Synaptic Plasticity and the Mechanism of Alzheimer's Disease PDF
Preview Synaptic Plasticity and the Mechanism of Alzheimer's Disease
researchandperspectivesinalzheimer’sdisease Dennis J. Selkoe Antoine Triller Yves Christen (Eds.) Synaptic Plasticity and the Mechanism of Alzheimer’s Disease With34Figures,28incolor 123 Dr.DennisJ.Selkoe CenterforNeurologicDiseases BrighamandWomen’sHospital HarvardMedicalSchool Boston,MA02115,USA email:[email protected] Dr.AntoineTriller Dr.YvesChristen LaboratoiredeBiologieCellulairedelaSynapse FondationIPSEN Institut National de la Santé et de la Recherche PourlaRechercheThérapeutique MédicaleUnite789 24,rueErlanger EcoleNormaleSupérieure,46rued’Ulm 75781ParisCedex16 75005Paris France France email:[email protected] email:[email protected] ISBN 978-3-540-76329-1 e-ISBN 978-3-540-76330-7 DOI10.1007/978-3-540-76330-7 LibraryofCongressControlNumber:2007938204 ©2008Springer-VerlagBerlinHeidelberg Thisworkissubjecttocopyright.Allrightsarereserved,whetherthewholeorpartofthematerial isconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation,broad- casting,reproductiononmicrofilmorinanyotherway,andstorageindatabanks.Duplicationof thispublicationorpartsthereofispermittedonlyundertheprovisionsoftheGermanCopyrightLaw ofSeptember9,1965,initscurrentversion,andpermissionforusemustalwaysbeobtainedfrom Springer.ViolationsareliabletoprosecutionundertheGermanCopyrightLaw. Theuseofgeneraldescriptivenames,registerednames,trademarks,etc.inthispublicationdoesnot imply, even in the absence of a specific statement, thatsuch names are exempt from the relevant protectivelawsandregulationsandthereforefreeforgeneraluse. Typesetting:LE-TEXJelonek,Schmidt&VöcklerGbR,Leipzig,Germany Production:LE-TEXJelonek,Schmidt&VöcklerGbR,Leipzig,Germany Coverdesign:WMXDesignGmbH,Heidelberg Printedonacid-freepaper 987654321 springer.com Preface Remarkable progress has been made in Alzheimer’s research over the last decade. Our understanding of which molecular mechanisms are involved in the cascade of events characteristic of the disease is growing. However, the mechanisms by which theyinducedeleteriouseffectarestillnotclear.Manyrecentstudieshaveconfirmed thatthesynapseisakeytargetinthepathogenesisofAlzheimer’sdisease.Notonly β doessynapticlossoccuratanearlystageofthedisease,butitseemsthat -amyloid peptidedepositsormicrotubulardisordersaffectsynapticfunction.Thismayexplain thememorydeficitsthataresocharacteristicofthedisease.Itisthereforelogicalto investigate therapeutic approaches targeting the deleterious mechanisms that affect the synapse. This area of research promises to be all the more productive because synapticdysfunctionisinvolvedinvariousotherneurodegenerativediseasesor,more generallyspeaking,centralnervoussystemdisorders. Thisnewawarenesshasemergedatatimewhenneuroscientificresearchisuncov- eringmoreaboutsynapticfunctionandthemultipleproteinsitinvolves;henceour decision to invite both fundamental researchers in synaptic biology and specialists inneurogenerativediseasetotheColloqueMédecineetRechercheorganizedbythe FondationIpseninParisonApril16,2007. D.J.Selkoe,A.TrillerandY.Christen Acknowledgements. TheeditorswanttothankJacquelineMervaillie,AstriddeGérardand SoniaLeCornecfortheorganizationofthismeetingandMaryLynnGagefortheeditingofthe book. TableofContents PermanenceoftheSynapseandMolecularInstability M.Renner,A.Triller...................................................... 1 CellularBiologyofAMPAReceptorTraffickingandSynapticPlasticity J.A.Esteban ............................................................. 19 ImagingofExperience-DependentStructuralPlasticity intheMouseNeocortexinvivo A.Holtmaat,V.DePaola,L.Wilbrecht,G.Knott.............................. 37 SynapseLoss,SynapticPlasticityandthePostsynapticDensity M.Sheng ............................................................... 51 ImpactofBetaAmyloidonExcitatorySynapticTransmissionandPlasticity R.Malinow,H.Hsieh,W.Wei.............................................. 63 QuantitativeNeuropathologyinAlzheimer’sMouseModels F.E.Bloom .............................................................. 69 MultipleLevelsofSynapticRegulationbyNMDA-typeGlutamateReceptor inNormalandDiseaseStates V.A.Alvarez,G.M.Shankar,B.L.Bloodgood,D.J.Selkoe,B.L.Sabatini ........... 75 β SolubleOligomersoftheAmyloid -Protein: ImpairSynapticPlasticityandBehavior D.J.Selkoe .............................................................. 89 WhyAlzheimer’sisaDiseaseofMemory: β SynapticTargetingbyPathogenicA Oligomers(ADDLs) W.L.Klein,F.d.Felice,P.N.Lacor,M.P.Lambert,W.-Q.Zhao ................... 103 SynapticTransmissionDynamicallyModulates β InterstitialFluidAmyloid- Levels J.R.Cirrito,F.R.Stewart,S.Mennerick,D.M.Holtzman........................ 133 β A -InducedToxicityMediatedbyCaspaseCleavage oftheAmyloidPrecursorProtein(APP) E.H.Koo,D.E.Bredesen................................................... 145 VIII TableofContents β β Long-TermPotentiationandA :TargetingA Species,CellularMechanisms andPutativeReceptors M.J.Rowan,I.Klyubin,W.K.Cullen,N.W.Hu,R.Anwyl ....................... 157 Genes,SynapsesandAutismSpectrumDisorders T.Bourgeron ............................................................ 169 SubjectIndex ........................................................... 181 ListofContributors Alvarez,VeronicaA. DepartmentofNeurobiology,HarvardMedicalSchool,BostonMA02115,USA Anwyl,Roger DepartmentofPhysiology,andTrinityCollegeInstituteofNeuroscience,TrinityCol- legeDublin2,Ireland Bloodgood,BrendaL. DepartmentofNeurobiology,HarvardMedicalSchool,BostonMA02115,USA Bloom,FloydE. MolecularandIntegrativeNeuroscienceDepartment,TheScrippsResearchInstitute, LaJollaCA92037,USA Bourgeron,Thomas InstitutPasteur,UniversitéDenisDiderotParis7,25rueduDocteurRoux,75724Paris Cedex15,France Bredesen,DaleE. Buck Institute for Age Research, Novato, CA 94945 and Department of Neurology, UniversityofCalifornia,SanFranciscoCA94143,USA Cirrito,JohnR. Department of Psychiatry, Neurology, Molecular Biology and Pharmacology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis,MO63110,USA Cullen,WilliamK. DepartmentofPharmacology&Therapeutics,BiotechnologyBuilding,TrinityCollege Dublin2,Ireland DeFelice,Fernanda Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer’s DiseaseCenter,NorthwesternUniversity,Evanston,IL60208 X ListofContributors Esteban,JoséA. DepartmentofPharmacology,UniversityofMichiganMedicalSchool,AnnArbor,MI 48109-0632,USA DePaola,V. ColdSpringHarborlaboratory,ColdSpringHarbor,NewYork11724,USA MRC-Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom Holtmaat,Antony ColdSpringHarborlaboratory,ColdSpringHarbor,NewYork11724,USA Départment des Neurosciences fondamentales, University of Geneva, 1211 Geneve, Switzerland Holtzman,DavidM. Department of Neurology, Molecular Biology and Pharmacology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110,USA Hsieh,Helen WatsonSchoolofBiologicalSciences,ColdSpringHarborLaboratory,NewYork,NY 11724-2213,USA Hu,NengWei DepartmentofPharmacology&Therapeutics,BiotechnologyBuilding,TrinityCollege Dublin2,Ireland Klein,WilliamL. Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer’s DiseaseCenter,NorthwesternUniversity,Evanston,IL60208 Klyubin,Igor DepartmentofPharmacology&Therapeutics,BiotechnologyBuilding,TrinityCollege Dublin2,Ireland Knott,Graham Départment de Biologie Cellulaire et de Morphologie, University of Lausanne, 1005 Lausanne,Switzerland Koo,EdwardH. DepartmentofNeurosciences,UniversityofCalifornia,SanDiego,LaJollaCA92037, USA Lacor,PascaleN. Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer’s DiseaseCenter,NorthwesternUniversity,EvanstonIL60208,USA ListofContributors XI Lambert,MaryP. Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer’s DiseaseCenter,NorthwesternUniversity,EvanstonIL60208,USA Malinow,Roberto ColdSpringHarborLaboratory,ColdSpringHarbor,NewYorkNY11724,USA StateUniversityofNewYorkandStonybrook,Dept.Neurobiology,USA WatsonSchoolofBiologicalSciences,ColdSpringHarborLaboratory,USA Mennerick,Steven DepartmentofPsychiatry,Anatomy,andNeurolobiology,HopeCenterforNeurological Disorders,WashingtonUniversitySchoolofMedicine,St.Louis,Missouri,63110,USA Renner,Marianne LaboratoiredeBiologieCellulairedelaSynapse,InstitutNationaldelaSantéetdela RechercheMédicaleUnite789,EcoleNormaleSupérieure,46rued’Ulm,75005Paris, France Rowan,MichaelJ. DepartmentofPharmacology&Therapeutics,BiotechnologyBuilding,TrinityCollege Dublin2,Ireland Sabatini,BernardoL. DepartmentofNeurobiology,HarvardMedicalSchool,BostonMA02115,USA Selkoe,DennisJ. CenterforNeurologicDiseases,BrighamandWomen’sHospitalandHarvardMedical School,BostonMA02115,USA Shankar,GaneshM. DepartmentofNeurobiology,HarvardMedicalSchool,BostonMA02115,USA CenterforNeurologicDiseases,BrighamandWomen’sHospitalandHarvardMedical School,BostonMA02115,USA Sheng,Morgan The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, DeptsofBrainandCognitiveSciences,andBiology,MassachusettsInstituteofTech- nology,77MassachusettsAvenue(46-4303)CambridgeMA02139,USA Stewart,FloyR. DepartmentofNeurology,HopeCenterforNeurologicalDisorders,WashingtonUni- versitySchoolofMedicine,St.Louis,MO63110,USA Triller,Antoine LaboratoiredeBiologieCellulairedelaSynapse,InstitutNationaldelaSantéetdela RechercheMédicaleUnite789,EcoleNormaleSupérieure,46rued’Ulm,75005Paris, France
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