Symptoms of Parkinson's disease

212 Pages·2011·3.565 MB·English

by  Abdul Qayyum Rana

SYMPTOMS OF
PARKINSON'S DISEASE

Edited by Abdul Qayyum Rana
Symptoms of Parkinson's Disease
Edited by Abdul Qayyum Rana

Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia

Copyright © 2011 InTech
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Publishing Process Manager Silvia Vlase
Technical Editor Teodora Smiljanic
Cover Designer Jan Hyrat
Image Copyright Laurin Rinder, 2011. Used under license from Shutterstock.com

First published September, 2011
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]

Symptoms of Parkinson's Disease, Edited by Abdul Qayyum Rana
p. cm.
978-953-307-464-1
free online editions of InTech
Books and Journals can be found at
www.intechopen.com

Contents

Preface IX
Chapter 1 Cognitive Dysfunction in Parkinson’s Disease 1
Sara Varanese, Bernardo Perfetti and
Alessandro Di Rocco
Chapter 2 Cognition and Gait Disturbances in Parkinson's Disease 25
Samo Ribarič
Chapter 3 Nocturnal Disturbances in
Patients with Parkinson’s Disease 53
Keisuke Suzuki, Tomoyuki Miyamoto,
Masayuki Miyamoto, Masaoki Iwanami and
Koichi Hirata
Chapter 4 Neuropsychological Deficits
in Initial Parkinson’s Disease 69
Raquel Rodriguez Fernandez and Jose Antonio Muñiz Casado
Chapter 5 Pathophysiology of Drug-Induced Dyskinesias 83
Christopher A. Lieu, Vikram Shivkumar,
Timothy P. Gilmour, Kala Venkiteswaran,
Mark J. Nolt, Milind Deogaonkar and
Thyagarajan Subramanian
Chapter 6 Preclinical Solutions for Insight in Premotor Parkinson 115
Ingrid H.C.H.M. Philippens and Peternella S. Verhave
Chapter 7 Cognitive and Psychiatric
Aspects of Parkinson’s Disease 143
Caspar Stephani
Chapter 8 The Psychosocial Impact of Parkinson’s
Disease on the Wider Family Unit:
A Focus on the Offspring of Affected Individuals 165
David Morley
VI Contents

Chapter 9 The Negative Impact of Apathy in Parkinson’s Disease 179
Iracema Leroi
Chapter 10 Gastrointestinal Dysfunction in Parkinson’s Disease 193
Klaus Krogh

Preface

Parkinson’s disease affects many different systems of human body and has both motor
as well as non-motor symptoms. As the disease advances, both motor and non-motor
symptoms progress and result in significant disability. Indeed with progression of
time non-motor symptoms may become major cause of disease caregiver’s burden and
morbidity. This book discusses in detail the various symptoms of Parkinson’s disease.
Postural and gait problems have been discussed at length as they are the main cause of
balance problems. Among the non-motor symptoms cognitive dysfunction which is
one of the important causes of long term care placement has also been reviewed in
detail. A review of gastrointestinal symptoms which affect almost 90% of patient
population has been given as well. A focused discussion of mechanisms involving the
psychiatric and mood disturbances which have a negative impact on the quality of life
of patients has also been provided. In addition to these symptoms, a synopsis of other
non-motor symptoms has also been given so that reader can have familiarity with the
diversity of non-motor symptoms of Parkinson’s disease.
The relevant information is not only detailed but at the same time focused and is
readily available to the reader. Health care professionals and other individuals
working in the field of science can benefit to a great extent from this book.
Every effort has been made to present correct and up to date information in this book
but medicine is a field with ongoing research and development, therefore readers may
use other sources if the content of this book is found to be insufficient. Authors, editor,
and publisher are not responsible for any errors, omissions, or consequences from the
application of this information.

Dr. Abdul Qayyum Rana
Parkinson's Clinic of Eastern Toronto & Movement Disorders Center, Toronto,
Canada