SyntheticBiology Editedby RobertA.Meyers RelatedTitles Meyers,R.A.(ed.) Luisi,P.P.(ed.) EncyclopediaofMolecular ChemicalSyntheticBiology CellBiology andMolecular 2011 Medicine ISBN:978-0-470-71397-6,alsoavailable indigitalformats 2007 OnlineISBN:978-3-527-60090-8 www.meyers-emcbmm.com Kahl,G. TheDictionary of Schmidt,M.(ed.) Genomics,Transcriptomics SyntheticBiology andProteomics IndustrialandEnvironmental 5thEdition Applications 2015 2012 ISBN:978-3-527-32852-9,alsoavailable ISBN:978-3-527-33183-3,alsoavailable indigitalformats indigitalformats Synthetic Biology Advances in Molecular Biology and Medicine Edited by Robert A. Meyers Volume 1 Synthetic Biology Advances in Molecular Biology and Medicine Edited by Robert A. Meyers Volume 2 TheEditor AllbookspublishedbyWiley-VCHarecarefully produced.Nevertheless,authors,editors,andpub- Dr.RobertA.Meyers lisherdonotwarranttheinformationcontained Editor-in-Chief inthesebooks,includingthisbook,tobefreeof RamtechLimited errors.Readersareadvisedtokeepinmindthat 122,EscalleLane statements,data,illustrations,proceduraldetails Larkspur,CA94939 orotheritemsmayinadvertentlybeinaccurate. USA LibraryofCongressCardNo.:appliedfor Cover BritishLibraryCataloguing-in-PublicationData Designandcustomizationofmicrocompartments. Acataloguerecordforthisbookisavailablefrom ©MartinJ.Warren.Detailfromfigure12in theBritishLibrary. chapter13‘‘SyntheticBiologyinMetabolic Engineering:FromComplexBiochemical Bibliographicinformationpublishedbythe PathwaystoCompartmentalizedMetabolic DeutscheNationalbibliothek Processes–aVitaminConnection’’. TheDeutscheNationalbibliothekliststhispublica- tionintheDeutscheNationalbibliografie;detailed bibliographicdataareavailableontheInternetat <http://dnb.d-nb.de>. ©2015Wiley-VCHVerlagGmbH&Co.KGaA, Boschstr.12,69469Weinheim,Germany Allrightsreserved(includingthoseoftranslation intootherlanguages).Nopartofthisbookmaybe reproducedinanyform–byphotoprinting, microfilm,oranyothermeans–nortransmitted ortranslatedintoamachinelanguagewithout writtenpermissionfromthepublishers. Registerednames,trademarks,etc.usedinthis book,evenwhennotspecificallymarkedassuch, arenottobeconsideredunprotectedbylaw. PrintISBN:978-3-527-33482-7 ePDFISBN:978-3-527-66855-7 ePubISBN:978-3-527-66856-4 MobiISBN:978-3-527-66857-1 CoverDesign AdamDesign,Weinheim,Germany Typesetting LaserwordsPrivateLimited,Chennai, India PrintingandBinding MarkonoPrintMediaPte Ltd,Singapore Printedonacid-freepaper V Contents Preface IX Volume1 1 SyntheticBiology:ImplicationsandUses 1 SanjayVashee,MikkelA.Algire,MichaelG.Montague,andMicheleS.Garfınkel PartI BiologicalBasis 33 2 TheEmergenceoftheFirstCells 35 AntoineDanchin 3 RegulationofGeneExpression 61 AnilKumar,SarikaGargandNehaGarg 4 Interactome 121 TeresaM.PrzytyckaandDong-YeonCho 5 Microbiomes 153 RamanaMadupu,Yu-HuiRogers,DougRusch,JasonMiller, KonstantinosKrampis,andKarenE.Nelson PartII Modeling 179 6 DynamicsofBiomolecularNetworks 181 EmanueleCozzo,Joaqu´ınSanz,andYamirMoreno 7 E-Cell:ComputerSimulationoftheCell 211 PawanK.Dhar,KouichiTakahashi,YoichiNakayama,andMasaruTomita 8 SynBioSSDesignerModelingSuite 229 KonstantinosBiliouris,EmmaWeeding,andYiannisN.Kaznessis VI Contents PartIII ModularPartsandCircuits 247 9 SyntheticGeneCircuits 249 BarbaraJusiak,RamizDaniel,FahimFarzadfard,LiorNissim,OliverPurcell, JacobRubensandTimothyK.Lu 10 DNAOrigamiNanorobots 305 IdoBachelet 11 RNAiSyntheticLogicCircuitsforSensing,InformationProcessing,and Actuation 333 ZhenXie,LilianaWroblewska,andRonWeiss 12 SyntheticHybridBiosensors 357 ApoorvShanker,KangwonLee,andJinsangKim 13 SyntheticBiologyinMetabolicEngineering:FromComplexBiochemical PathwaystoCompartmentalizedMetabolicProcesses–aVitaminConnection 393 EvelyneDeery,StefanieFrank,AndrewLawrence,SimonMoore, SusanneSchroeder,andMartinJ.Warren Volume2 PartIV SyntheticGenomes 441 14 TheMinimalGene-SetMachinery 443 RosarioGil 15 ProductionofMitochondrialGenomeandChromosomalDNASegments HighlyEngineeredforUseinMouseGeneticsbyaBacillussubtilis-Based BGMVectorSystem 479 MitsuhiroItaya 16 SyntheticGeneticPolymersFunctioningtoStoreandPropagateInformation byGeneticAlphabetExpansion 505 IchiroHirao PartV DiseasesandTherapeutics 521 17 SyntheticBiologyApproachesforRegenerativeMedicine 523 EliseCachat,KimC.Martin,andJamieA.Davies 18 TheSyntheticBiologyApproachtoStemCellsandRegenerativeMedicine 541 BoonChinHeng,andMartinFussenegger 19 SyntheticBiologyApproachestoCellTherapy 559 Sung-HoPaekandWarrenC.Ruder Contents VII 20 SyntheticBiologyApproachesforVaccineDevelopment 589 SamH.Shen,BruceFutcher,ChenYang,andEckardWimmer PartVI ChemicalsProduction 617 21 MetabolicEngineeringfortheProductionofDiols 619 KatarzynaLeja,DorotaSamul,PiotrKubiak,AgnieszkaDroz˙dz˙yn´ska, AlicjaKo´smider,WojciechJuzwa,MariuszLesiecki,andKatarzynaCzaczyk 22 SyntheticBiologyinBiofuelsProduction 665 RahulSingh,AnuJoseMattam,PavanJutur,andSyedShamsYazdani 23 SyntheticBiologyofAntibioticProduction 699 ErikoTakanoandRainerBreitling Index 723