T Cells in Arthritis

241 Pages·2000·4.94 MB·English

by  Katherine H. Y. Nguyen

Series Editor
Michael J. Parnham
PLiVA
Research Institute
Prilaz baruna Filipovica 25
1000 Zagreb
Croatia
T Cells in Arthritis
Pierre Miossec
Wim B. van den Berg
Gary S. Firestein
Editors
Birkhauser Verlag
Basel· Boston· Berlin
Editors
Prof. Pierre Miossec Prof. Dr. Wim B. van den Berg
University Claude Bernard Department of Rheumatology
Departments of Immunology and Rheumatology University Hospital Nijmegen
Hopital Edouard Herriot Geert Grooteplein 8
F-69437 Lyon Cedex 03 N L- 6525 Nijmegen
France The Netherlands
prof. Gary S. Firestein
Division of Rheumatology
UCSD School of Medicine
9500 Gilman Drive
San Diego, CA 92093-0656
USA
A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA
Deutsche Bibliothek Cataloging-in-Publication Data
T cells in arthritis / ed. by Pierre Miossec ... -Basel; Boston;
Berlin: Birkhauser, 1998
(Progress in inflammation research)
ISBN 3-7643-5853-X (Basel .. )
ISBN 0-8176-5853-X (Boston)
Cover illustration: Immunostaining of a T cell producing IL-17 in the rheumatoid synovium. (From J.M. Durand and P.
Miossec)
The publisher and editor can give no guarantee for the information on drug dosage and administration contained in
this publication. The respective user must check its accuracy by consulting other sources of reference in each individual
case.
The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that
they are exempt from the relevant protective laws and regulations or free for general use.
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned,
specifically the rights of translation, reprinting, re-use of illustrations, broadcasting, reproduction on microfilms or in
other ways, and storage in data banks. For any kind of use whatsoever, permission from the copyright owner must
be obtained.
© 1998 Birkhauser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland
Printed on acid-free paper produced from chlorine-free pulp. TCF =
Cover design: Markus Etterich, Basel
ISBN 3-7643-5853-X
ISBN 0-8176-5853-X
987654321
Contents
List of contributors .. vii
Preface. ix
Katherine H. Y. Nguyen and Gary S. Firestein
T cells as secondary players in rheumatoid arthritis ...
David A. Fox and Nora G. Singer
T cell receptor rearrangements in arthritis. 19
Juliane K. Franz, Thomas Pap, Uif Muller-Ladner. Renate E. Gay,
Gerd R. Burmester and Steffen Gay
T cell-independent joint destruction ........................ . 55
Wim B. van den Berg
Role of T cells in arthritis: Lessons from animal models. 75
Pierre Miossec
The Th1 ITh2 cytokine balance in arthritis. 93
Danielle Burger and Jean-Michel Dayer
Interactions between T cell plasma membranes and monocytes ................. 111
Nancy Oppenheimer-Marks and Peter E. Lipsky
Adhesion molecules in arthritis: Control of T cell migration
into the synovium ................................................................ 129
Marc Bonneville, Emmanuel Scotet, Marie-Alix Peyrat, Annick Lim,
Jacques David-Ameline and Elisabeth Houssaint
T cell reactivity to Epstein-Barr virus in rheumatoid arthritis ..................... 149
Joachim Sieper and Jilrgen Braun
T cell responses in reactive and Lyme arth ritis .................................... 169
Ferdinand C. Breedveld
T cell directed therapies and biologics. . ........... 189
Michael T. Falta and Brian L. Kotzin
T cells as primary players in rheumatoid arthritis ................................. 201
Index ... . ... 233
vi
List of contributors
Marc Bonneville, INSERM U463, Institut de Biologie, 9 quai Moncousu, F-44035
Nantes Cedex 01, France; e-mail: [email protected]
Jiirgen Braun, Department of Medicine, Division of Nephrology and Rheumatology,
Klinikum Benjamin Franklin, Free University, Hindenburgdamm 30, D-12200
Berlin, Germany; e-mail: [email protected]
Ferdinand C. Breedveld, Leiden University Medical Center, Department of Rheuma
tology, C4-R, P.O.Box 9600, NL-2300 RC Leiden, The Netherlands;
e-mail: [email protected]
Danielle Burger, Division of Immunology and Allergy, Hans Wilsdorf Laboratory,
University Hospital, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland;
e-mail: [email protected]
Gerd R. Burmester, Department of Rheumatology and Clinical Immunology, Char
ite University Hospital, Humboldt University of Berlin, Department of Rheumatol
ogy and Clinical Immunology, Schumannstr. 20-21, D-I0117 Berlin, Germany
Jacques David-Ameline, INSERM U463, Institut de Biologie, 9 quai Moncousu, F-
44035 Nantes Cedex 01, France
Jean-Michel Dayer, Division of Immunology and Allergy, Hans Wilsdorf Laborato
ry, University Hospital, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland;
e-mail: [email protected]
Gary S. Firestein, Division of Rheumatology, #0656, UCSD School of Medicine,
9500 Gilman Drive, La Jolla, CA 92093-0656, USA; e-mail: [email protected]
Michael T. Falta, Division of Basic Sciences, National Jewish Medical and Research
Center, 1400 Jackson Street, Denver, CO 80206, USA; e-mail: [email protected]
List of contributors
David A. Fox, Division of Rheumatology, Specialized Center of Research in
Rheumatoid Arthritis and Multipurpose Arthritis and Musculoskeletal Diseases
Center, University of Michigan, 3918 Taubman Center, Ann Arbor, MI 48109-0358,
USA; e-mail: [email protected]
Juliane K. Franz, Center of Experimental Rheumatology, Department of Rheuma
tology, University Hospital Zurich, Gloriastr. 25, CH-8091 Zurich, Switzerland; and
Department of Rheumatology and Clinical Immunology, Charite University Hospi
tal, Humboldt University of Berlin, Schumannstr. 20-21, D-I0117 Berlin, Germany
Renate E. Gay, Center of Experimental Rheumatology, Department of Rheumatol
ogy, University Hospital Zurich, Gloriastr. 25, CH-8091 Zurich, Switzerland;
e-mail: [email protected]
Steffen Gay, Center of Experimental Rheumatology, Department of Rheumatology,
University Hospital Zurich, Gloriastr. 25, CH-8091 Zurich, Switzerland;
e-mail: [email protected]
Elisabeth Houssaint, INSERM U463, Institut de Biologie, 9 quai Moncousu, F-
44035 Nantes Cedex 01, France
Brian L. Kotzin, Division of Basic Sciences, National Jewish Medical and Research
Center, 1400 Jackson Street, Denver, CO 80206; and Departments of Medicine and
Immunology, University of Colorado Health Sciences Center, 4200 East Ninth
Avenue, Denver, CO 80262, USA; e-mail: [email protected]
Annick Lim, INSERM U277, Institut Pasteur, 25, rue du Dr. Roux, F-75724 Paris,
France
Peter E. Lipsky, Rheumatic Diseases Division of The Depatment of Internal Medi
cine, The University of Texas Southwestern Medical School, 5323 Harry Hines
Blvd., Dallas, TX 75235-3577, USA; e-mail: [email protected]
Pierre Miossec, Clinical Immunology Unit, Departments of Immunology and
Rheumatology, H6pital Edouard Herriot, F-69437 Lyon Cedex 03, France;
e-mail: [email protected]
Ulf Muller-Ladner, Center of Experimental Rheumatology, Department of Rheuma
tology, University Hospital, Zurich, Gloriastr. 25, CH-8091 Zurich, Switzerland;
and Department of Internal Medicine, Division of Rheumatology and Clinical
Immunology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042
Regensburg, Germany
viii
List of contributors
Nancy Oppenheimer-Marks, Rheumatic Diseases Division of The Depatment of
Internal Medicine, The University of Texas Southwestern Medical School, 5323
Harry Hines Blvd., Dallas, TX 75235-3577, USA;
e-mail: [email protected]
Katherine H.Y. Nguyen, Division of Rheumatology, #0656, UCSD School of Medi
cine, 9500 Gilman Drive, La Jolla, CA 92093-0656, USA;
e-mail: [email protected]
Thomas Pap, Center of Experimental Rheumatology, Department of Rheumatology,
University Hospital Zurich, Gloriastr. 25, CH-8091 Zurich, Switzerland;
e-mail: [email protected]
Marie-Alix Peyrat, INSERM U463, Institut de Biologie, 9 quai Moncousu, F-44035
Nantes Cedex 01, France
Emmanuel Scotet, INSERM U463, Institut de Biologie, 9 quai Moncousu, F-44035
Nantes Cedex 01, France
Joachim Sieper, Department of Medicine, Division of Nephrology and Rheumatol
ogy, Klinikum Benjamin Franklin, Free University, Hindenburgdamm 30, D-12200
Berlin, Germany; e-mail: [email protected]
Nora G. Singer, Department of Internal Medicine Division of Rheumatic Diseases,
Case Western Reserve University Medical School, 11100 Rainbow Babies & Chil
drens Hospital, Cleveland, OH 44106, USA
Wim B. van den Berg, Dept. of Rheumatology, University Hospital Nijmegen, Geert
Grooteplein 8, NL-6500 HB Nijmegen, The Netherlands;
e-mail: [email protected]
ix
Preface
The pathogenesis of rheumatoid arthritis (RA) has been the subject of intense scruti
ny for several decades. The prevailing hypotheses have changed over the years, and
have attempted to incorporate the most recent data. The first major clue to an
immune-mediated process was the discovery that an autoantibody, i.e. rheumatoid
factor, was associated with the disease. This led to the simple assumption that anti
body responses to a defined antigen were responsible for articular inflammation.
However, the complexity of RA soon led to alternative paradigms, and the
"immune complex" model, which invoked intra-articular activation of complement
by rheumatoid factor-containing complexes, reconciled some of these problems.
The 1980's ushered in the era of the T cell. The molecular events involved with
antigen recognition, T cell response, cytokine production, and chronic inflammation
led to the hypothesis that cell-mediated (rather than antigen-mediated) processes
orchestrated synovial immune responses. Once again, this attractive model repre
sented an over-simplification of the incredibly complex interactions between cells in
the rheumatoid synovium.
Recent data on cytokine profiles, the role of macrophages, and partial transfor
mation of fibroblast-like synoviocytes have raised some questions about this model.
Nevertheless, compelling evidence supports at least some (and perhaps most) of the
key conclusions.
The goal of this book is to outline the major arguments and data suggesting that
T cells may, or may not, be central players in the pathogenesis of chronic RA. While
each of the editors has his own bias (as will be clear by reading the respective chap
ters), our hope is that the readers will enjoy a complete and balanced view of the
critical questions and experiments. This is not just an intellectual exercise; a great
deal is at stake when considering these important questions. Most significant, the
direction of future therapeutic interventions depends heavily on how one interprets
the pathogenesis of RA.
Considerable time and resources need to be devoted to these interventions.
Should they be focused on eliminating articular T cells, or enhancing T cell function
(especially Th2 cells)? Should T cell approaches be abandoned in order to focus on