Synthetic Immunology

210 Pages·2016·5.75 MB·English

by  Takeshi Watanabe

Takeshi Watanabe · Yousuke Takahama
Editors
Synthetic
Immunology
Synthetic Immunology
ThiSisaFMBlankPage
Takeshi Watanabe (cid:129) Yousuke Takahama
Editors
Synthetic Immunology
Editors
TakeshiWatanabe YousukeTakahama
KitanoHospital DivisionofExperimentalImmunology
Kita-ku,Osaka UniversityofTokushima
Japan Tokushima
Japan
ISBN978-4-431-56025-8 ISBN978-4-431-56027-2 (eBook)
DOI10.1007/978-4-431-56027-2
LibraryofCongressControlNumber:2016939272
©SpringerJapan2016
Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof
the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations,
recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission
or information storage and retrieval, electronic adaptation, computer software, or by similar or
dissimilarmethodologynowknownorhereafterdeveloped.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this
publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt
fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse.
Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthis
book are believed to be true and accurate at the date of publication. Neither the publisher nor the
authors or the editors give a warranty, express or implied, with respect to the material contained
hereinorforanyerrorsoromissionsthatmayhavebeenmade.
Printedonacid-freepaper
ThisSpringerimprintispublishedbySpringerNature
TheregisteredcompanyisSpringerJapanKK
Preface for Synthetic Immunology
Immunologyhasdevelopedrapidlyoverthelast50yearsthroughtheincorporation
of new technologies and concepts in cell and molecular biology, genetics, geno-
mics, and proteomics. This progress is the result of works by many scientists all
over the world. Currently, immunological research has accumulated detailed
knowledge on various mechanisms of immunity and is in the process to change
medical practices. Yet, due to the enormous complexity of the immune system,
many aspects on the regulation and function of the immune system remain
unknown.Syntheticbiologyisanemergingresearchfieldthatusesgain-of-function
rather than loss-of-function approaches. The goals of synthetic biology can be
described in a simple phrase “rebuild, alter, and understand,” namely, to rebuild
minimal functional systems using well-defined parts from nature and then to
perturb the system to understand its working principles. Given the richness of
accumulated knowledge in molecular and cellular mechanisms of the immune
system, we may now begin adapting the concepts of synthetic biology to immu-
nology.Withthisinmind,wehaveexperimentallystartedSyntheticImmunology
Workshopin2010andhaveorganizedfourmeetings,includingthreeinternational
meetings,bynow.Animmuneresponseisaspatiotemporalphenomenonoccurring
atagiventimeandataspecialized placeinthebody.Thus,onegoalofsynthetic
immunologyistoreconstructartificialmicroenvironmentsforbetterunderstanding
of an immune response in four dimensions. For this reason, one central theme of
synthetic immunology is “the synthesis of lymphoid niches and organs for lym-
phocytedevelopmentandfunction,”whichistheviewpointofthisbook.Wehope
thisyet-to-be-experimentalapproachofsyntheticimmunologyandthecompilation
of this book will aid our further understanding of the immune system and future
devisingthetoolstomanipulatetheimmunesystemfortherapyandpreventionof
the diseases. This book consists of the development and regeneration of immune
v
vi PrefaceforSyntheticImmunology
cells (Chaps. 1 and 2), the immune organ development and artificial regeneration
(Chaps. 3, 4, 5, and 6), and the synthetic approach towards understanding human
immunesystem(Chaps.7,8,and9).
Osaka,Japan TakeshiWatanabe
Tokushima,Japan YousukeTakahama
Contents
1 DevelopmentandRegenerationofHematopoieticStemCells. . . . . . 1
DanielJ.WescheandHiromitsuNakauchi
2 GenerationandRegenerationofTCells. . . . . . . . . . . . . . . . . . . . . . 31
HiroshiKawamoto,TomokatsuIkawa,TakuyaMaeda,
andKyokoMasuda
3 StrategiesforThymicRegeneration:RecentAdvancesTowards
ClinicalTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
MarcoBarsanti,MichaelHun,RichardBoyd,andAnnChidgey
4 ArtificialThymus:RecreatingMicroenvironmentalCuestoDirect
TCellDifferentiationandThymicRegeneration. . . . . . . . . . . . . . . 95
MahmoodMohtashami,ShreyaShukla,PeterZandstra,
andJuanCarlosZu´~niga-Pflu¨cker
5 SpleenDevelopmentandtheOriginofStromalDiversity. . . . . . . . . 121
ElisaLentiandAndreaBrendolan
6 ControllingLymphoidDevelopment. . . . . . . . . . . . . . . . . . . . . . . . . 135
SergioA.LiraandGlauciaC.Furtado
7 SynthesisofFunctionalTertiaryLymphoidOrgans. . . . . . . . . . . . . 151
YukaKobayashi,KoichiKato,MakotoNakamura,
andTakeshiWatanabe
8 GrowingaSurrogateOrganinLymphNode. . . . . . . . . . . . . . . . . . 171
EricLagasse
9 EngineeringofArtificialLymphNode. . . . . . . . . . . . . . . . . . . . . . . 181
MakotoNakamura,KenichiArai,TakahitoMimura,JungoTagawa,
HirotoshiYoshida,KoichiKato,TadashiNakaji-Hirabayashi,
YukaKobayashi,andTakeshiWatanabe
vii
ThiSisaFMBlankPage
Editors and Contributors
Editors
Yousuke Takahama, Division of Experimental Immunology, Institute for
GenomeResearch,UniversityofTokushima,Tokushima,Japan
Takeshi Watanabe, The Tazuke-Kofukai Medical Research Institute, Kitano
Hospital,Kita-ku,Osaka,Japan
Contributors
KenichiArai, GraduateSchoolofScienceandEngineeringforResearch,Univer-
sityofToyama,Toyama,Japan
Marco Barsanti, Department of Anatomy and Developmental Biology, Monash
University,Melbourne,Australia
Richard Boyd, Department of Anatomy and Developmental Biology, Monash
University,Melbourne,Australia
Andrea Brendolan, Division of Experimental Oncology, IRCCS San Raffaele
ScientificInstitute,Milan,Italy
Ann Chidgey, Department of Anatomy and Developmental Biology, Monash
University,Melbourne,Australia
Glaucia C. Furtado, Immunology Institute, Icahn School of Medicine at Mount
Sinai,NewYork,NY,USA
Michael Hun, Department of Anatomy and Developmental Biology, Monash
University,Melbourne,Australia
ix