Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SBRT)

351 Pages·2018·80.426 MB·English

by  Joseph M. Herman, Mohammed Saiful Huq, Dwight E. Heron

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STEREOTACTIC RADIOSURGERY AND E
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STEREOTACTIC BODY RADIATION THERAPY (SBRT) C
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Dwight E. Heron, MD, MBA, FACRO, FACR IO STEREOTACTIC
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M. Saiful Huq, PhD, FAAPM, FInstP U
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Joseph M. Herman, MD, MSc, MHCM, FACR E
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Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SBRT) is a comprehensive guide for the practicing D

physician and medical physicist in the management of complex intracranial and extracranial disease. It is a state-of- S
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the-science book presenting the scientific principles, clinical background and procedures, treatment planning, and E
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treatment delivery of SRS and SBRT for the treatment of tumors throughout the body. This unique textbook is enhanced E
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with supplemental video tutorials inclusive to the resource. TA AND STEREOTACTIC BODY
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radiobiological principles that govern treatment, imaging, the treatment planning process, technologies and O
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equipment used, as well as focused chapters on quality assurance, quality management, and patient safety. Part II
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contains the clinical application of SRS and SBRT for tumors throughout the body including those in the brain, head R RADIATION THERAPY (SBRT)
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and neck, lung, pancreas, adrenal glands, liver, prostate, cervix, spine, and in oligometastatic disease. Each clinical D
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chapter includes an introduction to the disease site, followed by a thorough review of all indications and exclusion A
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criteria, in addition to the important considerations for patient selection, treatment planning and delivery, and O
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outcome evaluation. These chapters conclude with a detailed and site-specific dose constraints table for critical
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structures and their suggested dose limits.
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International experts on the science and clinical applications of these treatments have joined together to assemble
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this must-have book for clinicians, physicists, and other radiation therapy practitioners. It provides a team-based (
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approach to SRS and SBRT coupled with case-based video tutorials in disease management, making this a unique
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companion for the busy radiosurgical team. )
Key Features:
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n Highlights the principles of radiobiology and radiation physics underlying SRS and SBRT e
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n P resents and discusses the expected patient outcomes for each indicated disease site and condition including n

a detailed analysis of Quality of Life (QOL) and Survival
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n Includes information about technologies used for the treatment of SRS and SBRT

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n R ichly illustrated with over 110 color images of the equipment, process flow diagrams and procedures, u
treatment planning techniques and dose distributions q Dwight E. Heron | M. Saiful Huq | Joseph M. Herman

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n 7 high-quality case videos reviewing anatomy, staging, treatment simulation and planning, contouring, and

management pearls H
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n D ose constraint tables at the end of each clinical chapter listing critical structures and their appropriate r
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dose limits
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n Includes access to the fully-searchable downloadable eBook
Recommended
Shelving Category:
Oncology
An Imprint of Springer Publishing
11 W. 42nd Street
New York, NY 10036-8002
www.springerpub.com 9 780826 168566
Stereotactic Radiosurgery
and Stereotactic Body
Radiation Therapy (SBRT)
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Stereotactic Radiosurgery
and Stereotactic Body
Radiation Therapy (SBRT)
Editors
Dwight E. Heron, MD, MBA, FACRO, FACR
Chairman, Department of Radiation Oncology, UPMC Hillman
Cancer Center–Shadyside
Professor of Radiation Oncology, Otolaryngology, and Head and Neck Surgery
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania
M. Saiful Huq, PhD, FAAPM, FInstP
Professor of Radiation Oncology
Director, Division of Medical Physics
Department of Radiation Oncology
UPMC Hillman Cancer Center
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania
Joseph M. Herman, MD, MSc, MHCM, FACR
Professor and Division Head ad Interim
Department of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas
An Imprint of Springer Publishing
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Visit our website at www.Springerpub.com
ISBN: 9780826168566
ebook ISBN: 9780826168573
Acquisitions Editor: David D’Addona
Compositor: Graphic World
Copyright © 2019 Springer Publishing Company.
Demos Medical Publishing is an imprint of Springer Publishing Company, LLC.
All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system,
or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without
the prior written permission of the publisher.
Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in
particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made
every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of
production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions
or for any consequences from application of the information in this book and make no warranty, expressed or implied,
with respect to the contents of the publication. Every reader should examine carefully the package inserts accompa-
nying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications
stated by the manufacturer differ from the statements made in this book. Such examination is particularly important
with drugs that are either rarely used or have been newly released on the market.
Library of Congress Cataloging-in-Publication Data
Names: Heron, Dwight E., editor. | Huq, M. Saiful (Mohammed Saiful), editor.
Herman, Joseph M., editor.
Title: Stereotactic radiosurgery and stereotactic body radiation therapy
(SBRT) / [edited by] Dwight E. Heron, M. Saiful Huq, Joseph M. Herman.
Description: New York : Demos, [2018] | Includes bibliographical references
and index.
Identifi ers: LCCN 2018026438 (print) | LCCN 2018026700 (ebook) | ISBN
9780826168573 () | ISBN 9780826168566 (hbk. : alk. paper) | ISBN
9780826168573 (eBook)
Subjects: | MESH: Neoplasms--radiotherapy | Radiosurgery | Neoplasms—surgery
Classifi cation: LCC RC271.R3 (ebook) | LCC RC271.R3 (print) | NLM QZ 269 |
DDC 616.99/40642--dc23
LC record available at https://lccn.loc.gov/2018026438
Contact us to receive discount rates on bulk purchases.
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For more information please contact: [email protected]
Publisher’s Note: New and used products purchased from third-party sellers are not guaranteed for quality, authenticity,
or access to any included digital components.
Printed in the United States of America.
18 19 20 21 22 / 5 4 3 2 1
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CONTENTS
Contributors vii 9. Patient Safety 133
Preface xi Peter B. Dunscombe and M. Saiful Huq
Share Stereotactic Radiosurgery and Stereotactic
Body Radiation Therapy (SBRT) Part II: Clinical Applications of SRS and SBRT
Part I: Principles of SRS and SBRT— 10. Brain Radiosurgery 141
Radiobiology, Physics, and Ronny Kalash, Johnathan A. Engh, and
Treatment Planning Nduka Amankulor
1. G eneral Overview of SRS and 11. Head and Neck SBRT 165
SBRT Program 3 John A. Vargo, Shlomo A. Koyfman,
Dwight E. Heron, M. Saiful Huq, and Robert L. Ferris, Dwight E. Heron, and
Annette Quinn Farzan Siddiqui
2. R adiobiology Principles of Radiosurgery 12. Lung SBRT 183
and SBRT 15 Arjun Pennathur, James D. Luketich,
Ellen Yorke, David Carlson, and Dwight E. Heron, Alexandre Escande,
Vitali Moiseenko David Pasquier, and Eric F. Lartigau
3. SRS and SBRT Process 39 13. Pancreas SBRT 201
M. Saiful Huq and Robin Stern Eric D. Miller, Steven A. Burton,
Lauren M. Rosati, and Terence M. Williams
4. Patient Immobilization for SRS
and SBRT 47 14. Adrenal SBRT 215
Ronald J. Lalonde and Priscilla K. Stumpf and Karyn A. Goodman
Richard A. Popple
15. Liver SBRT 227
5. Imaging for SRS and SBRT 53 Yushen Qian, Joseph P. Weiner,
Ronald J. Lalonde and Tianfang Li Everett J. Moding, Nataliya Kovalchuk,
Albert C. Koong, Theodore S. Hong, and
6. Treatment Planning for SRS Daniel T. Chang
and SBRT 65
Ronald J. Lalonde 16. Prostate SBRT 249
Beant S. Gill, Dwight E. Heron,
7. O verview of Technologies for SRS and Sean P. Collins, and Alan J. Katz
SBRT Delivery 73
Laura Padilla and Jatinder R. Palta 17. Gynecologic SBRT 271
Charles Kunos, Ronny Kalash, and
8. Quality Management 103 Sushil Beriwal
Ning Wen, Karen Chin Snyder, Brett Miller,
and Indrin J. Chetty
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vi CONTENTS
18. Spine SBRT 279 21. Stereotactic Radiosurgery and
John A. Vargo, Alina Mihai, Stereotactic Body Radiation Therapy
Johnathan A. Engh, Nduka Amankulor, and Case Videos 331
Steven A. Burton John C. Flickinger, Drew Moghanaki,
Joseph M. Herman, Yushen Qian,
19. SBRT for Oligometastatic Disease 293 Beant S. Gill, John A. Vargo, and
Alina Mihai and Michael T. Milano Alina Mihai
20. Immunoradiosurgery: The Convergence of
Index 333
SBRT and the Immune Response 321
Uzoma K. Iheagwara, David A. Clump, and
Dwight E. Heron
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CONTRIBUTORS
Nduka Amankulor, MD, PhD Peter B. Dunscombe, PhD
Associate Director, Neurosurgical Oncology Program, Professor, Department of Oncology, University of
UPMC, Pittsburgh, Pennsylvania Calgary, Calgary, Alberta, Canada
Assistant Professor, Department of Neurological
Surgery, University of Pittsburgh School of Johnathan A. Engh, MD
Medicine, Pittsburgh, Pennsylvania Director, Neuroendoport Surgery & Neurosurgical
Oncology Program, UPMC, Pittsburgh,
Sushil Beriwal, MD, MBA Pennsylvania
Clinical Professor and Residency Program Director, Associate Professor, Department of Neurological
UPMC Hillman Cancer Center—Radiation Surgery, University of Pittsburgh School of
Oncology, Magee—Womens Hospital of UPMC, Medicine, Pittsburgh, Pennsylvania
Pittsburgh, Pennsylvania
Alexandre Escande, MD
Steven A. Burton, MD Resident Oncologist, Department of Radiation
Associate Professor, Department of Radiation Oncology, Oscar Lambret Comprehensive Cancer
Oncology, UPMC Hillman Cancer Center–Shadyside, Center, Lille, France
Pittsburgh, Pennsylvania ONCOLille and University of Lille, Lille, France
David Carlson, PhD, DABR, FAAPM Robert L. Ferris, MD, PhD
Associate Professor, Department of Therapeutic Director of UPMC Hillman Cancer Center, Chief of
Radiology, Yale University School of Medicine, the Division of Head and Neck Oncologic Surgery,
New Haven, Connecticut Pittsburgh, Pennsylvania
Department of Otolaryngology, Division of Head
Daniel T. Chang, MD and Neck Surgery, UPMC, Pittsburgh,
Professor, Department of Radiation Oncology, Pennsylvania
Stanford University School of Medicine, Stanford,
California John C. Flickinger, MD, FACR
Professor, Department of Radiation Oncology,
Indrin J. Chetty, PhD UPMC Hillman Cancer Center–Shadyside,
Director, Physics Division, Department of Radiation Pittsburgh, Pennsylvania
Oncology, Henry Ford Health System, Detroit, University of Pittsburgh School of Medicine,
Michigan Pittsburgh, Pennsylvania
David A. Clump, MD, PhD Beant S. Gill, MD
Assistant Professor, Department of Radiation Assistant Professor, Department of Radiation Oncology,
Oncology, UPMC Hillman Cancer Center– UPMC Hillman Cancer Center, Pittsburgh,
Shadyside, Pittsburgh, Pennsylvania Pennsylvania
University of Pittsburgh School of Medicine,
Pittsburgh, Pennsylvania Karyn A. Goodman, MD, MS
Professor of Radiation Oncology, Department of
Sean P. Collins, MD, PhD Radiation Oncology, University of Colorado School
Associate Professor, Department of Radiation of Medicine, Aurora, Colorado
Medicine, Medstar Georgetown University Hospital, Associate Director of Clinical Research, University of
Washington, DC Colorado Cancer Center, Aurora, Colorado
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viii CONTTRIBUTORS
Joseph M. Herman, MD, MSc, MHCM, FACR Charles Kunos, MD, PhD
Professor and Division Head ad Interim, Medical Offi cer, Investigational Drug Branch,
Department of Radiation Oncology, The University Cancer Therapy Evaluation Program, Division
of Texas MD Anderson Cancer Center, Houston, of Cancer Treatment and Diagnosis, National
Texas Cancer Institute, National Institutes of Health,
Rockville, Maryland
Dwight E. Heron, MD, MBA, FACRO, FACR
Chairman, Department of Radiation Oncology, Ronald J. Lalonde, PhD, DABR
UPMC Hillman Cancer Center–Shadyside, Associate Professor, Department of Radiation
Pittsburgh, Pennsylvania Oncology, Division of Medical Physics,
Professor of Radiation Oncology, Otolaryngology UPMC Hillman Cancer Center, Pittsburgh,
and Head and Neck Surgery, University of Pennsylvania
Pittsburgh School of Medicine, Pittsburgh,
Pennsylvania Eric F. Lartigau, MD, PhD
Professor and General Director, Department of
Theodore S. Hong, MD Radiation Oncology, Oscar Lambret Comprehensive
Associate Professor, Department of Radiation Cancer Center, Lille, France
Oncology, Clark Center for Radiation Oncology, ONCOLille and University of Lille, Lille, France
Massachusetts General Hospital, Boston,
Massachusetts Tianfang Li, PhD
Associate Attending, Medical Physics,
M. Saiful Huq, PhD, FAAPM, FInstP Memorial Sloan Kettering Cancer Center,
Professor of Radiation Oncology, Director, New York, New York
Division of Medical Physics, Department of
Radiation Oncology, UPMC Hillman Cancer Center, James D. Luketich, MD
University of Pittsburgh School of Medicine, Henry T. Bahnson Professor and Chair, Department
Pittsburgh, Pennsylvania of Cardiothoracic Surgery, UPMC, Pittsburgh,
Pennsylvania
Uzoma K. Iheagwara, MD, PhD
Resident Physician, UPMC Hillman Cancer Center— Alina Mihai, MD, MS
Radiation Oncology, Pittsburgh, Pennsylvania Consultant Radiation Oncologist, Department of
Radiation Oncology, Beacon Hospital,
Ronny Kalash, DO Dublin, Ireland
Resident Physician, UPMC Hillman Cancer
Center—Radiation Oncology, Pittsburgh, Michael T. Milano, MD, PhD
Pennsylvania Associate Professor, Department of Radiation
Oncology, University of Rochester School of
Alan J. Katz, MD, JD Medicine and Dentistry, Rochester, New York
Clinican, Flushing Radiation Oncology, Flushing,
New York Brett Miller, MSc
Senior Staff Physicist, Department of Radiation
Albert C. Koong, MD, PhD Oncology, Henry Ford Health System,
Professor and Chair, Department of Radiation Detroit, Michigan
Oncology, The University of Texas MD Anderson
Cancer Center, Houston, Texas Eric D. Miller, MD, PhD
Assistant Professor, Radiation Oncology, The Ohio
Nataliya Kovalchuk, PhD State University Comprehensive Cancer Center,
Associate Staff and Clinical Assistant Professor, Columbus, Ohio
Department of Radiation Oncology, Stanford
University School of Medicine, Stanford, Everett J. Moding, MD, PhD
California Resident, Department of Radiation Oncology,
Stanford University School of Medicine,
Shlomo A. Koyfman, MD Stanford, California
Assistant Professor, Cleveland Clinic Lerner College
of Medicine, Section Head of Head and Neck and Drew Moghanaki, MD, MPH
Skin Cancer Radiation, Departments of Radiation Radiation Oncology Service, Hunter Holmes McGuire
Oncology and Bioethics, Cleveland Clinic, Veterans Affairs Medical Center, Richmond,
Cleveland, Ohio Virginia
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CONTRIBUTORS ix
Vitali Moiseenko, PhD, FCCPM Farzan Siddiqui, MD, PhD
Professor, Department of Radiation Medicine and Vice-Chairman, Department of Radiation Oncology,
Applied Sciences, University of California Henry Ford Health System, Detroit, Michigan
San Diego, La Jolla, California
Karen Chin Snyder, MSc
Laura Padilla, PhD, DABR Senior Associate Physicist, Department of Radiation
Assistant Professor, Department of Radiation Oncology, Oncology, Henry Ford Health System, Detroit,
Virginia Commonwealth University, Richmond, Virginia Michigan
Jatinder R. Palta, PhD, FAAPM, FASTRO, FACR Robin Stern, PhD, FAAPM
Professor and Chair of Medical Physics, Department Professor and Technical Director, Department of
of Radiation Oncology, Virginia Commonwealth Radiation Oncology, University of California, Davis
University, Richmond, Virginia Comprehensive Cancer Center, Sacramento, California
David Pasquier, MD, PhD Priscilla K. Stumpf, MD
Radiation Oncologist, Department of Radiation Oncology, Assistant Professor, Department of Radiation
Oscar Lambret Comprehensive Cancer Center, Lille, Oncology, University of Colorado Cancer Center,
France Aurora, Colorado
ONCOLille and University of Lille, Lille, France
John A. Vargo, MD
Arjun Pennathur, MD, FACS Assistant Professor, Department of Radiation Oncology,
Assistant Professor, Department of Cardiothoracic University of Pittsburgh Cancer Institute, Children’s
Surgery, UPMC, Pittsburgh, Pennsylvania Hospital of UPMC, Pittsburgh Pennsylvania
Department of Radiation Oncology, UPMC Hillman
Cancer Center, University of Pittsburgh School of Joseph P. Weiner, MD
Medicine, Pittsburgh, Pennsylvania Postdoctoral Medical Fellow, Department of Radiation
Oncology, Stanford University School of Medicine,
Richard A. Popple, PhD, FAAPM Stanford, California
Professor, Department of Radiation Oncology, University
of Alabama–Birmingham, Birmingham, Alabama Ning Wen, PhD, MBA
Director, Clinical Physics, Department of Radiation
Yushen Qian, MD Oncology, Henry Ford Health System, Detroit,
Associate Physician, Department of Radiation Michigan
Oncology, Southern California Permanente Medical
Group, Los Angeles, California Terence M. Williams, MD, PhD
Associate Professor, Radiation Oncology, The Ohio
Annette Quinn, RN, MSN State University Comprehensive Cancer Center,
UPMC Hillman Cancer Center, University of Pittsburgh Columbus, Ohio
School of Medicine, Pittsburgh, Pennsylvania
Ellen Yorke, PhD
Lauren M. Rosati Attending Physicist, Department of Medical Physics,
Medical Student, University of South Carolina School Memorial Sloan Kettering Cancer Center, New York,
of Medicine, Columbia, South Carolina New York
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