Steroids: From Physiology to Clinical Medicine

220 Pages·2016·8.26 MB·English

by  Ostojic S.M. (Ed.)

STEROIDS
FROM
PHYSIOLOGY TO
CLINICAL MEDICINE
Edited by Sergej M. Ostojic
-
STEROIDS - FROM
PHYSIOLOGY TO
CLINICAL MEDICINE
Edited by Sergej M. Ostojic
Steroids - From Physiology to Clinical Medicine
http://dx.doi.org/10.5772/46119
Edited by Sergej M. Ostojic
Contributors
Dai Mitsushima, Hajime Ueshiba, Rosário Monteiro, Cidália Pereira, Maria João Martins, Paul Dawson, Zulma Tatiana
Ruiz-Cortés, Anna Kokavec, Seung-Yup Ku, Sanghoon Lee, Marko D Stojanovic, Sergej Ostojic, Emad Al-Dujaili
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2012 InTech
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Notice
Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those
of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published
chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the
use of any materials, instructions, methods or ideas contained in the book.
Publishing Process Manager Ana Pantar
Technical Editor InTech DTP team
Cover InTech Design team
First published November, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Steroids - From Physiology to Clinical Medicine, Edited by Sergej M. Ostojic
p. cm.
ISBN 978-953-51-0857-3

Contents
Preface VII
Section 1 Physiology and Pathophysiology of Steroids 1
Chapter 1 Gonadal Sex Steroids: Production, Action and
Interactions in Mammals 3
Zulma Tatiana Ruiz-Cortés
Chapter 2 The Biological Roles of Steroid Sulfonation 45
Paul Anthony Dawson
Chapter 3 Hippocampal Function and Gonadal Steroids 65
Dai Mitsushima
Chapter 4 11β-Hydroxysteroid Dehydrogenases in the Regulation of
Tissue Glucocorticoid Availability 83
Cidália Pereira, Rosário Monteiro, Miguel Constância and Maria
João Martins
Section 2 Steroids: Clinical Application 107
Chapter 5 Sex Steroid Production from Cryopreserved and
Reimplanted Ovarian Tissue 109
Sanghoon Lee and Seung-Yup Ku
Chapter 6 Female Salivary Testosterone: Measurement, Challenges
and Applications 129
E.A.S. Al-DujailI and M.A. Sharp
Chapter 7 Limits of Anabolic Steroids Application in
Sport and Exercise 169
Marko D. Stojanovic and Sergej M. Ostojic
VI Contents
Chapter 8 Steroidogenic Enzyme 17,20-Lyase Activity in Cortisolsecreting
and Non-Functioning Adrenocortical Adenomas 187
Hajime Ueshiba
Chapter 9 Salivary or Serum Cortisol: Possible Implications
for Alcohol Research 199
Anna Kokavec
Preface
Understanding complex mechanisms of action and key roles in different biological processes
in the body has moved steroid science and medicine to expand rapidly in the past decades.
Dozens of distinct steroids are identified as both control and target molecules, with
regulation of physiological and pathophysiological steroidogenesis recognized as one of the
essential research topics in the field. On the other hand, steroids have been practiced as both
medical agents and clinical markers for many purposes, from bone marrow stimulation to
growth monitoring. This book covers contemporary basic science on steroid research, along
with steroid practical application in endocrinology and clinical medicine.
The book is divided in two parts. The first part deals with physiological and
pathophysiological roles of steroids, with reference to production and action of gonadal
steroids, role of steroid sulfonation in mammalian growth and development, sex specific
and steroids-dependent mechanism of hippocampal function, and the importance of
hydroxysteroid dehydrogenases for the modulation of tissue glucocorticoid availability. The
second part will cover different aspects of steroids application in clinical environment.
Topics covered in the second part include the endocrine function after ovarian
transplantation in terms of sex steroid production from the cryopreserved and reimplanted
ovaries, the diagnostic significance of collection, storage and measurement of androgens in
saliva of females, main drawbacks of steroids use in sport and exercise, analysis of serum
steroid hormone profiles in patients with adrenocortical tumors, and correlation between
salivary and serum cortisol responses after alcohol intake.
In response to the need to address novel and valuable information on steroids science and
medicine, we sincerely hope that this book will enable readers to comprehend this fast-
growing and exciting scientific field.
Sergej M. Ostojic, MD, PhD
Professor of Biomedical Sciences in Sport & Exercise
Center for Health, Exercise and Sport Sciences, Belgrade
Faculty of Sport and Physical Education, University of Novi Sad
Serbia

Section 1
Physiology and Pathophysiology of Steroids