Systemic Lupus Erythematosus

161 Pages·2016·3.103 MB·English

by  Caroline Gordon, David Isenberg (ed.)

O R L
OXFORD RHEUMATOLOGY LIBRARY
Systemic Lupus
Erythematosus

O R L
OXFORD RHEUMATOLOGY LIBRARY
Systemic Lupus
Erythematosus
Edited by
Professor Caroline Gordon
Professor of Rheumatology, College of Medical and Dental Sciences,
University of Birmingham, UK
Professor David Isenberg
Diamond Jubilee Arthritis Research UK Professor of Rheumatology,
University College London, London, UK
1
3
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Contents
Contributors vii
Abbreviations ix
 History of systemic lupus erythematosus  
Manuel F. Ugarte-Gil and Graciela S. Alarcón
2 Aetiopathogenesis of systemic lupus erythematosus  7
Peter Lloyd, Sarah Doaty, and Bevra H. Hahn
3 Epidemiology of systemic lupus erythematosus  23
Caroline Gordon and S. Sam Lim
4 Clinical features of systemic lupus erythematosus  45
Ben Rhodes and Caroline Gordon
v
5 Laboratory tests and investigations  63
Anthony Isaacs and David Isenberg
6 Conventional treatments in systemic lupus erythematosus  79
Anisur Rahman
7 Biologic therapies in systemic lupus erythematosus  89
Maria Mouyis and David Isenberg
8 Juvenile systemic lupus erythematosus  03
Claire Louise Murphy, Yiannis Ioannou, and Nicola Ambrose
9 Management of special situations in systemic lupus erythematosus  7
April Jorge and Rosalind Ramsey-Goldman
Index  35

Contributors
Dr Graciela S. Alarcón Dr S. Sam Lim
Division of Clinical Immunology and Department of Medicine, Division
Rheumatology, University of Alabama of Rheumatology, Emory University,
at Birmingham, AL, USA Atlanta, GA, USA
Dr Nicola Ambrose Dr Peter Lloyd
Adolescent and Adult Rheumatology University of California Los Angeles,
Unit, University College London Los Angeles, CA, USA
Hospitals, London, UK
Dr Maria Mouyis
Dr Sarah Doaty
Centre for Rheumatology, University
University of California Los Angeles, College Hospital, London, UK
Los Angeles, CA, USA
Dr Claire Louise Murphy
Professor Caroline Gordon Adolescent and Adult Rheumatology vii
College of Medical and Dental Sciences, Unit, University College London
University of Birmingham, UK Hospitals, London, UK
Professor Bevra H. Hahn Professor Anisur Rahman
University of California Los Angeles, Centre for Rheumatology, University
Los Angeles, CA, USA College London, London, UK
Dr Yiannis Ioannou Professor Rosalind
Ramsey-Goldman
Adolescent and Adult Rheumatology
Unit, University College London Northwestern University Feinberg
Hospitals, London, UK School of Medicine, Chicago, IL, USA
Dr Anthony Isaacs Dr Ben Rhodes
Centre for Rheumatology, University Department of Rheumatology,
College Hospital, London, UK Queen Elizabeth Hospital Birmingham,
Birmingham, UK
Professor David Isenberg
Dr Manuel F. Ugarte-Gil
Centre for Rheumatology, University
College London, London, UK Hospital Guillermo Almenara Irigoyen,
EsSalud, Lima, Peru
Dr April Jorge
Northwestern University Feinberg
School of Medicine, Chicago, IL, USA

Abbreviations
ACR American College of Rheumatology
6-MP 6-mercaptopurine
ACC American College of Cardiology
ACIP Advisory Committee on Immunization Practices (USA)
AHA American Heart Association
ALMS Aspreva Lupus Management Study
ALP alkaline phosphatase
ALT alanine amino transferase
ANA antinuclear antibodies
anti-Sm anti-Smith antibodies
apoA- apolipoprotein A-
APPLE Atherosclerosis Prevention in Pediatric Lupus Erythematosus
ix
APRIL a proliferation-inducing ligand
APS antiphospholipid syndrome
APTT activated partial thromboplastin time
AST aspartate aminotransferase
AutoAb autoantibody
BAFF B cell activating factor
BAL bronchoalveolar lavage
BCMA B cell maturation antigen
BICLA BILAG-based composite lupus assessment
BILAG British Isles Lupus Assessment Group
BLyS B lymphocyte stimulator inhibitor
BMD bone mineral density
BMI body mass index
Breg B-regulatory (cell)
CAPS catastrophic antiphospholipid syndrome
CCP cyclic citrullinated peptide
CI confidence interval
CIMT carotid intima-media thickness
CIN cervical intraepithelial neoplasia
CK creatine kinase
CKD chronic kidney disease
CLASI cutaneous lupus erythematosus disease area and severity index