Supplement Reference Guide 1st Edition 2009 SSRRGG- iCnotevrenra.iln.idndd d 1 1 57/1/234/0/099 1 11::0429::4058 PAMM Supplement Reference Guide First Edition 2009 Statements found in this guide have not been evaluated by the FDA. dotFIT products are not intended to treat, cure or prevent any disease. ©2009 dotFIT, LLC. 250 N. Westlake Blvd. Ste. 220 Westlake Village, CA 91362 877.4dotFIT (877.436.8348) www.dotFIT.com 2SupSpRG 1lst Eeditmion 20e09.nt R© deotFIfT Weorrldweidencew wGw.duotFIiT.dcome SRG internal.indd 2 7/24/09 1:02:48 PM Supplement Reference Guide Table of Contents Introduction ........................................................................................................................................ 5 About dotFIT™ ........................................................................................................................ 5 dotFIT Worldwide Faculty & Advisory Board ......................................................................... 6 Position on Use, Recommendation & Manufacture of Dietary Supplements ....................... 6 Position on Overall Dietary Supplement Use & Recommendations ...................................... 6 Position on Use of Supplements for Health ........................................................................... 7 Position on Use of Supplements in Support of Weight Control ............................................ 7 Position on Use of Supplements for Enhancing Performance ............................................... 8 Position on Final Individual Recommendations ..................................................................... 8 Position on Manufacturing and Facts Regarding dotFIT Products ......................................... 8 Product Testing Documentation ............................................................................................ 10 Product Evaluation Guidelines and Scoring ........................................................................... 10 The Products ....................................................................................................................................... 13 Definitions .............................................................................................................................. 13 Dietary Supplements for Health ........................................................................................................ 15 health dotFIT ...................................................................................................................................... 15 Multivitamin & Mineral Formulas .......................................................................................... 15 ActiveMV Formula .................................................................................................................. 20 Women’sMV Formula ............................................................................................................ 20 Over50MV Formula ................................................................................................................ 21 VegetarianMV Formula .......................................................................................................... 21 PrenatalMV Formula .............................................................................................................. 24 KidsMV Formula ..................................................................................................................... 28 SuperCalcium+ ........................................................................................................................ 31 SuperiorAntioxidant ............................................................................................................... 35 Joint Flexibility Plus ................................................................................................................ 40 SuperOmega-3 ........................................................................................................................ 44 Advanced Brain Health ........................................................................................................... 49 Fitness & Performance-Enhancing Dietary Supplements ................................................................ 54 weight loss dotFIT ............................................................................................................................... 54 FatReleaser FatRelease .......................................................................................................... 55 CarbKiller/CarbRepel ............................................................................................................... 59 ThermoShock/ThermAccel ...................................................................................................... 62 LeanMR Drink Mix .................................................................................................................. 70 performance dotFIT ............................................................................................................................ 68 CreatineMonohydrate ............................................................................................................ 69 CreatineXXL ............................................................................................................................ 79 NO7Rage ................................................................................................................................. 84 WorkoutExtreme ..................................................................................................................... 91 Recover&Build ........................................................................................................................ 96 AminoBoostXXL ...................................................................................................................... 100 MuscleDefender ..................................................................................................................... 108 2 3 SRG 1st Edition 2009. © dotFIT Worldwide www.dotFIT.com SRG internal.indd 3 7/24/09 1:02:51 PM Supplement Reference Guide nutrition dotFIT .................................................................................................................................. 112 Ready-to-Eat Baked Goods ................................................................................................................ 119 Iced Lemon Vanilla Protein Stick ............................................................................................ 120 Iced Peanut Butter Delight Protein Stick ................................................................................ 122 Iced Oatmeal Blueberry Breakfast Bar .................................................................................... 124 Iced Oatmeal Strawberry Breakfast Bar .................................................................................. 126 Triple Chocolate dotTREAT Creamy Peanut Butter dotTREAT Mocha Meal Replacement Bar Cookie Dough Meal Replacement Bar Chocolate Peanut Butter Crisp Meal Replacement Bar Powdered Mixes ................................................................................................................................. 128 LeanMR Drink Mix ................................................................................................................... 70 Pre/Post Workout Formula & Meal Replacement ................................................................. 130 FirstString ............................................................................................................................... 137 WheySmooth ........................................................................................................................... 140 Quick Reference Guide ....................................................................................................................... 145 Appendix 1: dotFIT™ Position on Vitamin & Mineral Supplementation ............................................ 145 Appendix 2: Three Proven Strategies for Weight Reduction, Maintenance of Weight Loss and Prevention of Weight Gain .................................................................................. 152 Appendix 3: Xtreme Muscle Stack: Creating the Perfect Anabolic Storm .......................................... 156 References .......................................................................................................................................... 168 Figure References Figure 1 - Glucosomine for Pain Control Study ................................................................................... 40 Figure 2 - Adverse Event Data, Pain Control Study ............................................................................. 41 Figure 3 - Rhododendron Weight Loss Study ...................................................................................... 56 Figure 4 - Phase 2® Weight Loss Study ............................................................................................... 59 Figure 5 - Caffiene/EGCG Study .......................................................................................................... 63 Figure 6 - Fat Oxidization in Caffiene/EGCG Study ............................................................................. 63 Figure 7 - Loleptin Weight Loss Study ................................................................................................. 64 Figure 8 - Meal Replacements & Weight Maintenance Figure 9 - Meal Replacements & Weight Loss Figure 10 - Creatine & High Intensity Exercise .................................................................................... 70 Figure 11 - Creatine Performance Study ............................................................................................. 72 Figure 12 - Creatine/LBM Study .......................................................................................................... 73 Figure 13 - Creatine/Muscle Hypertrophy Study ................................................................................ 74 Figure 14 - Metabolic Pathway for NO Production ............................................................................. 85 Figure 15 A & B - Caffiene and Performance ....................................................................................... 92 Figure 16 - Plasma Creatine Kinase ...................................................................................................... 109 Figure 17 - Plasma Glutamine Levels ................................................................................................... 109 Figure 18 - Meal Replacements & Weight Loss .................................................................................. 112 Figure 19 - Meal Replacements & Weight Maintenance .................................................................... 112 3 4 SRG 1st Edition 2009. © dotFIT Worldwide www.dotFIT.com SRG internal.indd 4 7/24/09 1:02:55 PM Supplement Reference Guide Figure 20 - Pre/Post Snacks and Training Results ............................................................................... 115 Figure 21 A & B - Meal Replacements & Weight Loss ......................................................................... 131 Figure 22 - Pre/Post Snacks and Training Results ............................................................................... 133 Figure 23 - Insulin Response to Post-Workout Drinks ........................................................................ 141 Figure 24 - Ultimate Goal of Nutrient Augmentation ......................................................................... 149 Figure 25 - Effectiveness of Regular Weighing .................................................................................... 153 Figure 26 - Meal Replacements & Weight Loss .................................................................................. 155 Figure 27 - Meal Replacements & Weight Maintenance .................................................................... 155 Figure 28—Pre/Post Snacks and Training Results ............................................................................... 160 Table References Table 1—Product Evaluation Score ..................................................................................................... 12 Table 2—Multivitamin & Mineral Formulas ....................................................................................... 18 Table 3—dotFIT™ Multivitamin & Mineral Recommendations .......................................................... 19 Table 4—Safe and Probable Optimal Range ....................................................................................... 23 Table 5—CreatineXXL™ Intake Recommendations ............................................................................ 81 Table 6—Toxicity in Animals ............................................................................................................... 105 Table 7—Safe and Probable Optimal Range ....................................................................................... 150 Table 8-- Sample Anabolic Diet Plan ................................................................................................... 163 Table 9—Maximal Protein Synthsis Periodization .............................................................................. 165 Table 10—CreatineXXL™ Strategy ...................................................................................................... 166 4 5 SRG 1st Edition 2009. © dotFIT Worldwide www.dotFIT.com SRG internal.indd 5 7/24/09 1:02:58 PM Introduction Supplement Reference Guide SRG internal.indd 6 7/24/09 1:03:00 PM Supplement Reference Guide Introduction About dotFIT Worldwide The group of individuals and organizations that make up dotFIT Worldwide www.dotfitww.com created the first and most successful complete nutrition/weight control and exercise program used by fitness professionals around the world. dotFIT Worldwide offers • Science-based research and support See dotFIT Worldwide Faculty & Advisory Board below o • Education and certification from The National Academy of Sports Medicine (NASM) The market leader in Fitness, Sports Medicine and Sports Performance credentials o NASM activates over 25,000 credentials annually with over 100,000 professionals o worldwide Works with over 6,000 health clubs and all professional sports organizations o • Evidence-based tools and applications R&D and support for nutrition/weight control and exercise programming for all ages o and goals Web-based, client- and trainer-centric programming: exercise, menu plans with o supplement screening, continuous feedback to client and/or trainer based on measurement inputs and goal • Worldwide professional delivery network Live fitness professionals as well as phone and e-coaching platforms o • Programs can connect to body sensing/tracking devices Calorie expenditure, steps, physical activity, etc. o • Unlimited education: For consumers and professionals via website, live webinars, certifications, and direct access to R&D team via our toll-free phone number (877.436.8348) • Complete, holistically integrated line of pharmaceutically manufactured dietary supplements and fitness foods including home delivery platform 5 5 SRG 1st Edition 2009. © dotFIT Worldwide www.dotFIT.com SRG internal.indd 5 7/27/09 8:32:21 AM Supplement Reference Guide dotFIT Worldwide FFaaccuullttyy && AAddvviissoorryy BBooaarrdd ddoottFFIITT WWoorrllddwwiiddee FFaaccuullttyy aanndd AAddvviissoorryy BBooaarrdd NNUUTTRRIITTIIOONN,, DDIIEETTEETTIICCSS AANNDD WWEEIIGGHHTT CCOONNTTRROOLL OOSSTTEEOOPPAATTHHYY AANNDD AANNTTII--AAGGIINNGG MMEEDDIICCIINNEE JJiillll FFaaiirrwweeaatthheerr,, MMSS,, RRDD BBoobb GGoollddmmaann,, PPhhDD,, DDOO NN UU TT RR IIGGTTaaIIOOyy NNRR,ii llDDeeIIyyEE,, TTMMEESSTT,,II CRRCSSDD ,,AA CCNNCCDDNN WW EEIIGGHHTT CCOONNTTRROOLL MEDICAL SCIENCE,, PHARMACEUTICALS AAllaaJnnil lTT Fiittaccihhrweenneaaatllh,, ePPrhh, MDD S, RD IINNSSTTAIINTTDUU TTDIIOOIENNTAAALLR YRR EESLLUAAPTTPIILOOENNMSSHHENIIPPTSSS AANNDD AADDVVIISSOORRYY Gay Riley, MS, RD, CCN RREESSOOUURRJCCimEE SSS tarr-Kalafat KKaattAhhlllaeenee Tnni tBBcaahrreeenffaiilee, llPddh,, DMMSS,, RRDD,, PPEESS,, NNAASSMM-- CCPPTT Timothy Ziegenfuss, PhD, CSCS, EPC Kat Barefield, MS, RD, NASM-CPT & PES, UUnnMiivveeicrrhssaiitteyyl Ooovff iNNedooorr,tt Mhh CCS,aa NrrooAllSiinnMaa- PES, CSCS Dr. Steven Shassberger, DO ACSM-HFS AArriizzoonnaa SScchhooooll ooff HHeeaalltthh SScciieenncceess EEXXEERRCCIISSEE SSCCIIEENNCCEE,, PPHHYYSSIICCAALL TTHHEERRAAPPYY Robinson Pharma, Inc. – AANNDD PPEERRFFOORRMMAANNCCEE EENNHHAANNCCEEMMEENNTT NNeellllssoonnPP hhNNauurmttrraaaccceeeuuutttiiciiccaaallllllyss//,,dd IIrnnuccg..- lliicensedd ffaciilliity, TTeexxaass WWincoolmmudeeinnng''ss s UUcinneniivvtieefirrcss iiattdyyv isory board E X E R C RRISiiccEhh SaaCrrddIE SSNttCeeEww,aa PrrHtt,, YMMSISSC,, ANNLAA TSSHMME--RCCAPPTTP,,Y PP EESS AND PERFORMANCE ENHANCEMENT UUnniivveerrhssiittttyyp :oo//ff wHHwaawww.aaroiiiib insonpharma.com/ NNaattiioonnaall AAccaaddeemmyy ooff SSppoorrttss MMeeddiicciinnee Richard Stewart, MS, NASM-CPT, PES National Academy of Sports Medicine INSTITUTIONAL RELATIONSHIPS AND ADVISORY NNAATTIIOONNAALL AACCAADDEEMMYY OOFF SSPPOORRTTSS MMEEDDIICCIINNEE NNUUTTRRIITTIIOONN AANNDD EEXXEERRCCIISSEE IINNSSTTRRUUCCTTOORRSS RREESSOOUURRCCEESS N U T R ISSTccIooOttNtt PPAuuNllllDee nnE XMMESSR,, CCCIEESSSE,, IPPNEESSST R UCTORS DDrrU.. MMniviiccehhrseeiaatyll oAAf.. NCCollaartrrhkk ,,C DDaPProTTl,,i nMMaSS,, PPTT,, PPEESS Arizona School of Health Sciences NNaaSttiicooonnttaa Pll AAulccleaandd eeMmmS,yy C ooEffS SS, ppPooErrSttss MMeeddiicciinnee ssttaaffff DDrrU.. DDniaavrreiirnns iPPtyaa ddofuu Haa,,a PPwhhaDDii,, AATTCC National Academy of Sports Medicine staff DDrr.. KKeevviinn GGuusskkiieewwiicczz,, PPhhDD,, AATTCC DDrr.. SStteevvee MMaarrsshhaallll,, PPhhDD MMEEDDIICCAALL SSCCIIEENNCCEE,, PPHHAARRMMAACCEEUUTTIICCAALLSS OSTEOPATHY, CHIROPRACTIC AND ANTI-AGING AANNDD DDIIEETTAARRYY SSUUPPPPLLEEMMEENNTTSS MEDICINE NCCAOOTMMIOMMNAAALNN ADDC NNAUUDETTRRMIITTYII OOOFNN SAAPLLOSS RTS MEDICINE JJiimm BSSottbaa rrGrr--oKKldaamllaaaffaantt, P hD, DO Dr. Micheal A. Clark, DPT, MS, PT, PES TTiimmEoorttihhc yyP lZZaiiseekggeeer,nn DffuuCssss,, PPhhDD,, CCSSCCSS,, EEPPCC hhttttDpp::r//. //Dwwawwrinww P..ccaoodmmuamm, PaahnnDdd,nn AuuTttCrriittiioonnaallss..ccoomm// Dr. Kevin Guskiewicz, PhD, ATC MMiicchhaaeell OOvviieeddoo,, MMSS,, NNAASSMM--PPEESS,, CCSSCCSS Dr. Steve Marshall, PhD Your Fitness. Connected. ddoottFFIITT WWoorrllddwwiiddee’’ss PPoossiittiioonn oonn UUssee,, RReeccoommmmeennddaattiioonnss && MMaannuuffaaccttuurree ooff DDiieettaarryy SSuupppplleemmeennttss TThhee ffuunnccttiioonn ooff ddiieettaarryy ssuupppplleemmeenntt pprreeppaarraattiioonnss iiss ttoo pprroovviiddee aa ssaaffee vveehhiiccllee ffoorr ddeelliivveerriinngg pprreecciissee aammoouunnttss ooff ddeessiirreedd iissoollaatteedd nnuuttrriieennttss aanndd ccoommppoouunnddss iinn aa llooww ttoo nnoo ccaalloorriiee ffoorrmm wwiitthh tthhee ppuurrppoossee ooff eennhhaanncciinngg hheeaalltthh,, ssppoorrtt aanndd ffiittnneessss ggooaallss,, ii..ee.. ddiieettaarryy ssuuppppoorrtt.. IInnddiivviidduuaall oouuttccoommeess ffrroomm tthhee uussee ooff ddiieettaarryy ssuupppplleemmeennttss,, aass wwiitthh ddrruuggss,, aarree pprreeddiiccaatteedd oonn tthhee pphhyyssiioollooggiiccaall aanndd ppssyycchhoollooggiiccaall ssttaattee ooff tthhee rreecciippiieenntt aass wweellll aass ddoossaaggeess,, rreeggiimmeenntt ccoommpplliiaannccee,, mmaannuuffaaccttuurriinngg pprroocceesssseess iinncclluuddiinngg tthhee uussee ooff pprrooppeerr ddeelliivveerryy ssyysstteemmss,, aanndd iinnggrreeddiieenntt ffoorrmmss oorr oorriiggiinnss.. PPoossiittiioonn oonn oovveerraallll ddiieettaarryy ssuupppplleemmeenntt uussee aanndd rreeccoommmmeennddaattiioonnss DDiieettaarryy ssuupppplleemmeenntt pprroodduuccttss mmuusstt bbee 110000%% ddeeffeennssiibbllee tthhrroouugghh sscciieennttiiffiicc rreesseeaarrcchh,, nnoott uusseedd ttoo ttrreeaatt mmeeddiiccaall ccoonnddiittiioonnss aanndd oonnllyy rreeccoommmmeennddeedd iinn ssuuppppoorrtt ooff tthhee ffoolllloowwiinngg ggooaallss:: 66 6 SRG 1st Edition 2009. © dotFIT Worldwide www.dotFIT.com SRG internal.indd 6 7/24/09 1:03:07 PM Supplement Reference Guide • Preserving health Objective: potentially stave off chronic or age-related disease by improving the daily o nutrient intake achieved through diet alone • Safely enhance sport and fitness outcomes Objective: hasten and support fitness/weight control goals o Objective: improve training-induced performance results o Position on use of supplements for health Multivitamin and mineral formula (MVM): all persons of all ages should use a daily MVM to complement one’s best efforts to define and consume a proper diet.1,2 At a minimum, MVM supplementation is insurance against common and unavoidable shortcomings driven by typical daily diets and local food supply or availability. At best, the daily increased level of all known vital nutrients supplied by the MVM may indeed allow optimal cellular performance. Levels of nutrition delivered by diet combined with a MVM (significantly higher but well within a safe range) has more potential than diet alone (especially within a range of acceptable calories) to supply all cellular entities/enzymes with enough materials to operate at full capacity thus avoiding a potential triage effect that may be at the root of many chronic and age-related diseases.3,4 (see Appendix 1: dotFIT Worldwide’s Position on Vitamin & Mineral Supplementation). Calcium & Vitamin D: supplement if daily needs of calcium (1000-1200mgs/day) and vitamin D (400- 800IUs/day) are not met by food, sunlight and multivitamin mineral formula.5,6 Position on use of supplements in support of weight control Dieting to lose weight is difficult for everyone and generally ends with most of the weight regained within the first year.7,8 The goal of incorporating a dietary supplement or drug into a weight loss program is to assist the participant in complying with the daily routine that leads to weight reduction. The supplement ingredients must have safely demonstrated the potential to act in one or more of the following ways: • Help create and maintain a calorie deficit by increasing daily calorie expenditure when compared to a non-supplemented state • Raise energy levels that may make one more active throughout the day • Reduce the drive to consume food • Decrease calorie absorption The dieter would cease supplementation once the weight goal is reached or when they have their daily routines under control to continue making progress without supplements. 7 7 SRG 1st Edition 2009. © dotFIT Worldwide www.dotFIT.com SRG internal.indd 7 7/24/09 1:03:11 PM Supplement Reference Guide Position on use of supplements for enhancing performance Maximizing potential during high-level competition involves athletes exploiting all available resources – some good and some bad. In the 2008 Olympics, 90% of the 11,000 athletes reported regularly using dietary supplements. There was not a single supplement contamination case, giving a “thumbs up” to the dietary supplement industry for making safe, unadulterated substances.9 There is unequivocal evidence that a limited number of natural substances prepared and ingested properly can safely improve training-induced size or performance for many athletes.10,11 Historically, however, athletes have had a tendency to not follow directions. Many subscribe to the old adage, “if a little works, more is better.” The practice of overconsumption of anything—such as foods, dietary compounds, and drugs—can lead to problems. On the other hand, proper supplementation for performance has often been shown to generate truly remarkable benefits, and this in itself can save many athletes from turning to illegal anabolic steroid use, which has well-known, harmful side effects. Present rationale to avoid training plateaus or improve performance and size by using a nutritional strategy centers around findings that the extent of negative protein balance induced by exercise appears to remain constant throughout a prolonged training regimen.12 Consequently, repeated exercise sessions continue to provide opportunity or “open the door” for positive muscle reorganization. Therefore, when the benefits of training and diet on muscle mass and performance have stabilized, specific nutrient supplement regimens may play a role in plateau avoidance and progressive development for some athletes. Position on final individual recommendations All dotFIT programs prepared by dotFIT Worldwide are designed to screen individuals based on physical characteristics and goals in order to safely and properly integrate dietary supplements into their fitness programs to accomplish the above stated outcomes. Position on manufacturing and facts regarding dotFIT™ products Before nutritional compounds become products or are recommended for consumer use, all ingredients must survive rigorous legal and scientific review and testing. The following conditions are met: • Identify best, current clinical research supporting use (evidence-based) • Identify data supporting safety and efficacy including long-term empirical data (see Table 1 below and Evaluation Guidelines) • Identify proper ingredient dosage and forms 8 8 SRG 1st Edition 2009. © dotFIT Worldwide www.dotFIT.com SRG internal.indd 8 7/24/09 1:03:14 PM
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