XiaoxiaWang,HaoCheng,YigeShen,andBinLi 6 TregCellsandEpigeneticRegulation. . . . . . . . . . . . . . . . 95 JosephA.BellantiandDongmeiLi 7 TCR/ITKSignalinginType1RegulatoryTcells. . . . . . . 115 MichaelC.McGee,AveryAugust,andWeishanHuang 8 AdiposeTissueTRegulatoryCells:ImplicationsforHealth andDisease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 DavidBradley,DhartiShantaram,AlanSmith, andWillaA.Hsueh 9 IntestinalRegulatoryTCells. . . . . . . . . . . . . . . . . . . . . . . 141 VanessaR.FigliuolodaPaz,DeepaR.Jamwal, andPawelR.Kiela 10 TheAssociationofGutMicrobiotaandTregDysfunction inAutoimmuneDiseases. . . . . . . . . . . . . . . . . . . . . . . . . . 191 YuyingLiu,DatQ.Tran,JohnWilliamLindsey, andJonMarcRhoads v vi Contents 11 TregsinAutoimmuneUveitis. . . . . . . . . . . . . . . . . . . . . . 205 ZhaohaoHuang,WenliLi,andWenruSu 12 UnderstandingandTargetingHumanCancerRegulatory TCellstoImproveTherapy. . . . . .. . . . . . . .. . . . . . . .. . 229 H.RyanKolb,NicholasBorcherding,andWeizhouZhang 13 TNF–TNFR2SignalPlaysaDecisiveRoleintheActivation ofCD4+Foxp3+RegulatoryTCells:Implicationsinthe TreatmentofAutoimmuneDiseasesandCancer. . . . . . . . 257 MdSahidulIslam,YangYang,andXinChen 14 ThePursuitofRegulatoryTCellsintheInduction ofTransplantTolerance. . . . . . . . . . . . . . . . . . . . . . . . . . 273 PrestonR.ArnoldandXianC.Li 15 RegulatoryTCellsfortheInductionofTransplantation Tolerance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 WeitaoQueandXiao-KangLi Contributors Preston R. Arnold Immunobiology and Transplant Science Center and DepartmentofSurgery,HoustonMethodistHospital,TexasMedicalCenter, Houston,TX,USA DepartmentofSurgery,WeillCornellMedicalCollegeofCornellUniversity, NewYork,NY,USA Avery August Department of Microbiology and Immunology, College of VeterinaryMedicine,CornellUniversity,Ithaca,NY,USA JosephA.Bellanti DepartmentofPediatrics,GeorgetownUniversityMedi- calCenter,Washington,DC,USA Department of Microbiology-Immunology, Georgetown University Medical Center,Washington,DC,USA International Center for Interdisciplinary Studies of Immunology (ICISI), GeorgetownUniversityMedicalCenter,Washington,DC,USA Nicholas Borcherding Department of Pathology and Medical Science TrainingProgram,UniversityofIowa,IowaCity,IA,USA David Bradley Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Departmentof Internal Medicine, TheOhioStateUniversity,Columbus,OH,USA TheOhioStateUniversityWexnerMedicalCenter,Columbus,OH,USA Xin Chen State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China Hao Cheng Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China Guoping Deng Department of Immunology, School of Basic Medical Sciences,PekingUniversity,Beijing,China Yi Dong Department of Cell Biology, Johns Hopkins University School of Medicine,Baltimore,MD,USA Yang Du Department of Pathology and Physiopathology, Guilin Medical University,Guilin,Guangxi,China vii viii Contributors Laboratory of Tumor Immunology and Microenvironmental Regulation, GuilinMedicalUniversity,Guilin,Guangxi,China Deyu Fang Department of Pathology, Northwestern University Feinberg SchoolofMedicine,Chicago,IL,USA Qiannan Fang Department of Clinical Immunology, The Third Affiliated HospitalofSunYat-senUniversity,Guangzhou,China Vanessa R. Figliuolo da Paz Department of Pediatrics, University of Arizona,Tucson,AZ,USA Mark I. Greene Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA,USA Willa A. Hsueh Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Departmentof Internal Medicine, TheOhioStateUniversity,Columbus,OH,USA Weishan Huang Department of Pathobiological Sciences, School of VeterinaryMedicine,LouisianaStateUniversity,BatonRouge,LA,USA Department of Microbiology and Immunology, College of Veterinary Medicine,CornellUniversity,Ithaca,NY,USA Zhaohao Huang State Key Laboratory of Ophthalmology, Zhongshan OphthalmicCenter,SunYat-senUniversity,Guangzhou,China Md Sahidul Islam State Key Laboratory of Quality Research in Chinese Medicine,InstituteofChineseMedicalSciences,UniversityofMacau,Macau SAR,China DeepaR.Jamwal DepartmentofPediatrics,UniversityofArizona,Tucson, AZ,USA Pawel R. Kiela Department of Pediatrics, University of Arizona, Tucson, AZ,USA DepartmentofImmunobiology,UniversityofArizona,Tucson,AZ,USA H. Ryan Kolb Department of Pathology, Immunology and Laboratory Medicine,UniversityofFlorida,Gainesville,FL,USA Bin Li Shanghai Institute of Immunology, Department of Immunology and Microbiology,ShanghaiJiaoTongUniversitySchoolofMedicine,Shanghai JiaoTongUniversity,Shanghai,China Dongmei Li Department of Microbiology-Immunology, Georgetown UniversityMedicalCenter,Washington,DC,USA International Center for Interdisciplinary Studies of Immunology (ICISI), GeorgetownUniversityMedicalCenter,Washington,DC,USA Wenli Li State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center,SunYat-senUniversity,Guangzhou,China Contributors ix XianC.Li ImmunobiologyandTransplantScienceCenterandDepartment of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX,USA DepartmentofSurgery,WeillCornellMedicalCollegeofCornellUniversity, NewYork,NY,USA Xiao-KangLi DivisionofTransplantationImmunology,NationalResearch InstituteforChildHealthandDevelopment,Tokyo,Japan JohnWilliamLindsey DepartmentofNeurology,DivisionofGastroenter- ology,TheUniversityofTexasHealthScienceCenteratHoustonMcGovern MedicalSchool,Houston,TX,USA Yuying Liu Department of Pediatrics, Division of Gastroenterology, The University of Texas Health Science Center at Houston McGovern Medical School,Houston,TX,USA Tengyun Ma Department of Immunology, School of Basic Medical Sciences,PekingUniversity,Beijing,China Michael C. McGee Department of Pathobiological Sciences, School of VeterinaryMedicine,LouisianaStateUniversity,BatonRouge,LA,USA Elena Montauti Department of Pathology, Northwestern University FeinbergSchoolofMedicine,Chicago,IL,USA Fan Pan Center for Cancer Immunology Research, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong,China CiriacoA.Piccirillo DepartmentofMicrobiologyandImmunology,McGill University,Montreal,QC,Canada CentreofExcellenceinTranslationalImmunology(CETI),ResearchInstitute oftheMcGillUniversityHealthCentre,Montreal,QC,Canada Weitao Que Division of Transplantation Immunology, National Research InstituteforChildHealthandDevelopment,Tokyo,Japan JonMarcRhoads DepartmentofPediatrics,DivisionofGastroenterology, The University of Texas Health Science Center at Houston McGovern MedicalSchool,Houston,TX,USA Dharti Shantaram Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Departmentof Internal Medicine, TheOhioStateUniversity,Columbus,OH,USA Yige Shen Shanghai Jiao Tong University School of Medicine, Shanghai JiaoTongUniversity,Shanghai,China Alan Smith Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Departmentof Internal Medicine, TheOhioStateUniversity,Columbus,OH,USA
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