Sweetness and Sweeteners. Biology, Chemistry, and Psychophysics

653 Pages·2008·61.171 MB·English

by  Deepthi K. Weerasinghe and Grant E. DuBois (Eds.)

ACS Symposium Series 979
Sweetness and Sweeteners: Biology,
Chemistry and Psychophysics
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Ajinomoto Company Linguagen Corporation
Cargill Mastertaste
Firmenich Nestlé
Givaudan Quest International
T. Hasegawa Senomyx
Treat PLC The Coca-Cola Company
Kraft Foods Global Inc. The NutraSweet Company
International Flavors & Fragrances Inc.
In Sweetness and Sweeteners; Weerasinghe, D., el al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2008.
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PRINTED IN THE UNITED STATES OF AMERICA
In Sweetness and Sweeteners; Weerasinghe, D., el al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2008.
ACS Symposium Series 979
Sweetness and Sweeteners: Biology,
Chemistry and Psychophysics
g
acs.orw001 Deepthi K. Weerasinghe, Editor
bs.9.f
u7
p9 The Coca-Cola Company
p://8-0
htt00
9 | k-2
0b
er 21, 2010.1021/ GrTahne tC oEc.a D-CuolBa oCiosm pEadnyi tor
8 on Octob2008 | doi: Based on a symposium at the 231st ACS National
34.4h 4,
2c Meeting, Atlanta, Georgia, March 26-30, 2006
16.Mar
1
200.ate:
y D
d bon
deati
wnloaPublic Sponsored by
o
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ACS Division of Agricultural and Food Chemistry
Ajinomoto Company Linguagen Corporation
Cargill Mastertaste
Firmenich Nestlé
Givaudan Quest International
T. Hasegawa Senomyx
Treat PLC The Coca-Cola Company
Kraft Foods Global Inc. The NutraSweet Company
International Flavors & Fragrances Inc.
In Sweetness and Sweeteners; Weerasinghe, D., el al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2008.
Foreword
The ACS Symposium Series was first published in 1974 to pro
vide a mechanism for publishing symposia quickly in book form. The
purpose of the series is to publish timely, comprehensive books devel
oped from ACS sponsored symposia based on current scientific re
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ubs.79.f audience.
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34.4h 4, papers are included in the volumes. Verbatim reproductions of previ
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In Sweetness and Sweeteners; Weerasinghe, D., el al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2008.
Preface
Most living beings aspire for satiety and in acceptance of food products sweet
taste plays a major role. Sugar, which is one of the most commonly used
materials to impart sweet taste, has the disadvantage of being associated with a
number of adverse health related issues. As a result, many research hours are
spent in trying to produce low and non- caloric sweeteners and to modify the
temporal profiles of these to mimic that of sugar.
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wP Synthetic Non-Caloric Sweeteners, and (7) Advances in the Discovery and
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Deepthi Κ Weerasinghe Grant Ε DuBois
Flavor Creation Department Strategic Research Department
The Coca-Cola Company The Coca-Cola Company
P.O.Box 1734 P.O.Box 1734
Atlanta, GA 30301 Atlanta, GA 30301
xv
In Sweetness and Sweeteners; Weerasinghe, D., el al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 2008.
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Biology, Chemistry, andPsychophysics during Nation
ISBN13: 9780841274327 Week 2009, O
Editor(s): Deepthi K. Weerasinghe1, GrantE. DuBois2 eISBN: 9780841221116 24th. To exte
Volume 979 trial period, p
Publication Date (Print): March 04,2008 DOI:10.1021/bk-2008-0979 the recommen
Copyright © 2008 American ChemicalSociety notify your Lib
Information S
1 The Coca-Cola Company
2 The Coca-Cola Company
Sponsoring Divisions:Division of Agricultural & FoodChemistry TheACS Symp
Online
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Sweetness and Sweeteners, Copyright, Foreword First Page
Biology, Chemistry, and Psychophysics
pp i-vii Hi-Res PDF[280K]
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DOI: 10.1021/bk-2008-0979.fw001 PDF w/ Links[281K]
Facts
Sponsored Access Approxima
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900+ books
Symposium
250+ books
Preface First Page Advances i
Deepthi K Weerasinghe and Grant E DuBois Book Serie
Hi-Res PDF[188K] 19,000+ pe
pp xv
chapters
DOI: 10.1021/bk-2008-0979.pr001 PDF w/ Links[189K]
Features
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organizatio
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advanceds
Sweetness and Sweeteners: What Is All the Excitement About? Abstract
Indexed by
Grant E. DuBois Downloada
Hi-Res PDF[1341K]
Chapter 1, pp 1-16 chaptercit
DOI: 10.1021/bk-2008-0979.ch001 PDF w/ Links[1362K]
More Inform
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Subscriptio
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library
STRUCTURAL STUDIES OF THE SWEETENER RECEPTOR
Genetic Architecture of Sweet Taste Abstract StayCurrent
Alexander A. Bachmanov Get your rese
Hi-Res PDF[2756K]
Chapter 2, pp 18-47
e-Alerts|RSS
DOI: 10.1021/bk-2008-0979.ch002
Sponsored Access
Making Sense of the Sweet Taste Receptor Abstract
Peihua Jiang, Emeline Maillet, Meng Cui, Roman Osman, Marianna Max, and Robert F. Margolskee
Hi-Res PDF[1901K]
Chapter 3, pp 48-64
DOI: 10.1021/bk-2008-0979.ch003 PDF w/ Links[1902K]
Sponsored Access
http://w3.hidemyass.com/index.php?q=aHR0cDovL3B1YnMuYWNzLm9yZy9pc2Ju... 23/10/2009
Página 2de 6
T1R2, T1R3, and the Detection of Sweet Stimuli Abstract
Stephan Vigues, Jeanette R. Hobbs, Yiling Nie, Graeme L. Conn, and Steven D. Munger
Hi-Res PDF[955K]
Chapter 4, pp 65-75
DOI: 10.1021/bk-2008-0979.ch004 PDF w/ Links[973K]
Sponsored Access
In Vitro Models to Study Taste: Can Sweetness Be Modeled in a Dish? Abstract
Nancy E. Rawson and M. Hakan Ozdener
Hi-Res PDF[1993K]
Chapter 5, pp 76-93
DOI: 10.1021/bk-2008-0979.ch005 PDF w/ Links[2001K]
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MODELING OF THE SWEETENER RECEPTOR
Structure-Activity Relationship and AH-B after 40 Years Abstract
Terry E. Acree and Michael Lindley
Hi-Res PDF[1243K]
Chapter 6, pp 96-108
DOI: 10.1021/bk-2008-0979.ch006 PDF w/ Links[1248K]
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Crystal Structures of the Sweet Protein MNEI: Insights into Sweet Protein-Receptor Abstract
Interactions
Hi-Res PDF[919K]
Jeanette R. Hobbs, Steven D. Munger, and Graeme L. Conn
Chapter 7, pp 109-116 PDF w/ Links[933K]
DOI: 10.1021/bk-2008-0979.ch007
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Molecular Models of Sweet Taste Receptors Provide Insights into Function Abstract
Meng Cui, Peihua Jiang, Emeline Maillet, Marianna Max, Robert F. Margolskee, and Roman Osman
Hi-Res PDF[1835K]
Chapter 8, pp 117-132
DOI: 10.1021/bk-2008-0979.ch008 PDF w/ Links[1861K]
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Pharmacophore Modeling of Sweet and Bitter Tasting Molecules Abstract
Nicolas Froloff
Hi-Res PDF[1316K]
Chapter 9, pp 133-146
DOI: 10.1021/bk-2008-0979.ch009 PDF w/ Links[1327K]
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Multiple Receptors or Multiple Sites? Modeling the Human T1R2-T1R3 Sweet Taste Abstract
Receptor
Hi-Res PDF[1533K]
Gabriella Morini, Angela Bassoli, and Piero A. Temussi
Chapter 10, pp 147-161 PDF w/ Links[1564K]
DOI: 10.1021/bk-2008-0979.ch010
Sponsored Access
Computational Docking to Sweet Taste Receptor Models Abstract
D. Eric Walters
Hi-Res PDF[659K]
Chapter 11, pp 162-167
DOI: 10.1021/bk-2008-0979.ch011 PDF w/ Links[675K]
Sponsored Access
SWEET TASTE TRANSDUCTION
What Can Psychophysical Studies with Sweetness Inhibitors Teach Us about Abstract
Taste?
Hi-Res PDF[1557K]
Veronica Galindo-Cuspinera and Paul A. S. Breslin
Chapter 12, pp 170-184 PDF w/ Links[1565K]
DOI: 10.1021/bk-2008-0979.ch012
Sponsored Access
Abstract
Hi-Res PDF[1671K]
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A Method to Measure Taste Qualities, Taste Intensity, and Temporal Profile of PDF w/ Links[1683K]
Compounds Aimed at Human Consumption by Taste Nerve Recordings in
Sponsored Access
Monkeys
Göran Hellekant and Yiwen Wang
Chapter 13, pp 185-201
DOI: 10.1021/bk-2008-0979.ch013
The Bittersweet Search for Bitter-Sweet Interactions: Cell to Cell Communication Abstract
in the Taste Bud
Hi-Res PDF[1979K]
M. Scott Herness, Fang-li Zhao, and Yu Cao
Chapter 14, pp 202-219 PDF w/ Links[1983K]
DOI: 10.1021/bk-2008-0979.ch014
Sponsored Access
cAMP: A Role in Sweet Taste Adaptation Abstract
Nirupa Chaudhari and Sue C. Kinnamon
Hi-Res PDF[847K]
Chapter 15, pp 220-229
DOI: 10.1021/bk-2008-0979.ch015 PDF w/ Links[863K]
Sponsored Access
Saccharin: Artificial Sweetener, Bitter Tastant, and Sweet Taste Inhibitor Abstract
Marcel Winnig, Christina Kuhn, Oliver Frank, Bernd Bufe, Maik Behrens, Thomas Hofmann, and
Wolfgang Meyerhof Hi-Res PDF[1150K]
Chapter 16, pp 230-240 PDF w/ Links[1161K]
DOI: 10.1021/bk-2008-0979.ch016
Sponsored Access
Permeation of Amphipathic Sweeteners into Taste-Bud Cells and Their Abstract
Interactions with Post-Receptor Signaling Components: Possible Implications for
Sweet-Taste Quality Hi-Res PDF[1708K]
M. Naim, M. E. Shaul, A. I. Spielman, L. Huang, and I. Peri PDF w/ Links[1735K]
Chapter 17, pp 241-255 Sponsored Access
DOI: 10.1021/bk-2008-0979.ch017
QUANTIFYING THE RESPONSES OF SWEET-SENSITIVE TASTE BUD CELLS
We Are What We Eat, but Why? Relationships between Oral Sensation, Genetics, Abstract
Pathology, and Diet
Hi-Res PDF[2670K]
Derek J. Snyder, Valerie B. Duffy, Susan E. Marino, and Linda M. Bartoshuk
Chapter 18, pp 258-284 PDF w/ Links[2684K]
DOI: 10.1021/bk-2008-0979.ch018
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Perception and Acceptance of Sweeteners Abstract
Jeannine F. Delwiche and Amanda R. Warnock
Hi-Res PDF[1199K]
Chapter 19, pp 285-295
DOI: 10.1021/bk-2008-0979.ch019 PDF w/ Links[1215K]
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Interindividual Differences of Taste Sensitivity in Humans and Hamsters: Multiple Abstract
Receptor Sites for Single Organic Molecules
Hi-Res PDF[3694K]
Annick Faurion
Chapter 20, pp 296-334 PDF w/ Links[3708K]
DOI: 10.1021/bk-2008-0979.ch020
Sponsored Access
The "Bitter-Sweet" Truth of Artificial Sweeteners Abstract
C. T. Simons, C. Adam, G. LeCourt, C. Crawford, C. Ward, W. Meyerhof, and J. P. Slack
Hi-Res PDF[1844K]
Chapter 21, pp 335-354
DOI: 10.1021/bk-2008-0979.ch021 PDF w/ Links[1848K]
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Abstract
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Página 4de 6
The Use of Rodent Models to Link Neurobiological Processes with the Hi-Res PDF[1192K]
Psychophysics of Sweet Taste PDF w/ Links[1202K]
A. C. Spector, S. Eylam, and C. D. Dotson
Sponsored Access
Chapter 22, pp 355-366
DOI: 10.1021/bk-2008-0979.ch022
MODULATION OF SWEET-SENSITIVE TASTE BUD CELL SIGNALING
Functional Characterization of the Human Sweet Taste Receptor: High-Throughput Abstract
Screening Assay Development and Structural Function Relation
Hi-Res PDF[1767K]
Xiaodong Li and Guy Servant
Chapter 23, pp 368-385 PDF w/ Links[1768K]
DOI: 10.1021/bk-2008-0979.ch023
Sponsored Access
Development of Transient Receptor Potential Melanostatin 5 Modulators for Abstract
Sweetness Enhancement
Hi-Res PDF[1729K]
R. W. Bryant, K. S. Atwal, I. Bakaj, M. T. Buber, S. Carlucci, R. Cerne, R. Cortés, H. R. Devantier, C.
J. Hendrix, S. P. Lee, R. K. Palmer, C. Wilson, Q. Yang, and F. R. Salemme PDF w/ Links[1743K]
Chapter 24, pp 386-399
DOI: 10.1021/bk-2008-0979.ch024 Sponsored Access
Enhancers for Sweet Taste from the World of Non-Volatiles: Polyphenols as Taste Abstract
Modifiers
Hi-Res PDF[1059K]
Jakob P. Ley, Maria Blings, Susanne Paetz, Günter Kindel, Kathrin Freiherr, Gerhard E. Krammer,
and Heinz-Jürgen Bertram PDF w/ Links[1068K]
Chapter 25, pp 400-409
DOI: 10.1021/bk-2008-0979.ch025 Sponsored Access
Evaluation of High-Intensity Sweetener Modulators Abstract
Cheryl R. Mitchell, Richard Ray, and Marian Schwartz
Hi-Res PDF[1264K]
Chapter 26, pp 410-419
DOI: 10.1021/bk-2008-0979.ch026 PDF w/ Links[1265K]
Sponsored Access
Improving the Taste of Artificial Sweeteners Using Flavors Abstract
Masashi Ishikawa, Akio Nakamura, Ayano Fujiki, Junichi Ide, and Kensaku Mori
Hi-Res PDF[1392K]
Chapter 27, pp 420-429
DOI: 10.1021/bk-2008-0979.ch027 PDF w/ Links[1395K]
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ADVANCES IN THE DISCOVERY AND COMMERCIAL DEVELOPMENT OF SYNTHETIC NON-CALORIC SWEETENERS
Why Should an Organic Chemist Study Sweet Taste? Abstract
Angela Bassoli, Gigliola Borgonovo, Gilberto Busnelli, and Gabriella Morini
Hi-Res PDF[1728K]
Chapter 28, pp 432-443
DOI: 10.1021/bk-2008-0979.ch028 PDF w/ Links[1733K]
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Sweeteners and Sweetness Modulators: Requirements for Commercial Viability Abstract
Grant E. DuBois
Hi-Res PDF[2910K]
Chapter 29, pp 444-462
DOI: 10.1021/bk-2008-0979.ch029
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Development of New, Low Calorie Sweetener: New Aspartame Derivative Abstract
Yusuke Amino, Kenich Mori, Yasuyuki Tomiyama, Hiroyuki Sakata, and Takeshi Fujieda
Hi-Res PDF[1650K]
Chapter 30, pp 463-480
DOI: 10.1021/bk-2008-0979.ch030 PDF w/ Links[1655K]
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Challenges to Reducing Sugar in Foods Abstract
D. Kilcast, C. den Ridder, and C. Narain
http://w3.hidemyass.com/index.php?q=aHR0cDovL3B1YnMuYWNzLm9yZy9pc2Ju... 23/10/2009