GROWTH FACTORS AND CYTOKINES IN HEALTH AND DISEASE A Multi-Volume Treatise Volume 3A 1997 SYSTEMS TTTTTTTTTTTTTThhhhhhhhhhhhhhiiiiiiiiiiiiiissssssssssssss PPPPPPPPPPPPPPaaaaaaaaaaaaaaggggggggggggggeeeeeeeeeeeeee IIIIIIIIIIIIIInnnnnnnnnnnnnntttttttttttttteeeeeeeeeeeeeennnnnnnnnnnnnnttttttttttttttiiiiiiiiiiiiiioooooooooooooonnnnnnnnnnnnnnaaaaaaaaaaaaaallllllllllllllllllllllllllllyyyyyyyyyyyyyy LLLLLLLLLLLLLLeeeeeeeeeeeeeefffffffffffffftttttttttttttt BBBBBBBBBBBBBBllllllllllllllaaaaaaaaaaaaaannnnnnnnnnnnnnkkkkkkkkkkkkkk GROWH FACTORS AND CYJOKINES IN HEALTH AND DISEASE A Multi-Volume Treatise SYSTEMS Editors: DEREK LEROITH Diabetes Branch NlDDK National Institutes of Health Bethesda, Maryland CAROLYN BONDY Developmental Endocrine Branch NlCH D National Institutes of Health Bethesda, Maryland ~ Volume 3A 1997 @ JAI PRESS INC. Greenwich, Connecticut London, England Copyright 0 7 997 )A1 PRESS INC. 55 Old Post Road No. 2 Greenwich, Connecticut 06836 MI PRESS LTD. 38 Javistock Street Covent Garden London WC2E 7PB England All rights reserved. No part of this publication may be reproduced, stored on a retrieval system, or transmitted in any way, or by any means, electronic, mechanical, photocopying, recording, filming or otherwise without prior permission in writing from the publisher. ISBN: 0-7623-07 78-X Manufactured in the United States of America CONTENTS LIST OF CONTRIBUTORS ix PREFACE ... Derek LeRoith and Carolyn Bondy Xlll PART A GROWTH FACTORS AND CYTOKINES IN THE FETUS AND PLACENTA David). Hill and Victor K.M . Han 1 THE IMMUNE SYSTEM: A FUNCTIONAL PERSPECTIVE Philip ). Morrissey 55 GROWTH FACTORS AND BONE Anne M. Delany and Ernest0 Canalis 127 HEMATOPOIESIS: CLINICAL APPLICATION OF COLONY STl MUL ATlN G FACTORS lohn E. )anik and Langdon 1. Miller 157. IN SU LIN -LIK E GROWTH FACTOR BINDING PROTEI NS David R. Clernrnons 191 GROWTH FACTORS AND CYTOKINES IN THE REPRODUCTIVE TRACT OF WOMEN: PHYSIOLOGY AND PATHOPHYSIOLOGY Linda C. Giudice, Yasrnin A. Chandrasekher, Nicholas A. Cataldo, Thierry van Dessel, Walid Saleh, 0.W . Stephanie Yap, and Gary A. Ulaner 223 V TTTTTTTTTTTTTThhhhhhhhhhhhhhiiiiiiiiiiiiiissssssssssssss PPPPPPPPPPPPPPaaaaaaaaaaaaaaggggggggggggggeeeeeeeeeeeeee IIIIIIIIIIIIIInnnnnnnnnnnnnntttttttttttttteeeeeeeeeeeeeennnnnnnnnnnnnnttttttttttttttiiiiiiiiiiiiiioooooooooooooonnnnnnnnnnnnnnaaaaaaaaaaaaaallllllllllllllllllllllllllllyyyyyyyyyyyyyy LLLLLLLLLLLLLLeeeeeeeeeeeeeefffffffffffffftttttttttttttt BBBBBBBBBBBBBBllllllllllllllaaaaaaaaaaaaaannnnnnnnnnnnnnkkkkkkkkkkkkkk CONTENTS LIST OF CONTRIBUTORS IX PREFACE ... Derek LeRoith and Carolyn Bondy Xlll PART B GROWTH FACTORS AND CYTOKINES IN HEALTH AND DISEASE: BREAST CANCER Carlos 1. Arteaga 293 INSULIN-LIKE GROWTH FACTORS AND CYTOKINES IN PE DI A TRl C CANCER lee 1. Helman and Leonard H. Wexler 331 GROWTH FACTORS IN LUNG CANCER: CURRENT STATUS AND IMPLICATIONS FOR THERAPY Stefan C. Grant, Sally A. lynch, andlohn Mendelsohn 355 GROWTH FACTORS AND CYTOKINES IN TUMOR INVASION AND METASTASIS Marie E. Beckner and lance A. liotta 381 THERAPEUTIC POTENTIAL OF NERVE GROWTH FACTOR IN ALZHEIMER’S DISEASE Michael S. Saporito and Susan Carswell 439 CMOKINES AND OSTEOPOROSIS Weerapan Khovidhunkit and Solomon Epstein 459 vii ... Vlll CONTENTS GROWTH FACTORS AND WOUND HEALING Paul Martin, lane McCluskey, Patrick Mallucci, and Sue Nodder 499 Index 529 LIST OF CONTRIBUTORS Carlos L Arteaga Departments of Medicine and Cell Biology Vanderbilt University School of Medicine Marie Beckner Laboratory of Pathology Bethesda, Maryland Ernesto Canalis Department of Research Saint Francis Hospital and Medical Center Susan Carswell Cephalon, Inc. West Chester, Pennsylvania Nicholas A. Cataldo Department of Obstetrics, Gynecology, and Reproductive Sciences University of California, San Francisco Yasmin A. Chandrasekher Department of Gynecology and Obstetrics Division of Reproductive Endocrinology Stanford University Medical Center David R. Clemmons Department of Medicine University of North Carolina School of Medicine Anne M. Delany Departments of Research and Medicine Saint Francis Hospital and Medical Center Solomon Epstein Department of Medicine Albert Einstein Medical Center
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