Stem cell therapeutics for cancer PDF
Preview Stem cell therapeutics for cancer
Stem Cell Therapeutics for Cancer Stem Cell Therapeutics for Cancer Editor Khalid Shah Massachusetts General Hospital Harvard Medical School Boston, Massachusetts, USA Copyright © 2013 by John Wiley & Sons, Inc. All rights reserved Published by John Wiley & Sons, Inc., Hoboken, New Jersey Published simultaneously in Canada No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 750-4470, or on the web at www.copyright.com. 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No warranty may be created or extended by any promotional statements for this work. Neither the publisher nor the author shall be liable for any damages arising herefrom. For general information on our other products and services or for technical support, please contact our Customer Care Department within the United States at (800) 762-2974, outside the United States at (317) 572-3993 or fax (317) 572-4002. Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic formats. For more information about Wiley products, visit our web site at www.wiley.com. Library of Congress Cataloging-in-Publication Data: Stem cell therapeutics for cancer / edited by Khalid Shah. p. ; cm. Includes bibliographical references and index. ISBN 978-1-118-28242-7 (hardback : alk. paper) – ISBN 978-1-118-66033-1 – ISBN 978-1-118-66042-3 – ISBN 978-1-118-66049-2 (mobi) – ISBN 978-1-118-66062-1 I. Shah, Khalid. [DNLM: 1. Neoplasms–therapy. 2. Mesenchymal Stem Cell Transplantation–methods. 3. Mesenchymal Stromal Cells–physiology. 4. Stem Cells–physiology. QZ 266] RC271.C44 616.99′406–dc23 2013010437 Printed in Malaysia 10 9 8 7 6 5 4 3 2 1 Contents Contributors vii Preface xi Section 1 Introduction 1 1 Stem Cell Sources and Their Potential for Cancer Therapeutics 3 Khalid Shah Section 2 Migration and Fate of Stem Cells 11 2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural Precursor Cell Migration 13 Moneeb Ehtesham, Elliot Min, and Rebecca Kasl 3 Tumor Tropism of Mesenchymal Stem Cells 21 Paula Y. P. Lam and Ivy A.W. Ho Section 3 Stem Cell Therapy in Brain Cancer 39 4 Stem Cell-Mediated TRaIl Therapy for Highly aggressive Brain Tumors 41 Khalid Shah 5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade Brain Tumors 57 Cestmir Altaner 6 Role of Naïve Cord Blood Stem Cells in Glioma Therapy 73 Venkata Ramesh Dasari, Kiran Kumar Velpula, and Jasti S. Rao 7 Stem Cell-Based antiangiogenic Therapies for Brain Tumors 87 Navid Redjal and Khalid Shah 8 Treatment of Metastatic Neuroblastoma with Mesenchymal Stem Cell-Based Oncolytic Virotherapy 103 Manuel Ramírez and Javier García-Castro Section 4 Stem Cell Therapy in Other Cancer Types 111 9 Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast Cancer 113 Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu Ishiguro, Deryl Troyer, and Masaaki Tamura 10 Mesenchymal Stromal Cells as Effective Tumor antigen-Presenting Cells in Cancer Therapeutics 127 Raphaëlle Romieu-Mourez and Jacques Galipeau v vi Contents 11 Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast Cancer Treatment 145 Róisín Dwyer 12 Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal Malignancy 159 Emily Keung, Peter J. Nelson, and Claudius Conrad 13 Mesenchymal Stem Cells in Prostate Cancer: Clinical Opportunities 171 Diptiman Chanda and Selvarangan Ponnazhagan 14 Primed Mesenchymal Stromal Cells for Cancer Therapy 187 Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto Pallini, and Giulio Alessandri Section 5 Combinatorial Stem Cell Therapies 203 15 MicroRNa adjuvants in Stem Cell-Based Cancer Therapy 205 Maarten C. J. Anderegg and Maarten F. Corsten 16 Stem Cell-Based Combination Therapies for Cancer: Systemic Delivery of a PI3K/mTOR Inhibitor (PI-103) and Stem Cell-Mediated Delivery of TRaIl in Brain Tumors 219 Tugba Bagci-Onder 17 The Efficacy of Clinically approved agents with Stem Cell-Delivered Therapeutics for Cancer Therapy 235 Hiroaki Wakimoto and Khalid Shah Section 6 Tracking Stem Cells and Stem Cell-Based Therapeutics 245 18 Imaging Migration and Fate of Stem Cells in Experimental Models of Cancer 247 Deepak Bhere and Khalid Shah 19 Multifunctional Molecules for Interrogating Stem Cell-Based Therapeutics 257 Shawn Hingtgen 20 Tracking Cancer-Targeted MSC with PET Imaging 273 Véronique Roelants and Jean-Louis Vanoverschelde Index 289 Color plate is located between pages 244 and 245. Contributors Giulio alessandri Diptiman Chanda Department of Cerebrovascular Department of Pathology Diseases The University of Alabama at Birmingham Fondazione IRCCS Neurological Birmingham, Alabama, USA Institute Carlo Besta Milan, Italy Claudius Conrad Department of Surgery/ Division of Surgical Cestmir altaner Oncology Cancer Research Institute Affiliated Faculty Harvard Stem Cell Institute Slovak Academy of Sciences Massachusetts General Hospital Bratislava, Slovakia and Brigham and Women’s Hospital and Harvard Medical School Cell Transplantation Centre Boston, Massachusetts, USA St. Elisabeth Oncological Institute Bratislava, Slovakia Maarten F. Corsten Meander Medical Center Department of Internal Medicine Maarten C.J. anderegg Amersfoort, The Netherlands Academic Medical Center Department of Surgery Venkata Ramesh Dasari Amsterdam, The Netherlands Department of Cancer Biology and Pharmacology Tugba Bagci-Onder University of Illinois College of Medicine Koç University at Peoria School of Medicine Peoria, Illinois, USA Istanbul, Turkey Róisín Dwyer Deepak Bhere Discipline of Surgery Department of Radiology School of Medicine Massachusetts General Hospital National University of Ireland Galway Harvard Medical School Galway, Ireland Boston, Massachusetts, USA Moneeb Ehtesham arianna Bonomi Department of Neurological Surgery Department of Biomedical, Surgical, Vanderbilt University Medical Center and Dental Sciences Nashville, Tennessee, USA University of Milan Milan, Italy vii viii Contributors Jacques Galipeau Elliot Min Department of Hematology/Oncology Department of Neurological Surgery and Pediatrics Vanderbilt University Medical Center Winship Cancer Institute of Emory Nashville, Tennessee, USA University Atlanta, Georgia, USA Peter J. Nelson Medizische Klinik und Poliklinik IV Javier García-Castro Munich, Germany Instituto de Salud Carlos III Majadahonda, Spain Naomi Ohta Department of Anatomy and Physiology Shawn Hingtgen Kansas State University UNC Eshelman School of Pharmacy Manhattan, Kansas, USA The University of North Carolina at Chapel Hill Roberto Pallini Chapel Hill, North Carolina, USA Institute of Neurosurgery Catholic University School of Medicine Ivy a. W. Ho Rome, Italy Humphrey Oei Institute of Cancer Research Eugenio Parati National Cancer Centre of Singapore Department of Cerebrovascular Diseases Singapore Fondazione IRCCS Neurological Institute Carlo Besta Susumu Ishiguro Milan, Italy Department of Anatomy and Physiology augusto Pessina Kansas State University Department of Biomedical, Surgical, and Manhattan, Kansas, USA Dental Sciences University of Milan Rebecca Kasl Milan, Italy Department of Neurological Surgery Vanderbilt University Medical Center Selvarangan Ponnazhagan Nashville, Tennessee, USA Department of Pathology The University of Alabama at Birmingham atsushi Kawabata Birmingham, Alabama, USA Department of Anatomy and Physiology Manuel Ramírez Kansas State University Pediatric Hematology and Oncology Manhattan, Kansas, USA Hospital Universitario Niño Jesús Madrid, Spain Emily Keung Department of Surgery Jasti S. Rao Brigham and Women’s Hospital Departments of Cancer Biology and Harvard Medical School Pharmacology and Neurosurgery Boston, Massachusetts, USA University of Illinois College of Medicine at Peoria Paula Y. P. lam Peoria, Illinois, USA Humphrey Oei Institute of Cancer Research National Cancer Centre of Singapore Singapore
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