SUDDEN CARDIAC DEATH Developments in Cardiovascular Medicine VOLUME 110 The titles published in this series are listed at the end of this volume. Sudden Cardiac Death edited by A. BAYES DE LUNA Hospital de la Santa Creu i Sant Pau, Barcelona, Spain P.BRUGADA University Hospital, Maastricht, The Netherlands J. eOSIN AGUILAR Hospital La Fe, Valencia, Spain and F. NAVARRO-LOPEZ University of Barcelona, Hospital Clinic, Barcelona, Spain Kluwer Academic Publishers DORDRECHT/LONDON/BOSTON Library of Congress Cataloging-in-Publication Data Sudden cardiac death / edited by A. Bayes de Luna ... [et a1.]. p. cm. - (Developments in cardiovascular medicine; v. 110) ISBN -13: 978-94-010-6745-4 e-ISBN-13 :978-94-009-0573-3 DOl: 10.1007/978-94-009-0573-3 1. Cardiac arrest. I. Bayes de Luna, Antonio. II. Series. [DNLM: 1. Arrhythmia. 2. Death, Sudden. 3. Heart Arrest. WI DE997VME v. 110 /WG 205 S94 124] RC685.C173S77 1990 616.1 '23'025-dc20 DNLM/DLC for library of Congress 90-4217 CIF ISBN -13: 978-94-010-6745-4 Published by Kluwer Academic Publishers, P.O. Box 17, 3300 AA Dordrecht, The Netherlands. Kluwer Academic Publishers incorporates the publishing programmes of Martinus Nijhoff, Dr W. Junk, D. Reidel and MTP Press. Sold and distributed in the U.S.A. and Canada by Kluwer Academic Publishers, 101 Philip Drive, Norwell, MA 02061, U.S.A. In all other countries, sold and distributed by Kluwer Academic Publishers Group, P.O. Box 322, 3300 AH Dordrecht, The Netherlands. Printed on acid-free paper All Rights Reserved © 1991 by Kluwer Academic Publishers Softcover reprint of the hardcover 1st edition 1991 No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission from the copyright owner. Table of contents Preface ix List of contributors xi 1. Sudden cardiac death 1990: An update by A. Bayes de Luna, J. Guindo, J. Bartolucci, P. Tomer, M. Dominguez, and R. Oter 1 2. Epidemiology of sudden cardiac death by A.J. Moss 13 3. Out-of-hospital sudden death in Spain by J. Cosin Aguilar 19 4. Thrombosis, antithrombotic therapy and sudden death by J.H. Ip and V. Fuster 31 5. The potential for antiarrhythmic drugs to reduce mortality from sudden cardiac death by J.Th. Bigger, Jr. 41 6. Value of beta-blockers in the treatment of ventricular arrhythmias by N. Rehnqvist 63 7. Psychological stress and sudden cardiac death by S. Garcia-Sanchez, J. Guindo and A. Bayes de Luna 71 8. Acute and chronic components of ischaemia in acute ischaemic syndromes by A. Maseri 83 vi Table of contents 9. Markers and trigger mechanisms of sudden cardiac death: Excercise and sports activity by F. Furlanello, R. Bettini, G. Vergara, A. Bertoldi, M. Del Greco, G.B. Durante and L. Frisanco 87 10. Lessons from recordings of sudden death by Holter monitoring by J.-F. Leclercq and Ph. Coumel 99 11. Profile of the candidate for sudden cardiac death by R.W.F. Campbell 113 12. Sudden death in patients with intraventricular conduction disorders by H.E. Kulbertus 121 13. Acute drug test by A. Bayes de Luna, J. Guindo, S. Garda-Sanchez, P. Tomer and R. Oter 127 14. Malignant ventricular arrhythmias: Serial electrophysiologic testing by J. Almendral and A. Arenal 135 15. Non pharmacological treatment of ventricular tachycardia by H.-J. Trappe, H. Klein, G. Frank, P. Wenzlaff and P.R. Lichtlen 147 16. Fulguration of chronic ventricular tachycardia. Results on 53 consecu- tive cases with a follow-up ranging from 8 to 70 months by G. Fontaine, R. Frank, J. Tonet, I. Rougier, G. Farenq, G. Lascault and Y. Grosgogeat 163 17. Transcoronary chemical ablation of tachycardias by P. Brugada, H. de Swart, J.L.R.M. Smeets and H.J.J. Wellens 179 18. Sudden death and the autonomic nervous system: The prognostic value of heart rate variability by Ph. Coumel and J.-P. Deschamps 191 19. Ventricular electrical instability: Markers and trigger mechanisms by G. Breithardt, M. Borggrefe, A. Martinez-Rubio 209 20. Risk factors of sudden cardiac death after acute myocardial infarction: Ventricular disfunction, ischemia and ventricular arrhythmias by F. Navarro-Lopez 223 21. Acute non-Q wave myocardial infarction: A summary of the diltiazem reinfarction study (DRS) and the multicenter diltiazem post-infarction trial (MDPIT) by W.E. Boden and R.E. Kleiger 239 Table of contents vii 22. Treatment of heart failure: Impact on sudden death by J. Guindo, A. Bayes de Luna, P. Tomer, J. Bartolucci and R. Estiarte 255 23. Can sudden death be avoided by timely revascularization of obstructed coronary arteries? by P.G. Hugenholz and J.R.T.C. Roelandt 267 24. Sudden cardiac death: A multifactorial problem by H.J.J. Wellens and P. Brugada 285 25. Final conclusions by P. Puech 297 Index 299 Preface Sudden death is probably the greatest challenge facing modem cardiology today. This is mainly due to the impact of its brusque appearance and the socioeconomic implications. The incidende is presently decreasing somewhat, mainly due to the decline in new cases of ischemic heart disease on one hand, and to better preven tion in risk patients on the other. Nevertheless, the figures are still high and represent over 300.000 patients per year in the United States alone. This book is an updating of the problem of sudden death from a multifactorial standpoint. It includes not only electrophysiologic data but also covers aspects ranging from epidemiology to prevention. Risk markers and triggering mechanicsms of sudden death are reviewed, with special emphasis on the role of electrical instability, ischemia and depressed ventricular function. The book includes the contributions from many experts, often pioneers in their respective fields. It is our hope that the book serves as an Updating for those cardiologist who are not specialized in these subjects, but may also be of interest to the expert. We wish to express our sincerest gratitude to the authors for sending in their work so promptly, and also Kluwer Academic Publishers for their exactitude and perfection in this edition. Barcelona, September 1990 The Editors List of contributors J. ALMENDRAL Servico de Cardiologia, Hospital Gral. 'Gregorio Marafi6n', Madrid, Spain Chapter 14 co-author: A. ARENAL A. BAYES DE LUNA Department of Cardiology, Hospital de la Santa Creu i Sant Pau, University of Barcelona, Avda. San Antonio Maria Claret 167, Barcelona 08025, Spain Chapter 1 co-authors: J. GUINDO, J. BARTOLUCCI, P. TORNER, M. DOMIN GUEZ and R. OTER Chapter 13 co-authors: J. GUINDO, S. GARdA-sANCHEZ, P. TORNER and R. OTER J.Th. BIGGER, Jr. Arrhythmia Control Unit, Columbia-Presbyterian Medical Center, 630 West 168th Street, New York, NY 10032/401 East 86th Street, New York, NY 10028, USA Chapter 5 W.E.BODEN Division of Cardiology, Department of Internal Medicine, Harper Hospital, 3990 John R. Street, Detroit, MI 48021, USA Chapter 21: co-author: R.E. KLEIGER G. BREITHARDT Medizinische Klinik und Poliklinik, Innere Medizin C (Kardiologie, Angiologie), WestfaIische Wilhelms-Universitiit, Albert-Schweitzer-Str. 33, D-4400 Miinster, Germany Chapter 19 co-authors: M. BORGGREFE and A. MARTiNEZ-RUBIO P.BRUGADA Department of Cardiology, Academic Hospital, University of Limburg, P.O. Box 1918,6201 BX Maastricht, The Netherlands Chapter 17 co-authors: H. DE SWART, J.L.R.M. SMEETS and H.J.J WELLENS xii List of contributors R.W.F. CAMPBELL Professor of Cardiology, University of Newcastle upon Tyne, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK Chapter 11 J. COSIN AGUILAR Research Group Spanish Trail on Sudden Death, Hospital 'La Fe', Av de Cam panar 21, 46009 Valencia, Spain Chapter 3 Ph.COUMEL Hopital Lariboisiere, 2 rue Ambroise-Pare, F-75475 Paris, France Chapter 18 co-author: J.-P. DESCHAMPS G.FONTAINE Hopital Jean Rostand, 39-41 rue Jean Le Galleu, F-94200 Ivry, France Chapter 16 co-authors: R. FRANK, J. TONET, I. ROUGIER, G. FARENQ, G. LASCAULT and Y. GROSGOGEAT F. FURLANELLO Divisione di Cardiologia e Centro Aritmologico, Ospedale S. Chiara, 38100 Trento, Italy Chapter 9 co-authors: R. BETTINE, G. VERGARA, A. BERTOLDI, M. DEL GRECO, G.B. DURANTE and L. FRISANCO S. GARciA-sANCHEZ Department of Cardiology, Sant Pau Hospital, Research Foundation Santa Creu i Sant Pau, Barcelona, Spain Chapter 7 co-authors: J. GUINDO and A. BAYES DE LUNA J.GUINDO Departamento de Cardiologfa, Hospital de la Santa Creu i Sant Pau, Universidad Autonoma de Barcelona, Avda. San Antonio Maria Claret 167, Barcelona 08025, Spain Chapter 22 co-authors: A. BAYES DE LUNA, P. TORNER, J. BARTOLUCCI and R. ESTIARTE P.G. HUGENHOLTZ Erasmus University, Rotterdam, The Netherlands Chapter 23 co-author: J.R.T.C. ROELANDT J.H.IP Department of Medicine, Division of Cardiology, The Mount Sinai Medical Center, One Gustave Levi Place, New York, NY 10029, USA Chapter 4 co-author: V. FUSTER
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